Cutar McCune-Albright

Cutar McCune-Albright cuta ce ta kwayar halitta wacce ke shafar ƙasusuwa, hormones, da launi (launi) na fata.

Cutar McCune-Albright ta haifar da maye gurbi a cikin GNAS kwayar halitta Numberaramin adadi, amma ba duka ba, na ƙwayoyin mutum suna ɗauke da wannan lalatacciyar ƙwayar (mosaicism).

Wannan cutar ba ta gado ba.

Babban alamar cutar McCune-Albright shine farkon balaga ga isan mata. Lokacin jinin haila na iya farawa tun lokacin ƙuruciya, tun kafin nonon ya girma ko gashinta (wanda yawanci yakan fara faruwa). Matsakaicin shekarun da bayyanar cututtuka ke bayyana shine shekaru 3. Koyaya, balaga da jinin al'ada suna faruwa tun daga watanni 4 zuwa 6 ga girlsan mata.

Hakanan ci gaban jima'i na farko yana iya faruwa ga yara maza, amma ba kamar na 'yan mata ba.

Sauran cututtukan sun hada da:

• Kashin karaya
• Lalacewar kasusuwa a fuska
• Gigantism
• Ba daidai ba ne, babban cafe au lalatattun wuraren shakatawa

Nazarin jiki na iya nuna alamun:

• Ciwan ƙashi mara kyau a cikin kwanyar
• Heartwayar zuciya mara kyau (arrhythmias)
• Acromegaly
• Gigantism
• Manyan wuraren cafe-au-lait a fata
• Ciwon hanta, jaundice, hanta mai mai
• Tako-kamar nama a cikin kashi (fibrous dysplasia)

Gwaji na iya nuna:

• Matsalolin mara kyau
• Babban matakin parathyroid hormone (hyperparathyroidism)
• Babban matakin hormone na thyroid (hyperthyroidism)
• Matsalar rashin lafiyar adrenal
• Levelananan matakin phosphorous a cikin jini (hypophosphatemia)
• Ovarian cysts
• Pituitary ko ciwan ƙwayar thyroid
• Matsakaicin matakin prolactin na jini
• Matsayi mai girma na al'ada

Sauran gwaje-gwajen da za'a iya yi sun haɗa da:

• MRI na kai
• X-ray na ƙasusuwa

Ana iya yin gwajin kwayar halitta don tabbatar da cutar.

Babu takamaiman magani don cutar ta McCune-Albright. An gwada magungunan da ke toshe haɓakar estrogen, kamar testolactone, tare da samun nasara.

Abubuwa masu rikitarwa na jiki (kamar su Cushing syndrome) za a iya bi da su tare da tiyata don cire glandon adrenal. Gigantism da adenoma na pituitary zasu buƙaci bi da su tare da magungunan da ke toshe haɓakar hormone, ko tare da tiyata.

Wasu lokuta ana cire cututtukan ƙashi (fibrous dysplasia) tare da tiyata.

Iyakance adadin x-ray da aka ɗauka na wuraren da abin ya shafa na jiki.

Yawan rayuwa daidai yake.

Matsaloli na iya haɗawa da:

• Makaho
• Matsalar gyaran jiki daga rashin daidaito na kashi
• Kurma
• Osteitis fibrosa ciwon ciki
• Balaga da wuri
• Maimaita karayar ƙasusuwa
• Tumosu na kashi (m)

Kira mai kula da lafiyar ku idan ɗanku ya fara balaga da wuri, ko kuma yana da wasu alamun rashin lafiya na McCune-Albright. Ba da shawara kan kwayoyin halitta, da yiwuwar gwajin kwayoyin, ana iya ba da shawarar idan aka gano cutar.

Polyostotic fibrous cutar

• Gwajin kasusuwa na gaba
• Neurofibromatosis - katuwar cafe-au-lait tabo

Garibaldi LR, Chemaitilly W. Rashin lafiya na ci gaban haihuwa. A cikin: Kliegman RM, St.Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Littafin koyar da ilimin yara. 21st ed. Philadelphia, PA: Elsevier; 2020: babi na 578.

Styne DM. Ilimin halittar jiki da rikicewar balaga. A cikin: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Littafin Williams na Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020: babi na 26.