Amyloidosis na farko

Amyloidosis na farko cuta ce mai saurin yaduwa wanda yawancin sunadaran da ba na al'ada ke ginawa cikin kyallen takarda da gabobi. Rushewar sunadaran da basu dace ba ana kiran su amyloid adiits.

Ba a fahimci dalilin amyloidosis na farko ba. Kwayar halitta na iya taka rawa.

Yanayin yana da alaƙa da mahaukaci da yawan samar da sunadarai. Kumburaren sunadaran da basu dace ba suna ginawa a wasu gabobin. Wannan yana sanya wuya ga gabobin suyi aiki daidai.

Amyloidosis na farko na iya haifar da yanayin da ya haɗa da:

• Ciwon ramin rami na carpal
• Lalacewar jijiyoyin zuciya (cardiomyopathy) wanda ke haifar da gazawar zuciya
• Cutar malabsorption
• Kumburin hanta da matsalar aiki
• Rashin koda
• Ciwon ƙuruciya (rukunin alamun da suka haɗa da furotin a cikin fitsari, ƙarancin furotin na jini a cikin jini, babban matakan cholesterol, babban matakan triglyceride, da kumburi cikin jiki)
• Matsalar jijiya (neuropathy)
• Tsarin jini na orthostatic (saukar da hawan jini idan ka tashi tsaye)

Kwayar cutar ta dogara da gabobin da abin ya shafa. Wannan cuta na iya shafar gabobi da kayan ciki da yawa, gami da harshe, hanji, kwarangwal da santsi, jijiyoyi, fata, jijiyoyi, zuciya, hanta, baƙin ciki, da koda.

Kwayar cutar na iya haɗawa da ɗayan masu zuwa:

• Bugun zuciya mara kyau
• Gajiya
• Umbarar hannu ko ƙafa
• Rashin numfashi
• Canjin fata
• Matsalar haɗiya
• Kumburi a hannaye da kafafu
• Harshen kumbura
• Handarfin hannu mara ƙarfi
• Rage nauyi ko nauyi

Sauran alamun da zasu iya faruwa tare da wannan cuta:

• Rage fitowar fitsari
• Gudawa
• Sandarewa ko sauya murya
• Hadin gwiwa
• Rashin ƙarfi

Mai ba da sabis na kiwon lafiya zai bincika ku. Za a tambaye ku game da tarihin lafiyar ku da alamun bayyanar ku. Gwajin jiki na iya nuna cewa kuna da kumbura hanta ko baƙin ciki, ko alamun lalacewar jijiya.

Mataki na farko a bincikar amyloidosis ya zama gwajin jini da fitsari don neman sunadaran da ba na al'ada ba.

Sauran gwaje-gwajen sun dogara ne da alamun cutar da gabobin da za a iya shafa. Wasu gwaje-gwaje sun haɗa da:

• Ciki duban dan tayi don duba hanta da saifa
• Gwajin zuciya, kamar ECG, ko echocardiogram, ko MRI
• Gwajin aikin koda don bincika alamun gazawar koda (ciwon nephrotic)

Gwaje-gwajen da zasu iya taimakawa wajen tabbatar da cutar sun hada da:

• Burin fata mai ƙoshin ciki
• Gwajin kasusuwa
• Gwajin ƙwayar tsoka
• Hanyar biopsy na hanji

Jiyya na iya haɗawa da:

• Chemotherapy
• Dasawar dasa kara
• Dasawar kwayoyin halitta

Idan wata cuta ce ta haifar da cutar, ya kamata a magance cutar da karfi. Wannan na iya inganta bayyanar cututtuka ko rage cutar daga yin muni. Matsaloli kamar su ciwon zuciya, gazawar koda, da sauran matsaloli wasu lokuta ana iya magance su, lokacin da ake bukata.

Yadda za ku yi daidai ya dogara da gabobin da abin ya shafa. Zuciya da shigar koda na iya haifar da gazawar gabobi da mutuwa. Amyloidosis a cikin jiki duka na iya haifar da mutuwa cikin shekaru 2.

Kira mai ba ku sabis idan kuna da alamun wannan cutar. Hakanan kira idan an gano ku da wannan cuta kuma kuna da:

• Rage fitsari
• Rashin numfashi
• Kumburin sawu ko wasu sassan jiki wadanda basa tafiya

Babu sanannun rigakafin don amyloidosis na farko.

Amyloidosis - na farko; Amyloidosis sarkar haske na Immunoglobulin; Tsarin amyloidosis na farko

• Amyloidosis na yatsunsu
• Amyloidosis na fuska

Gertz MA, Buadi FK, Lacy MQ, Hayman SR. Imynooglobulin-sarkar amyloidosis (na farko amyloidosis). A cikin: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Ka'idoji da Aiki. 7th ed. Philadelphia, PA: Elsevier; 2018: babi na 88.

Hawkins PN. Amyloidosis. A cikin: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Rheumatology. 7th ed. Philadelphia, PA: Elsevier; 2019: babi na 177.