Gudanar da Cholesterol: PCSK9 Inhibitors vs. Statins

Wadatacce

• Game da statins
• Yadda suke aiki
• Iri
• Game da masu hanawa PCSK9
• Lokacin da aka tsara su
• Yadda suke aiki
• Sakamakon sakamako
• Inganci
• Kudin
• Yi magana da likitanka
• Yi magana da likitanka

Gabatarwa

Kusan kusan Amurkawa miliyan 74 suke da babban cholesterol, a cewar. Koyaya, ƙasa da rabi ke karɓar magani don shi. Wannan ya sanya su cikin babbar haɗarin bugun zuciya da shanyewar jiki. Duk da yake motsa jiki da abinci mai kyau na iya taimakawa sau da yawa don sarrafa matakan cholesterol, wani lokacin ana buƙatar magani.

Nau'ikan magunguna guda biyu da aka tsara don magance babban cholesterol sun haɗa da statins da PCSK9 masu hanawa. Statins sanannen magani ne wanda aka samo shi tun cikin 1980s. PCSK9 masu hanawa, a gefe guda, sabbin nau'ikan maganin cholesterol ne. Hukumar Abinci da Magunguna ta amince da su a cikin 2015.

Lokacin da ku da likitanku ke yanke shawara akan maganin cholesterol a gare ku, zaku iya yin la'akari da dalilai irin su sakamako masu illa, tsada, da fa'ida. Karanta don ƙarin koyo game da waɗannan kwayoyi da yadda nau'ikan biyun suke kwatantawa.

Game da statins

Statins sune ɗayan nau'ikan magungunan da aka saba amfani dasu don taimakawa ƙananan cholesterol. Idan kuna da babban ƙwayar cholesterol ko wasu haɗarin zuciya, likitanku na iya ba da shawarar ku fara shan wani yanayi. Sau da yawa ana amfani dasu azaman farkon layin farko na babban cholesterol. Wannan yana nufin su ne magani na farko da likitanku zai iya ba da shawara.

Yadda suke aiki

Statins suna aiki ta hanyar toshe wani abu da ake kira HMG-CoA reductase. Wannan mahaɗan ne hanta ke buƙatar yin cholesterol. Toshe wannan abu yana rage adadin cholesterol da hantar ku takeyi. Hakanan Statins suna aiki ta hanyar taimakawa jikinka sake dawo da duk wani cholesterol da ya taru a bangon hanyoyin jinin ku. Don ƙarin koyo, karanta game da yadda statins ke aiki.

Iri

Statins suna zuwa cikin sifar Allunan ko kawunansu da kuke ɗauka da baki. Akwai nau'ikan statins da yawa da ake da su a Amurka a yau. Sun hada da:

• atorvastatin (Lipitor)
• fluvastatin (Lescol)
• lovastatin (Altoprev)
• farashi (Pravachol)
• rosuvastatin (Crestor)
• simvastatin (Zocor)
• pitavastatin (Livalo)

Game da masu hanawa PCSK9

Ana iya tsara alamun don mutane da yawa tare da babban cholesterol, amma PCSK9 masu hanawa yawanci ana tsara su ne kawai don wasu nau'in mutane. Saboda tsauraran matakai sun daɗe sosai, mun san ƙarin tasirin su. PCSK9 masu hanawa sababbi ne kuma don haka suna da ƙarancin bayanan tsaro na dogon lokaci.

Hakanan, masu hanawa na PCSK9 suna da tsada sosai idan aka kwatanta da statins.

Ana ba da magungunan PCSK9 ta hanyar allura kawai. Akwai masu hanawa PCSK9 guda biyu kawai a yau a Amurka: Praluent (alirocumab) da Repatha (evolocumab).

Lokacin da aka tsara su

Kwalejin Kwalejin Zuciya ta Amurka ta ba da shawarar ku da likitan ku yi la'akari da mai hana PCSK9 kawai idan:

• An dauke ku babban haɗari ga matsalar zuciya da jijiyoyin jini kuma ba a sarrafa cholesterol ɗinku tare da ƙwayoyi ko wasu ƙwayoyin rage ƙwayoyin cholesterol
• kana da yanayin kwayar halitta da ake kira familial hypercholesterolemia, wanda ya kunshi matuka da yawa na matakan cholesterol

A kowane ɗayan waɗannan sharuɗɗan, yawanci ana ba da magungunan PCSK9 bayan nau'ikan magunguna biyu ba su taimaka rage matakan cholesterol ba. Misali, likitanka na farko zai iya bada umarnin samarda wani yanayi.Idan hakan bai rage matakan cholesterol yadda ya kamata ba, likitanku na iya ba da shawarar ezetimibe (Zetia) ko magungunan da ake kira resin bile acid. Misalan waɗannan sun haɗa da cholestyramine (Locholest), colesevelam (Welchol), ko colestipol (Colestid).

Idan har yanzu matakan cholesterol sun yi yawa sosai bayan wannan nau'in magani na biyu, to likitanku na iya ba da shawarar mai hana PCSK9.

Yadda suke aiki

PCSK9 masu hanawa za a iya amfani da su ban da ko maimakon statins. Wadannan kwayoyi suna aiki daban. Masu hana PCSK9 suna niyya furotin a cikin hanta da ake kira proprotein convertase subtilisin kexin 9, ko PCSK9. Ta rage adadin PCSK9 a jikinka, masu hanawa PCSK9 suna bawa jikinka damar cire cholesterol sosai.

Sakamakon sakamako

Statins da PCSK9 masu hanawa kowane ɗayan na iya haifar da lahani kuma mafi tsanani, kuma tasirin ya bambanta tsakanin magungunan.

Inganci

Statins an nuna ƙananan cholesterol a cikin mutane da yawa. An yi amfani da su tun daga 1980s kuma ana nazarin tasirin su a cikin dubunnan mutane waɗanda ke ɗaukar statins don hana ciwon zuciya da bugun jini.

Sabanin haka, ba da jimawa ba aka amince da masu hana PCSK9, don haka bayanan tsaro na dogon lokaci ba su da kyau. Duk da haka masu hana PCSK9 suna da tasiri sosai ga wasu mutane.Wani bincike ya nuna cewa alirocumab ya rage matakan cholesterol da kashi 61. Hakanan ya rage yiwuwar abubuwan da suka shafi zuciya kamar zuciya da bugun jini. Wani binciken ya samo irin wannan sakamakon tare da evolocumab.

Kudin

Akwai wadatar Statins a cikin nau'ikan suna da nau'ikan nau'ikan tsari. Abubuwan ilimin kimiyyar lissafi gabaɗaya sunkai ƙasa da nau'ikan sigar, don haka tsaran na iya zama marasa tsada.

PCSK9 masu hanawa sabo ne, don haka ba su da nau'ikan sifofin da ake dasu har yanzu. Saboda wannan, sun fi statins tsada. Kudin masu hanawa na PCSK9 na iya kan $ 14,000 a shekara. Bugu da kari, don samun wannan kudin da inshorarku ta rufe, dole ne ku fada cikin daya daga cikin bangarorin biyu da aka ba da shawarar don amfani da masu hanawa na PCSK9. Idan baku dace da ɗayan waɗannan rukunin ba, wataƙila za ku biya wa PCSK9 mai hana kansa da kanku.

Yi magana da likitanka

Statins da PCSK9 masu hanawa sune mahimman zaɓuɓɓukan magani don magance matakan cholesterol mai girma. Duk da yake nau'ikan magungunan biyu suna taimakawa ƙananan matakan cholesterol, akwai wasu manyan bambance-bambance. Tebur da ke ƙasa yana nuna waɗannan bambance-bambancen a kallo ɗaya.

Yi magana da likitanka

Idan kuna da babban cholesterol kuma kuna tunanin ɗayan waɗannan nau'ikan ƙwayoyi na iya zama daidai a gare ku, matakinku na farko ya kamata ku yi magana da likitanku. Za su iya gaya muku ƙarin bayani game da waɗannan magungunan da sauran zaɓuɓɓukan maganinku. Wasu tambayoyi don tattaunawa tare da likitanku na iya zama:

• Shin magani ne mataki na gaba a gare ni wajen kula da babban kwalastaral na?
• Shin na cika sharudda guda biyu don mutanen da za'a iya sanya masu hana masu PCSK9?
• Shin ya kamata in yi magana da kwararren mai?
• Shin zan fara shirin motsa jiki don taimakawa wajen kula da cholesterol?
• Shin zaku iya tura ni zuwa likitan abinci mai rijista don taimaka min wajen sarrafa abincin na?