Peutz-Jeghers ciwo

Ciwon Peutz-Jeghers (PJS) cuta ce da ba a cika samun ci gabanta da ake kira polyps a cikin hanjinsa. Mutumin da ke da PJS yana da babban haɗarin kamuwa da wasu cututtukan kansa.

Ba a san yawan mutanen da PJS ya shafa ba. Koyaya, Cibiyoyin Kiwon Lafiya na ƙasa sun kiyasta cewa yana shafar kusan 1 cikin haihuwa 25,000 zuwa 300,000.

PJS ya samo asali ne daga maye gurbi a cikin kwayar halittar da ake kira STK11 (wanda a da ake kira LKB1). Akwai hanyoyi guda biyu da za'a iya gado PJS:

• Iyali PJS an gada ta cikin iyalai azaman babbar sifar autosomal. Wannan yana nufin idan ɗayan iyayenku suna da wannan nau'in PJS, kuna da damar kashi 50% na gado da kwayar cutar.
• Ba a gado PJS maras ma'ana daga iyaye. Canjin kwayar halitta yana faruwa da kansa. Da zarar wani ya ɗauki canjin halittar, 'ya'yansu na da damar kaso 50% na su.

Kwayar cutar PJS sune:

• Launi mai laushi ko launin toka a lebe, gumis, rufin bakin ciki, da fata
• Yatsun kafa ko yatsun kafa
• Jin zafi a cikin yankin ciki
• Duhu mai duhu akan leɓunan yaro
• Jini a cikin shimfidar da za'a iya gani da ido (wani lokacin)
• Amai

Kwayoyin halittar sun fi girma a cikin karamin hanji, amma kuma a cikin babban hanji (hanji). Gwajin cikin hanji da ake kira colonoscopy zai nuna ciwon hanji. An kimanta karamar hanji ta hanyoyi biyu. Isaya shine x-ray na barium (ƙaramin jerin hanji). Isayan kuma shine ƙarshen maganin, wanda a cikin sa aka haɗiɗa ƙaramar kyamara sannan kuma a ɗauki hoto da yawa yayin tafiya ta cikin ƙananan hanji.

Examarin gwaji na iya nuna:

• Wani bangare na hanjin nannade kansa (intussusception)
• Tumananan ciwace-ciwace a cikin hanci, hanyoyin iska, fitsari, ko mafitsara

Gwajin gwaje-gwaje na iya haɗawa da:

• Cikakken ƙidayar jini (CBC) - na iya bayyana karancin jini
• Gwajin kwayoyin halitta
• Stool guaiac, don neman jini a cikin kujerun
• Capacityarfin ƙarfin ɗaure ƙarfe (TIBC) - na iya alaƙa da karancin karancin ƙarfe

Ana iya buƙatar aikin tiyata don cire polyps wanda ke haifar da matsaloli na dogon lokaci. Arin ƙarfe na taimakawa wajen magance zubar jini.

Mutanen da ke da wannan yanayin ya kamata mai kula da kiwon lafiya ya sanya musu ido kuma a duba su akai-akai don canjin cututtukan da suka kamu da cutar kansa.

Abubuwan masu zuwa na iya ba da ƙarin bayani kan PJS:

• Nationalungiyar forasa don Rare Rashin Lafiya (NORD) - rarediseases.org/rare-diseases/peutz-jeghers-syndrome
• NIH / NLM Tsarin Gida na Gida - ghr.nlm.nih.gov/condition/peutz-jeghers-syndrome

Zai iya zama babban haɗari ga waɗannan polyps su zama masu cutar kansa. Wasu nazarin suna danganta PJS tare da cututtukan daji na hanji, huhu, nono, mahaifa, da ƙwai.

Matsaloli na iya haɗawa da:

• Intussusception
• Polyps da ke haifar da cutar kansa
• Ovarian cysts
• Wani nau'in ciwan kwan mace da ake kira tumbin igiyar jima'i

Kira don alƙawari tare da mai ba da sabis idan ku ko yaranku suna da alamun wannan yanayin. Tsananin ciwon ciki na iya zama alamar yanayin gaggawa kamar intussusception.

Ana ba da shawarar ba da shawara kan kwayar halitta idan kuna shirin haihuwar yara kuma ku sami tarihin iyali na wannan yanayin.

PJS

• Gabobin tsarin narkewar abinci

McGarrity TJ, Amos CI, Baker MJ. Peutz-Jeghers ciwo. A cikin: Adam MP, Ardinger HH, Pagon RA, et al, eds.GeneReviews. Seattle, WA: Jami'ar Washington. www.ncbi.nlm.nih.gov/books/NBK1266. An sabunta Yuli 14, 2016. An shiga Nuwamba 5, 2019.

Wendel D, Murray KF. Tumurai na narkewa kamar fili. A cikin: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Littafin koyar da ilimin yara. 21st ed. Philadelphia, PA: Elsevier; 2020: babi na 372.