Minocycline na Rheumatoid Arthritis: Shin Yana Aiki?

Wadatacce

• Game da amfani da lakabin lakabi
• Menene binciken ya ce?
• Tarihin bincike na farko
• Karin bayanai na karatu tare da minocycline
• Ta yaya minocycline ke aiki don magance RA?
• Wanene zai ci gajiyar minocycline na RA?
• Menene yarjejeniya?
• Menene illar?
• Takeaway

Bayani

Minocycline wani maganin rigakafi ne a cikin dangin tetracycline. An yi amfani dashi fiye da magance yawan ƙwayoyin cuta.

, masu bincike sun nuna anti-mai kumburi, garkuwar jiki, da kaddarorin da ke kare jiki.

Tun daga lokacin, wasu likitocin rheumatologists sunyi nasarar amfani da tetracyclines don maganin cututtukan rheumatoid (RA). Wannan ya hada da minocycline. Yayin da aka samo sabbin ajin kwayoyi, amfani da minocycline ya ƙi. A lokaci guda, ya nuna cewa minocycline yana da amfani ga RA.

Ba a yarda da Minocycline musamman ta Hukumar Abinci da Magunguna ta Amurka (FDA) don amfani tare da RA. Yana lokaci-lokaci wajabta "kashe-lakabin."

Duk da fa'idodi mai fa'ida a cikin gwaji, gaba ɗaya ba'a amfani da minocycline don magance RA a yau.

Game da amfani da lakabin lakabi

Amfani da lakabin-lakabin amfani yana nufin cewa magani wanda FDA ta yarda dashi don manufa ɗaya ana amfani dashi don wata manufa daban wacce ba a yarda da ita ba. Koyaya, likita har yanzu yana iya amfani da miyagun ƙwayoyi don wannan dalili. Wannan saboda FDA ta tsara gwajin da yarda da magunguna, amma ba yadda likitoci ke amfani da kwayoyi don kula da marasa lafiya ba.Don haka likitanku na iya ba da umarnin magani duk da haka suna ganin shine mafi kyau don kulawa. Ara koyo game da amfani da lakabin magani ba tare da lakabi ba.

Menene binciken ya ce?

tun a ƙarshen 1930s cewa ƙwayoyin cuta suna da hannu wajen haifar da RA.

Nazarin binciken asibiti da sarrafawa na amfani da minocycline don RA gabaɗaya sun yanke hukunci cewa minocycline yana da amfani kuma yana da aminci ga mutanen da ke da RA.

Sauran kwayoyin cutar sun hada da sinadarin sulfa, wasu tetracyclines, da kuma rifampicin. Amma minocycline ya kasance batun karin binciken makafi biyu da kuma gwaji na asibiti saboda yawan kayan sa.

Tarihin bincike na farko

A cikin 1939, masanin ilimin cututtukan Ba'amurke Thomas McPherson-Brown da abokan aikinsa sun ware wani abu mai kama da kwayar cuta daga kayan RA. Sun kira shi mycoplasma.

Daga baya McPherson-Brown ya fara gwajin gwaji na RA tare da maganin rigakafi. Wasu mutane da farko sun yi muni. McPherson-Brown ya danganta wannan ne ga tasirin Herxheimer, ko kuma "mutu-ka-mutu," sakamakon: Lokacin da aka kai hari kan kwayoyin cuta, sukan saki gubobi waɗanda da farko suke haifar da alamun cututtukan da ke tashi. Wannan yana nuna cewa maganin yana aiki.

A cikin lokaci mai tsawo, marasa lafiya sun sami sauki. Dayawa sun sami gafara bayan sun sha maganin na rigakafi har tsawon shekaru uku.

Karin bayanai na karatu tare da minocycline

A na nazarin 10 idan aka kwatanta maganin rigakafin tetracycline zuwa magani na al'ada ko placebo tare da RA. Binciken ya kammala cewa tetracycline (kuma musamman minocycline) magani yana da nasaba da ci gaban da ke da mahimmanci a asibiti.

Nazarin 1994 da aka gudanar na minocycline tare da mahalarta 65 ya ba da rahoton cewa minocycline yana da amfani ga waɗanda ke da RA mai aiki. Yawancin mutane a cikin wannan binciken sun ci gaba da RA.

A na mutanen 219 tare da RA sun kwatanta magani tare da minocycline zuwa placebo. Masu binciken sun kammala cewa minocycline yana da tasiri kuma yana da aminci a cikin ƙananan yanayin RA.

Nazarin 2001 na mutane 60 tare da RA sun kwatanta magani tare da minocycline zuwa hydroxychloroquine. Hydroxychloroquine magani ne mai canza cututtukan ƙwayar cuta (DMARD) wanda ake amfani dashi don magance RA. Masu binciken sun bayyana cewa minocycline ya fi tasiri fiye da DMARDs don farkon kwayar cutar RA.

Binciken shekaru hudu ya kalli marasa lafiya 46 a cikin binciken makafi biyu wanda ya kwatanta jiyya tare da minocycline zuwa placebo. Hakanan ya ba da shawarar minocycline magani ne na RA. Mutanen da aka kula da su tare da minocycline suna da ragi kaɗan kuma suna buƙatar ƙaramin maganin gargajiya. Wannan haka lamarin yake kodayake aikin minocycline ya kasance wata uku zuwa shida ne kawai.

Yana da mahimmanci a lura cewa yawancin waɗannan karatun sun shafi amfani da gajeren lokaci na minocycline. McPherson-Brown ya jaddada cewa hanyar magani don isa gafara ko ci gaba mai mahimmanci na iya ɗaukar shekaru uku.

Ta yaya minocycline ke aiki don magance RA?

Ba a fahimci ainihin ma'anar minocycline ba azaman RA magani. Bugu da ƙari ga aikin maganin ƙwayoyin cuta, minocycline yana da abubuwan anti-inflammatory. Musamman, minocycline zuwa:

• shafi nitric oxide synthase, wanda ke cikin lalacewar collagen
• inganta interleukin-10, wanda ke hana cytokine mai kumburi a cikin ƙwayar synovial (kayan haɗin kai kusa da haɗin gwiwa)
• kawar da aikin kwayar B da T na tsarin garkuwar jiki

Minocycline na iya samun. Wannan yana nufin zai iya inganta RA yayin da aka haɗu da ƙwayoyin cututtukan ƙwayoyin cuta ko wasu magunguna.

Wanene zai ci gajiyar minocycline na RA?

An ba da shawara a cikin cewa mafi kyawun candidatesan takarar su ne waɗanda suke a farkon matakin RA. Amma wasu daga cikin binciken suna nuna cewa mutanen da ke da ingantaccen RA na iya amfana.

Menene yarjejeniya?

Yarjejeniyar magani ta yau da kullun a cikin binciken bincike shine milligram 100 (MG) sau biyu a rana.

Amma kowane mutum ya bambanta, kuma yarjejeniyar minocycline na iya bambanta. Wasu mutane na iya buƙatar farawa tare da ƙananan kashi kuma suyi aiki har zuwa 100 MG ko sau biyu a rana. Wasu na iya buƙatar bin tsarin bugun jini, shan minocycline kwana uku a mako ko bambanta shi da wasu magunguna.

Kamar maganin rigakafi na cututtukan Lyme, babu wata hanyar da ta dace da juna. Hakanan, yana iya ɗaukar tsawon shekaru uku don ganin sakamako a wasu maganganun RA.

Menene illar?

Minocycline an haƙura sosai. Illolin da ake iya samu sune matsakaici kuma yayi kama da na sauran kwayoyin rigakafi. Sun hada da:

• matsalolin ciki
• jiri
• ciwon kai
• kumburin fata
• ƙara ƙwarewa zuwa hasken rana
• farji yisti kamuwa da cuta
• hauhawar jini

Takeaway

Minocycline, musamman da aka yi amfani da shi na dogon lokaci, an nuna shi don inganta bayyanar cututtukan RA kuma don taimakawa saka mutane cikin gafara. Ba'a amfani dashi sosai a yau, duk da ingantaccen rikodin sa.

Muhawara ta yau da kullun da aka bayar akan amfani da minocycline don RA sune:

• Babu isassun karatu.
• Maganin rigakafi yana da illoli.
• Sauran kwayoyi suna aiki mafi kyau.

Wasu masu bincike da likitocin rheumatologist basu yarda da wadannan hujjojin ba kuma suna nuna sakamakon binciken da akeyi.

Yana da mahimmanci a shiga cikin shirya maganin ku da kuma bincika hanyoyin. Tattauna tare da likitanka wanda zai iya zama mafi kyau ga yanayinku na musamman.

Idan kana son gwada minocycline kuma likitanka ya hana shi, ka tambayi dalili. Nuna rubutaccen tarihin amfani da minocycline. Yi magana da likita game da illolin shan magungunan steroid na dogon lokaci idan aka kwatanta da ƙananan tasirin illa na minocycline. Kuna so ku nemi cibiyar bincike wacce tayi aiki tare da minocycline da RA.