Agammaglobulinemia

Agammaglobulinemia cuta ce ta gado wacce mutum ke da ƙarancin matakan kariya daga garkuwar jiki wanda ake kira immunoglobulins. Immunoglobulins nau'ikan antibody ne. Levelsananan matakan waɗannan ƙwayoyin cuta suna sa ku iya kamuwa da cututtuka.

Wannan cuta ce da ba a cika samun ta ba wacce ta fi shafar maza. Hakan na faruwa ne sanadiyyar raunin kwayar halitta wanda ke toshe haɓakar al'ada, ƙwaƙƙwaran ƙwayoyin ƙwayoyin cuta waɗanda ake kira B lymphocytes.

A sakamakon haka, jiki yana yin kadan (idan akwai) immunoglobulins. Immunoglobulins suna taka muhimmiyar rawa a cikin amsawar rigakafi, wanda ke kariya daga rashin lafiya da kamuwa da cuta.

Mutanen da ke wannan cuta suna ci gaba da kamuwa da cuta sau da yawa. Cututtuka na yau da kullun sun haɗa da waɗanda ke faruwa saboda ƙwayoyin cuta kamar Haemophilus mura, pneumococci (Streptococcus ciwon huhu), da kuma staphylococci. Shafukan yanar gizo na kamuwa da cuta sun haɗa da:

• Maganin ciki
• Gidajen abinci
• Huhu
• Fata
• Hanyar numfashi ta sama

Agammaglobulinemia an gada, wanda ke nufin wasu mutane a cikin danginku na iya samun yanayin.

Kwayar cututtuka sun haɗa da lokuta masu yawa na:

• Bronchitis (ƙwayar iska)
• Ciwon mara na kullum
• Conjunctivitis (ciwon ido)
• Otitis media (ciwon kunne na tsakiya)
• Ciwon huhu (huhu kamuwa da cuta)
• Sinusitis (sinus kamuwa da cuta)
• Cututtukan fata
• Manyan cututtukan fili na numfashi

Cututtuka yawanci suna bayyana a farkon shekaru 4 na rayuwa.

Sauran cututtukan sun hada da:

• Bronchiectasis (wata cuta ce wacce ƙaramar jakar iska a cikin huhu ke lalacewa kuma ta faɗaɗa)
• Asma ba tare da sanannen sanadi ba

An tabbatar da rashin lafiyar ta gwajin jini wanda ke auna matakan immunoglobulins.

Gwajin sun hada da:

• Gudura cytometry don auna zagawar B lymphocytes
• Immunoelectrophoresis - magani
• Yawan immunoglobulins masu yawa - IgG, IgA, IgM (yawanci ana auna su nephelometry)

Yin jiyya ya haɗa da ɗaukar matakai don rage lamba da tsananin kamuwa da cuta. Sau da yawa ana buƙatar maganin rigakafi don magance cututtukan ƙwayoyin cuta.

Ana ba da rigakafin immunoglobulins ta wata jijiya ko ta hanyar allura don ƙarfafa garkuwar jiki.

Za'a iya yin la'akari da dashen jijiya na kashi.

Waɗannan albarkatun na iya samar da ƙarin bayani game da agammaglobulinemia:

• Foundationungiyar Rashin Foundationasa Immasa - primaryimmune.org
• Nationalungiyar forasa don Rare Rashin Lafiya - rarediseases.org/rare-diseases/agammaglobulinemia
• NIH / NLM Tsarin Gida na Gida - ghr.nlm.nih.gov/condition/x-linked-agammaglobulinemia

Jiyya tare da immunoglobulins ya inganta lafiyar waɗanda ke da wannan matsalar.

Ba tare da magani ba, yawancin cututtuka masu tsanani suna da haɗari.

Matsalolin kiwon lafiya da zasu iya haifar sun hada da:

• Amosanin gabbai
• Sinus na kullum ko cutar huhu
• Cancanta
• Ciwon malabsorption na hanji

Kira don alƙawari tare da mai ba da lafiyar ku idan:

• Kai ko yaronka kun sha fama da cututtuka.
• Kuna da tarihin iyali na agammaglobulinemia ko wata cuta ta rashin kariya kuma kuna shirin haihuwar yara. Tambayi mai bayarwa game da shawarwarin kwayoyin halitta.

Ya kamata a ba da shawara kan kwayar halitta ga iyaye masu zuwa tare da tarihin iyali na agammaglobulinemia ko wasu cututtukan rashin ƙarancin cuta.

Bruton ta agammaglobulinemia; Agammaglobulinemia mai nasaba da X; Immunosuppression - agammaglobulinemia; Immunodepressed - agammaglobulinemia; Immunosuppressed - agammaglobulinemia

• Antibodies

Cunningham-Rundles C. Cutar cututtukan rashin ƙarfi na farko. A cikin: Goldman L, Schafer AI, eds. Magungunan Goldman-Cecil. 26th ed. Philadelphia, PA: Elsevier; 2020: babi na 236.

Pai SY, Notarangelo LD. Cutar ciki na aikin lymphocyte. A cikin: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Ka'idoji da Aiki. 7th ed. Philadelphia, PA: Elsevier; 2018: babi na 51.

Sullivan KE, Buckley RH. Laifin farko na samar da sinadarin antibody. A cikin: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Littafin koyar da ilimin yara. 21st ed. Philadelphia, PA: Elsevier; 2020: babi na 150.