Polyarteritis nodosa

Polyarteritis nodosa babbar cuta ce ta magudanar jini. Arananan jijiyoyin jini sun zama kumbura sun lalace.

Arteries sune jijiyoyin jini waɗanda ke ɗauke da wadataccen jini zuwa gabobi da kyallen takarda. Ba a san musabbabin cutar polyarteritis nodosa ba. Yanayin yana faruwa yayin da wasu ƙwayoyin ƙwayoyin cuta ke kai hari ga jijiyoyin da abin ya shafa. Abubuwan da jijiyoyin da abin ya shafa ke shayar dasu basa samun iskar oxygen da abincin da suke bukata. Lalacewa na faruwa a sakamakon haka.

Yawancin yara fiye da yara suna samun wannan cutar.

Mutanen da ke da cutar hepatitis B ko hepatitis C na iya haifar da wannan cutar.

Kwayar cutar ana haifar ta lalacewar gabobin da abin ya shafa. Fata, gidajen abinci, tsoka, sashin jiki, zuciya, kodan, da tsarin juyayi galibi ana shafa su.

Kwayar cutar sun hada da:

• Ciwon ciki
• Rage ci
• Gajiya
• Zazzaɓi
• Hadin gwiwa
• Ciwon tsoka
• Rashin nauyi mara nauyi
• Rashin ƙarfi

Idan jijiyoyi sun shafi, kuna iya samun suma, zafi, ƙonawa, da rauni. Lalacewa ga tsarin mai juyayi na iya haifar da shanyewar jiki ko kamuwa.

Babu takamaiman gwaje-gwajen gwaje-gwaje da ke akwai don tantance cutar nodosa. Akwai cuta da yawa waɗanda ke da siffofi irin na nodosa na polyarthritis. Wadannan an san su da "mimics."

Za ku sami cikakken gwajin jiki.

Gwajin gwaje-gwajen da za su iya taimakawa wajen gano asali da kuma yin watsi da mimics sun hada da:

• Cikakken lissafin jini (CBC) tare da banbanci, creatinine, gwaje-gwajen hepatitis B da C, da fitsarin jini
• Erythrocyte sedimentation rate (ESR) ko furotin C-mai amsawa (CRP)
• Maganin furotin electrophoresis, cryoglobulins
• Mahimman matakan ci gaba
• Arteriogram
• Kwayar halitta
• Sauran gwaje-gwajen jini za a yi su don kawar da yanayi makamancin wannan, kamar su lupus erythematosus na tsari (ANA) ko granulomatosis tare da polyangiitis (ANCA)
• Gwajin HIV
• Cryoglobulins
• Magungunan anti-phospholipid
• Al'adun jini

Jiyya ya haɗa da magunguna don kawar da kumburi da garkuwar jiki. Waɗannan na iya haɗawa da magungunan ƙwayoyi, kamar su prednisone. Irin waɗannan magunguna, kamar azathioprine, methotrexate ko mycophenolate wanda ke ba da izinin rage yawan kwayar cutar kwayar cutar ana amfani da ita kuma. Ana amfani da Cyclophosphamide a cikin yanayi mai tsanani.

Don polyarteritis nodosa da ke da alaƙa da cutar hanta, magani na iya ƙunsar plasmapheresis da magungunan antiviral.

Magunguna na yanzu tare da steroids da wasu kwayoyi waɗanda ke hana tsarin rigakafi (kamar azathioprine ko cyclophosphamide) na iya inganta alamun bayyanar da damar rayuwa ta dogon lokaci.

Rikitarwa mafi tsanani galibi galibi sun haɗa da kodan da fili na ciki.

Ba tare da magani ba, hangen nesa ba shi da kyau.

Matsaloli na iya haɗawa da:

• Ciwon zuciya
• Necrosis na hanji da perforation
• Rashin koda
• Buguwa

Kira mai ba da sabis na kiwon lafiya idan kun ci gaba da alamun wannan cuta. Gano asali da magani na iya haɓaka damar kyakkyawan sakamako.

Babu sanannun rigakafin. Koyaya, jiyya na farko na iya hana wasu lalacewa da alamomi.

Periarteritis nodosa; PAN; Tsarin cuta mai lalata cuta

• Microscopic polyarteritis 2
• Tsarin jini

Luqmani R, Awisat A. Polyarteritis nodosa da rikice-rikice masu alaƙa. A cikin: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, eds. Littafin Rubutun Rheumatology na Firestein & Kelley. 11th ed. Philadelphia, PA: Elsevier; 2021: babi 95.

Puéchal X, Pagnoux C, Baron G, et al. Dingara azathioprine don gafarar-shigar da glucocorticoids don eosinophilic granulomatosis tare da polyangiitis (Churg-Strauss), polyyangiitis na microscopic, ko polyarteritis nodosa ba tare da dalilai masu kyau na hangen nesa ba: bazuwar, gwajin sarrafawa. Arthritis Rheumatol. 2017; 69 (11): 2175-2186. PMID: 28678392 www.pubmed.ncbi.nlm.nih.gov/28678392/.

Shanmugam VK. Vasculitis da sauran cututtukan arteriopathies. A cikin: Sidawy AN, Perler BA, eds. Rutherford's Vascular Surgery da Endovascular Far. 9th ed. Philadelphia, PA: Elsevier; 2019: sura 137.

Dutse JH. Tsarin vasculitides. A cikin: Goldman L, Schafer AI, eds. Magungunan Goldman-Cecil. 26th ed. Philadelphia, PA: Elsevier; 2020: babi na 254.