TP53 Gwajin Halitta

Wadatacce

• Menene gwajin kwayar TP53?
• Me ake amfani da shi?
• Me yasa nake buƙatar gwajin kwayar TP53?
• Menene ya faru yayin gwajin kwayar TP53?
• Shin zan bukaci yin komai don shirya wa gwajin?
• Shin akwai haɗari ga gwajin?
• Menene sakamakon yake nufi?
• Shin akwai wani abin da nake buƙatar sani game da gwajin TP53?
• Bayani

Menene gwajin kwayar TP53?

Gwajin kwayar TP53 yana neman canji, wanda aka sani da maye gurbi, a cikin kwayar halittar da ake kira TP53 (ƙwayar tumo 53). Kwayar halitta sune asalin asalin gadon da mahaifinka da mahaifinka suka mallaka.

TP53 wata kwayar halitta ce wacce ke taimakawa dakatar da haɓakar ciwace-ciwacen ƙwayoyi. An san shi a matsayin mai hana ƙwayar cuta. Kwayar cututtukan ƙwayar tumo tana aiki kamar birki a kan mota. Yana sanya "birki" akan sel, don haka kar su rarraba da sauri. Idan kana da maye gurbi na TP53, kwayar halittar ba zata iya sarrafa ci gaban kwayoyin halittar ka ba. Ci gaban ƙwayoyin da ba a sarrafawa na iya haifar da cutar kansa.

Canjin TP53 zai iya zama gado daga iyayenku, ko samu daga baya daga rayuwa ko daga kuskuren da ke faruwa a jikinku yayin rarraba ƙwayoyin halitta.

• Canjin maye gurbin TP53 an san shi da cutar Li-Fraumeni.
• Ciwon Li-Fraumeni wani yanayi ne mai saurin yaduwa wanda zai iya haifar da haɗarin wasu cututtukan kansa.
• Wadannan cututtukan sun hada da kansar mama, sankarar kashi, cutar sankarar bargo, da cututtukan nama masu laushi, wanda ake kira sarcomas.

Saukewa (wanda aka sani da suna somatic) maye gurbi na TP53 yafi na kowa. Wadannan maye gurbi an same su a kusan rabin dukkan cutar kansa, kuma a yawancin nau'o'in cutar kansa.

Sauran sunaye: TP53 bincike na maye gurbi, TP53 cikakken binciken kwayoyin halitta, TP53 maye gurbi na yanayi

Me ake amfani da shi?

Ana amfani da gwajin don neman maye gurbin TP53. Ba jarabawa ce ta yau da kullun ba. Yawanci ana ba mutane ne bisa ga tarihin iyali, alamomi, ko kuma ganewar asali na cutar kansa.

Me yasa nake buƙatar gwajin kwayar TP53?

Kuna iya buƙatar gwajin TP53 idan:

• An gano ku da cutar ƙashi ko taushi mai laushi kafin shekaru 45
• An riga an gano ku tare da, cutar sankara ta pre-menopausal, ƙwaƙwalwar ƙwaƙwalwa, cutar sankarar bargo, ko cutar huhu kafin shekara 46
• Kun taba samun ƙari ko fiye da shekaru 46
• Aya ko fiye daga cikin danginku sun kamu da cutar Li-Fraumeni kuma / ko sun kamu da cutar daji kafin shekara 45

Waɗannan alamomi ne da wataƙila ka sami maye gurbi na kwayar halittar TP53.

Idan an gano ku da ciwon daji kuma ba ku da tarihin cutar game da cutar, mai ba ku kiwon lafiya na iya yin wannan gwajin don ganin idan maye gurbin TP53 na iya haifar da kansar ku. Sanin ko kuna da maye gurbi na iya taimaka wa mai ba ku sabis don tsara magani da kuma hango yiwuwar cutar.

Menene ya faru yayin gwajin kwayar TP53?

Gwajin TP53 galibi ana yin sa ne a kan jini ko ɓacin kashi.

Idan kuna yin gwajin jini, wani kwararren mai kula da lafiya zai dauki samfurin jini daga jijiyar hannunka, ta amfani da karamin allura. Bayan an saka allurar, za a tara karamin jini a cikin bututun gwaji ko kwalba. Kuna iya jin ɗan kaɗan lokacin da allurar ta shiga ko fita. Wannan yawanci yakan dauki kasa da minti biyar.

Idan kuna samun gwajin kashin kashi, tsarinku na iya haɗawa da matakai masu zuwa:

• Za ku kwanta a gefenku ko cikinku, ya danganta da wane ƙashi za a yi amfani da shi don gwaji. Yawancin gwaje-gwajen kasusuwa ana ɗauke su daga ƙashin ƙugu.
• Za a rufe jikinka da zane, don haka yankin da ke wurin gwajin kawai yake nunawa.
• Za a tsabtace shafin tare da maganin kashe kwayoyin cuta.
• Za a yi muku allurar maganin narkar da numba. Yana iya jin zafi
• Da zarar yankin ya dushe, mai ba da kiwon lafiya zai ɗauki samfurin. Kuna buƙatar yin kwance sosai yayin gwaje-gwajen.
• Mai ba da sabis na kiwon lafiya zai yi amfani da kayan aiki na musamman wanda ya murɗa cikin ƙashi don fitar da samfurin ƙashin kashin ƙashi. Kuna iya jin danniya akan shafin yayin ɗaukar samfurin.
• Bayan gwajin, mai ba da lafiyar zai rufe shafin da bandeji.
• Yi shirin sanya wani ya kore ka gida, tun da ana iya ba ka maganin ƙyama kafin gwaji, wanda zai iya sa ka yin bacci.

Shin zan bukaci yin komai don shirya wa gwajin?

Yawanci baku buƙatar kowane shiri na musamman don gwajin jini ko ƙashi.

Shin akwai haɗari ga gwajin?

Akwai haɗari kaɗan don yin gwajin jini. Kuna iya samun ɗan ciwo ko rauni a wurin da aka sanya allurar, amma yawancin alamun suna tafi da sauri.

Bayan gwajin ɓarna, za ka iya jin tauri ko ciwo a wurin allurar. Wannan yawanci yakan shuɗe cikin daysan kwanaki. Mai ba da sabis na kiwon lafiya na iya bayar da shawarar ko kuma ba da umarnin rage zafi don taimakawa.

Menene sakamakon yake nufi?

Idan an gano ku tare da ciwo na Li-Fraumeni, shi ba ya yana nufin kuna da ciwon daji, amma haɗarinku ya fi na yawancin mutane. Amma idan kuna da maye gurbi, zaku iya ɗaukar matakai don rage haɗarinku, kamar:

• Mafi yawan binciken kansar. Ciwon daji ya fi sauƙi idan aka samo shi a farkon matakan.
• Yin canjin rayuwa, kamar ƙara motsa jiki da cin abinci mai ƙoshin lafiya
• Chemoprevention, shan wasu magunguna, bitamin, ko wasu abubuwa don rage haɗarin ko jinkirta ci gaban cutar kansa.
• Cire nama mai hatsari

Waɗannan matakan zasu bambanta dangane da tarihin lafiyar ku da asalin iyali.

Idan kana da cutar daji kuma sakamakonka yana nuna maye gurbin TP53 da aka samu (an sami maye gurbi, amma ba ka da tarihin iyali na cutar kansa ko cutar Li-Fraumeni), mai ba ka sabis zai iya amfani da bayanin don taimakawa hango yadda cutarka za ta ci gaba da shiryar magani.

Learnara koyo game da gwaje-gwajen gwaje-gwaje, jeri na tunani, da fahimtar sakamako.

Shin akwai wani abin da nake buƙatar sani game da gwajin TP53?

Idan an gano ku tare ko kuma kuna tsammanin kuna da cutar Li-Fraumeni, yana iya taimakawa wajen yin magana da mai ba da shawara kan kwayoyin halitta. Mai ba da shawara kan kwayar halitta kwararren kwararren masani ne a fannin ilimin kwayoyin halitta da gwajin kwayoyin halitta. Idan har yanzu ba a gwada ku ba, mai ba da shawara zai iya taimaka muku fahimtar haɗari da fa'idodin gwaji. Idan an gwada ku, mai ba da shawara zai iya taimaka muku fahimtar sakamakon kuma ya umurce ku da tallafawa ayyukan da sauran albarkatu.

Bayani

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5. Cibiyoyin Kula da Rigakafin Cututtuka [Intanet]. Atlanta: Ma'aikatar Kiwon Lafiya ta Amurka da Ayyukan Dan Adam; Rigakafin Ciwon daji da Kulawa: Gwajin gwaji; [sabunta 2018 Mayu 2; wanda aka ambata 2018 Jun 29]; [game da fuska 3]. Akwai daga: https://www.cdc.gov/cancer/dcpc/prevention/screening.htm
6. Ciwon Cutar Li-Fraumeni: Lungiyar LFSA [Intanet]. Holliston (MA): Liungiyar Ciwon Cutar Li-Fraumeni; c2018. Menene LFS?: Li-Fraumeni ciwo Association; [wanda aka ambata 2018 Jun 29]; [game da allo 2]. Akwai daga: https://www.lfsassociation.org/what-is-lfs
7. Mayo Clinic [Intanet]. Gidauniyar Mayo don Ilimin Likita da Bincike; c1998–2018. Gwajin kasusuwa da fata: Siffar bayani; 2018 Jan 12 [wanda aka ambata 2018 Jun 29]; [game da fuska 4]. Akwai daga: https://www.mayoclinic.org/tests-procedures/bone-marrow-biopsy/about/pac-20393117
8. Mayo Clinic: Mayo Laboratories Medical [Internet]. Gidauniyar Mayo don Ilimin Likita da Bincike; c1995–2018. Gwajin ID: P53CA: Neoplasms na Hematologic, TP53 Mutatic Mutation, DNA Sequencing Exons 4-9: Clinical and Interpretive; [wanda aka ambata 2018 Jun 29]; [game da fuska 4]. Akwai daga: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/62402
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11. Shafin Kasuwancin Merck Manual [Internet]. Kenilworth (NJ): Kamfanin Merck & Co., Inc.; c2018. Jarrabawar Kashin Kashi; [wanda aka ambata 2018 Jun 29]; [game da allo 2]. Akwai daga: http://www.merckmanuals.com/home/blood-disorders/symptoms-and-diagnosis-of-blood-disorders/bone-marrow-examination
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Ba za a yi amfani da bayanan da ke wannan rukunin yanar gizon a madadin madadin ƙwararrun likitocin ko shawara ba. Tuntuɓi mai ba da kiwon lafiya idan kuna da tambayoyi game da lafiyarku.