BRAF Gwajin Halitta

Wadatacce

• Menene gwajin kwayar cutar BRAF?
• Me ake amfani da shi?
• Me yasa nake bukatar gwajin kwayar cutar BRAF?
• Abin da ya faru a lokacin BRAF kwayoyin gwajin?
• Shin zan bukaci yin komai don shirya wa gwajin?
• Shin akwai haɗari ga gwajin?
• Menene sakamakon yake nufi?
• Shin akwai wani abin da ya kamata in sani game da gwajin BRAF?
• Bayani

Menene gwajin kwayar cutar BRAF?

Wani gwajin kwayar halittar BRAF yana neman canji, wanda aka fi sani da maye gurbi, a cikin kwayar halittar da ake kira BRAF. Kwayar halitta sune asalin asalin gadon da mahaifinka da mahaifinka suka mallaka.

Kwayar BRAF tana samar da furotin wanda ke taimakawa sarrafa kwayar halitta. An san shi azaman oncogene. Oncogene yana aiki kamar feda gas akan mota. A yadda aka saba, oncogene kan kunna ci gaban kwayar halitta kamar yadda ake buƙata. Amma idan kana da maye gurbi na BRAF, to kamar feda mai ya makale ne, kuma kwayar halittar ba zata iya hana kwayoyin cigaba ba. Ci gaban ƙwayoyin da ba a sarrafawa na iya haifar da cutar kansa.

Canjin BRAF zai iya zama gado daga iyayenku ko kuma ya samu daga baya. Maye gurbi wanda ke faruwa daga baya rayuwa yawanci yana faruwa ne ta hanyar yanayi ko kuma daga kuskuren da ke faruwa a jikinka yayin rabewar sel. Ganin maye gurbin BRAF ba safai ake samun sa ba, amma suna iya haifar da babbar matsalar lafiya.

Samun (wanda aka sani da suna somatic) maye gurbi na BRAF yafi na kowa. Waɗannan maye gurbi an samo su a cikin kusan rabin duk abin da ya shafi melanoma, mafi tsananin nau'in cutar kansa. Hakanan sau da yawa ana samun maye gurbi na BRAF a cikin wasu rikice-rikice da nau'o'in ciwon daji daban-daban, gami da cututtukan daji na cikin hanji, taroid, da kwai. Cancers tare da maye gurbi na BRAF sun kasance sunfi tsanani fiye da waɗanda ba tare da maye gurbi ba.

Sauran sunaye: BRAF nazarin canjin yanayi, Melanoma, maye gurbin BRAF V600, cobas

Me ake amfani da shi?

Ana amfani da gwajin sau da yawa don neman maye gurbin BRAF a cikin marasa lafiya tare da melanoma ko wasu cututtukan da ke da alaƙa da BRAF. Wasu magunguna na kansar suna da tasiri musamman ga mutanen da suke da maye gurbi na BRAF. Magunguna iri ɗaya basu da tasiri kuma wani lokacin suna da haɗari ga mutanen da basu da maye gurbi.

Hakanan za'a iya amfani da gwajin BRAF don ganin ko kuna cikin haɗarin kamuwa da cutar kansa dangane da tarihin iyali da / ko tarihin lafiyarku.

Me yasa nake bukatar gwajin kwayar cutar BRAF?

Kuna iya buƙatar gwajin BRAF idan an gano ku tare da melanoma ko wani nau'in ciwon daji. Sanin ko kuna da maye gurbi na iya taimaka wa mai ba ku sabis ya rubuta maganin da ya dace.

Hakanan zaka iya buƙatar wannan gwajin don ganin idan kana cikin haɗarin kamuwa da cutar kansa. Abubuwan haɗarin haɗari sun haɗa da tarihin iyali na cutar kansa da / ko ciwon daji a ƙuruciya. Specificayyadadden shekarun ya dogara da nau'in cutar kansa.

Abin da ya faru a lokacin BRAF kwayoyin gwajin?

Yawancin gwaje-gwajen BRAF ana yin su ne a cikin hanyar da ake kira biopsy na ƙari. Yayin nazarin halittu, mai ba da kiwon lafiya zai fitar da wata karamar piecean nama ta hanyar yankan ko goge saman ƙari. Idan mai ba da sabis ɗinku yana buƙatar gwada ƙwayoyin cuta daga cikin jikinku, zai iya amfani da allura ta musamman don cire samfurin.

Shin zan bukaci yin komai don shirya wa gwajin?

Kullum baku buƙatar kowane shiri na musamman don gwajin BRAF.

Shin akwai haɗari ga gwajin?

Wataƙila kuna da ɗan rauni ko zubar jini a wurin biopsy. Hakanan kuna iya samun ɗan rashin jin daɗi a shafin na yini ɗaya ko biyu.

Menene sakamakon yake nufi?

Idan kana da melanoma ko wani nau'in ciwon daji, kuma sakamakon ya nuna kana da maye gurbi na BRAF, mai ba ka sabis zai iya ba da magungunan da aka tsara don magance maye gurbi. Wadannan magunguna na iya zama masu tasiri fiye da sauran jiyya.

Idan kana da melanoma ko wani nau'in ciwon daji, kuma sakamakon ya nuna maka kar a yi yi maye gurbi, mai ba ka sabis zai rubuta nau'ikan magunguna don magance cutar kansa.

Idan ba a gano ku da cutar kansa ba kuma sakamakonku yana nuna kuna da maye gurbin BRAF, shi ba ya yana nufin kuna da cutar kansa, amma kuna da haɗarin cutar kansa mafi girma. Amma yawan binciken kansar, kamar gwajin fata, na iya rage haɗarin ka. Yayin gwajin fata, mai ba da kiwon lafiya zai duba fatar jikinka a hankali don bincika ƙwayoyin cuta da sauran ci gaban da ba a tsammani.

Yi magana da mai baka game da wasu matakai da zaka iya ɗauka don rage haɗarin ka.

Learnara koyo game da gwaje-gwajen gwaje-gwaje, jeri na tunani, da fahimtar sakamako.

Shin akwai wani abin da ya kamata in sani game da gwajin BRAF?

Kuna iya jin mai ba ku magana game da maye gurbin V600E. Akwai nau'ikan maye gurbi na BRAF. V600E shine mafi yawan nau'in maye gurbi na BRAF.

Bayani

1. Canungiyar Ciwon Cancer ta Amurka [Intanet]. Atlanta: Cibiyar Cancer ta Amurka Inc ;; c2018. Ciwon Skin Cutar Melanoma; [wanda aka ambata 2018 Jul 10]; [game da fuska 3]. Akwai daga: https://www.cancer.org/cancer/melanoma-skin-cancer.html
2. Canungiyar Ciwon Cancer ta Amurka [Intanet]. Atlanta: Cibiyar Cancer ta Amurka Inc ;; c2018. Oncogenes da cututtukan ƙwayoyin cuta; [sabunta 2014 Jun 25; wanda aka ambata 2018 Jul 10]; [game da fuska 4]. Akwai daga: https://www.cancer.org/cancer/cancer-causes/genetics/genes-and-cancer/oncogenes-tumor-suppressor-genes.html
3. Canungiyar Ciwon Cancer ta Amurka [Intanet]. Atlanta: Cibiyar Cancer ta Amurka Inc ;; c2018. Cutar da Aka Yi niyya don Ciwon Skin Melanoma; [sabunta 2018 Jun 28; wanda aka ambata 2018 Jul 10]; [game da fuska 3]. Akwai daga: https://www.cancer.org/cancer/melanoma-skin-cancer/treating/targeted-therapy.html
4. Ciwon daji.Net [Intanet]. Alexandria (VA): Societyungiyar (asar Amirka ta Clinical Oncology; c2005–2018. Gwajin Halitta don Hadarin Cutar Kansa; 2017 Jul [wanda aka ambata 2018 Jul 10]; [game da fuska 4]. Akwai daga: https://www.cancer.net/navigating-cancer-care/cancer-basics/genetics/genetic-testing-cancer-risk
5. Ciwon daji.Net [Intanet]. Alexandria (VA): Societyungiyar (asar Amirka ta Clinical Oncology; c2005–2018. Fahimtar Maƙasudin Kulawa; 2018 Mayu [wanda aka ambata 2018 Jul 10]; [game da fuska 4]. Akwai daga: https://www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/understanding-targeted-therapy
6. Hadadden Oncology [Intanet]. Kamfanin Laboratory na Amurka; c2018. BRAF Nazarin Canjin Halitta; [wanda aka ambata 2018 Jul 10]; [game da fuska 3]. Akwai daga: https://www.integratedoncology.com/test-menu/braf-gene-mutation-analysis/07d322d7-33e3-480f-b900-1b3fd2b45f28
7. Gwaje-gwajen Lab a kan layi [Intanet]. Washington DC: Associationungiyar (asar Amirka don Magungunan Kiwon Lafiya; c2001–2018. Biopsy; [sabunta 2017 Jul 10; wanda aka ambata 2018 Jul 10]; [game da allo 2]. Akwai daga: https://labtestsonline.org/glossary/biopsy
8. Gwaje-gwajen Lab a kan layi [Intanet]. Washington DC: Associationungiyar (asar Amirka don Nazarin Kimiyyar Clinical; c2001–2018. Gwajin Halitta don Ciwon Cutar Cancer; [sabunta 2018 Jul 10; wanda aka ambata 2018 Jul 10]; [game da allo 2]. Akwai daga: https://labtestsonline.org/tests/genetic-tests-targeted-cancer-therapy
9. Mayo Clinic: Mayo Laboratories Medical [Internet]. Gidauniyar Mayo don Ilimin Likita da Bincike; c1995–2018. Gwajin ID: BRAFT: BRAF Mutation Analysis (V600E), Tumor: Clinical and Interpretive; [wanda aka ambata 2018 Jul 10]; [game da fuska 4]. Akwai daga: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/35370
10. Cibiyar Cancer ta Kasa [Intanet]. Bethesda (MD): Ma'aikatar Kiwon Lafiya ta Amurka da Ayyukan Dan Adam; Gwajin Halitta don Ciwon Cutar Cancer; [wanda aka ambata 2018 Jul 10]; [game da fuska 3]. Akwai daga: https://www.cancer.gov/about-cancer/causes-prevention/genetics/genetic-testing-fact-sheet
11. Cibiyar Cancer ta Kasa [Intanet]. Bethesda (MD): Ma'aikatar Kiwon Lafiya ta Amurka da Ayyukan Dan Adam; NCI Dictionary of Cancer Terms: kwayar BRAF; [wanda aka ambata 2018 Jul 10]; [game da fuska 3]. Akwai daga: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/braf-gene
12. Cibiyar Cancer ta Kasa [Intanet]. Bethesda (MD): Ma'aikatar Kiwon Lafiya ta Amurka da Ayyukan Dan Adam; NCI Dictionary of Terms Cancer Terms: maye gurbin BRAF (V600E); [wanda aka ambata 2018 Jul 10]; [game da fuska 3]. Akwai daga: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/braf-v600e-mutation
13. Cibiyar Cancer ta Kasa [Intanet]. Bethesda (MD): Ma'aikatar Kiwon Lafiya ta Amurka da Ayyukan Dan Adam; NCI Dictionary of Cancer Sharuddan: gene; [wanda aka ambata 2018 Jul 10]; [game da fuska 3]. Akwai daga: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=gene
14. Cibiyar Cancer ta Kasa [Intanet]. Bethesda (MD): Ma'aikatar Kiwon Lafiya ta Amurka da Ayyukan Dan Adam; NCI Dictionary na Sharuɗɗan Ciwon daji: oncogene; [wanda aka ambata 2018 Jul 10]; [game da fuska 3]. Akwai daga: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/oncogene
15. NIH US National Library of Medicine: Nasihu na Gidajen Gida [Intanet]. Bethesda (MD): Ma'aikatar Kiwon Lafiya ta Amurka da Ayyukan Dan Adam; Kwayar BRAF; 2018 Jul 3 [wanda aka ambata 2018 Jul 10]; [game da fuska 3]. Akwai daga: https://ghr.nlm.nih.gov/gene/BRAF
16. NIH US National Library of Medicine: Nasihu na Gidajen Gida [Intanet]. Bethesda (MD): Ma'aikatar Kiwon Lafiya ta Amurka da Ayyukan Dan Adam; Menene canzawar kwayar halitta kuma ta yaya maye gurbi ke faruwa ?; 2018 Jul 3 [wanda aka ambata 2018 Jul 10]; [game da fuska 3]. Akwai daga: https://ghr.nlm.nih.gov/primer/mutationsanddisorders/genemutation
17. Binciken Bincike [Intanet]. Binciken Bincike; c2000–2017. Cibiyar Gwaji: Melanoma, BRAF V600 Mutation, Cobas: Jagoran fassara; [wanda aka ambata 2018 Jul 10]; [game da fuska 4]. Akwai daga: https://www.questdiagnostics.com/testcenter/testguide.action?dc=TS_BRAF_V600&tabview
18. Binciken Bincike [Intanet]. Binciken Bincike; c2000–2017. Cibiyar Gwaji: Melanoma, BRAF V600 Mutation, Cobas: Bayani; [wanda aka ambata 2018 Jul 10]; [game da fuska 3]. Akwai daga: https://www.questdiagnostics.com/testcenter/TestDetail.action?ntc=90956
19. Jami'ar Rochester Medical Center [Intanet]. Rochester (NY): Jami'ar Rochester Medical Center; c2018. Kundin Lafiya na Kiwon Lafiya: Melanoma: Targeted Far; [wanda aka ambata 2018 Jul 10]; [game da allo 2]. Akwai daga: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=34&contentid=BMelT14
20. Kiwon Lafiya UW [Intanet]. Madison (WI): Jami'ar Wisconsin Asibitoci da Hukumomin Kula da Lafiya; c2018. Bayanin Kiwon Lafiya: Nazarin Jiki na Fata don Ciwon Skin Fata: Siffar Jarabawa; [sabunta 2017 Mayu 3; wanda aka ambata 2018 Jul 18]; [game da allo 2]. Akwai daga: https://www.uwhealth.org/health/topic/testdetail/physical-exam/hw206422.html#hw206425UW
21. Kiwan lafiya [Intanet]. Madison (WI): Jami'ar Wisconsin Asibitoci da Hukumomin Kula da Lafiya; c2018. Bayanin Kiwon Lafiya: Ciwon Skin, Melanoma: Topic Overview; [sabunta 2017 Mayu 3; wanda aka ambata 2018 Jul 10]; [game da allo 2]. Akwai daga: https://www.uwhealth.org/health/topic/major/skin-cancer-melanoma/hw206547.html
22. Kiwon Lafiya na UW: Asibitin Yaran Iyali na Amurka [Intanet]. Madison (WI): Jami'ar Wisconsin Asibitoci da Hukumomin Kula da Lafiya; c2018. Kiwan yara: Biopsy; [wanda aka ambata 2018 Jul 10]; [game da fuska 3]. Akwai daga: https://www.uwhealthkids.org/kidshealth/en/parents/biopsy.html/
23. Zial J, Hui P. BRAF gwajin gwaji a cikin aikin asibiti. Gwani Rev Mol Diagn [Intanet]. 2012 Mar [wanda aka ambata 2018 Jul 10]; 12 (2): 127-38. Akwai daga: https://www.ncbi.nlm.nih.gov/pubmed/22369373

Ba za a yi amfani da bayanan da ke wannan rukunin yanar gizon a madadin madadin ƙwararrun likitocin ko shawara ba. Tuntuɓi mai ba da kiwon lafiya idan kuna da tambayoyi game da lafiyarku.