Mawallafi: Peter Berry
Ranar Halitta: 19 Yuli 2021
Sabuntawa: 13 Yiwu 2024
Anonim
All About Darzalex (daratumumab)
Video: All About Darzalex (daratumumab)

Wadatacce

Menene Darzalex?

Darzalex magani ne mai suna wanda aka ba da suna. Ana amfani dashi don magance myeloma mai yawa, wanda shine nau'in ciwon daji wanda ke shafar wasu ƙwayoyin farin jini waɗanda ake kira ƙwayoyin plasma.

Darzalex ya ƙunshi daratumumab. Wannan wani nau'in magani ne wanda ake kira antibody.

Darzalex ba magani ba ne. Yana da nau'in maganin da aka yi niyya kuma wani lokacin ana kiransa immunotherapy. Wannan yana nufin cewa an tsara Darzalex ne don aiki tare da garkuwar jikinka (garkuwar jikinka daga kamuwa da cuta).

Mai ba da sabis na kiwon lafiya zai ba ku Darzalex azaman maganin intravenous (IV) a cikin ofishin likitanku ko asibiti. Inshorar inabi ta IV allura ce a cikin jijiyarka wanda aka bayar na wani lokaci.

Yadda ake amfani da shi

Darzalex za'a iya rubuta shi shi kaɗai ko tare da wasu magunguna. Hukumar Abinci da Magunguna (FDA) ta amince da amfani da Darzalex:

  • A cikin manya tare da sabon myeloma da aka gano da yawa wanda ba zai iya karɓar ƙwayar ƙwayar ƙwayar ƙwayar cuta ba. (Tare da dasawar kwayar halitta mai kwatankwacin kansa, ana amfani da kwayoyin halittar ku.) A wannan halin:
    • Ana iya amfani da Darzalex tare da magungunan lenalidomide (Revlimid) da dexamethasone.
    • Hakanan za'a iya amfani da Darzalex tare da magungunan bortezomib (Velcade), melphalan, da prednisone.
  • A cikin manya waɗanda suka karɓi magani ɗaya ko fiye da suka gabata waɗanda basu yi aiki mai kyau ba ko kuma wanda myeloma da yawa suka dawo. A wannan halin, ana amfani da Darzalex tare da lenalidomide da dexamethasone.
  • A cikin manya waɗanda suka karɓi ɗayan ko fiye da yawa na maganin myeloma (s) da yawa. A wannan halin, ana amfani da Darzalex tare da bortezomib da dexamethasone.
  • A cikin tsofaffi waɗanda suka karɓi magunguna biyu ko fiye da yawa waɗanda suka haɗa da lenalidomide da mai hana kariya, wanda shine nau'in magani. A wannan halin, ana amfani da Darzalex tare da magungunan pomalidomide (Pomalyst) da dexamethasone.
  • A cikin manya waɗanda suka karɓi jiyya na myeloma sau uku ko fiye da suka gabata waɗanda suka haɗa da mai hana kariya da kuma rigakafin magani. A wannan halin, Darzalex ana amfani da shi da kansa.
  • A cikin manya waɗanda suka gwada maƙarƙashiya mai hana kariya da magungunan rigakafi, amma babu magungunan da ke aiki don myeloma da yawa. A wannan yanayin, ana amfani da Darzalex da kanta.

Inganci

Karatun asibiti shida sun duba yadda Darzalex yayi tasiri wajen magance myeloma da yawa, shi kadai kuma aka hada shi da wasu magungunan yaki da cutar kansa.Wadannan karatuttukan ana kiransu MAIA, ALCYONE, POLLUX, CASTOR, EQUULEUS, da SIRIUS. Binciken ya nuna cewa jiyya na myeloma da yawa ya fi tasiri idan aka kara Darzalex cikin maganin kansar na yau da kullun fiye da yadda aka ba wadannan daidaitattun maganin shi kadai. Don ƙarin bayani game da inganci, duba sashin “Darzalex don yawan myeloma” a ƙasa.


Darzalex janar

Darzalex yana samuwa ne kawai azaman magani mai suna. Babu shi a halin yanzu a cikin sifa iri.

Darzalex ya ƙunshi sinadarin magani guda ɗaya mai aiki: daratumumab.

Darzalex sakamako masu illa

Darzalex na iya haifar da lahani ko mummunan sakamako. Jerin na gaba yana ƙunshe da wasu mahimman abubuwan illa da zasu iya faruwa yayin shan Darzalex. Wannan jerin ba ya haɗa da duk illa mai illa.

Don ƙarin bayani game da yuwuwar illa na Darzalex, yi magana da likitanka ko likitan magunguna. Za su iya ba ku shawarwari kan yadda za ku magance duk wata illa da ke iya zama damuwa.

Commonarin sakamako masu illa na kowa

Sakamakon illa na yau da kullun na Darzalex na iya haɗawa da:

  • jin kasala
  • rauni ko rashin ƙarfi
  • jijiyoyin jijiyoyi (twitches)
  • tashin zuciya ko amai
  • ciwon ciki ciki har da gudawa ko maƙarƙashiya
  • rage yawan ci
  • matsalar bacci
  • zazzaɓi
  • jin sanyi
  • karancin numfashi ko tari
  • kamuwa da cuta ta sama, kamar mura
  • mashako, wani irin huhu kamuwa da cuta
  • ciwon jiki
  • hadin gwiwa ko ciwon baya
  • jiri

Idan illolin da kake ji kamar sun fi tsanani ko ba ka tafi ba, yi magana da likitanka ko likitan magunguna.


M sakamako mai tsanani

Mahimman sakamako masu illa daga Darzalex ba na kowa bane, amma suna iya faruwa. Kira likitanku nan da nan idan kuna da mummunar illa. Kira 911 idan alamunku suna jin barazanar rai ko kuma idan kuna tunanin kuna samun gaggawa na likita.

M sakamako masu illa da alamomin su na iya haɗawa da masu zuwa:

  • Jiko dauki, wani nau'i na rashin lafiyan dauki. Kwayar cutar na iya haɗawa da:
    • matsalar numfashi
    • matse makogwaro
    • jin saukin kai ko jiri daga ƙananan hawan jini
    • tari ko shakar iska
    • hanci ko hanci
    • tashin zuciya ko amai
    • jin sanyi
    • zazzaɓi
    • ciwon kai
    • ƙaiƙayi
  • Ciwon huhu, wani nau'in huhun huhu. Kwayar cutar na iya haɗawa da:
    • tari na fitsari (gamsai)
    • zazzabi da sanyi
    • karancin numfashi
    • ciwon kirji
  • Hepatitis B, idan kun sha shi a baya. Kwayar cutar na iya haɗawa da:
    • kara gajiya
    • raunin fata ko farin ɓangaren idanunka
  • Neurowararren neuropathy na jiki (lalacewar jijiya wanda ke haifar da tingling, numbness, ko zafi). Kwayar cutar na iya haɗawa da:
    • suma ko tsukewa
    • zafi mai zafi
    • ji na ƙwarai
    • rauni a hannuwanku ko ƙafafunku
  • Harshen gefe (kumburin hannu da ƙafa). Kwayar cutar na iya haɗawa da:
    • kumburin hannu ko ƙafa
    • miƙa fata
    • fatar da take dits (rami) lokacin da aka dannata ta 'yan dakiku

Sauran cututtukan da ke tattare da cutarwa, waɗanda aka yi bayani dalla-dalla a ƙasa a cikin “effectarin bayanan sakamako,” sun haɗa da:


  • rashin lafiyan halayen
  • thrombocytopenia, karamin matakin jini, wanda wani nau'in kwayar halitta ce wacce ke taimakawa gudan jini
  • neutropenia, ƙananan matakin neutrophils, waɗanda sune nau'ikan ƙwayar farin jini wanda ke taimakawa yaƙi da cututtuka
  • shingles (herpes zoster kamuwa da cuta)

Bayanin sakamako na gefe

Kuna iya mamakin yadda sau da yawa wasu cututtukan illa ke faruwa tare da wannan magani. Ga wasu bayanai dalla-dalla kan mawuyacin tasirin da wannan maganin zai iya haifarwa.

Maganin rashin lafiyan

Kamar yadda yake da yawancin kwayoyi, wasu mutane na iya samun rashin lafiyan bayan shan Darzalex. Ba a san yadda sau da yawa mutane ke amfani da Darzalex ke da halayen rashin lafiyan ba. Kwayar cututtukan rashin lafiyan rashin lafiya na iya haɗawa da:

  • kumburin fata ko amya (ƙuƙƙwarar fata a cikin fata)
  • ƙaiƙayi
  • flushing (dumi da kuma ja a fatar ka)
  • zazzaɓi

Reactionwayar rashin lafiyan da ta fi tsanani ba safai ba amma zai yiwu. Kwayar cututtukan rashin lafiya mai haɗari na iya haɗawa da:

  • kumburi a ƙarƙashin fatar ku, galibi a cikin ƙasan idanunku, leɓunanku, hannuwanku, ko ƙafafunku
  • kumburin harshenka, bakinka, ko maqogwaronka
  • matsalar numfashi

Kira likitanku nan da nan idan kuna da mummunan rashin lafiyar Darzalex. Kira 911 idan alamunku suna jin barazanar rai ko kuma idan kuna tunanin kuna samun gaggawa na likita.

Jiko dauki

An ba Darzalex wani ƙwayar jijiya (IV) a cikin ofishin likitanku ko asibiti. Wannan allura ce a cikin jijiyar ku wanda aka bayar na wani lokaci. Kamar yadda yake tare da yawancin kwayoyi waɗanda aka basu azaman jiko na IV, ƙila ku sami tasirin jiko bayan karɓar Darzalex. (Hanyar jigilar nau'in nau'in rashin lafiyan abu ne.)

A lokacin karatun asibiti, halayen jiko sun faru a kusan rabin mutanen da aka bi da maganin jana'izar Darzalex. Yawanci, halayen ya faru yayin farkon jiko kuma ya kasance mai laushi zuwa matsakaici. Yawancin mutanen da suka karɓi Darzalex suna da amsa yayin cikin ko awanni 4 na ƙarshen jiko. Hanyoyin haɗi ba su da yiwuwar faruwa tare da jiyya na gaba. A cikin karatuttukan, mutanen da suka karɓi magunguna ban da Darzalex ba a ba su magungunan ta hanyar infusions.

Idan kuna da maganin kumburi wanda ke da sauƙi ko matsakaici, likitanku na iya tsayar da maganin ku don magance maganin. Hakanan zasu iya sake farawa jiko a ƙananan ƙananan (gudun) don haka ku sami maganin a hankali. Idan jigilar ku ta kasance mai tsanani ko rashin ƙarfi (barazanar rai), likitan ku na iya dakatar da jiyya tare da Darzalex kuma fara kulawar gaggawa.

Don rage damar yin tasirin jiko, likitanku zai ba ku haɗin ƙwayoyi. Sa'a daya zuwa uku kafin kowane jigon Darzalex, zaku karɓi:

  • a corticosteroid (don rage kumburi)
  • antipyretic (don hana ko rage zazzabi)
  • antihistamine (don hana ko rage alamun rashin lafiyan halayen)

Hakanan zaka iya karɓar corticosteroid 1 kwana bayan jiko don kauce wa halayen jinkiri. Amma idan kun riga kun sha steroid kamar dexamethasone ko prednisone, ƙila ba za ku buƙaci ƙarin haɓakar steroid ba.

Idan kuna da mummunan rashin lafiyan rashin lafiyar Darzalex bayan kun bar ofishin likitanku ko cibiyar jiko, kira likitanku nan da nan. Kira 911 idan alamunku suna jin barazanar rai ko kuma idan kuna tunanin kuna samun gaggawa na likita.

Rikicin ƙwayoyin jini

Darzalex na iya haifar da thrombocytopenia, wanda shine raguwar matakin platelet dinka. (Waɗannan nau'ikan ƙwayoyin jini ne wanda ke taimakawa daskarewar jini.) Alamun cutar na iya haɗawa da zagewa da zubar jini.

A cikin karatun asibiti, kimanin 48% zuwa 90% na mutanen da suka ɗauki Darzalex ko Darzalex tare da daidaitaccen maganin myeloma suna da thrombocytopenia. Idan aka kwatanta, kashi 58% zuwa 88% na mutanen da suka sami daidaitattun jiyya suma suna da thrombocytopenia.

Darzalex shima na iya haifar da kwayar cutar. Wannan raguwa ne a matakin neutrophils, wanda shine wani irin kwayar farin jini wanda ke taimakawa wajen yakar cutuka. Kwayar cutar na iya haɗawa da zazzaɓi da kamuwa da cuta.

A cikin karatun asibiti, kimanin kashi 58% zuwa 95% na mutanen da suka ɗauki Darzalex ko Darzalex tare da daidaitaccen maganin myeloma suna da neutropenia. Idan aka kwatanta, kashi 40% zuwa 87% na mutanen da suka sami kulawa ta yau da kullun suma suna da ƙwayoyin cuta.

Yayin da kuke jinya na Darzalex, likitanku zai duba ƙwanan jini da ƙirin ƙwayoyin jinin ku akai-akai. Hakanan za su sa maka ido kan duk wani rauni, zubar jini, ko cututtuka. Idan ka ci gaba da ɗayan waɗannan alamun ko alamun, gaya wa likitanka.

Shingles

Yayin da kake shan Darzalex, zaka iya kamuwa da wata cuta da ake kira shingles (herpes zoster). Wannan saboda samun myeloma da yawa da karɓar magungunan myeloma da yawa na iya ƙara haɗarin kamuwa da ku.

Lokacin da kake samun shingles, zaka iya samun:

  • zafi mai zafi
  • tingling
  • ƙaiƙayi
  • kumburi da kumburi a gefe ɗaya kawai na jikinku

Haka kwayar cutar da ke haifar da shingles na iya haifar da kaza. Idan ka taba yin cutar kaji a da, kwayar ba ta barin jikinka bayan ka warke daga kamuwa da cutar. Maimakon haka, kwayar cutar kawai "tafi bacci" a cikin jijiyoyin ku.

Babu wanda ya san takamaiman dalilin, amma kwayar cutar na iya sake kunnawa ko “farka” tare da wasu abubuwan da ke haifar da su kamar tsarin garkuwar jiki mara ƙarfi. (Tsarin garkuwar ku shine kariya ta jikin ku game da cututtuka.)

Ciwon daji ko maganin kansa na iya raunana garkuwar ku kuma sake kunna ƙwayoyin cutar ta herpes zoster. Lokacin da ta farka, tana bayyana kanta kamar shingles maimakon kaji.

A cikin karatun asibiti, an ba da rahoton shingles a cikin 3% na mutanen da aka kula da su tare da Darzalex kawai. Idan aka kwatanta, shingles ya faru a cikin 2% zuwa 5% na mutanen da suka ɗauki Darzalex tare da ƙarin maganin ciwon daji.

Idan kuna da ciwon kaji ko shingles a baya kuma kuna shan Darzalex, likitanku na iya ba da umarnin maganin rigakafin ƙwayar cuta. Wannan nau'in magani na iya taimakawa hana shingles daga ci gaba a jikin ku. Kuna buƙatar shan maganin rigakafin cikin mako 1 na fara karɓar Darzalex. Sannan zaku ci gaba da shan shi tsawon watanni 3 bayan kun gama jiyya tare da Darzalex.

Namoniya

Shan Darzalex na iya haifar da ci gaban cutar huhu da ake kira ciwon huhu. Wannan saboda idan kuna da myeloma da yawa, kuna iya kamuwa da cututtuka fiye da masu lafiya.

A cikin karatun asibiti, kashi 11% zuwa 26% na mutanen da suka ɗauki Darzalex sun sami ciwon huhu. An kwatanta wannan zuwa 6% zuwa 14% na mutanen da suka ɗauki placebo (ba magani).

Ciwon huhu shi ne mafi yawan rahoton rahoton kamuwa da cuta mai tsanani. Har zuwa 4% na mutane a duk faɗin karatun Darzalex sun daina shan magani saboda ciwon huhu. Mutuwa daga cutar huhu ba ta da yawa. Amma idan mutuwa ta faru, to ya kasance saboda ciwon huhu da cutar sepsis (amsar barazanar rai ga kamuwa da cuta).

Kwayar cututtukan huhu na iya haɗawa da:

  • tari na fitsari (gamsai)
  • zazzabi da sanyi
  • karancin numfashi
  • ciwon kirji

Idan ka ci gaba da kowane irin alamun cutar huhu, gaya wa likitanka. Suna iya tsayar da allurar Darzalex ɗinka don magance cutar huhu. A cikin karatun asibiti, kimanin kashi 1% zuwa 4% na mutanen da suka ɗauki Darzalex ko kuma maganin cutar kansa kaɗai ya dakatar da magungunan su saboda tsananin ciwon huhu.

Kudin Darzalex

Kamar yadda yake tare da duk magunguna, farashin Darzalex na iya bambanta. Don neman farashin yanzu na Darzalex a yankinku, bincika WellRx.com. Kudin da kuka samo akan WellRx.com shine abin da zaku iya biya ba tare da inshora ba. Ainihin farashin da zaku biya zai dogara ne akan inshorarku da kuma kantin da kuke amfani dashi.

Tsarin inshorarku na iya buƙatar ku sami izini kafin su amince da ɗaukar hoto don Darzalex. Wannan yana nufin cewa likitanka zai buƙaci aika buƙata zuwa kamfanin inshorarku yana neman su rufe maganin. Kamfanin inshorar zasu sake nazarin buƙatar kuma su sanar da kai da likitanka idan shirinku zai rufe Darzalex.

Idan baku da tabbas idan kuna buƙatar samun izini kafin Darzalex, tuntuɓi shirin inshorar ku.

Taimakon kuɗi da inshora

Idan kuna buƙatar tallafi na kuɗi don biyan Darzalex, ko kuma idan kuna buƙatar taimako game da ɗaukar inshorar ku, akwai taimako.

Janssen Biotech, Inc., wanda ya ƙera Darzalex, yana ba da wani shiri mai suna Janssen CarePath. Don ƙarin bayani kuma don gano idan kun cancanci tallafi, kira 844-553-2792 ko ziyarci gidan yanar gizon shirin.

Darzalex sashi

Mizanin likitan Darzalex wanda likitanku ya rubuta zai dogara ne da dalilai da yawa. Wadannan sun hada da:

  • idan yanayin ku ya kasance sabon bincike ko kuma kun sami daya ko fiye da yawa na maganin myeloma (s)
  • duk wani magani da kuke karɓa tare da Darzalex don magance myeloma mai yawa
  • wasu yanayin kiwon lafiyar da zaka iya samu
  • duk wani illar da bata tafi ba

Bayani mai zuwa yana bayanin abubuwan da ake amfani dasu ko aka ba da shawarar. Likitan ku zai ƙayyade mafi kyawun sashi don dacewa da bukatun ku. Don samun fa'ida sosai daga wannan jiyya, yana da mahimmanci kaje duk alƙawuran ka ba tsallake kowace rana.

Magungunan ƙwayoyi da ƙarfi

Darzalex ya zo a matsayin mafita (cakuda na ruwa) wanda za ku karɓa a cikin hanyar allura. Maganin na iya zama mara launi don launin rawaya. Darzalex yana samuwa a cikin girma biyu:

  • 100 mg / 5 mL a cikin kwaya ɗaya
  • 400 mg / 20 mL a cikin kwaya ɗaya

Mai ba da sabis na kiwon lafiya zai haɗu da wani ɓangare na Darzalex tare da 0.9% sodium chloride (wani nau'in ruwan gishiri). Sannan za su ba ku wannan magani ta allurar da aka sa a jijiyar ku. Wannan ana kiran sa jijiya (IV).

Yawanci, likitanku zai fara muku a kan samfurin da aka ba da shawara amma a ƙananan ƙananan (saurin) na jiko. Bayan lokaci, za su daidaita jiko zuwa ƙimar da ya dace da kai. Wannan zai dogara ne akan kowane halayen jiko da kuke dashi.

Haɗin ku na farko na Darzalex na iya ɗaukar awanni 7. Wannan saboda likitan ku zai ba ku (ba ku) magungunan ku a hankali cikin jijiyar ku. A nan gaba, yin jigilar abubuwa zai ɗauki kimanin awanni 3 zuwa 5 saboda zaku sami maganin da sauri. Mai ba da sabis na kiwon lafiya koyaushe zai sa ido a kanku lokacin shaƙatawa.

Sashi don yawan myeloma

Darzalex an tsara shi da kansa ko kuma tare da wasu nau'ikan hanyoyin magance cutar kansa don manya tare da myeloma mai yawa. Tsarin magani da tsawonsa zasu dogara ne idan kun kasance sabon binciken ko kuma kuna da jiyya na baya. Ba a yi karatun Darzalex a cikin yara ba.

Adadin da aka ba da shawarar na Darzalex shine milligram 16 / kilogram (mg / kg) na ainihin nauyin jiki azaman jiko na IV. Misali, mace mai fam 110 tana da kimanin kilo 50. Wannan yana nufin cewa shawararta na Darzalex zata kasance 50 kilogiram ninki 16 mg / kg, wanda shine 800 MG.

Manya tare da sabuwar kwayar cutar myeloma da ba a iya ganowa ba wanda ba zai iya karɓar dashen ƙwayar ƙwayar ba

Tare da daskararren kwayar halitta mai canzawa, ana amfani da kwayoyin halittar ka. Optionaya daga cikin zaɓin magani shine Darzalex tare da lenalidomide (Revlimid) da dexamethasone. Jadawalin sashi jadawalin shine:

  • Makonni 1 zuwa 8: Doseaya daga cikin kashi a kowane mako (don jimlar allurai takwas)
  • Makonni 9 zuwa 24: Doseaya daga cikin kashi kowane mako 2 (don jimlar allurai takwas)
  • Makon 25 gaba: Doseaya daga cikin allurai kowane sati 4

Wani zaɓin magani shine Darzalex tare da bortezomib (Velcade), melphalan, da kuma prednisone. Jadawalin sashi jadawalin shine:

  • Makonni 1 zuwa 6: Doseaya daga cikin kashi a kowane mako (don jimlar allurai shida)
  • Makonni 7 zuwa 54: Doseaya daga cikin kashi kowane mako 3 (don jimlar allurai 16)
  • Makon 55 gaba: Doseaya daga cikin allurai kowane sati 4

Manya waɗanda suka karɓi magani ɗaya ko fiye da suka gabata waɗanda basu yi aiki mai kyau ba ko kuma wanda myeloma da yawa suka dawo

Za ku karɓi Darzalex tare da lenalidomide da dexamethasone. Jadawalin sashi jadawalin shine:

  • Makonni 1 zuwa 8: Doseaya daga cikin kashi a kowane mako (don jimlar allurai takwas)
  • Makonni 9 zuwa 24: Doseaya daga cikin kashi kowane mako 2 (don jimlar allurai takwas)
  • Makon 25 gaba: Doseaya daga cikin allurai kowane sati 4

Manya waɗanda suka karɓi ɗayan ko fiye da yawa na maganin myeloma (s)

Za ku karɓi Darzalex tare da bortezomib da dexamethasone. Jadawalin sashi jadawalin shine:

  • Makonni 1 zuwa 9: Doseaya daga cikin kashi a kowane mako (don jimlar allurai tara)
  • Makonni 10 zuwa 24: Doseaya daga cikin kashi kowane mako 3 (don jimlar allurai biyar)
  • Makon 25 gaba: Doseaya daga cikin kwayoyi kowane mako 4

Manya waɗanda suka karɓi magunguna myeloma biyu ko fiye da suka gabata, gami da lenalidomide da mai hana yaduwar cutar

Za ku karɓi Darzalex tare da pomalidomide (Pomalyst) da dexamethasone. Jadawalin sashi jadawalin shine:

  • Makonni 1 zuwa 8: Doseaya daga cikin kashi a kowane mako (don jimlar allurai takwas)
  • Makonni 9 zuwa 24: Doseaya daga cikin kashi kowane mako 2 (don jimlar allurai takwas)
  • Makon 25 gaba: Doseaya daga cikin allurai kowane sati 4

Manya waɗanda suka karɓi jiyya na myeloma sau uku ko fiye da suka gabata, gami da mai hana yaduwar cuta da kuma maganin rigakafi, ko kuma ba su mai da martani ga mai hana ba da kariya da kuma maganin rigakafi

Za ku karɓi Darzalex ne kawai. Jadawalin sashi jadawalin shine:

  • Makonni 1 zuwa 8: Doseaya daga cikin kashi a kowane mako (don jimlar allurai takwas)
  • Makonni 9 zuwa 24: Doseaya daga cikin kashi kowane mako 2 (don jimlar allurai takwas)
  • Makon 25 gaba: Doseaya daga cikin allurai kowane sati 4

Don rage damar yin tasirin jiko, likitanku zai ba ku haɗin ƙwayoyi. Sa'a daya zuwa uku kafin kowane jigon Darzalex, zaku karɓi:

  • a corticosteroid (don rage kumburi)
  • antipyretic (don hana ko rage zazzabi)
  • antihistamine (don hana ko rage alamun rashin lafiyan halayen).

Hakanan zaka iya karɓar corticosteroid 1 kwana bayan jiko don kauce wa halayen jinkiri. Amma idan kun riga kun ɗauki steroid kamar dexamethasone ko prednisone, ƙila ba za ku buƙaci ƙarin haɓakar steroid ba.

Menene idan na rasa kashi?

Idan kun rasa alƙawari don jigilar Darzalex, kira likitanku nan da nan don sake tsara jadawalin. Zasu daidaita jadawalin maganinku don tabbatar da cewa kun karɓi adadin magungunan da ya dace a cikin lokacin da ya dace.

Shin zan buƙaci amfani da wannan magani na dogon lokaci?

A cikin karatun asibiti, matsakaicin lokacin da ya dauki Darzalex ya fara aiki shine wata 1.

Koyaya, za'a iya ba ku allurai a cikin dogon lokaci. Wannan zai dogara ne akan yadda jikinku yake amsawa ga Darzalex kuma idan yawan myeloma ɗinku ya fara zama mafi muni.

Tsawon jiyya zai kuma dogara ne idan yawan kwayar myeloma ɗin ku sabon kamu ne ko kuma kun sha magani a baya.

Darzalex don yawan myeloma

Hukumar Abinci da Magunguna (FDA) ta amince da Darzalex don maganin myeloma da yawa.

Wannan wani nau'i ne na cutar kansa wanda ke shafar wasu ƙwayoyin jini fari wanda ake kira ƙwayoyin plasma. Kwayoyin Plasma sun zama wani bangare na garkuwar jikin ku kuma suna taimakawa yaki da cututtuka a jikin ku. A cikin myeloma da yawa, kwayoyin plasma sun canza zuwa kwayoyin myeloma da yawa. Yayinda kwayoyin myeloma da yawa ke girma da yaduwa, zasu iya fitar da kwayoyin lafiya kuma suyi lahani a kusa dasu.

Darzalex ya yarda ayi amfani dashi:

  • A cikin manya tare da sabon myeloma da aka gano da yawa wanda ba zai iya karɓar ƙwayar ƙwayar ƙwayar ƙwayar cuta ba. (Tare da dasawar kwayar halitta mai kwatankwacin kansa, ana amfani da kwayoyin halittar ku.) A wannan halin:
    • Ana iya amfani da Darzalex tare da magungunan lenalidomide (Revlimid) da dexamethasone.
    • Hakanan za'a iya amfani da Darzalex tare da magungunan bortezomib (Velcade), melphalan, da prednisone.
  • A cikin manya waɗanda suka karɓi magani ɗaya ko fiye da suka gabata waɗanda basu yi aiki mai kyau ba ko kuma wanda myeloma da yawa suka dawo. A wannan halin, ana amfani da Darzalex tare da lenalidomide da dexamethasone.
  • A cikin manya waɗanda suka karɓi ɗayan ko fiye da yawa na maganin myeloma (s) da yawa. A wannan halin, ana amfani da Darzalex tare da bortezomib da dexamethasone.
  • A cikin tsofaffi waɗanda suka karɓi magunguna biyu ko fiye da yawa waɗanda suka haɗa da lenalidomide da mai hana kariya, wanda shine nau'in magani. A wannan halin, ana amfani da Darzalex tare da magungunan pomalidomide (Pomalyst) da dexamethasone.
  • A cikin manya waɗanda suka karɓi jiyya na myeloma sau uku ko fiye da suka gabata waɗanda suka haɗa da mai hana kariya da kuma rigakafin magani. A wannan yanayin, ana amfani da Darzalex da kanta.
  • A cikin manya waɗanda suka gwada maƙarƙashiya mai kariya da kuma rigakafi na rigakafi amma babu magungunan da ke aiki don myeloma da yawa. A wannan yanayin, ana amfani da Darzalex da kanta.

Inganci

Karatuttukan asibiti shida sun duba yadda Darzalex yayi tasiri wajen magance myeloma da yawa shi kadai kuma an hada shi da wasu magungunan yaki da cutar kansa. Wadannan karatuttukan ana kiransu MAIA, ALCYONE, POLLUX, CASTOR, EQUULEUS, da SIRIUS. Binciken ya nuna cewa jiyya ta fi tasiri idan aka kara Darzalex cikin maganin kansar na yau da kullun fiye da yadda aka bada wadannan ingantattun maganin shi kadai.

Nazarin MAIA

Nazarin MAIA ya kalli mutanen da aka gano kwanan nan tare da myeloma da yawa waɗanda ba za su iya karɓar dashen ƙwayar ƙwayar ƙwayar cuta ba. Mutane sun karɓi ko dai daidaitaccen maganin cutar kansa na lenalidomide (Revlimid) da ƙananan ƙwayar dexamethasone ko magani iri ɗaya tare da Darzalex. Idan aka kwatanta da rukunin kulawa na yau da kullun, ƙungiyar Darzalex tana da ƙananan haɗarin 44% na myeloma da yawa na ƙara muni ko mutuwa.

A cikin watanni 42 na binciken, myeloma da yawa bai zama mafi muni a cikin mutanen da suka ɗauki Darzalex tare da daidaitaccen magani ba. Ga mutanen da suka ɗauki magani na yau da kullun, ya ɗauki kimanin watanni 31.9 kafin yawan myeloma ɗin su ya fara zama mummunan. Cikakken matakin da aka bayar shine 47.6% na mutanen da aka yiwa magani tare da Darzalex da kuma 24.9% ga waɗanda suka karɓi daidaitaccen magani. (Cikakken amsa yana nufin duk kansar ya tafi kuma babu alamun cuta a cikin gwaje-gwajen gwaje-gwaje, rayukan X, ko gwajin asibiti.)

Karatun ALCYONE

Nazarin na ALCYONE ya kalli mutanen da suka kamu da cutar myeloma da yawa wadanda basu iya karbar dashen kwayar halittar ba. Waɗannan mutane sun karɓi ko dai daidaitaccen magani na bortezomib (Velcade), melphalan, da prednisone ko wannan magani tare da Darzalex. Idan aka kwatanta da rukunin kulawa na yau da kullun, ƙungiyar Darzalex tana da ƙananan kasada na 50% na myeloma da yawa na ƙara muni ko mutuwa.

Daga cikin mutanen da suka karɓi maganin Darzalex, kashi 42.6% sun sami cikakken amsa. An kwatanta wannan da 24.4% na mutanen da suka sami daidaitaccen magani.

Nazarin POLLUX

Nazarin POLLUX ya kalli mutanen da ke da myeloma da yawa waɗanda ke da aƙalla magani guda daya da ya gabata. Mutanen sun ɗauki ko dai daidaitaccen magani na lenalidomide da dexamethasone ko magani iri ɗaya tare da Darzalex. Sakamako ya nuna cewa kimanin kashi 91.3% na mutane sun amsa jinya tare da Darzalex kusan 74.6% na mutanen da suka karɓi magani kawai.

Idan aka kwatanta da rukunin kulawa na yau da kullun, ƙungiyar da aka kula da ita tare da Darzalex tana da ƙananan kasada na 63% na yawan myeloma na su na ƙara muni. Bayan watanni 13.5, kashi 19% na ƙungiyar Darzalex sun ga myeloma da yawa suna daɗa muni ko sun mutu. An kwatanta wannan zuwa 41% na ƙungiyar kulawa ta yau da kullun.

Nazarin CASTOR

Binciken CASTOR ya kuma kalli mutanen da ke da myeloma masu yawa waɗanda ke da aƙalla magani guda daya da ya gabata. Mutanen sun ɗauki ko dai daidaitaccen magani na bortezomib da dexamethasone ko magani iri ɗaya tare da Darzalex. Sakamakon ya kasance daidai da na binciken POLLUX. Kimanin 73.9% na mutane sun sami amsa ga jiyya tare da Darzalex idan aka kwatanta da kusan 59.9% na mutanen da suka karɓi magani na yau da kullun kawai.

Idan aka kwatanta da daidaitaccen magani, maganin Darzalex yana da nasaba da kasadar 61% na ƙananan myeloma na ƙara muni ko mutuwa. Mutanen da suka ɗauki Darzalex suma sun sami damar kasancewa cikin gafara na dogon lokaci. (Gafara yana nufin cewa yawan cutar kansa yana yaduwa ƙasa.)

Nazarin EQUULEUS

Nazarin EQUULEUS ya kalli mutane 103 tare da myeloma da yawa waɗanda a baya aka ba su magani sau huɗu don yawan myeloma. Wadannan mutane sun riga sun sami nau'ikan jiyya guda biyu: mai hana yaduwar cuta da kuma rigakafin rigakafi. Duk waɗanda ke cikin binciken sun ɗauki daidaitaccen maganin pomalidomide (Pomalyst) da dexamethasone da Darzalex. Babban burin binciken shi ne ganin yadda mutane da yawa suka amsa magani.

Gabaɗaya, maganin ya fara aiki cikin kusan wata 1 a cikin yawancin mutane. Maganin ya yi aiki na kimanin watanni 13.6. Kwayoyin cututtukan myeloma da yawa sun sauƙaƙe da 90% ko fiye a cikin 42% na mutane. Wasu mutane ma ba su da ciwon daji a ƙarshen binciken.

Karatun SIRIUS

Binciken SIRIUS ya kalli mutane 106 tare da myeloma da yawa waɗanda ba su da lafiya kuma sun karɓi kusan jiyya biyar a baya. Duk mutanen da ke cikin binciken an ba su Darzalex ne kawai. Babban burin binciken shi ne ganin yadda mutane da yawa suka amsa magani.

Gabaɗaya, mutanen 31 waɗanda suka karɓi Darzalex sun sami alamun bayyanar myeloma da yawa. Kimanin kashi 64.8% na mutanen da suka ɗauki Darzalex a cikin wannan binciken sun rayu aƙalla watanni 12.

Don rage damar samun tasirin jiko, mutane a duk waɗannan karatun an ba su haɗin magunguna. Aya zuwa uku kafin kowane jiko na Darzalex, sun karɓi:

  • a corticosteroid (don rage kumburi)
  • antipyretic (don hana ko rage zazzabi)
  • antihistamine (don hana ko rage alamun rashin lafiyan halayen)

Hakanan watakila sun sami corticosteroid 1 kwana bayan jiko don kauce wa halayen jinkiri. Amma idan mutane sun riga suna shan steroid kamar dexamethasone ko prednisone, da alama basu buƙatar ƙarin haɓakar steroid ba.

Darzalex don wasu yanayi

Bugu da kari myeloma mai yawa, ana nazarin Darzalex a matsayin magani ga amyloidosis na sarkar haske na immunoglobulin.

Darzalex don amyloidosis sarkar haske na immunoglobulin (a karkashin karatu)

Sarkar amyloidosis (AL) ta rigakafin Immunoglobulin wani yanayi ne wanda wasu sunadarai da ake kira sarƙoƙin haske suke ginawa a cikin gabobinku a cikin jikinku duka. Yawanci, ana cutar zuciyar ka, koda, saifa, da hanta. Ginin gina jiki na iya lalata kuma ya haifar da waɗannan gabobin.

Darzalex ba FDA ta yarda dashi don kula da AL. Koyaya, akwai iyakantaccen bincike ta amfani da lakabin Darzalex don magance wannan yanayin. (Amfani da lakabin lakabi shine lokacin da aka yi amfani da maganin da aka yarda don magance yanayin guda ɗaya don magance wani yanayi na daban.)

A cikin binciken daya, an baiwa Darzalex ga mutanen da ke da AL waɗanda aƙalla, suka karɓi magunguna daban-daban guda uku waɗanda ba su aiki ba. Darzalex ya samar da cikakkiyar amsa ko cikakke a cikin 76% na mutanen da suka sha maganin. (Cikakken amsa yana nufin cewa duk cutar ta tafi kuma babu alamun cuta a cikin gwaje-gwajen gwaje-gwaje, X-rays, gwajin asibiti.) Waɗannan mutane suna da sakamako masu illa irin waɗanda ake tsammani a cikin mutanen da suka ɗauki Darzalex don magance myeloma da yawa. A wasu maganganun da aka ruwaito, Darzalex ya yi tasiri wajen kula da AL da inganta ƙimar rayuwar mutanen da suka sha maganin.

Ana buƙatar ƙarin karatu don tabbatar da cewa Darzalex na aiki sosai kuma yana da aminci yayin amfani da shi cikin mutanen da ke da AL. Har zuwa wannan lokacin, masu bincike na iya amfani da Darzalex don mutanen da ke da AL waɗanda ba su da zaɓi na farko, zaɓin magani da aka yarda da FDA ya rage.

Darzalex yayi amfani da wasu magunguna don myeloma mai yawa

Darzalex an tsara shi da kansa ko kuma tare da wasu nau'ikan maganin kansar ga manya tare da myeloma mai yawa. Tsarin magani da tsawonsa zasu dogara ne idan kun kasance sabon binciken ko kuma kuna da jiyya na baya.

Darzalex an yarda dashi don amfani tare da:

  • lenalidomide (Revlimid) da dexamethasone a cikin manya tare da sabon myeloma da aka gano da yawa wanda ba zai iya karɓar jigilar kwayar halitta ta autologous ba. (Tare da daskararren kwayar halitta ta atomatik, ana amfani da kwayoyin halittar ku.)
  • lenalidomide da dexamethasone a cikin manya waɗanda suka karɓi magani ɗaya ko fiye da suka gabata waɗanda ba su aiki sosai ko kuma wanda myeloma mai yawa ya dawo.
  • bortezomib (Velcade), melphalan, da kuma prednisone a cikin manya tare da sabon myeloma da aka gano da yawa wanda ba zai iya karɓar jigilar kwayar halitta ta autologous ba.
  • bortezomib da dexamethasone a cikin manya waɗanda suka karɓi ɗayan ko fiye da yawa na maganin myeloma da yawa a baya.
  • pomalidomide (Pomalyst) da dexamethasone a cikin manya waɗanda suka karɓi biyun myeloma na baya da yawa. Wadannan maganin dole ne sun hada da lenalidomide da mai hana yaduwar cutar.

Karatun asibiti shida sun duba yadda Darzalex yayi tasiri wajen magance myeloma da yawa, shi kadai kuma aka hada shi da wasu magungunan yaki da cutar kansa. Wadannan karatuttukan ana kiransu MAIA, ALCYONE, POLLUX, CASTOR, EQUULEUS, da SIRIUS. Binciken ya nuna cewa jiyya na myeloma da yawa ya fi tasiri idan aka kara Darzalex cikin maganin kansar na yau da kullun fiye da yadda aka ba wadannan daidaitattun maganin shi kadai. Don cikakkun bayanai game da waɗannan karatun, da fatan za a duba sashin “Darzalex don yawan myeloma” na sama.

Madadin Darzalex

Akwai wasu kwayoyi waɗanda zasu iya magance myeloma da yawa. Wasu na iya zama sun fi dacewa da kai fiye da wasu. Idan kuna sha'awar neman madadin Darzalex, yi magana da likitan ku don ƙarin koyo game da wasu magunguna waɗanda zasu iya muku aiki da kyau.

Da ke ƙasa akwai jerin magungunan da Shawarwarin Cibiyar Nazarin Ciwon Cutar Nationalasa ta Kasa ta ba da shawarar don magance myeloma da yawa:

  • Chemotherapy magunguna, kamar:
    • bendamustine (Bendeka ko Treanda)
    • cisplatin
    • cyclophosphamide (Cytoxan)
    • doxorubicin (Doxil)
    • Shirye-shirye (Etopophos)
    • Distance Watsa-melphalan (Alkeran)
  • Masu hana kariya, kamar:
    • bortezomib (Velcade)
    • carfilzomib (Kyprolis)
    • ixazomib (Ninlaro)
  • Kwayoyin cuta na Monoclonal, kamar su:
    • elotuzumab (Fassara)
  • Histone deacetylase masu hanawa, kamar:
    • panobinostat (Farydak)
  • Immunomodulators, kamar su:
    • Fadar Bege (Revlimid)
    • pomalidomide (Pomalyst)
    • 'tidarin' (Thalomid)
  • Corticosteroids, kamar:
    • dexamethasone (Decadron)

Lura: Wasu daga cikin magungunan da aka jera a nan ana iya amfani dasu ta hanyar lakabi don magance myeloma da yawa.

Darzalex da Gimbiya

Kuna iya mamakin yadda Darzalex yake kwatankwacin sauran magunguna waɗanda aka tsara don amfani iri ɗaya. Anan zamu kalli yadda Darzalex da Empliciti suke daidai da banbanci.

Game da

Darzalex ya ƙunshi daratumumab, yayin da Empliciti ya ƙunshi elotuzumab. Dukansu Darzalex da Empliciti suna cikin rukunin magungunan da ake kira antibodies monoclonal. (Ajin magunguna wani rukuni ne na magunguna waɗanda ke aiki iri ɗaya.) Dukansu Darzalex da Empliciti ana ɗaukarsu hanyoyin kwantar da hankali don maganin myeloma da yawa.

Yana amfani da

Hukumar Abinci da Magunguna (FDA) ta amince da duka Darzalex da Empliciti don magance myeloma da yawa.

Darzalex ya yarda ayi amfani dashi:

  • A cikin manya tare da sabon myeloma da aka gano da yawa wanda ba zai iya karɓar ƙwayar ƙwayar ƙwayar ƙwayar cuta ba. (Tare da dasawar kwayar halitta mai kwatankwacin kansa, ana amfani da kwayoyin halittar ku.) A wannan halin:
    • Ana iya amfani da Darzalex tare da magungunan lenalidomide (Revlimid) da dexamethasone.
    • Hakanan za'a iya amfani da Darzalex tare da magungunan bortezomib (Velcade), melphalan, da prednisone.
  • A cikin manya waɗanda suka karɓi magani ɗaya ko fiye da suka gabata waɗanda basu yi aiki mai kyau ba ko kuma wanda myeloma da yawa suka dawo. A wannan halin, ana amfani da Darzalex tare da lenalidomide da dexamethasone.
  • A cikin manya waɗanda suka karɓi ɗayan ko fiye da yawa na maganin myeloma (s) da yawa. A wannan halin, ana amfani da Darzalex tare da bortezomib da dexamethasone.
  • A cikin tsofaffi waɗanda suka karɓi magunguna biyu ko fiye da yawa waɗanda suka haɗa da lenalidomide da mai hana kariya, wanda shine nau'in magani. A wannan halin, ana amfani da Darzalex tare da magungunan pomalidomide (Pomalyst) da dexamethasone.
  • A cikin manya waɗanda suka karɓi jiyya na myeloma sau uku ko fiye da suka gabata waɗanda suka haɗa da mai hana kariya da kuma rigakafin magani. A wannan yanayin, ana amfani da Darzalex da kanta.
  • A cikin manya waɗanda suka gwada maƙarƙashiya mai kariya da kuma rigakafi na rigakafi amma babu magungunan da ke aiki don myeloma da yawa. A wannan yanayin, ana amfani da Darzalex da kanta.

An yarda da amfani don amfani:

  • A cikin manya waɗanda suka karɓi jiyya ɗaya zuwa uku da suka gabata don maganin myeloma da yawa. Ana amfani da Empliciti tare da lenalidomide (Revlimid) da dexamethasone.
  • A cikin manya waɗanda suka karɓi aƙalla jiyya guda biyu da suka gabata waɗanda suka haɗa da lenalidomide da mai hana kariya. Ana amfani da Empliciti tare da pomalidomide (Pomalyst) da dexamethasone.

Yawanci, Ana ba da kyauta idan yawan myeloma naka ya dawo bayan wasu jiyya.

Magungunan ƙwayoyi da gudanarwa

Dukansu Darzalex da Empliciti an ba su azaman jigilar jini (IV). Wannan allura ce wacce ake sanyawa a hankali a kan lokaci ta hanyar allurar da aka sanya a cikin jijiyar ku.

Ga Darzalex

Darzalex ya zo a matsayin mafita (cakuda na ruwa) wanda za ku karɓa a cikin hanyar allura. Maganin na iya zama mara launi don rawaya rawaya. Akwai magani a cikin girma biyu:

  • 100 mg / 5 mL a cikin kwaya ɗaya
  • 400 mg / 20 mL a cikin kwaya ɗaya

Don rage damar yin tasirin jiko, likitanku zai ba ku haɗin ƙwayoyi. Sa'a daya zuwa uku kafin kowane jigon Darzalex, zaku karɓi:

  • a corticosteroid don rage kumburi
  • antipyretic don hana ko rage zazzabi
  • antihistamine don hana ko rage alamun bayyanar rashin lafiyan halayen

Hakanan zaka iya karɓar corticosteroid 1 kwana bayan jiko don kauce wa halayen jinkiri. Amma idan kun riga kun ɗauki steroid kamar dexamethasone ko prednisone, ƙila ba za ku buƙaci ƙarin haɓakar steroid ba.

Don Kwarewa

Tasirin hankali yana zuwa kamar fari zuwa fari-fat. Mai ba da sabis na kiwon lafiya zai haɗu da wannan tare da maganin don ba ku a matsayin allura. Ana samun ikon yin amfani da ƙarfi guda biyu:

  • 300 MG a cikin kwaya ɗaya
  • 400 MG a cikin kwaya ɗaya

Don rage damar yin tasirin jiko, likitanku zai ba ku haɗin ƙwayoyi. Kimanin mintuna 45 zuwa 90 kafin jiko na Empliciti, zaku karɓi:

  • acetaminophen don hana ko rage zazzabi
  • diphenhydramine (Benadryl) don hana ko rage alamun alamun rashin lafiyan halayen
  • ranitidine don hana ko rage alamun bayyanar rashin lafiyan halayen
  • dexamethasone don rage kumburi

Sakamakon sakamako da kasada

Darzalex da Empliciti duk suna ƙunshe da ƙwayoyi waɗanda suke aiki iri ɗaya. Sabili da haka, duka magunguna na iya haifar da sakamako mai kama da juna. Da ke ƙasa akwai misalai na waɗannan tasirin.

Commonarin sakamako masu illa na kowa

Waɗannan jerin suna ƙunshe da misalai na cututtukan cututtukan yau da kullun waɗanda zasu iya faruwa tare da Darzalex, tare da Empliciti, ko tare da magungunan biyu (lokacin da aka ɗauka ɗayansu).

  • Zai iya faruwa tare da Darzalex:
    • rauni
    • ciwon jiki ko ciwon gabobi
    • tashin zuciya
    • matsalar bacci
    • mashako, wani irin huhu kamuwa da cuta
    • jiri
  • Zai iya faruwa tare da Tasiri:
    • hawan jini mai yawa *
    • zafi mai zafi a hannuwanku ko kafafuwanku * * *
  • Zai iya faruwa tare da duka Darzalex da Empliciti:
    • jin kasala ko rashin ƙarfi
    • ciwon ciki ciki har da gudawa ko maƙarƙashiya
    • rage yawan ci
    • zazzaɓi
    • jin sanyi
    • karancin numfashi ko tari
    • kamuwa da cuta ta sama kamar mura
    • jijiyoyin jijiyoyi (twitches)
    • amai
    • edema na gefe, wanda ke kumburin hannu da ƙafa

** Lokacin da ake amfani da Empliciti tare da lenalidomide da dexamethasone

M sakamako mai tsanani

Waɗannan jerin suna ƙunshe da misalai na larura masu haɗari waɗanda zasu iya faruwa tare da Darzalex, tare da Empliciti, ko tare da magungunan duka biyu (lokacin da aka ɗauka ɗayansu).

  • Zai iya faruwa tare da Darzalex:
    • thrombocytopenia, karamin matakin jini, wanda wani nau'in kwayar halitta ce wacce ke taimakawa gudan jini
    • neutropenia, ƙananan matakin neutrophils, waɗanda sune nau'ikan ƙwayar farin jini wanda ke taimakawa yaƙi da cututtuka
    • shingles (herpes zoster kamuwa da cuta)
  • Zai iya faruwa tare da Tasiri:
    • sabon cutar kansa
    • matsalolin hanta
  • Zai iya faruwa tare da duka Darzalex da Empliciti:
    • jiko halayen
    • ciwon huhu, wani nau'in cutar huhu
    • cututtukan jijiyoyin jiki na jiki, wani nau'in lalacewar jijiya wanda ke haifar da tingling, numbness, ko zafi

Inganci

Darzalex da Empliciti suna da amfani daban-daban na FDA-da aka yarda da su, amma dukansu biyu ana amfani dasu don magance myeloma da yawa a cikin manya.

Wadannan kwayoyi ba a kwatanta su kai tsaye ba a cikin nazarin asibiti (wanda ake kira karatun kai da kai). Koyaya, nazarin nazarin karatun asibiti na 13 na Darzalex da Empliciti ya gano cewa duka kwayoyi sunyi tasiri wajen jinkirta ci gaban (damuwa) na myeloma da yawa.

Ga mutanen da myeloma da yawa suka dawo ko ci gaba da girma koda bayan an sha magani da yawa, jagororin Cibiyar Sadarwar Ciwon Nationalasa ta recommendasa sun ba Darzalex shawarar farko. Idan Darzalex baya aiki, magani tare da Empliciti wani zaɓi ne.

Kudin

Darzalex da Empliciti duka magunguna ne masu suna. A halin yanzu babu nau'ikan nau'ikan nau'ikan magunguna. Magungunan sunaye suna yawanci suna da tsada fiye da na zamani.

Dangane da ƙididdiga akan WellRx.com, Darzalex gaba ɗaya farashinsa bai kai na Empliciti ba. Ainihin farashin da zaku biya ko dai magani ya dogara da tsarin inshorar ku da wurin ku.

Darzalex da Kyprolis

Kamar Empliciti (a sama), maganin Kyprolis yana da amfani irin na Darzalex. Yanzu bari mu kalli yadda Darzalex da Kyprolis suke da kama da juna.

Game da

Darzalex ya ƙunshi daratumumab, yayin da Kyprolis ya ƙunshi carfilzomib. Dukansu magungunan ana ɗaukar su ne don maganin myeloma da yawa. Koyaya, magungunan suna cikin azuzuwan magunguna daban-daban. (Ajin magunguna wani rukuni ne na magunguna waɗanda ke aiki iri ɗaya.) Darzalex wani nau'in magani ne da ake kira antibody monoclonal. Kyprolis wani nau'in magani ne wanda ake kira mai hana kariya.

Yana amfani da

Hukumar Abinci da Magunguna (FDA) ta amince da amfani da Darzalex:

  • A cikin manya tare da sabon myeloma da aka gano da yawa wanda ba zai iya karɓar ƙwayar ƙwayar ƙwayar ƙwayar cuta ba. (Tare da dasawar kwayar halitta mai kwatankwacin kansa, ana amfani da kwayoyin halittar ku.) A wannan halin:
    • Ana iya amfani da Darzalex tare da magungunan lenalidomide (Revlimid) da dexamethasone.
    • Hakanan za'a iya amfani da Darzalex tare da magungunan bortezomib (Velcade), melphalan, da prednisone.
  • A cikin manya waɗanda suka karɓi magani ɗaya ko fiye da suka gabata waɗanda basu yi aiki mai kyau ba ko kuma wanda myeloma da yawa suka dawo. A wannan halin, ana amfani da Darzalex tare da lenalidomide da dexamethasone.
  • A cikin manya waɗanda suka karɓi ɗayan ko fiye da yawa na maganin myeloma (s) da yawa. A wannan halin, ana amfani da Darzalex tare da bortezomib da dexamethasone.
  • A cikin tsofaffi waɗanda suka karɓi magunguna biyu ko fiye da yawa waɗanda suka haɗa da lenalidomide da mai hana kariya, wanda shine nau'in magani. A wannan halin, ana amfani da Darzalex tare da magungunan pomalidomide (Pomalyst) da dexamethasone.
  • A cikin manya waɗanda suka karɓi jiyya na myeloma sau uku ko fiye da suka gabata waɗanda suka haɗa da mai hana kariya da kuma rigakafin magani. A wannan yanayin, ana amfani da Darzalex da kanta.
  • A cikin manya waɗanda suka gwada maƙarƙashiya mai kariya da kuma rigakafi na rigakafi amma babu magungunan da ke aiki don myeloma da yawa. A wannan yanayin, ana amfani da Darzalex da kanta.

Kyprolis an yarda da FDA don amfani dashi:

  • A cikin manya waɗanda suka karɓi jiyya ɗaya zuwa uku da suka gabata don maganin myeloma da yawa. Ana amfani da Kyprolis tare da dexamethasone ko tare da lenalidomide da dexamethasone.
  • A cikin manya waɗanda suka karɓi magani ɗaya ko sama da suka gabata don myeloma mai yawa. Ana amfani da Kyprolis da kanta.

Magungunan ƙwayoyi da gudanarwa

Dukansu Darzalex da Kyprolis an ba su azaman jigilar jini (IV). Wannan allura ce wacce ake sanyawa a hankali a kan lokaci ta hanyar allurar da aka sanya a cikin jijiyar ku.

Ga Darzalex

Darzalex ya zo a matsayin mafita (cakuda na ruwa) wanda za ku karɓa a cikin hanyar allura. Maganin na iya zama mara launi don rawaya rawaya. Akwai magani a cikin girma biyu:

  • 100 mg / 5 mL a cikin kwaya ɗaya
  • 400 mg / 20 mL a cikin kwaya ɗaya

Don rage damar yin tasirin jiko, likitanku zai baku haɗuwa da. kwayoyi. Sa'a daya zuwa uku kafin kowane jigon Darzalex, zaku karɓi:

  • a corticosteroid don rage kumburi
  • antipyretic don hana ko rage zazzabi
  • antihistamine don hana ko rage alamun bayyanar rashin lafiyan halayen

Hakanan zaka iya karɓar corticosteroid 1 kwana bayan jiko don kauce wa halayen jinkiri. Amma idan kun riga kun ɗauki steroid kamar dexamethasone ko prednisone, ƙila ba za ku buƙaci ƙarin haɓakar steroid ba.

Ga Kyprolis

Kyprolis ya zo a cikin biredin ko fom ɗin foda a cikin vial-dose guda ɗaya. Ya zo a cikin ƙarfi uku: 10 MG, 30 MG, da 60 MG.

Don rage damar samun tasirin jiko, likitanku zai ba ku steroid. Za ku karɓi maganin steroid na minti 30 zuwa 4 hours kafin jakar ku ta Kyprolis. Amma idan kun riga kun sha steroid kamar dexamethasone, likitanku bazai buƙatar ba ku ƙarin adadin ba.

Sakamakon sakamako da kasada

Darzalex da Kyprolis na iya haifar da sakamako mai kama da juna. Da ke ƙasa akwai misalai na waɗannan tasirin.

Commonarin sakamako masu illa na kowa

Wadannan jerin suna dauke da misalai na cututtukan cututtukan da suka fi dacewa wanda zai iya faruwa tare da Darzalex, tare da Kyprolis, ko tare da magungunan biyu (lokacin da aka ɗauka ɗayansu).

  • Zai iya faruwa tare da Darzalex:
    • rauni ko rashin ƙarfi
    • mashako, wani irin huhu kamuwa da cuta
    • ciwon jiki ko ciwon gabobi
  • Zai iya faruwa tare da Kyprolis:
    • ƙarancin ƙwayar jinin jini
    • ƙarancin ƙwayar ƙwayar ƙwayar jini
    • matsalar numfashi
    • rage matakan potassium
  • Zai iya faruwa tare da duka Darzalex da Kyprolis:
    • jijiyoyin jijiyoyi (twitches)
    • matsalar bacci
    • jin kasala
    • ciwon ciki ciki har da gudawa ko maƙarƙashiya
    • zazzaɓi
    • jin sanyi
    • karancin numfashi
    • tari
    • kamuwa da cuta ta sama, kamar mura
    • tashin zuciya ko amai
    • rage yawan ci
    • edema na gefe, wanda ke kumburin hannu da ƙafa
    • jiri

M sakamako mai tsanani

Waɗannan jerin suna ƙunshe da misalai na larura masu haɗari waɗanda zasu iya faruwa tare da Darzalex, tare da Kyprolis, ko tare da magungunan duka biyu (lokacin ɗauka daban-daban).

  • Zai iya faruwa tare da Darzalex:
    • neutropenia, ƙananan matakin neutrophils, wanda shine nau'in ƙwayar ƙwayar farin jini wanda ke taimakawa yaƙi da cututtuka
    • shingles (herpes zoster kamuwa da cuta)
    • cututtukan jijiyoyin jiki na jiki, wani nau'in lalacewar jijiya wanda ke haifar da tingling, numbness, ko zafi
  • Zai iya faruwa tare da Kyprolis:
    • cututtukan huhu kamar jini, kumburin jini, kumburi, ko cututtuka a cikin huhu
    • lalacewar zuciya ko gazawar zuciya
    • matsalolin hanta, kamar haɓaka matakin sunadarin hanta ko gazawar hanta
    • gazawar koda
    • cututtukan ƙwayar cuta, yanayin da ƙwayoyin kansa ke mutuwa da sauri kuma abin da ke ciki ya zube a cikin jininka
    • cututtukan encephalopathy na baya-baya, cutar jijiyoyi a cikin kwakwalwa
    • hawan jini
    • hauhawar jini na huhu, wanda shine hawan jini a cikin huhu
    • daskarewar jini
    • matsanancin matsaloli na zub da jini kamar zubar jini a ciki, huhu, ko kwakwalwa
  • Zai iya faruwa tare da duka Darzalex da Kyprolis:
    • jiko halayen
    • thrombocytopenia, karamin matakin platelet, wanda shine nau'in kwayar jini da ke taimakawa daskarewar jini
    • ciwon huhu, wani nau'in cutar huhu

Inganci

Darzalex da Kyprolis suna da amfani da FDA daban-daban, amma dukansu ana amfani dasu don magance myeloma da yawa.

Ba a kwatanta amfani da Darzalex da Kyprolis don myeloma da yawa kai tsaye a cikin nazarin asibiti. Koyaya, karatu ya gano duka Darzalex da Kyprolis sunyi tasiri don magance myeloma da yawa.

Masu binciken yanzu suna nazarin yin amfani da magungunan biyu tare da dexamethasone don kula da irin wannan cutar ta daji. Sakamakon ya nuna cewa mutanen da aka riga aka ba da magani game da myeloma da yawa sun amsa da kyau game da haɗin haɗin. Amma ana buƙatar ƙarin gwaje-gwaje kafin FDA ta iya amincewa da haɗin haɗin Darzalex da Kyprolis don myeloma da yawa.

Kudin

Darzalex da Kyprolis duka magunguna ne masu suna. A halin yanzu babu nau'ikan nau'ikan nau'ikan magunguna. Magungunan sunaye suna yawanci suna da tsada fiye da na zamani.

Dangane da ƙididdiga akan WellRx.com, Darzalex gabaɗaya farashinsa bai kai Kyprolis ba. Ainihin farashin da zaku biya ko dai magani zai dogara ne akan shirin inshorar ku da wurin ku.

Yadda Darzalex ke aiki

Myeloma da yawa shine ciwon daji wanda ke farawa a cikin wani farin ƙwayoyin jini wanda ake kira cell plasma. Kwayoyin Plasma sun zama wani bangare na garkuwar jikin ku kuma suna taimakawa yaki da cututtuka a jikin ku.

Wasu lokuta canje-canje kwatsam a cikin kwayoyin halittar ku, wanda ake kira maye gurbi, na iya juya lafiyayyun ƙwayoyin zuwa na kansa. (Genes sune jerin umarnin da zasu taimaka wajan lura da yadda kwayoyin ku suke girma da nuna hali). Lokacin da kwayoyin plasma suka canza zuwa kwayoyin myeloma da yawa, sai su fara ginawa a cikin kashin kashi (cikin kashinku). Yayinda kwayoyin myeloma da yawa ke girma da yaduwa, zasu iya fitar da kwayoyin lafiya kuma suyi lahani a kusa dasu.

Darzalex wani magani ne da mutum ya kirkira wanda ake kira monoclonal antibody. (Kwayoyin cuta na Monoclonal sunadarai ne a cikin garkuwar jikin ku. An tsara su ne don hari da kuma kaiwa wani yanki na kwayar cutar kansa hari.)

Lokacin da kwayoyin jini suka juye zuwa kwayoyin myeloma masu yawa, suna bunkasa adadi mai yawa wanda ake kira CD38 a saman su. Bodyungiyar antizalex mai ɗaukaka monoclonal tana aiki ta haɗuwa da furotin CD38 akan kwayar myeloma mai yawa. Ta yin wannan, Darzalex kai tsaye yana kashe ko yana taimakawa tsarin rigakafin ku ya lalata ƙwayoyin myeloma da yawa.

Yaya tsawon lokacin aiki?

A cikin karatun asibiti, matsakaicin lokacin da ya ɗauki Darzalex ya fara aiki shine wata 1. Koyaya, za'a iya ba ku allurai a cikin dogon lokaci. Wannan ya dogara da yadda jikinku zai amsa da Darzalex kuma idan yawan myeloma ɗinku ya fara zama mafi muni. Tsawon magani kuma ya dogara ne idan ƙwayar myeloma da yawa an sabon bincike ko kuma kun riga kun sami jiyya a baya.

Darzalex da barasa

Babu sanannun hulɗa tsakanin Darzalex da barasa. Amma an ba da shawarar ka guji shan barasa yayin shan Darzalex. Wannan yana da alaƙa da tsawon lokacin da za a karɓi maganin.

An ba Darzalex azaman jigilar jini (IV). Wannan allura ce a cikin jijiyar ku wanda aka bayar na wani lokaci. Jikowa na Darzalex na iya wucewa daga awanni 3 zuwa 7. Don haka yana da mahimmanci mutum ya kasance yana da ruwa kafin da yayin shigar ku. Abin sha na giya na iya sanya ku bushewa, don haka guji shan barasa yayin shan Darzalex.

Idan kuna da tambayoyi game da barasa da Darzalex, tambayi likitan ku.

Hadin gwiwar Darzalex

Kafin shan Darzalex, tabbatar cewa ka gaya wa likitanka da likitan magunguna game da duk takardun magani, kan-kan-kan-kan, da sauran magunguna da kuke sha. Har ila yau, gaya musu game da kowane bitamin, ganye, da abubuwan da kuke amfani da su. Raba wannan bayanin na iya taimaka maka ka guji yiwuwar mu'amala.

Idan kuna da tambayoyi game da ma'amalar miyagun ƙwayoyi waɗanda zasu iya shafar ku, tambayi likitan ku ko likitan magunguna.

Darzalex da gwaje-gwaje na dakin gwaje-gwaje

Shan Darzalex na iya canza sakamakon wasu gwaje-gwajen gwaje-gwaje.

Kuskuren dakin gwaje-gwaje na jini

Idan kana shan Darzalex kuma kayi gwajin jini don dacewa da nau'in jininka, sakamakon bazai zama daidai ba. Kurakurai a kan waɗannan gwaje-gwajen na iya wucewa har zuwa watanni 6 bayan aikinku na ƙarshe na Darzalex.

Darzalex yana aiki ta haɗuwa da furotin na CD38 a saman kwayar myeloma mai yawa kuma yana lalata furotin. Wani lokacin kuma jajayen kwayoyin jini na iya samun furotin na CD38 a kansu. Darzalex na iya haɗuwa da haɗari ga furotin CD38 akan ƙwayar jinin jini maimakon ɗigon ƙwayar myeloma mai yawa. Lokacin da wannan ya faru, yana canza yadda kwayar jinin jini “take” akan gwajin jini. Koyaya, Darzalex ba zai tasiri nau'in jininka ba.

Don kauce wa kurakuran buga jini, likitanku zai gwada nau'in jinku kafin farawar ku ta farko ta Darzalex. Zasuyi wannan idan har kana bukatar karin jini a gaba.

Yadda ake bayar da Darzalex

Don karɓar maganinku na Darzalex, zaku je ofishin likitanku ko cibiyar jiko. Magungunan yana zuwa azaman bayani (ruwan magani). Mai ba da sabis na kiwon lafiya zai haɗu Darzalex tare da 0.9% sodium chloride (wani nau'in ruwan gishiri). Sannan za su ba ku wannan magani a kan lokaci ta allurar da aka sa a jijiyar ku. Wannan ana kiran sa jijiya (IV). Kuna iya karɓar Darzalex da kansa ko tare da wasu magunguna.

Likitan ku zai yanke shawara nawa Darzalex zai ba ku dangane da nauyinku da takamaiman shirinku na magani. Mai ba da sabis na kiwon lafiya koyaushe zai sa ido a kan ku yayin lokacin jiko.

Yaushe za'a dauka

Likitan ku zai yanke shawara akan lokaci tsakanin allurai da kuma yawan jiyya da zaku buƙata. Wannan zai dogara ne akan ko kuna shan Darzalex shi kaɗai ko tare da sauran magunguna. Tambayi likitanku don ba da shawarar mafi kyawun rana da lokaci don samun infusions dangane da aikinku na yau da kullun.

Sau nawa kuke samun Darzalex kuma tsawon lokacin jigilar zai ragu akan lokaci. Haɗin ku na farko na Darzalex na iya ɗaukar awanni 7. Wannan saboda likitanka zai sanya maganin a hankali cikin jijiyar ku. Jiko a nan gaba zai ɗauki lokaci kaɗan kuma zai ɗauki kimanin awanni 3 zuwa 5 saboda za a sa maganin cikin sauri.

Shan Darzalex tare da abinci

Lokutan jiko na Darzalex na iya zama daga 3 zuwa 7 awanni, ya danganta da tsarin maganinku. Abin da ya sa ke da kyau a zo a shirya tare da lafiyayyun abinci da abin sha idan ya yi daidai da likitanka.

Darzalex da ciki

Ba a yi nazarin Darzalex a cikin mata masu ciki ko dabbobi ba. Amma Darzalex shine mai ba da kariya ta monoclonal, wanda shine nau'ikan magani wanda ke magance ƙwayoyin kansa. Kuma sanannun kwayoyi masu yaduwa suna ratsa mahaifa. (Mahaifa) wani yanki ne dake cikin mahaifar ka wanda yake bayar da abinci daga jikin ka zuwa ga jaririn ka.)

Dangane da aikin Darzalex, maganin na iya haifar da raguwar ƙashi a cikin jaririn da ba a haifa ba. Hakanan yana iya rage adadin jini da ƙwayoyin rigakafin da jariri mai girma keyi.

Kafin ka fara shan Darzalex, ka tabbata ka fadawa likitanka idan kana da ciki, mai yiwuwa tana da ciki, ko kuma kayi shirin yin ciki.

Darzalex tare da lenalidomide ko pomalidomide

Wasu lokuta ana shan Darzalex tare da magani mai suna lenalidomide (Revlimid) ko pomalidomide (Pomalyst) don yawan myeloma. Lenalidomide da pomalidomide duk suna da gargaɗin dambe * don tsananin lahani na haihuwa da barazanar rayuwa. Idan kun kasance mace kuma likitanku ya ba da umarnin Darzalex tare da lenalidomide ko pomalidomide, ba za ku yi ciki ba:

  • na akalla makonni 4 kafin fara magani
  • yayin shan magani
  • yayin kowane tsaiko a magani
  • aƙalla makonni 4 bayan tsayawa lenalidomide ko pomalidomide

Idan kuna da tambayoyi game da shan Darzalex, lenalidomide, ko pomalidomide yayin da kuke ciki, yi magana da likitanku.

Darzalex da kulawar haihuwa

Idan akwai damar da zaku iya samun ciki, ana ba da shawarar yin amfani da maganin haihuwa yayin shan Darzalex. Ya kamata ku ci gaba da amfani da maganin haihuwa na tsawon watanni 3 bayan an gama maganin Darzalex ɗin ku. Wannan shi ne saboda miyagun ƙwayoyi na iya zama a cikin tsarin ku na ɗan gajeren lokaci bayan kun daina shan shi.

Idan kai namiji ne kuma kana yin jima'i da mace, akwai damar samun ciki ya faru. Yi la'akari da amfani da hanyar shinge na hana haihuwa, kamar kwaroron roba, koda kuwa abokin jima'i ma yana amfani da maganin haihuwa.

Darzalex tare da lenalidomide ko pomalidomide

A wasu lokuta, zaka iya shan Darzalex tare da magunguna da ake kira lenalidomide (Revlimid) ko pomalidomide (Pomalyst). Idan macece kuma kuna shan Darzalex tare da lenalidomide ko pomalidomide, dole ne ku yarda ku yi amfani da nau'i biyu na hana haihuwa. Kuna buƙatar fara amfani da maganin haihuwa aƙalla makonni 4 kafin fara fara shan magunguna. Ci gaba da amfani da maganin haihuwa yayin shan Darzalex da lenalidomide ko pomalidomide, kuma yayin kowane tsaiko a magani. Hakanan kuna buƙatar ci gaba da amfani da maganin hana haihuwa na aƙalla makonni 4 bayan daina dakatar da shan lenalidomide ko pomalidomide.

Lenalidomide da pomalidomide na iya wucewa zuwa maniyyin ɗan adam. Don haka ya kamata duk maza suyi amfani da leda ko roba mai roba lokacin saduwa da mace wacce zata iya daukar ciki. Ya kamata maza su yi amfani da wannan hanyar ta hana haihuwa don daidai lokacin da abokin saduwarsu ke karɓar haihuwa.

Idan kuna yin jima'i kuma ku ko abokin jima'i na iya yin ciki, yi magana da likitan ku. Zasu iya taimaka muku yanke shawara akan bukatunku na hana haihuwa yayin da kuke amfani da Darzalex.

Darzalex da nono

Ba a san ko Darzalex zai iya shiga cikin nono ko kuma yadda maganin zai iya shafar nono. Hakanan ba a san ko Darzalex zai iya shafar ɗan da ke shayarwa ba.

Darzalex tare da lenalidomide ko pomalidomide

A wasu lokuta, zaka iya shan Darzalex tare da magunguna da ake kira lenalidomide (Revlimid) ko pomalidomide (Pomalyst). Idan kai mace ce mai shayarwa, bai kamata ka yi amfani da lenalidomide ko pomalidomide ba. Ba a san ko wannan magani zai iya shiga cikin nono na nono kuma ya cutar da jaririn ku ba.

Idan kana son shayar da yaronka kuma kana tunanin shan Darzalex, yi magana da likitanka. Zasu iya gaya muku game da fa'idodi da rashin amfani na amfani da wannan magani yayin shayarwa.

Tambayoyi gama gari game da Darzalex

Anan akwai amsoshi ga wasu tambayoyin da akai akai akai game da Darzalex.

Me yasa nake buƙatar shan steroids da sauran magunguna a alƙawurra na na ruwan Darzalex?

Lokacin da kuka karɓi Darzalex, ƙila ku sami matsalar rashin lafiyan. Don taimakawa hana wannan, likitanku na iya ba ku magunguna da ake kira corticosteroids da sauran magunguna.

Mai ba da sabis na kiwon lafiya zai ba ku Darzalex azaman maganin intravenous (IV) a cikin ofishin likitanku ko asibiti. Wannan allura ce a cikin jijiyar ku wanda aka bayar na wani lokaci. Aya zuwa uku kafin kowane jiko na Darzalex, yawanci zaku karɓi waɗannan magungunan:

  • a corticosteroid (don rage kumburi)
  • antipyretic (don hana ko rage zazzabi)
  • antihistamine (don hana ko rage alamun rashin lafiyan halayen)

Hakanan zaka iya karɓar corticosteroid 1 kwana bayan jiko don kauce wa halayen jinkiri. Amma idan kun riga kun ɗauki steroid kamar dexamethasone ko prednisone, ƙila ba za ku buƙaci ƙarin haɓakar steroid ba.

Idan kuna da tambayoyi game da kowane magungunan da aka bayar tare da shayarwar Darzalex, tambayi likitan ku.

Shin zan iya tuka kaina gida bayan da na shiga cikin Darzalex?

Ba a ba da shawarar ba. Wannan shi ne saboda abu ne na yau da kullun don jin gajiya bayan jiko ko ma samun tasirin jiko. (Dubi "Hanyoyin jigilar abubuwa" a cikin ɓangaren "Bayanin sakamako na illa" a sama don ƙarin koyo.) Don haka don zama cikin aminci, sa danginku, aboki, ko mai ba da kulawa ya tuƙa ku zuwa kuma daga alƙawurran da kuka yi na jiko.

Kula da yadda kuke ji bayan infus ɗinku kuma adana bayanan alamunku. Wannan na iya taimaka muku yanke shawara idan za ku iya tuka kanku, idan kuna buƙatar hakan.

Idan ba za ku iya samun direba ba, Janssen Biotech, Inc., wanda ya ƙera Darzalex, na iya taimaka. Kuna iya magana da mai kula da Janssen CarePath game da zuwa da dawowa daga alƙawurranku da karɓar taimako tare da farashin tafiya. Don ƙarin koyo, kira 844-553-2792 ko ziyarci gidan yanar gizon Darzalex.

Zan iya amfani da Darzalex idan na sami shingles?

Ee, zaku iya amfani da Darzalex idan kuna da kamuwa da cuta da ake kira shingles. Amma kafin ka ɗauki Darzalex, yana da mahimmanci ka gaya wa likitanka idan ka taɓa yin shingles ko kaza. (Wannan kwayar cutar da take haifar da shingles na iya haifar da kaza.)

Idan ka taba yin cutar kaji a da, kwayar ba ta barin jikinka bayan ka warke daga kamuwa da cutar. Maimakon haka, kwayar cutar kawai "tafi bacci" a cikin jijiyoyin ku.

Babu wanda ya san takamaiman dalilin, amma kwayar cutar na iya sake kunnawa ko “farka” tare da wasu abubuwan da ke haifar da su kamar tsarin garkuwar jiki mara ƙarfi. (Tsarin garkuwar ku shine kariya ta jikin ku game da cututtuka.)

Maganin cutar kansa kamar Darzalex na iya raunana garkuwar ku kuma sake kunna ƙwayoyin cuta. Lokacin da ta farka, tana bayyana kanta kamar shingles maimakon kaji.

Don haka idan kun kasance shingles ko kaza, likitanku zai ba da umarnin maganin rigakafin rigakafin rigakafin cutar don hana shingles sake tasowa a jikinku. Kuna buƙatar shan maganin ƙwayar cuta a cikin mako 1 da fara ɗaukar Darzalex. Sannan zaku ci gaba da shan kwayar cutar na tsawon watanni 3 bayan kun gama jiyya tare da Darzalex.

Idan baku da tabbas ko kuna da shingles ko kaza, yi magana da likitan ku.

Shin Darzalex yana maganin myeloma mai yawa?

A yanzu, babu magani don myeloma mai yawa. Amma abin da Darzalex zai iya yi shine haɓaka ƙimar ka da tsawon rayuwar ka, gwargwadon ganewar asali. Likitanku na iya gaya muku ƙarin bayani.

Kariyar Darzalex

Kafin ɗaukar Darzalex, yi magana da likitanka game da tarihin lafiyar ku. Darzalex bazai dace da kai ba idan kana da wasu halaye na likita ko wasu abubuwan da suka shafi lafiyar ka. Wadannan sun hada da:

  • Ciwon hanta na B Idan kuna da cutar hepatitis B ko kuna da shi a baya, shan Darzalex na iya haifar da sake yin aiki. Kafin ka fara shan Darzalex, likitanka zai duba ka game da hepatitis B. Zasu kuma duba ka bayan ka gama maganin ka. Alamomin cutar hanta sun hada da kasala da ke ta'azzara, da kuma launin kalar rawaya da fari da idanunku. Idan ka lura da wadannan alamun, ka gaya wa likitanka.
  • Shingles. Yayin da kake shan Darzalex, zaka iya kamuwa da cuta da ake kira shingles. Haka kwayar cutar da ke haifar da shingles na iya haifar da kaza. Don haka idan kuna da ciwon kaji ko shingles a baya kuma kuna shan Darzalex, likitanku na iya ba da umarnin maganin rigakafin ƙwayar cuta. Wannan nau'in magani na iya taimakawa hana shingles daga ci gaba a jikin ku.
  • Ciwon cututtukan huhu na ƙarshe (COPD). Idan kana da tarihin rashin lafiyar numfashi da ake kira cututtukan huhu na huhu (COPD), gaya wa likitanka kafin ka fara shan Darzalex. Suna iya ba ku abin sha don taimaka muku numfashi cikin sauƙi da corticosteroids don taimakawa rage kumburi a cikin huhu.
  • Ciki. Ba a yi nazarin Darzalex a cikin mata masu ciki ba. Amma wani nau'in magani ne wanda zai iya ratsa mahaifa. (Maziyyi shine wata mahaifa a cikin mahaifar ka wanda ke isar da abinci daga jikinka zuwa ga jaririn.) Don ƙarin bayani, duba sashen "Darzalex da juna biyu" a sama.
  • Shan nono. Ba a sani ba idan yana da lafiya don shayarwa yayin shan Darzalex. Don ƙarin bayani, da fatan za a duba sashin “Darzalex da shayarwa” a sama.

Faɗa wa likitan lafiyar ku idan kuka ci gaba da ɗayan waɗannan halayen yayin ko bayan jiyya tare da Darzalex.

Lura: Don ƙarin bayani game da tasirin mummunan tasirin Darzalex, duba sashin "Darzalex Side Effects" a sama.

Bayani na kwararru don Darzalex

Ana ba da bayanin nan na gaba don likitoci da sauran ƙwararrun likitocin kiwon lafiya.

Manuniya

Hukumar Abinci da Magunguna (FDA) ta amince kuma ta nuna Darzalex don amfani:

  • A cikin manya tare da sabon myeloma da aka gano da yawa wanda ba zai iya karɓar ƙwayar ƙwayar ƙwayar ƙwayar cuta ba. (Tare da dasawar kwayar halitta mai kwatankwacin kansa, ana amfani da kwayoyin halittar ku.) A wannan halin:
    • Ana iya amfani da Darzalex tare da magungunan lenalidomide (Revlimid) da dexamethasone.
    • Hakanan za'a iya amfani da Darzalex tare da magungunan bortezomib (Velcade), melphalan, da prednisone.
  • A cikin manya waɗanda suka karɓi magani ɗaya ko fiye da suka gabata waɗanda basu yi aiki mai kyau ba ko kuma wanda myeloma da yawa suka dawo. A wannan halin, ana amfani da Darzalex tare da lenalidomide da dexamethasone.
  • A cikin manya waɗanda suka karɓi ɗayan ko fiye da yawa na maganin myeloma (s) da yawa. A wannan halin, ana amfani da Darzalex tare da bortezomib da dexamethasone.
  • A cikin tsofaffi waɗanda suka karɓi magunguna biyu ko fiye da yawa waɗanda suka haɗa da lenalidomide da mai hana kariya, wanda shine nau'in magani. A wannan halin, ana amfani da Darzalex tare da magungunan pomalidomide (Pomalyst) da dexamethasone.
  • A cikin manya waɗanda suka karɓi jiyya na myeloma sau uku ko fiye da suka gabata waɗanda suka haɗa da mai hana kariya da kuma rigakafin magani. A wannan yanayin, ana amfani da Darzalex da kanta.
  • A cikin manya waɗanda suka gwada maƙarƙashiya mai kariya da kuma rigakafi na rigakafi amma babu magungunan da ke aiki don myeloma da yawa. A wannan yanayin, ana amfani da Darzalex da kanta.

Hanyar aiwatarwa

Darzalex shine mai kare mutumci kuma yana hana ko lalata haɓakar ƙwayar ƙwayar ƙwayoyin myeloma da yawa. Lokacin da kwayoyin jini suka juye zuwa kwayoyin myeloma masu yawa, suna bunkasa adadi mai yawa na sunadaran da ake kira CD38. Darzalex yayi niyya kuma ya rataya kansa ga wadannan sunadarai na CD38. Ta hanyar rigakafin sulhu da kai tsaye kan ayyukan ciwace-ciwace, Darzalex ya hana ci gaban kwayar myeloma da yawa kuma ya fara aiwatar da apoptosis (mutuwar kwayar halitta).

Pharmacokinetics da metabolism

Babu wani bambance-bambance masu mahimmanci na asibiti a cikin magungunan magani na Darzalex azaman kulawa ɗaya ko azaman haɗin haɗuwa da aka lura bisa ga takamaiman yawan jama'a.

Bayan jiko na maganin da aka bayar da shi na Darzalex shi kadai ko kuma a matsayin hadewar magani, yawan jinin Darzalex ya ninka har sau uku a karshen maganin na mako-mako idan aka kwatanta shi da na farko.

Raba kashi na farko na Darzalex ya haifar da haɗuwar jini daban-daban fiye da idan mutum ya karɓi cikakken ƙwayar farko. Koyaya, an ga irin wannan kololuwa da wuraren shayarwar jini bayan an karɓi kashi na biyu a sati 1, ranar 2 na jiyya.

Lokacin da aka baiwa Darzalex shi kaɗai, an sami daidaiton matakin zub da jini (ci gaba) wanda ya kai kimanin watanni 5 a cikin kowane lokacin allurai na kowane mako 4 (ta hanyar haɗuwa ta 21). A cikin kwanciyar hankali, Darzalex yana nufin rarar tarin don matsakaicin adadin jini shine 1.6.

Rarraba:

  • monotherapy: 4.7 ± 1.3 L
  • hade far: 4.4 ± 1.5 L

Rarraba rabin-rabi don kulawa da jinƙai da haɗin gwiwa shine kwanaki 18 ± 9. Haɓakar Darzalex ta ragu tare da ƙaruwa da kuma yawan allurai. An kiyasta yarda ya zama 171.4 ± 95.3 mL / rana. Yayinda nauyin jiki ya karu, girman rarrabawa da saurin da aka cire Darzalex daga jiki ya karu.

Contraindications

Darzalex an hana shi cikin marasa lafiya tare da tarihin halayen rashin ƙarfi na rashin ƙarfi ga daratumumab ko ɗayan masu karɓar maganin. Abubuwa masu tsanani na rashin nutsuwa, thrombocytopenia, ko halayen jiko saboda magani na iya buƙatar dakatar da Darzalex ko kuma tsayar dashi har abada.

Ma'aji

Darzalex ya kamata a ajiye shi cikin firiji a 36 ° F zuwa 46 ° F (2 ° C zuwa 8 ° C).

Kar a girgiza ko daskare Darzalex. Ya kamata a kiyaye miyagun ƙwayoyi daga haske. Darzalex bai ƙunshi wasu abubuwan kiyayewa ba.

Bayanin sanarwa: Labaran Likita a Yau sun yi iya kokarinsu don tabbatar da cewa dukkan bayanan gaskiya ne, cikakke, kuma na zamani. Koyaya, wannan labarin bai kamata ayi amfani dashi azaman madadin ilimi da ƙwarewar ƙwararren likita mai lasisi ba. Ya kamata koyaushe ku tuntuɓi likitanku ko wasu masu sana'a na kiwon lafiya kafin shan kowane magani. Bayanin magani da ke cikin wannan batun na iya canzawa kuma ba ana nufin ya rufe duk amfanin da zai yiwu ba, kwatance, kiyayewa, gargaɗi, hulɗar miyagun ƙwayoyi, halayen rashin lafiyan, ko cutarwa. Rashin gargadin ko wasu bayanai don maganin da aka bayar baya nuna cewa magani ko haɗin magungunan yana da aminci, tasiri, ko dacewa ga duk marasa lafiya ko duk takamaiman amfani.

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