Dexamethasone danniya gwajin

Gwajin gwajin Dexamethasone yana auna matakan adrenocorticotrophic hormone (ACTH) ta hanyar pituitary ana iya murkushe su.

Yayin wannan gwajin, zaku sami dexamethasone. Wannan magani ne mai karfi wanda mutum yayi (roba). Bayan haka, ana zana jininka don a iya auna matakin cortisol a cikin jininka.

Akwai gwaje-gwaje iri biyu na dexamethasone danniya: ƙananan kashi da babban kashi. Kowane nau'in ana iya yin shi a cikin dare ɗaya (gama gari) ko kuma daidaitaccen (na kwana 3) (ba safai ba). Akwai matakai daban-daban waɗanda za a iya amfani dasu don kowane gwajin. Misalan waɗannan an bayyana su a ƙasa.

Na kowa:

• -Aramin ƙarfi a cikin dare - Za ku sami milligram 1 (mg) na dexamethasone a ƙarfe 11 na dare, kuma mai ba da sabis na kiwon lafiya zai zana jininka washegari da ƙarfe 8 na awo don ma'aunin cortisol.
• -Abi'a mai tsayi a dare - Mai bayarwa zai auna cortisol ɗinka a safiyar gwajin. Sannan zaka sami 8 mg na dexamethasone da karfe 11 na dare. Ana zana jininka washegari da ƙarfe 8 na auna ma'aunin cortisol.

Rare:

• Matsakaici mai ƙarancin ƙarfi - Ana tattara Fitsari sama da kwanaki 3 (an adana shi cikin kwantena masu tarin awanni 24) don auna cortisol. A ranar 2, zaka sami ƙananan kashi (0.5 MG) na dexamethasone ta baki kowane 6 hours na 48 hours.
• Matsakaiciyar madaidaiciya - Ana tattara Fitsari sama da kwanaki 3 (an ajiye su a cikin kwantena masu tarin awanni 24) don auna cortisol. A ranar 2, zaka sami babban kashi (2 mg) na dexamethasone ta baki kowane 6 awanni 48.

Karanta kuma ka bi umarnin a hankali. Babban sanadin sakamakon gwajin mahaukaci shine lokacin da ba'a bin umarnin.

Mai ba da sabis ɗin na iya gaya maka ka daina shan wasu magunguna da za su iya shafar gwajin, gami da:

• Maganin rigakafi
• Magungunan rigakafi
• Magungunan da ke dauke da sinadarin corticosteroids, kamar su hydrocortisone, prednisone
• Estrogen
• Tsarin haihuwa na haihuwa (maganin hana haihuwa)
• Magungunan ruwa (diuretics)

Lokacin da aka saka allurar don zana jini, wasu mutane suna jin matsakaicin ciwo. Wasu kuma suna jin ƙyalli ko harba. Bayan haka, ƙila za a sami wasu rauni ko ƙwanƙwasa rauni. Wannan da sannu zai tafi.

Ana yin wannan gwajin lokacin da mai bayarwa yayi zargin cewa jikinku yana samar da cortisol mai yawa. Anyi shi don taimakawa gano cutar Cushing da gano musababbin.

Gwajin mara ƙarfi zai iya taimaka gaya ko jikinku yana samar da ACTH mai yawa. Gwajin gwaji mai yawa na iya taimakawa wajen tantance ko matsalar tana cikin gland din pituitary (Cutar Cushing).

Dexamethasone wani kwayar cuta ce da mutum yayi (roba) wanda yake bayarwa ga mai karba guda daya kamar cortisol. Dexamethasone yana rage sakin ACTH a cikin mutane na al'ada. Sabili da haka, shan dexamethasone ya kamata ya rage matakin ACTH kuma ya kai ga rage matakin cortisol.

Idan glandon ku na pituitary yayi yawa ACTH, zaku sami amsa mara kyau ga gwajin ƙarancin ƙarfi. Amma zaka iya samun amsa na yau da kullun ga gwajin gwaji mai yawa.

Matsayin Cortisol ya kamata ya ragu bayan ka karɓi dexamethasone.

Doseananan kashi:

• Daren dare - 8 na plasma cortisol ƙasa da microgram 1.8 a kowace deciliter (mcg / dL) ko 50 nanomoles a kowace lita (nmol / L)
• Daidaitacce - Cortisol na kyauta na fitsari a ranar 3 ƙasa da microgram 10 kowace rana (mcg / rana) ko 280 nmol / L

Babban kashi:

• Dare - mafi girma fiye da 50% raguwa a cikin plasma cortisol
• Matsakaici - mafi girma fiye da 90% raguwa a cikin cortisol kyauta na urinary

Jeri na darajar yau da kullun na iya ɗan bambanta kaɗan tsakanin ɗakunan gwaje-gwaje daban-daban. Wasu ɗakunan gwaje-gwaje suna amfani da ma'aunai daban-daban ko na iya gwada samfuran daban. Yi magana da likitanka game da ma'anar takamaiman sakamakon gwajin ku.

Amsar da ba ta dace ba ga gwaji mai ƙarancin ƙarfi na iya nufin cewa kuna da sakewar mahaukaci na cortisol (Cushing syndrome). Wannan na iya zama saboda:

• Ciwon ƙwayar adrenal wanda ke samar da cortisol
• Ciwon ƙwayar cuta wanda ke haifar da ACTH
• Tumor a cikin jiki wanda ke samar da ACTH (ectopic Cushing syndrome)

Gwajin gwaji mai yawa na iya taimakawa wajen faɗi abin da ke haifar da raunin jiki (Cutar Cushing) daga wasu dalilai. Gwajin jini na ACTH na iya taimakawa gano asalin babban cortisol.

Sakamako mara kyau ya bambanta dangane da yanayin da ke haifar da matsalar.

Ciwon Cushing wanda ya haifar da ƙari na ƙari:

• Testananan gwajin gwaji - babu raguwa a cikin jinin cortisol
• ACTH matakin - ƙasa
• A mafi yawan lokuta, ba a buƙatar gwajin gwaji mai yawa

Ciwon rashin kumburin mahaifa:

• Testananan gwajin gwaji - babu raguwa a cikin jinin cortisol
• ACTH matakin - babba
• Gwajin gwaji mai yawa - babu raguwa a cikin jinin cortisol

Ciwon Cushing wanda cutar sankarau (Cushing cuta) ta haifar

• Testananan gwajin gwaji - babu raguwa a cikin jinin cortisol
• Gwajin-kashi mai girma - tsammanin tsammanin ragewar cortisol na jini

Sakamakon gwajin karya na iya faruwa saboda dalilai da yawa, gami da magunguna daban-daban, kiba, damuwa, da damuwa. Sakamakon karya ya fi yawa ga mata fiye da maza.

Akwai 'yar hatsarin da ke tattare da daukar jininka. Jijiyoyi da jijiyoyin jini sun banbanta cikin girma daga ɗaya mai haƙuri zuwa wancan, kuma daga wannan gefe na jiki zuwa wancan. Bloodaukar jini daga wasu mutane na iya zama da wahala fiye da wasu.

Sauran haɗarin da ke tattare da ɗaukar jinni ba su da yawa, amma na iya haɗawa da:

• Zub da jini mai yawa
• Sumewa ko jin an sassauta kai
• Mahara huda don gano wuri jijiyoyinmu
• Hematoma (jini yana taruwa a ƙarƙashin fata)
• Kamuwa (ƙananan haɗari kowane lokaci fata ta karye)

DST; ACTH danniya gwajin; Gwajin Cortisol

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Guber HA, Farag AF. Kimantawa akan aikin endocrine. A cikin: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Hanyoyin Laboratory. 23 ga ed. St Louis, MO: Elsevier; 2017: babi na 24.

Stewart PM, Newell-Price JDC. Tsarin adrenal. A cikin: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Littafin Williams na Endocrinology. 13th ed. Philadelphia, PA: Elsevier; 2016: babi na 15.