Ciwon Hyperimmunoglobulin E

Hyperimmunoglobulin E ciwo ne mai wuya, cutar gado. Yana haifar da matsaloli tare da fata, sinus, huhu, ƙashi, da haƙori.

Hyperimmunoglobulin E ciwo kuma ana kiransa Ciwon Aiki. An lakafta shi ne bayan halin Littafi Mai-Tsarki Ayuba, wanda aka gwada amincinsa ta hanyar wahala tare da zubar da ciwon fata da pustules. Mutanen da ke da wannan yanayin suna da dogon lokaci, tsananin cututtukan fata.

Alamun cutar galibi suna kasancewa a yarinta, amma saboda cutar ba ta da yawa, yakan ɗauki shekaru kafin a yi cikakken ganewar asali.

Binciken da aka yi kwanan nan ya nuna cewa sau da yawa cutar na faruwa ne ta hanyar canjin kwayar halitta (maye gurbi) da ke faruwa a cikin MATSAYI 3gene on chromosome 17. Ta yaya ba a fahimci yadda wannan mummunan yanayin yake haifar da alamun cutar ba. Koyaya, mutanen da ke fama da cutar suna da matakin-sama-da-na al'ada na wani antibody da ake kira IgE.

Kwayar cutar sun hada da:

• Kashi da lahani na haƙori, haɗe da karaya da rasa haƙoran jariri a makare
• Cancanta
• Abun ƙwayar fata da kamuwa da cuta
• Maimaita cututtukan sinus
• Maimaita cututtukan huhu

Gwajin jiki na iya nuna:

• Curving na kashin baya (kyphoscoliosis)
• Osteomyelitis
• Maimaita cututtukan sinus

Gwaje-gwajen da aka yi amfani da su don tabbatar da cutar sun hada da:

• Cikakkar lissafin eosinophil
• CBC tare da bambancin jini
• Serum globulin electrophoresis don neman babban matakin IgE
• Gwajin kwayoyin halitta na MATSAYI 3 kwayar halitta

Gwajin ido na iya bayyana alamun rashin lafiyar ido.

X-ray na kirji na iya bayyana ƙwayoyin huhu.

Sauran gwaje-gwajen da za a iya yi:

• CT scan na kirji
• Al’adun wurin cutar
• Gwajin jini na musamman don bincika sassan tsarin garkuwar jiki
• X-ray na ƙasusuwa
• CT scan na sinuses

Za'a iya amfani da tsarin zira kwallaye wanda ya haɗu da matsaloli daban-daban na cututtukan Hyper IgE don taimakawa ganewar asali.

Babu sanannen magani ga wannan yanayin. Manufar magani ita ce shawo kan cututtukan. Magunguna sun haɗa da:

• Maganin rigakafi
• Magungunan antifungal da antiviral (idan ya dace)

A wasu lokuta ana buƙatar tiyata don magudanar ɓarna.

Gamma globulin da aka bayar ta jijiya (IV) na iya taimakawa wajen inganta garkuwar jiki idan kuna da cututtuka masu tsanani.

Ciwon Hyper IgE cuta ce ta rayuwa mai ɗorewa. Kowane sabon kamuwa da cuta na bukatar magani.

Matsaloli na iya haɗawa da:

• Maimaita cututtuka
• Sepsis

Kira likitan ku idan kuna da alamun rashin lafiyar Hyper IgE.

Babu tabbatacciyar hanyar da za a iya hana cututtukan Hyper IgE. Kyakkyawan tsabtar jiki na taimaka wajan hana kamuwa da cututtukan fata.

Wasu masu samarwa na iya ba da shawarar maganin rigakafin rigakafi don mutanen da ke haifar da cututtuka da yawa, musamman tare da Staphylococcus aureus. Wannan maganin baya canza yanayin, amma yana iya rage rikitarwarsa.

Ciwon Aiki; Ciwon Hyper IgE

Chong H, Green T, Larkin A. Allergy da rigakafi. A cikin: Zitelli BJ, McIntire SC, Nowalk AJ, eds. Zitelli da Davis 'Atlas na Ciwon Lafiyar Jiki na Yara. 7th ed. Philadelphia, PA: Elsevier; 2018: babi na 4.

Holland SM, Gallin JI. Kimantawa na mai haƙuri tare da wanda ake zargi da rashin ƙarfi. A cikin: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, da Ka'idojin Bennett da Aiwatar da Cututtukan Cutar. 9th ed. Philadelphia, PA: Elsevier; 2020: babi na 12.

Hsu AP, Davis J, Puck JM, Holland SM, Freeman AF. Autosomal rinjaye hauhawar IgE ciwo. Ra'ayoyin Gene. 2012; 6. PMID: 20301786 www.ncbi.nlm.nih.gov/pubmed/20301786. An sabunta Yuni 7, 2012. An shiga Yuli 30, 2019.