Yawancin endoprine neoplasia (MEN) II

Yawancin endoprine neoplasia, nau'in II (MEN II) cuta ce da ta auku ta cikin dangi wanda ɗayan ko fiye da yawa na ƙarancin endocrine suke cika aiki ko kuma haifar da ƙari. Endocrine gland mafi yawan wadanda suka hada sun hada da:

• Adrenal gland (kusan rabin lokacin)
• Parathyroid gland (20% na lokaci)
• Glandar thyroid (kusan kowane lokaci)

Yawancin endoprine neoplasia (MEN I) yanayi ne mai alaƙa.

Dalilin MUTAN II nakasa ce a cikin kwayar halittar da ake kira RET. Wannan lahani yana haifar da ƙari da yawa sun bayyana a cikin mutum ɗaya, amma ba lallai bane a lokaci guda.

Kasancewa cikin gland adrenal galibi yana tare da ƙari wanda ake kira pheochromocytoma.

Yin amfani da glandar thyroid shine mafi yawan lokuta tare da ƙari wanda ake kira medullary carcinoma na thyroid.

Tumurai a cikin glandar ka, adrenal, ko parathyroid gland na iya faruwa shekara baya.

Rashin lafiyar na iya faruwa a kowane zamani, kuma yana shafar maza da mata daidai wa daida. Babban mawuyacin haɗarin shine tarihin iyali na MAZA II.

Akwai nau'ikan subut na maza biyu. Su ne MEN IIa da IIb. MEN IIb ba shi da yawa.

Kwayar cutar na iya bambanta. Koyaya, suna kama da na:

• Carcinoma na Medullary na thyroid
• Pheochromocytoma
• Parathyroid adenoma
• Parathyroid cutar hyperplasia

Don bincika wannan yanayin, mai bada sabis na kiwon lafiya yana neman maye gurbi a cikin jigidar RET. Ana iya yin wannan tare da gwajin jini. Testsarin gwaje-gwaje ana yin su don tantance ko waɗanne irin ƙwayoyin cutar ne ake yin samfura da yawa.

Gwajin jiki na iya bayyana:

• Larin lymph nodes a cikin wuyansa
• Zazzaɓi
• Hawan jini
• Saurin bugun zuciya
• Magungunan thyroid

Gwajin gwajin da aka yi amfani da su don gano ciwace-ciwace na iya haɗawa da:

• CT scan na ciki
• Hoto na kodan ko ureters
• MIBG scintiscan
• MRI na ciki
• Thyroid scan
• Duban dan tayi

Ana amfani da gwajin jini don ganin yadda wasu gland a jiki ke aiki. Suna iya haɗawa da:

• Matsayin Calcitonin
• Jinin alkaline phosphatase
• Calcium na jini
• Matakin hormone parathyroid
• Jini phosphorus
• Fitsari catecholamines
• Fitsari metanephrine

Sauran gwaje-gwaje ko hanyoyin da za'a iya yi sun haɗa da:

• Adrenal biopsy
• Lantarki (ECG)
• Kwayar cutar taroid

Ana bukatar tiyata don cire pheochromocytoma, wanda ka iya zama barazanar rai saboda homonin da yake yi.

Don ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta, dole ne a cire glandar thyroid da glandon lymph gaba ɗaya. Ana ba da maganin maye gurbin maye gurbinku bayan tiyata.

Idan yaro ya san yana ɗaukar rikidar kwayar halitta ta RET, ana yin tiyata don cire kalandar kafin ta zama ta daji. Wannan ya kamata a tattauna tare da likitan da ya saba da wannan yanayin. Za'a yi shi da wuri (kafin shekara 5) a cikin mutanen da aka san su da MEN IIa, kuma kafin shekara 6 da wata mutane da ke da MEN IIb.

Pheochromocytoma galibi ba shi da cutar kansa (mara kyau). Carcinoma na Medullary na thyroid cuta ne mai tsananin tashin hankali da kuma yiwuwar mutuwa, amma ganewar wuri da tiyata na iya haifar da magani. Yin tiyata ba ya warkar da mazan na II.

Yaduwar kwayar cutar kansa cuta ce mai wahala.

Kira mai ba ku sabis idan kun lura da alamun cutar MEN II ko kuma idan wani a cikin danginku ya karɓi irin wannan cutar.

Binciken dangi na kusa da mutane tare da MEN II na iya haifar da gano farkon cutar da cututtukan da ke da alaƙa. Wannan na iya ba da izinin matakai don hana rikitarwa.

Ciwon mara; MAZA II; Pheochromocytoma - MAZA II; Ciwon daji na thyroid - pheochromocytoma; Parathyroid ciwon daji - pheochromocytoma

• Endocrine gland

Yanar gizo Yanar Gizon Cutar Kanjamau ta Kasa. Ka'idojin aikin asibiti a cikin ilimin ilimin halittar jiki (NCCN guideines): ciwan neuroendocrine. Sigar 1.2019. www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf. An sabunta Maris 5, 2019. An shiga Maris 8, 2020.

Newey PJ, Thakker RV. Yawancin endoprine neoplasia. A cikin: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Littafin Williams na Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020: babi na 42.

Nieman LK, Spiegel AM. Cutar polyglandular. A cikin: Goldman L, Schafer AI, eds. Magungunan Goldman-Cecil. 26th ed. Philadelphia, PA: Elsevier; 2020: babi na 218.

Tacon LJ, Learoyd DL, Robinson BG. Yawancin nau'in endoprine neoplasia 2 da medullary thyroid carcinoma. A cikin: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Manya da Yara. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016: babi na 149.