Aimovig (erenumab-aooe)

Wadatacce

• Menene Aimovig?
• Wani sabon nau'in magani
• Aimovig gama gari
• Aimovig sakamako masu illa
• Commonarin sakamako masu illa na kowa
• M sakamako mai tsanani
• Maganin rashin lafiyan
• Rage nauyi / nauyi
• Tasirin dogon lokaci
• Maƙarƙashiya
• Rashin gashi
• Ciwan mara
• Gajiya
• Gudawa
• Rashin bacci
• Ciwon tsoka
• Itching
• Kudin Aimovig
• Taimakon kuɗi
• Aimovig yayi amfani
• Aimovig don ciwon kai na ƙaura
• Amfani da ba a yarda da shi ba
• Aimovig sashi
• Sigogi da ƙarfi
• Sashi don ƙaura
• Menene idan na rasa kashi?
• Shin zan buƙaci amfani da wannan magani na dogon lokaci?
• Madadin Aimovig
• Masu adawa da CGRP
• Aimovig da sauran magunguna
• Aimovig da Ajovy
• Aimovig vs. Botox
• Aimovig da Emgality
• Aimovig vs. Topamax
• Aimovig da barasa
• Aimovig hulɗa
• Yadda ake amfani da Aimovig
• Umarni kan yadda ake shan Aimovig
• Yadda ake yin allura
• Lokaci
• Shan Aimovig da abinci
• Ma'aji
• Yadda Aimovig yake aiki
• Yaya tsawon lokacin aiki?
• Aimovig da ciki
• Aimovig da nono
• Tambayoyi gama gari game da Aimovig
• Shin dakatar da Aimovig yana haifar da janyewa?
• Shin Aimovig ilimin halittu ne?
• Shin zaku iya amfani da Aimovig don magance ƙaura?
• Shin Aimovig yana maganin ƙaura?
• Ta yaya Aimovig ya bambanta da sauran magungunan ƙaura?
• Idan na sha Aimovig, zan iya daina shan wasu magunguna na na rigakafin?
• Aimovig yawan abin sama
• Symptomsara yawan ƙwayoyi
• Abin da za a yi idan ya wuce gona da iri
• Gargadin Aimovig
• Imoarewar Aimovig da adana shi
• Bayanan sana'a don Aimovig
• Hanyar aiwatarwa
• Pharmacokinetics da metabolism
• Contraindications
• Ma'aji

Menene Aimovig?

Aimovig wani nau'in magani ne wanda ake amfani dashi don hana ciwon kai na ƙaura a cikin manya. Ya zo a cikin wani prefilled autoinjector alkalami. Kuna amfani da autoinjector don yiwa kanku allura a gida sau ɗaya a wata. Aimovig za a iya tsara shi a ɗayan allurai biyu: 70 MG kowace wata ko 140 MG kowace wata.

Aimovig ya ƙunshi kwayar erenumab. Erenumab shine mai maganin monoclonal, wanda shine nau'in magani wanda aka haɓaka a cikin lab. Magungunan Monoclonal magunguna ne da aka yi daga ƙwayoyin cuta. Suna aiki ta hanyar toshe aikin wasu sunadarai a jikinka.

Ana iya amfani da Aimovig don hana duka ƙaurar episodic da ciwon kai na ƙaura na kullum. Headungiyar Ciwon Kai ta Amurka ta ba da shawarar Aimovig ga mutanen da suka:

• ba za su iya rage yawansu na yawan ciwon kai na wata-wata da isa tare da wasu magunguna
• ba za a iya ɗaukar wasu magungunan ƙaura saboda sakamakon illa ko hulɗa da ƙwayoyi

An nuna Aimovig yana da tasiri a cikin karatun asibiti. Ga mutanen da ke fama da ƙaura, tsakanin kashi 40 zuwa 50 na waɗanda suka ɗauki Aimovig na tsawon watanni shida sun yanke adadin kwanakin ƙaurarsu da aƙalla rabin. Kuma ga mutanen da ke fama da ƙaura na ƙaura, kusan kashi 40 cikin ɗari na waɗanda suka ɗauki Aimovig sun yanke adadin kwanakin ƙaurarsu da rabi ko fiye.

Wani sabon nau'in magani

Aimovig wani ɓangare ne na sabon rukunin magunguna da ake kira antagonists masu alaƙa da peptide (CGRP). An kirkiro wannan nau'in magani don rigakafin ciwon kai na ƙaura.

Aimovig ya sami amincewar Hukumar Abinci da Magunguna (FDA) a watan Mayu 2018. Shi ne magani na farko da aka amince da shi a cikin rukunin masu adawa da CGRP.

An amince da wasu kwayoyi biyu a wannan rukunin magungunan bayan Aimovig: Emgality (galcanezumab) da Ajovy (fremanezumab). Magani na hudu, wanda ake kira eptinezumab, a halin yanzu ana nazarin shi a cikin gwajin asibiti.

Aimovig gama gari

Babu Aimovig a cikin sifa iri ɗaya. Ya zo ne kawai azaman magani mai suna.

Aimovig ya ƙunshi kwayoyi erenumab, wanda kuma ake kira erenumab-aooe. “Arshen “-aooe” wani lokaci ana ƙara shi don nuna cewa maganin ya bambanta da magunguna iri ɗaya waɗanda za a iya ƙirƙira su a nan gaba. Sauran kwayoyi masu hana yaduwar cuta suna da tsarin suna kamar haka.

Aimovig sakamako masu illa

Aimovig na iya haifar da lahani ko mummunan sakamako. Jerin na gaba yana ƙunshe da wasu mahimman sakamako masu illa waɗanda zasu iya faruwa yayin shan Aimovig. Wannan jerin ba ya haɗa da duk illa mai illa.

Don ƙarin bayani game da yuwuwar tasirin Aimovig, ko nasihu game da yadda za'a magance matsalar illa, yi magana da likitanka ko likitan magunguna.

Lura: Hukumar Abinci da Magunguna (FDA) tana bin diddigin tasirin magungunan da suka amince da su. Idan kuna son yin rahoto ga FDA sakamakon tasirin da kuka samu tare da Aimovig, zaku iya yin hakan ta hanyar MedWatch.

Commonarin sakamako masu illa na kowa

Abubuwan da suka fi dacewa na Aimovig na iya haɗawa da:

• halayen shafin allura (redness, itchy skin, zafi)
• maƙarƙashiya
• Ciwon tsoka
• jijiyoyin tsoka

Yawancin waɗannan illolin na iya tafiya bayan fewan kwanaki ko makonni biyu. Kira likitan ku ko likitan magunguna idan kuna da ƙarin sakamako masu illa ko lahani waɗanda ba za su tafi ba.

M sakamako mai tsanani

Mahimman sakamako masu illa daga Aimovig na iya faruwa, amma ba su da yawa. Babban mahimmin sakamako mai illa na Aimovig shine mummunan tasirin rashin lafiyan. Duba ƙasa don cikakkun bayanai.

Maganin rashin lafiyan

Wasu mutane suna da rashin lafiyan abu bayan shan Aimovig. Irin wannan halayen yana yiwuwa tare da yawancin magunguna. Kwayar cututtukan rashin lafiyan rashin lafiya na iya haɗawa da:

• da ciwon kumburi a kan fata
• jin ƙaiƙayi
• yin wanka (yana da dumi da ja a fata)

Ba da daɗewa ba, halayen rashin lafiyar mai tsanani na iya faruwa. Kwayar cututtukan rashin lafiya mai haɗari na iya haɗawa da:

• samun kumburi a ƙarƙashin fatarka (galibi a cikin gashin ido, lebe, hannu, ko ƙafa)
• jin ƙarancin numfashi ko matsalar numfashi
• ciwon kumburi a cikin harshenka, bakinka, ko maƙogwaronka

Kira likitanku nan da nan idan kuna tsammanin kuna fuskantar mummunan rashin lafiyan cutar Aimovig. Kira 911 idan alamunku suna jin barazanar rai ko kuma idan kuna cikin gaggawa na likita.

Rage nauyi / nauyi

Ba a bayar da rahoton asarar nauyi da ƙimar nauyi a cikin karatun asibiti na Aimovig ba. Koyaya, wasu mutane na iya ganin canje-canje a cikin nauyin su yayin maganin Aimovig. Wannan na iya zama saboda ƙaura kanta maimakon Aimovig.

Wasu mutane ba sa jin yunwa a da, yayin, ko bayan ciwon kai na ƙaura. Idan wannan ya faru sau da yawa isa, zai iya haifar da asarar nauyi maras so. Idan ka rasa sha'awarka lokacin da kake fama da ciwon kai na ƙaura, yi aiki tare da likitanka don haɓaka tsarin abinci wanda zai tabbatar ka samu dukkan abubuwan gina jiki da kake buƙata.

A wani gefen bakan, karin nauyi ko kiba sun zama ruwan dare ga mutanen da ke fama da cutar ƙaura. Kuma karatuttukan asibiti sun nuna cewa kiba na iya zama haɗarin haɗarin ciwon kai na ƙaura ko yawan ciwon kai na yawan ƙaura.

Idan kun damu game da yadda nauyin ku ke shafar ciwon kai na ƙaura, yi magana da likitan ku game da hanyoyin da za ku iya sarrafa nauyin ku.

Tasirin dogon lokaci

Aimovig magani ne da aka yarda dashi kwanan nan a cikin sabon rukunin magunguna. Sakamakon haka, akwai ɗan ƙaramin bincike na dogon lokaci da ake samu akan amincin Aimovig, kuma ba a san komai game da tasirinsa na dogon lokaci.

A cikin binciken lafiya guda daya wanda ya dauki tsawon shekaru uku, illolin da aka samu tare da Aimovig sune:

• ciwon baya
• cututtuka na numfashi na sama (kamar sanyi na yau da kullun ko cutar sinus)
• cututtuka masu kama da mura

Idan kana da waɗannan cututtukan kuma suna da tsanani ko kuma basu tafi ba, yi magana da likitanka.

Maƙarƙashiya

Maƙarƙashiya ta faru har zuwa kashi 3 na mutanen da suka ɗauki Aimovig a cikin karatun asibiti.

Wannan tasirin na iya kasancewa saboda yadda Aimovig ke shafar peptide mai alaƙa da ƙwayoyin calcitonin (CGRP) a cikin jikinka. CGRP shine furotin wanda za'a iya samu a cikin hanji kuma yana taka rawa cikin motsin hanji na yau da kullun. Aimovig yana toshe ayyukan CGRP, kuma wannan aikin zai iya hana saurin hanji na al'ada faruwa.

Idan kun sami maƙarƙashiya yayin jiyya tare da Aimovig, yi magana da likitanku ko likitan magunguna game da magunguna waɗanda zasu iya taimakawa sauƙaƙe shi.

Rashin gashi

Rashin gashi ba sakamako ne na gefen da aka danganta da Aimovig ba. Idan ka gano cewa ka rasa gashi, yi magana da likitanka game da yiwuwar haddasawa da jiyya.

Ciwan mara

Nausea ba sakamako ne na gefen da aka ruwaito tare da amfani da Aimovig ba. Koyaya, mutane da yawa tare da ƙaura na iya jin ɓacin rai yayin ciwon kai na ƙaura.

Idan kun ji jiri a lokacin ciwon kai na ƙaura, zai iya taimaka a tsaya a cikin duhu, daki mai nutsuwa, ko kuma fita waje don iska mai kyau. Hakanan zaka iya tambayar likitanka ko likitan magunguna game da magunguna waɗanda zasu iya taimakawa hana ko magance tashin zuciya.

Gajiya

Gajiya (rashin kuzari) ba sakamako ne na gefen da ke da alaƙa da Aimovig ba. Amma jin gajiya alama ce ta ƙaura da yawancin mutane ke ji kafin, yayin, ko bayan ciwon kai na ƙaura ya auku.

Wani binciken asibiti ya nuna cewa mutanen da ke fama da cutar ƙaura wacce ke da tsananin ciwon kai suna iya jin gajiya.

Idan gajiya ta dame ka, yi magana da likitanka game da hanyoyin inganta matakan kuzarin ku.

Gudawa

Gudawa ba wani sakamako ne na gefen da aka ruwaito tare da amfani da Aimovig. Koyaya, alama ce mai mahimmanci ta ƙaura. Hakanan ma akwai hanyar haɗi tsakanin ƙaura da cutar hanji da sauran cututtukan ciki.

Idan kana da gudawa wanda ya daɗe fiye da fewan kwanaki, yi magana da likitanka.

Rashin bacci

Rashin bacci (matsalar bacci) ba wani sakamako bane wanda aka samo shi a karatun asibiti na Aimovig. Koyaya, wani binciken asibiti ya gano cewa mutanen da ke fama da cutar ƙaura wanda ke da rashin barci suna yawan samun yawan ciwon kai na ƙaura. A zahiri, karancin bacci na iya zama sanadiyar ciwon kai na ƙaura da ƙara haɗarin ɓullowar cutar ƙaura na yau da kullun.

Idan kana da rashin bacci kuma kayi tunanin hakan na iya shafar ciwon kai na ƙaura, yi magana da likitanka game da hanyoyin samun ingantaccen bacci.

Ciwon tsoka

A cikin karatun asibiti, mutanen da suka karɓi Aimovig ba su sami ciwo na tsoka ba. Wadansu sun yi jijiyoyin jijiyoyin jiki da naƙasassu, kuma a cikin nazarin lafiya na dogon lokaci, mutanen da ke shan Aimovig sun sami ciwon baya.

Idan kuna da ciwon tsoka yayin shan Aimovig, yana iya zama saboda wasu dalilai. Misali, ciwon tsoka a wuyansa na iya zama alama ta ƙaura ga wasu mutane. Hakanan, halayen wurin allura, gami da ciwo a yankin da ke kewaye da allurar, na iya jin kamar ciwon tsoka. Irin wannan ciwo ya kamata ya tafi tsakanin fewan kwanaki kaɗan bayan allurar.

Idan kana da ciwon tsoka wanda ba zai tafi ba ko kuma yana shafar ingancin rayuwar ka, yi magana da likitanka game da zaɓuɓɓukan magance zafi.

Itching

Jinƙai na gaba ɗaya ba tasirin sakamako bane wanda aka gani a cikin karatun asibiti na Aimovig. Koyaya, ana yawan bayar da rahoto game da fata mai kaushi a yankin da aka yi wa Aimovig allura.

Fata mai kaushi kusa da wurin allurar ya kamata ya tafi nan da 'yan kwanaki. Idan kana da ciwon mara wanda ba zai tafi ba, ko kuma idan ƙaiƙayin ya yi yawa, yi magana da likitanka.

Kudin Aimovig

Kamar yadda yake tare da duk magunguna, farashin Aimovig na iya bambanta.

Kudin ku na ainihi zai dogara ne akan inshorar inshorar ku, wurin ku, da kuma kantin magani da kuke amfani da shi.

Taimakon kuɗi

Idan kuna buƙatar tallafin kuɗi don biyan Aimovig, akwai taimako.

Amgen da Novartis, masana'antun Aimovig, suna ba da Aimovig Ally Access Card shirin wanda zai iya taimaka muku biyan kuɗi kaɗan don kowace takardar sayen magani. Don ƙarin bayani kuma don gano idan kun cancanci, kira 833-246-6844 ko ziyarci gidan yanar gizon shirin.

Aimovig yayi amfani

Hukumar Abinci da Magunguna (FDA) ta amince da magungunan ƙwayoyi kamar Aimovig don magance ko hana wasu yanayi.

Aimovig don ciwon kai na ƙaura

Aimovig an yarda da FDA don rigakafin ciwon kai na ƙaura a cikin manya. Wadannan ciwon kai mai tsanani sune mafi yawancin alamun ƙaura, wanda shine yanayin yanayin jijiya.

Sauran bayyanar cututtuka na iya faruwa tare da ciwon kai na ƙaura, kamar su:

• tashin zuciya
• amai
• hankali ga haske da sauti
• matsala magana

Migraine za a iya rarraba shi azaman episodic ko na ƙarshe, a cewar Headungiyar Ciwon Kai ta Duniya. An yarda da Aimovig don hana duka ƙaurar episodic da ciwon kai na ƙaura na kullum. Bambanci tsakanin waɗannan nau'ikan ƙaura shine:

• ƙaura ta episodic yana haifar da ƙasa da ciwon kai na 15 ko ranakun ƙaura a wata
• Ciwon ƙaura na yau da kullun yana haifar da 15 ko fiye da kwanakin ciwon kai a kowane wata na tsawon aƙalla watanni uku, tare da aƙalla kwanaki takwas cikin kwanakin na ƙaura

Amfani da ba a yarda da shi ba

Hakanan za'a iya amfani da Aimovig a kashe-lakabin don wasu yanayi. Amfani da lakabin lakabi shine lokacin da aka ba da magani wanda aka yarda da shi don magance ɗayan yanayi don magance wani yanayi na daban.

Aimovig don tarin ciwon kai

Aimovig ba a amince da FDA don hana ciwon kai ba, amma ana iya amfani da shi ba tare da lakabi don wannan dalili ba. Ba a san shi a halin yanzu idan Aimovig yana da tasiri wajen hana ciwon kai na tari ba.

Cututtukan mahaifa sune ciwon kai mai raɗaɗi wanda ke faruwa a gungu (yawancin ciwon kai cikin ɗan gajeren lokaci). Suna iya zama ko dai episodic ko na kullum. Maganin ciwon kai na Episodic yana da lokaci mai tsayi tsakanin ɓangarorin ciwon kai. Headungiyar ciwon kai na yau da kullun yana da ɗan gajeren lokaci tsakanin gungu masu ciwon kai.

Ba a gwada Aimovig don rigakafin ciwon kai na tari a cikin karatun asibiti ba. Koyaya, an gwada wasu kwayoyi waɗanda suke cikin rukunin magunguna iri ɗaya kamar na Aimovig, gami da Emgality da Ajovy.

A cikin wani binciken asibiti, an gano Emgality don taimakawa hana ciwon kai na episodic. Amma don gwajin Ajovy na asibiti, mai kera magunguna ya dakatar da binciken da wuri saboda Ajovy ba ya aiki don rage yawan ciwon kai na tari na mutane a cikin binciken.

Aimovig don ciwon kai na vestibular

Aimovig ba FDA ta amince dashi ba don hana ko magance ciwon kai na vestibular. Ciwon kai na Vestibular ya bambanta da ciwon kai na ƙaura na gargajiya saboda yawanci ba su da zafi. Mutanen da ke da ciwon kai na vestibular na iya jin jiri ko kuma su sami nutsuwa. Wadannan cututtukan na iya wuce dakika zuwa awanni.

Ba a yi karatun asibiti ba don nuna ko Aimovig na da tasiri wajen hana ko magance ciwon kai na vestibular. Amma wasu likitocin na iya zaɓar su rubuta takardar lakabin miyagun ƙwayoyi don wannan yanayin.

Aimovig sashi

Mizanin Aimovig da likitanka ya umurta zai dogara ne da dalilai da yawa. Waɗannan sun haɗa da tsananin yanayin da kake amfani da Aimovig don magancewa.

Yawanci, likitanku zai fara ku a kan ƙananan sashi kuma ya daidaita shi akan lokaci don isa sashin da ya dace da ku. A ƙarshe zasu tsara ƙaramin sashi wanda ke ba da tasirin da ake buƙata.

Bayani mai zuwa yana bayanin abubuwan da ake amfani dasu ko aka ba da shawarar. Koyaya, tabbatar da shan maganin da likitanka yayi maka. Likitan ku zai ƙayyade mafi kyawun sashi don dacewa da bukatun ku.

Sigogi da ƙarfi

Aimovig ya zo a cikin allurai guda, prefilled autoinjector wanda ake amfani da shi don bayar da allurar karkashin jiki (allurar da ke shiga karkashin fata). Injinin inji ya zo da ƙarfi ɗaya: 70 MG da allura. Kowane autoinjector ana nufin amfani dashi sau ɗaya kawai sannan a jefar dashi.

Sashi don ƙaura

Aimovig za a iya tsara shi a cikin allurai biyu: 70 MG ko 140 MG. Ko dai ana shan kashi sau daya a wata.

Idan likitanku ya ba da shawarar MG 70, za ku ba da kanku allura ɗaya a kowane wata (ta amfani da autoinjector ɗaya). Idan likitanku ya ba da umarnin MG 140, za ku ba da kanku allura biyu a wata, ɗayan bayan ɗayan (ta amfani da allurar autoinjectors biyu).

Kwararka zai fara maganin ka a 70 MG kowace wata. Idan wannan sashi bai rage yawan kwanakin ƙaura ba, likitanku na iya ƙara sashinku zuwa 140 MG kowace wata.

Menene idan na rasa kashi?

Aauki kashi da zarar kun fahimci cewa kun rasa ɗaya. Yawan ku na gaba ya zama wata ɗaya bayan wancan. Ka tuna da sabon kwanan wata don haka zaka iya shirya don allurarka ta gaba.

Shin zan buƙaci amfani da wannan magani na dogon lokaci?

Idan Aimovig yana da tasiri wajen hana ciwon kai na ƙaura a gare ku, ku da likitan ku na iya yanke shawarar ci gaba da jiyya tare da Aimovig na dogon lokaci.

Madadin Aimovig

Akwai wasu kwayoyi don taimakawa hana ciwon kai na ƙaura. Wasu na iya aiki mafi kyau a gare ku fiye da wasu. Idan kuna sha'awar gwada wani magani banda Aimovig, yi magana da likitan ku don ƙarin koyo game da wasu kwayoyi waɗanda zasu iya muku aiki da kyau.

Misalan wasu magunguna waɗanda aka yarda da FDA don hana ciwon kai na ƙaura sun haɗa da:

• sauran masu adawa da alaƙa da peptide (CGRP) masu adawa:
• fremanezumab-vrfm (Ajovy)
• galcanezumab-gnlm (Tsammani)
• wasu magunguna masu kamawa, kamar su:
• divalproex sodium (Depakote)
• topiramate (Topamax, Trokendi XR)
• neurotoxin onabotulinumtoxinA (Botox)
• beta-blocker propranolol (Inderal, Inderal LA)

Ana amfani da wasu magungunan kashe-lakabi don hana ciwon kai na ƙaura. Wadannan magunguna sun hada da:

• wasu magungunan kwantar da hankali, kamar amitriptyline ko venlafaxine (Effexor XR)
• wasu magungunan kamawa, kamar su valproate sodium
• wasu beta-blockers, kamar metoprolol (Lopressor, Toprol XL) ko atenolol (Tenormin)

Masu adawa da CGRP

Aimovig wani ɓangare ne na sabon rukunin ƙwayoyi da ake kira antagonists masu alaƙa da peptide (CGRP). FDA ta amince da Aimovig a cikin 2018 don hana ciwon kai na ƙaura. An kuma amince da wasu masu adawa da CGRP guda biyu da ake kira Ajovy da Emgality kwanan nan. Wani magani na huɗu a cikin wannan aji (eptinezumab) ana tsammanin za a amince da shi ba da daɗewa ba.

Yadda suke aiki

Approvedwararrun masu adawa da CGRP suna aiki ta hanyoyi iri ɗaya don hana ciwon kai na ƙaura.

CGRP wani furotin ne a jikinka wanda yake da alaƙa da kumburi da kuma vasodilation (faɗaɗa jijiyoyin jini) a cikin kwakwalwa. Wannan kumburi da vasodilation na iya haifar da ciwo daga ciwon kai na ƙaura. Don haifar da waɗannan tasirin, CGRP yana buƙatar ɗaure (haɗawa) ga masu karɓa, waɗanda shafuka ne a saman wasu ƙwayoyin kwakwalwarku.

Ajovy da Emgality duk suna aiki ta hanyar ɗaure ga CGRP kanta. A sakamakon haka, CGRP ba zai iya ɗaure ga masu karɓa ba. Ba kamar sauran magungunan biyu a cikin wannan aji ba, Aimovig yana aiki ta hanyar ɗaure ga masu karɓar ƙwayoyin kwakwalwa. Wannan yana toshe CGRP daga yin wannan.

Ta hana CGRP yin hulɗa tare da mai karɓar ta, duk magungunan guda uku suna taimakawa dakatar da kumburi da vasodilation. Wannan na iya taimakawa wajen hana ciwon kai na ƙaura.

Gefen gefe

Shafin da ke ƙasa yana kwatanta bayanai na asali game da ƙwayoyi uku da aka yarda da su a cikin wannan aji waɗanda ake amfani da su don hana ciwon kai na ƙaura. Don ƙarin koyo game da yadda Aimovig yake kwatankwacin waɗannan magungunan, duba sashe mai zuwa (“Aimovig vs. other drugs”).

* Farashi na iya bambanta dangane da wurinku, kantin da kuka yi amfani da shi, inshorarku na inshora, da shirye-shiryen taimakon masana'anta.

Aimovig da sauran magunguna

Kuna iya mamakin yadda Aimovig yake kwatankwacin sauran magunguna waɗanda aka tsara don amfani iri ɗaya. Da ke ƙasa akwai kwatancen tsakanin Aimovig da magunguna da yawa.

Aimovig da Ajovy

Aimovig ya ƙunshi erenumab na miyagun ƙwayoyi, wanda shine kwayar monoclonal. Ajovy yana dauke da kwayar fremanezumab, wanda kuma shine kwayar cutar ta monoclonal. Kwayoyin cutar Monoclonal magunguna ne da aka kirkira a cikin dakin gwaje-gwaje. Wadannan kwayoyi an haɓaka su ne daga ƙwayoyin garkuwar jiki. Suna aiki ta hanyar toshe aikin wasu sunadarai a jikinka.

Aimovig da Ajovy duk sun dakatar da aikin wani furotin da ake kira peptide mai dangantaka da kwayar calcitonin (CGRP). CGRP yana haifar da kumburi da vasodilation (faɗaɗa jijiyoyin jini) a cikin kwakwalwa, wanda na iya haifar da ciwon kai na ƙaura. Toshe CGRP yana taimakawa hana ciwon kai na ƙaura.

Yana amfani da

Aimovig da Ajovy duk sun sami izinin FDA don hana ciwon kai na ƙaura a cikin manya.

Sigogi da gudanarwa

Aimovig da Ajovy duk sun zo cikin sifa mai yaduwa wacce ake gudanarwa a karkashin fatar ku (subcutaneous). Zaka iya yiwa kanka allurar a gida. Dukansu magungunan na iya yin allurar kai tsaye a wasu yankuna, kamar su:

• cikinka
• gaban cinyoyin ku
• baya na hannunka na sama

Ana kawo Aimovig azaman kwaya ɗaya tak da aka zaba autoinjector. Yawanci ana bayar dashi azaman allurar 70-mg sau ɗaya a wata. Koyaya, ana ba da wasu mutane mafi girma na 140 MG kowace wata.

Ana bayar da Ajovy azaman sirinji mai cikakken prefilled. Ana iya ba shi azaman allura guda ɗaya na 225 MG sau ɗaya a kowane wata. Ko za'a iya bashi kamar allurai uku na 225 MG sau ɗaya a kowane watanni uku.

Sakamakon sakamako da kasada

Aimovig da Ajovy suna aiki ta hanyoyi iri ɗaya kuma suna haifar da wasu sakamako masu illa iri ɗaya. Abubuwa masu illa da na yau da kullun da ke cikin magungunan duka suna ƙasa.

Commonarin sakamako masu illa na kowa

Waɗannan jerin suna ƙunshe da misalai na cututtukan da ke faruwa na yau da kullun waɗanda zasu iya faruwa tare da Aimovig, tare da Ajovy, ko kuma tare da magungunan biyu (lokacin da aka ɗauka ɗayansu).

• Zai iya faruwa tare da Aimovig:
• maƙarƙashiya
• jijiyoyin tsoka ko kumburi
• cututtukan numfashi na sama (kamar sanyi na yau da kullun ko cutar ta sinus)
• cututtuka masu kama da mura
• ciwon baya
• Zai iya faruwa tare da Ajovy:
• babu wani tasiri na musamman na yau da kullun
• Zai iya faruwa tare da Aimovig da Ajovy:
• halayen wurin allura kamar ciwo, ƙaiƙayi, ko ja

M sakamako mai tsanani

Babban mahimmin sakamako mai illa ga Aimovig da Ajovy shine mummunan rashin lafiyar. Irin wannan amsa ba ta kowa ba ce, amma yana yiwuwa. (Don ƙarin bayani, duba “Yanayin rashin lafiyan” a ƙarƙashin “tasirin Aimovig” a sama).

Hanyar rigakafi

A cikin gwaji na asibiti da aka yi wa Aimovig da Ajovy, ƙananan mutane sun sami maganin rigakafin ƙwayoyi. Abinda ya faru ya haifar da jikinsu don haɓaka ƙwayoyin cuta akan magunguna.

Antibodies sunadarai ne wanda tsarin garkuwar jiki yayi don yaƙar baƙin abubuwa a jikin ku. Jikinku na iya haɓaka ƙwayoyin cuta zuwa kowane abu na ƙasashen waje, gami da ƙwayoyin cuta masu guba. Idan jikinku ya yi rigakafi ga Aimovig ko Ajovy, ƙwayar ba za ta ƙara yi muku aiki ba.

A cikin gwaji na asibiti don Aimovig, fiye da kashi 6 cikin ɗari na mutane sun ɓullo da ƙwayoyin cuta don maganin. A cikin karatun asibitin da ke gudana, ƙasa da kashi 2 cikin ɗari na mutane sun inganta rigakafin cutar ta Ajovy.

Saboda an yarda da Aimovig da Ajovy a cikin 2018, har yanzu bai yi wuri ba don sanin yadda wannan tasirin zai iya kasancewa da kuma yadda zai iya shafar yadda mutane ke amfani da waɗannan magungunan a gaba.

Inganci

Aimovig da Ajovy duk suna da tasiri wajen hana ciwon kai na ƙaura, amma ba a kwatanta su kai tsaye a cikin gwajin asibiti.

Koyaya, jagororin kula da ƙaura suna ba da shawarar ko dai magani azaman zaɓi don wasu mutane. Wadannan sun hada da mutanen da:

• ba za su iya rage kwanakin ƙaura na wata wata isasshe tare da wasu magunguna ba
• ba zai iya jure wa sauran magunguna ba saboda illolin ko tasirin hulɗa da magunguna

Episodic ƙaura

Binciken daban na Aimovig da Ajovy sun nuna inganci don hana ciwon kai na episodic migraine.

• A cikin karatun asibiti na Aimovig, kimanin kashi 40 cikin ɗari na mutanen da ke fama da ƙaura ta episodic waɗanda suka karɓi 70 MG na miyagun ƙwayoyi kowane wata suna yanke kwanakin ƙaurarsu da aƙalla rabin sama da watanni shida. Har zuwa 50 bisa dari na mutanen da suka karɓi MG 140 suna da irin wannan sakamakon.
• A cikin binciken asibiti na Ajovy, kusan kashi 48 na mutanen da ke fama da cutar ƙaura wanda ke karɓar magani a kowane wata tare da miyagun ƙwayoyi sun yanke kwanakin ƙaurarsu aƙalla rabin sama da watanni uku. Kimanin kashi 44 cikin ɗari na mutanen da ke karɓar Ajovy duk bayan watanni uku suna da irin wannan sakamakon.

Ciwon ƙaura na kullum

Binciken daban na Aimovig da Ajovy kuma sun nuna tasiri don hana ciwon kai na ƙaura na kullum.

• A cikin nazarin asibiti na watanni uku na Aimovig, kimanin kashi 40 cikin 100 na mutanen da ke fama da ƙaura mai ƙaura wanda ya karɓi 70 MG ko 140 MG na miyagun ƙwayoyi a kowane wata yana da rabin yawan kwanakin ƙaura ko kaɗan.
• A cikin binciken asibiti na watanni uku na Ajovy, kusan kashi 41 cikin 100 na mutanen da ke fama da ƙaurar ƙaura wanda ke karɓar maganin Ajovy na wata-wata suna da rabin kwanakin ƙaura da yawa bayan jiyya ko kaɗan. Daga cikin mutanen da suke karɓar Ajovy kowane watanni uku, kusan kashi 37 cikin ɗari suna da irin wannan sakamakon.

Kudin

Aimovig da Ajovy duka magungunan sunaye ne. Babu nau'ikan nau'ikan nau'ikan ko dai akwai magunguna. Magungunan sunaye suna yawan kuɗi fiye da nau'ikan sifofi.

Dangane da kimantawa daga GoodRx.com, Aimovig da Ajovy sunkai kimanin kuɗi guda. Ainihin farashin da za ku biya don ko dai magani zai dogara ne akan shirin inshorar ku, wurin ku, da kuma kantin da kuka yi amfani da shi. Farashin ku don Aimovig zai dogara ne akan nauyin ku.

Aimovig vs. Botox

Aimovig ya ƙunshi kwayar cutar monoclonal da ake kira erenumab. Kwayar cutar monoclonal wani nau'in magani ne wanda aka kirkira a cikin dakin gwaje-gwaje. Ana yin waɗannan kwayoyi ne daga ƙwayoyin garkuwar jiki. Aimovig yana aiki don hana ciwon kai na ƙaura ta hanyar toshe aikin wani takamaiman furotin da zai iya haifar da su.

Botox yana dauke da magani onabotulinumtoxinA. Wannan magani yana cikin nau'ikan magungunan da ake kira neurotoxins. Botox yana aiki ta hanyar shayar da tsokoki na wani lokaci. Wannan tasirin yana hana siginonin ciwo a cikin tsokoki don kunnawa.Ana tunanin cewa wannan tsari yana taimakawa hana ciwon kai na ƙaura kafin su fara.

Yana amfani da

FDA ta amince da Aimovig don hana episodic ko ci gaba da ciwon kai na ƙaura a cikin manya.

Botox an yarda da FDA don hana yawan ciwon kai na ƙaura a cikin manya. Botox kuma an yarda dashi don magance wasu sharuɗɗa da yawa, kamar:

• mahaifa dystonia (zafi mai karkatarwa wuyansa)
• fatar ido
• mafitsara mai aiki
• tsokanar tsoka
• yawan zufa

Sigogi da gudanarwa

Aimovig yazo a matsayin kwaya daya tak wanda aka zaba autoinjector. An ba da shi azaman allura ne a ƙarƙashin fatarka (subcutaneous) wanda za ku iya ba da kanku a gida. An bayar da shi a kashi 70 na MG ko 140 MG kowace wata.

Ana iya yin allurar Aimovig a wasu wurare na jiki. Wadannan su ne:

• cikinka
• gaban cinyoyin ku
• baya na hannunka na sama

Ana ba da Botox ne kawai a ofishin likita. An yi masa allura tare da sirinji a cikin jijiya (intramuscular), yawanci kowane mako 12. Shafukan da aka saba don allura sun haɗa da:

• goshinka
• bayan wuyanka da kafadu
• sama da kusa da kunnuwanku
• kusa da layin gashin ka a gindin wuyan ka

Kullum likitanku zai ba ku ƙananan ƙwayoyi 31 a cikin waɗannan yankuna a kowane alƙawari.

Sakamakon sakamako da kasada

Aimovig da Botox duka ana amfani dasu don hana ciwon kai na ƙaura, amma suna aiki ta hanyoyi daban-daban. Saboda haka, suna da wasu nau'ikan sakamako masu kama da wasu daban.

Commonarin sakamako masu illa na kowa

Waɗannan jerin suna ƙunshe da misalai na larura masu haɗari waɗanda zasu iya faruwa tare da Aimovig, tare da Botox, ko tare da magungunan duka biyu (lokacin da aka ɗauka ɗayansu).

• Zai iya faruwa tare da Aimovig:
• maƙarƙashiya
• Ciwon tsoka
• tsokoki
• ciwon baya
• cututtukan numfashi na sama (kamar sanyi na yau da kullun ko cutar ta sinus)
• Zai iya faruwa tare da Botox:
• ciwon kai ko damuwa migraine
• fatar ido faɗuwa
• nakasar da ƙwayar tsoka
• wuyan wuya
• taurin kafa
• ciwon tsoka da rauni
• Zai iya faruwa tare da Aimovig da Botox:
• allurar shafin halayen
• cututtuka masu kama da mura

M sakamako mai tsanani

Waɗannan jerin suna ƙunshe da misalai na larura masu haɗari waɗanda zasu iya faruwa tare da Aimovig, tare da Botox, ko tare da magungunan duka biyu (lokacin da aka ɗauka ɗayansu).

• Zai iya faruwa tare da Aimovig:
• uniquean ƙananan sakamako masu illa na musamman
• Zai iya faruwa tare da Botox:
• yaduwar cutar nakasa ga tsokoki na kusa *
• matsala haɗiyewa da numfashi
• mai tsanani kamuwa da cuta
• Zai iya faruwa tare da Aimovig da Botox:
• tsanani rashin lafiyan halayen

* Botox yana da gargaɗin dambe daga FDA don yaɗuwar inna ga tsokoki nan kusa bayan allura. Gargadi mai ban tsoro shine gargadi mafi karfi da FDA ke buƙata. Yana faɗakar da likitoci da marasa lafiya game da tasirin kwayoyi waɗanda zasu iya zama haɗari.

Inganci

Halin da kawai ake amfani da Aimovig da Botox don hanawa shine ciwon kai na ƙaura na kullum.

Jagororin jiyya sun ba da shawarar Aimovig a matsayin zaɓi ga mutanen da ba za su iya rage yawansu na ƙaura na ƙaura tare da wasu magungunan maye ba. Hakanan an ba da shawarar ga mutanen da ba za su iya shan wasu magunguna ba saboda sakamakon illa ko hulɗa da ƙwayoyi.

Botox ya ba da shawarar ta Cibiyar Nazarin Neurology ta Amurka a matsayin zaɓi don magani a cikin mutanen da ke fama da ƙaura na kullum.

Ba a kwatanta tasirin waɗannan magungunan kai tsaye a cikin nazarin asibiti. Koyaya, a cikin karatu daban, Aimovig da Botox duk sun sami sakamako mai kyau wajen hana ciwon kai na ƙaura mai tsanani.

• A cikin nazarin asibiti na Aimovig, kimanin kashi 40 cikin 100 na mutanen da ke fama da ƙaura ta ƙaura wanda ya karɓi 70 mg ko 140 MG suna da rabin kwanakin ƙaura ko kuma kaɗan bayan watanni uku.
• A cikin nazarin asibiti na mutanen da ke fama da ƙaura, Botox ya rage adadin kwanakin ciwon kai har zuwa kwanaki 9.2 a matsakaici a kowane wata, sama da makonni 24. A wani binciken kuma, kusan kashi 47 cikin dari na mutane sun rage yawan kwanakin ciwon kai da aƙalla rabin.

Kudin

Aimovig da Botox duka magunguna ne masu suna. A halin yanzu babu nau'ikan sifofin da ake samu na ko dai magunguna.

Dangane da ƙididdiga daga GoodRx.com, Botox yawanci bashi da tsada fiye da Aimovig. Gaskiyar farashin da za ku biya don ko dai magani zai dogara ne akan adadin ku, shirin inshora, wurin ku, da kuma kantin da kuka yi amfani da shi.

Aimovig da Emgality

Aimovig ya ƙunshi kwayar cutar monoclonal da ake kira erenumab. Emgality ya ƙunshi wani abu mai guba wanda ake kira galcanezumab. Kwayar cutar monoclonal wani nau'in magani ne wanda aka kirkira a cikin dakin gwaje-gwaje. Ana yin waɗannan kwayoyi ne daga ƙwayoyin garkuwar jiki. Suna aiki ta hanyar toshe aikin wasu sunadarai na musamman a jikin ku.

Aimovig da Emgality duka suna toshe aikin sunadarai a cikin jikin ku wanda ake kira peptide mai nasaba da ƙwayoyin calcitonin (CGRP). CGRP yana haifar da kumburi da vasodilation (faɗaɗa jijiyoyin jini) a cikin kwakwalwa, wanda zai iya haifar da ciwon kai na ƙaura. Ta hanyar toshe ayyukan CGRP, waɗannan kwayoyi suna taimakawa dakatar da kumburi da vasodilation. Wannan yana taimakawa wajen hana ciwon kai na ƙaura.

Yana amfani da

Aimovig da Emgality duka an yarda da FDA don hana ciwon kai na ƙaura a cikin manya.

Sigogi da gudanarwa

Ana samarda Aimovig a cikin kwaya daya tak da aka zaba autoinjector. Ana ba da Emgality a cikin sirinji da aka cika da kwaya guda da kuma alƙalami mai cike da ƙarfi ɗaya. Ana ba da magungunan duka biyu azaman allurar ƙarƙashin fata (allura ƙarƙashin fata). Kuna iya ba da allurar da kanku a gida sau ɗaya a wata.

Dukansu magungunan ana iya allurar su a karkashin fata a wasu wurare a jikin ku. Wadannan su ne:

• cikinka
• gaban cinyoyin ku
• baya na hannunka na sama

Hakanan za'a iya allurar emgality a ƙarƙashin fatar gindi.

An tsara Aimovig azaman allurar 70-mg ko 140-mg kowane wata. An tsara emgality azaman allurar 120-mg kowane wata.

Sakamakon sakamako da kasada

Aimovig da Emgality sune ire-iren kwayoyi waɗanda ke haifar da wasu larura iri ɗaya da mawuyacin sakamako. Da ke ƙasa akwai misalai na waɗannan tasirin.

Commonarin sakamako masu illa na kowa

Waɗannan jerin suna ƙunshe da misalai na mummunar illa waɗanda zasu iya faruwa tare da Aimovig, tare da Emgality, ko kuma tare da magungunan duka biyu (lokacin ɗauka daban-daban).

• Zai iya faruwa tare da Aimovig:
• maƙarƙashiya
• Ciwon tsoka
• tsokoki
• cututtuka masu kama da mura
• Zai iya faruwa tare da Emgality:
• ciwon wuya
• Zai iya faruwa tare da Aimovig da Emgality:
• allurar shafin halayen
• ciwon baya
• kamuwa da cuta ta numfashi ta sama (kamar sanyi na yau da kullun ko cutar ta sinus)

M sakamako mai tsanani

Raunin rashin lafiyan abu ne mai matukar wahala ga Aimovig da Emgality. (Don ƙarin bayani, duba “Yanayin rashin lafiyan” a ƙarƙashin “tasirin Aimovig” a sama).

Hanyar rigakafi

A cikin gwaji na asibiti don kowane magani, ƙaramin mutane suna da maganin rigakafi ga Aimovig da Emgality. Tare da irin wannan tasirin, garkuwar jiki ta samar da kwayoyin kariya daga kwayoyi.

Antibodies sunadarai ne a cikin garkuwar jikinku wadanda ke yaki da baƙon abubuwa a jikin ku. Jikinku na iya yin maganin ƙwayoyin cuta ga duk wani abu na ƙasashen waje, gami da ƙwayoyin cuta masu haɗari kamar Aimovig da Emgality.

Idan jikinku ya haɓaka ƙwayoyin cuta ga ɗayan waɗannan ƙwayoyin, yana yiwuwa cewa maganin ba zai ƙara aiki don hana ciwon kai na ƙaura a gare ku ba.

A cikin karatun asibiti na Aimovig, fiye da kashi 6 cikin ɗari na mutanen da ke shan maganin sun ɓullo da ƙwayoyin cuta a ciki. Kuma a cikin karatun asibiti na Emgality, kusan kashi 5 cikin ɗari na mutane sun ɓullo da ƙwayoyin cuta ga Emgality.

Saboda an yarda da Aimovig da Emgality a cikin 2018, ya yi wuri don sanin yadda mutane da yawa za su iya samun irin wannan halin. Har ila yau, lokaci ya yi da za a san yadda hakan zai iya shafar yadda mutane ke amfani da waɗannan magungunan a gaba.

Inganci

Ba a kwatanta Aimovig da Emgality a cikin karatun asibiti ba, amma dukansu suna da tasiri don hana ciwon kai na ƙaura.

Jagororin jiyya sun ba da shawarar Aimovig da Emgality azaman zaɓuɓɓuka don mutanen da ke fama da rikice-rikice ko ƙaura na ci gaba wanda ya:

• ba za a iya shan wasu magunguna ba saboda sakamako masu illa ko hulɗa da ƙwayoyi
• ba zai iya rage adadin kwanakin ƙaura na wata da isa tare da wasu magunguna

Episodic ƙaura

Binciken daban na Aimovig da Emgality ya nuna cewa duka magungunan suna da tasiri don hana ciwon kai na episodic migraine:

• A cikin karatun asibiti na Aimovig, har zuwa kashi 50 na mutanen da ke fama da ƙaura na episodic waɗanda suka karɓi MG 140 na miyagun ƙwayoyi sun rage kwanakin ƙaurarsu da aƙalla rabin sama da watanni shida. Kimanin kashi 40 cikin 100 na mutanen da suka karɓi MG 70 suka ga irin wannan sakamakon.
• A cikin karatun asibiti na Emgality na mutanen da ke fama da ƙaura ta episodic, kusan kashi 60 cikin ɗari na mutane sun rage adadin kwanakin ƙaurarsu da aƙalla rabin sama da watanni shida na maganin Emgality. Har zuwa 16 bisa dari ba su da ƙaura bayan watanni shida na jiyya.

Ciwon ƙaura na kullum

Binciken daban na Aimovig da Emgality ya nuna cewa duka magunguna suna da tasiri don hana ciwon kai na ƙaura mai tsanani:

• A cikin nazarin asibiti na watanni uku na mutanen da ke fama da ƙaura mai ƙaura, kimanin kashi 40 cikin ɗari na mutanen da suka ɗauki ko dai 70 MG ko 140 MG na Aimovig suna da rabin kwanakin ƙaura ko kuma kaɗan tare da magani.
• A cikin binciken asibiti na tsawon watanni uku na mutanen da ke fama da ƙaura, kusan kashi 30 cikin 100 na mutanen da suka ɗauki Emgality na tsawon watanni uku suna da rabin kwanakin ƙaura ko kuma kaɗan tare da magani.

Kudin

Aimovig da Emgality duka magunguna ne masu alamar iri. A halin yanzu babu nau'ikan sifofin da ake samu na ko dai magunguna. Magungunan sunaye na yawanci suna da tsada fiye da yadda ake amfani da su.

Dangane da ƙididdiga daga GoodRx.com, Aimovig da Emgality sun kusan kusan kuɗi ɗaya. Gaskiyar farashin da za ku biya don ko dai magani zai dogara ne akan adadin ku, shirin inshora, wurin ku, da kuma kantin da kuka yi amfani da shi.

Aimovig vs. Topamax

Aimovig ya ƙunshi kwayar cutar monoclonal da ake kira erenumab. Magungunan monoclonal wani nau'in magani ne wanda aka haɓaka daga ƙwayoyin cuta. Ana yin ƙwayoyi irin wannan a cikin dakin gwaje-gwaje. Aimovig yana taimakawa wajen hana ciwon kai na ƙaura ta hanyar dakatar da aikin takamaiman furotin da ke haifar da su.

Topamax ya ƙunshi Topiramate foda, wani nau'in magani ne wanda shima ake amfani dashi don magance kamuwa da cuta. Ba a fahimci yadda Topamax ke aiki don hana ciwon kai na ƙaura ba. Ana tunanin cewa magani yana rage ƙwayoyin jijiyoyin da ke aiki a cikin kwakwalwa wanda zai iya haifar da ciwon kai na ƙaura.

Yana amfani da

Dukansu Aimovig da Topamax duk an amince da FDA don hana ciwon kai na ƙaura. An yarda da Aimovig don amfani dashi a cikin manya, yayin da Topamax aka amince dashi don amfani da manya da yara yan shekaru 12 zuwa sama.

Topamax kuma an yarda dashi don magance farfadiya.

Sigogi da gudanarwa

Aimovig ya zo a cikin allurai guda guda wanda aka riga aka cika shi da autoinjector. Ana ba da shi azaman allura ne a ƙarƙashin fatarka (subcutaneous) wanda kuke ba da kanku gida sau ɗaya a wata. Halin na yau da kullun shine 70 MG, amma wasu mutane na iya cin gajiyar nauyin 140-MG.

Topamax ya zo ne azaman kwantaccen baka ko kwamfutar hannu ta baka. Hanyar da aka saba amfani da ita ita ce MG 50 sau biyu a rana. Dogaro da shawarar likitanka, zaka iya farawa akan ƙananan sashi kuma ƙara shi zuwa sashin da aka saba yi tsawon watanni biyu.

Sakamakon sakamako da kasada

Aimovig da Topamax suna aiki ta hanyoyi daban-daban a cikin jiki kuma saboda haka suna da sakamako daban daban. Wasu daga cikin mawuyacin sakamako masu illa na magungunan duka suna ƙasa. Jerin da ke ƙasa ba ya haɗa da duk illa mai illa.

Commonarin sakamako masu illa na kowa

Waɗannan jerin suna ƙunshe da misalai na larura masu haɗari waɗanda zasu iya faruwa tare da Aimovig, tare da Topamax, ko tare da magungunan duka biyu (lokacin da aka ɗauka ɗayansu).

• Zai iya faruwa tare da Aimovig:
• allurar shafin halayen
• ciwon baya
• maƙarƙashiya
• Ciwon tsoka
• jijiyoyin tsoka
• cututtuka masu kama da mura
• Zai iya faruwa tare da Topamax:
• ciwon wuya
• gajiya
• paresthesia (jin "fil da allurai")
• tashin zuciya
• gudawa
• asarar nauyi
• rasa ci
• matsalar tattara hankali
• Zai iya faruwa tare da Aimovig da Topamax:
• cututtuka na numfashi (kamar sanyi na yau da kullun ko cutar ta sinus)

M sakamako mai tsanani

Waɗannan jerin suna ƙunshe da misalai na larura masu haɗari waɗanda zasu iya faruwa tare da Aimovig, tare da Topamax, ko tare da magungunan duka biyu (lokacin ɗauka daban-daban).

• Zai iya faruwa tare da Aimovig:
• uniquean ƙananan sakamako masu illa na musamman
• Zai iya faruwa tare da Topamax:
• matsalolin hangen nesa, gami da glaucoma
• rage gumi (rashin iya sarrafa yanayin zafin jiki)
• acidosis na rayuwa
• tunani da ayyukan kashe kansa
• matsalolin tunani kamar su rikicewa da matsalolin ƙwaƙwalwa
• damuwa
• encephalopathy (cutar kwakwalwa)
• tsakuwar koda
• karuwar kamuwa lokacin da aka dakatar da magani kwatsam (lokacin da ake amfani da magani don maganin kamawa)
• Zai iya faruwa tare da Aimovig da Topamax:
• tsanani rashin lafiyan halayen

Inganci

Dalilin kawai Aimovig da Topamax sune FDA ta yarda dasu shine rigakafin ƙaura.

Jagororin jiyya sun ba da shawarar Aimovig a matsayin zaɓi don hana episodic ko ciwon kai na ƙaura na kullum cikin mutanen da:

• ba za a iya shan wasu magunguna ba saboda sakamako masu illa ko hulɗa da ƙwayoyi
• ba za su iya rage yawansu na yawan ciwon kai na wata-wata isasshe tare da wasu magunguna

Jagororin jiyya suna ba da shawarar Topiramate a matsayin zaɓi don hana ciwon kai na episodic migraine.

Nazarin asibiti bai gwada tasirin waɗannan kwayoyi ba kai tsaye don hana ciwon kai na ƙaura. Amma magungunan an yi nazarin su daban.

Episodic ƙaura

Binciken daban na Aimovig da Topamax ya nuna cewa duka kwayoyi sunyi tasiri wajen hana ciwon kai na episodic:

• A cikin karatun asibiti na Aimovig, har zuwa kashi 50 cikin 100 na mutanen da ke fama da ƙaura ta episodic waɗanda suka karɓi 140 MG sun yanke kwanakin ƙaurarsu da aƙalla rabin sama da watanni shida na jiyya. Kimanin kashi 40 cikin 100 na mutanen da suka karɓi MG 70 suka ga irin wannan sakamakon.
• A cikin karatun asibiti na mutanen da ke fama da cutar ƙaura wanda ya ɗauki Topamax, waɗanda shekarunsu suka kai 12 zuwa sama suna da ƙarancin ciwon kai na ƙaura biyu a kowane wata. Yaran da shekarunsu suka kai 12 zuwa 17 tare da cutar ƙaura ta episodic suna da ƙananan ciwon kai na ƙaura sau uku a kowane wata.

Ciwon ƙaura na kullum

Binciken daban na magungunan ya nuna cewa duka Aimovig da Topamax suna da tasiri wajen hana ciwon kai na ƙaura mai tsanani:

• A cikin nazarin asibiti na watanni uku na Aimovig, kimanin kashi 40 cikin dari na mutanen da ke fama da ciwon kai na ƙaura wanda ya sami ko dai 70 MG ko 140 MG suna da rabin kwanakin ƙaura ko kuma kaɗan bayan jiyya.
• A wani binciken da ya duba sakamakon wasu gwaje-gwaje na asibiti da aka gano cewa a cikin mutanen da ke fama da cutar ƙaura, Topamax ya rage yawan ciwon kai ko ciwon kai da kimanin biyar zuwa tara kowane wata.

Kudin

Aimovig da Topamax duka magunguna ne masu suna. Magungunan sunaye na yawanci suna tsada fiye da magunguna na asali. Babu Aimovig a cikin sifa iri ɗaya, amma Topamax ya zo ne kamar yadda ake kira topiramate.

Dangane da ƙididdiga daga GoodRx.com, Topamax na iya tsada ko ƙasa da Aimovig, gwargwadon yawan kuɗin ku. Kuma Topiramate foda, nau'ikan nau'ikan nau'ikan Topamax, zai ɗauki kuɗi ƙasa da na Topamax ko Aimovig.

Gaskiyar farashin da za ku biya don ɗayan waɗannan ƙwayoyin zai dogara ne akan yawan ku, shirin inshorar ku, wurin ku, da kuma kantin da kuke amfani da shi.

Aimovig da barasa

Babu ma'amala tsakanin Aimovig da barasa.

Duk da haka, wasu mutane na iya jin cewa maganin ba shi da tasiri idan suka sha barasa yayin shan Aimovig. Wannan saboda barasa na iya zama sanadin ƙaura ga mutane da yawa. Ko da giya kaɗan na iya haifar musu da ƙaura.

Ya kamata ku guji shaye-shayen da ke ɗauke da barasa idan kun gano cewa giya tana haifar da raɗaɗin ciwo ko yawan ƙaura.

Aimovig hulɗa

Yawancin kwayoyi na iya hulɗa tare da sauran magunguna. Za'a iya haifar da sakamako daban-daban ta hanyar ma'amala daban-daban. Misali, wasu ma'amaloli na iya tsoma baki game da yadda kwayoyi ke aiki sosai, yayin da wasu na iya haifar da ƙarin sakamako masu illa.

Aimovig bashi da ma'amala da ƙwayoyi. Wannan saboda hanyar sarrafa Aimovig ne a jikin ku.

Yadda ake amfani da Aimovig

Yawancin kwayoyi, ganye, da kari suna haɗuwa (sarrafawa) ta hanyar enzymes a cikin hanta. Amma ba a sarrafa magungunan ƙwayoyin cuta na monoclonal, kamar Aimovig, a cikin hanta. Madadin haka, ana sarrafa irin wannan magani a cikin sauran ƙwayoyin jikinku.

Saboda ba a sarrafa Aimovig a cikin hanta kamar sauran kwayoyi da yawa, gabaɗaya baya hulɗa da wasu magunguna.

Idan kana da wata damuwa game da hada Aimovig da wasu magunguna da zaka iya sha, yi magana da likitanka. Kuma ka tabbata ka gaya musu game da duk takardar sayen magani, a kan-kan-kanta, da sauran magungunan da kake sha. Hakanan ya kamata ku gaya musu game da kowane ganye, bitamin, da abubuwan gina jiki da kuke amfani da su.

Umarni kan yadda ake shan Aimovig

Aimovig ya zo a matsayin allurar da aka bayar a ƙarƙashin fatarka (subcutaneous). Kuna yiwa kanku allurar a gida sau ɗaya a wata. A karo na farko da ka samu takardar sayen magani don Aimovig, mai ba ka kiwon lafiya zai yi bayanin yadda za ka yiwa kanka allurar.

Aimovig ya zo a cikin kwaya ɗaya (70 MG) autoinjector. Kowane autoinjector ya ƙunshi kashi ɗaya kawai kuma ana nufin amfani da shi sau ɗaya sannan a jefa shi. (Idan likitanku ya ba da umarnin MG 140 kowace wata, za ku yi amfani da injina biyu a kowane wata.)

Da ke ƙasa akwai bayani kan yadda ake amfani da sirinji da aka riga aka sa shi. Don wasu cikakkun bayanai, bidiyo, da hotunan umarnin allura, duba gidan yanar gizon masana'anta.

Yadda ake yin allura

Kwararka zai rubuta ko dai 70 MG sau ɗaya a wata ko 140 MG sau ɗaya a wata. Idan an wajabta maka MG 70 kowane wata, zaka yiwa kanka allura guda. Idan an sanya muku MG 140 a kowane wata, zaku ba da kanku allura daban-daban guda biyu, ɗayan bayan ɗayan.

Ana shirin yin allura

• Yourauki Aimovig autoinjector ɗinka daga firiji mintuna 30 kafin ka shirya yin allurarka. Wannan zai ba da izinin maganin ya dumi zuwa zafin jiki na ɗaki. Bar hula a kan na'urar autoinjector har sai kun shirya yin allurar ƙwayoyi.
• Kada a yi ƙoƙari don zafafa aikin injiniya cikin sauri ta hanyar sanya ta cikin microwaving ko kuma watsa ruwan zafi a kanta. Hakanan, karka girgiza injiniyar. Yin waɗannan abubuwan na iya sa Aimovig ya zama ba mai aminci da tasiri ba.
• Idan kayi kuskure sauke autoinjector, kar kayi amfani dashi. Ananan abubuwan da aka gyara na autoinjector na iya karyewa a ciki, koda kuwa ba za ku iya ganin lalacewa ba.
• Duk da yake kuna jiran Aimovig ya zo zafin jiki na ɗaki, samo wasu kayan da zaku buƙata. Wadannan sun hada da:
• mai shaye shaye
• auduga ko auduga
• bandeji mai ɗaura
• kwandon shara don kaifi
• Bincika autoinjector kuma tabbatar cewa maganin bai yi kama da hadari ba. Ya zama mara launi don launin rawaya mai launi. Idan yayi kama da launi, gajimare, ko kuma yana da wani yanki mai ƙarfi a cikin ruwa, kada ayi amfani dashi. Idan ana buƙata, tuntuɓi likitanka game da samun sabo. Hakanan, bincika ranar karewa akan na'urar don tabbatar da cewa maganin bai ƙare ba.
• Bayan ka wanke hannuwanka da sabulu da ruwa, zabi wurin allura. Ana iya allurar Aimovig a waɗannan wuraren:
• cikinka (akalla inci 2 daga maɓallin ciki)
• gaban cinyoyinku (aƙalla inci 2 sama da gwiwa ko inci 2 ƙasa da duwawarku)
• ta bayan hannunka na sama (idan wani yana yi maka allurar)
• Yi amfani da goge giya don tsabtace wurin da kuka shirya yin allurar. Bari giya ta bushe gaba ɗaya kafin a yi muku maganin.
• Kada a yi wa Aimovig allurar wani yanki na fatar da ta yi rauni, tauri, ja, ko taushi.

Yin amfani da autoinjector

1. Cire farin hular kai tsaye daga autoinjector. Yi wannan kar ya wuce minti biyar kafin kayi amfani da na'urar.
2. Mikewa ko tsunkule yankin fata inda kuka shirya yin allurar magani. Createirƙiri tsayayyen yanki na fata kimanin inci 2 faɗi don allurarku.
3. Sanya autoinjector akan fatarka a kusurwar digiri 90. Da tabbaci danna ƙasa akan fatarka gwargwadon yadda zai tafi.
4. Latsa maballin farawa mai launin shunayya a saman maƙallan har sai kun ji an danna.
5. Saki maballin farawa mai laushi amma ci gaba da riƙe autoinjector ƙasa a kan fata har taga a kan autoinjector ta zama rawaya. Hakanan kuna iya ji ko jin “danna” Wannan na iya ɗaukar dakika 15. Yana da mahimmanci a yi wannan matakin don tabbatar da cewa an sami dukkan nauyin.
6. Cire autoinjector daga cikin fatar ka ka jefa shi cikin kwandon shara na kaifin kwakwalwar ka.
7. Idan akwai wani jini a wurin allurar, latsa auduga ko gauze akan fata, amma kar a goge. Yi amfani da bandeji mai ɗaura idan an buƙata.
8. Idan yawan ku yakai MG 140 a kowane wata, maimaita waɗannan matakan tare da autoinjector na biyu. Kada kayi amfani da wurin yin allura iri ɗaya kamar na farko.

Lokaci

Yakamata a sha Aimovig sau daya a wata. Ana iya ɗauka a kowane lokaci na rana.

Idan ka rasa kashi, ɗauki Aimovig da zaran ka tuna. Abun da zai biyo baya ya zama wata daya bayan shan wannan. Amfani da kayan aikin tunatar da magani zai iya taimaka muku tuna ɗaukar Aimovig akan lokaci.

Shan Aimovig da abinci

Ana iya ɗaukar Aimovig tare da ko ba tare da abinci ba.

Ma'aji

Ya kamata a adana Aimovig a cikin firiji. Ana iya ɗauke shi daga cikin firiji amma dole ne a yi amfani da shi a cikin kwanaki bakwai. Kar a mayar da shi cikin firiji da zarar an fitar da shi a kawo shi cikin zafin jiki na daki.

Kada a daskare Aimovig. Hakanan, adana shi a cikin kunshinsa na asali don kare shi daga haske.

Yadda Aimovig yake aiki

Aimovig magani ne da ake kira antibody na monoclonal. Irin wannan magani ana yin sa ne a cikin dakin gwaje-gwaje daga sunadarai na tsarin garkuwar jiki. Aimovig yana aiki ne ta hanyar dakatar da aikin wani furotin a jikinka wanda ake kira peptide mai nasaba da ƙwayoyin calcitonin (CGRP). CGRP na iya haifar da kumburi da vasodilation (faɗaɗa jijiyoyin jini) a cikin kwakwalwar ku.

Inflammationonewa da lalatawar da CGRP ya kawo shine dalilin da ke haifar da ciwon kai na ƙaura. A zahiri, lokacin da ciwon kai na ƙaura ya fara faruwa, mutane suna da matakan CGRP mafi girma a cikin jini. Aimovig yana taimakawa hana ƙaura ta hanyar dakatar da aikin CGRP.

Duk da yake yawancin magunguna suna aiki ta hanyar shafar abubuwa da yawa a cikin jikinku, ƙwayoyin cuta irin su Aimovig suna aiki akan furotin ɗaya kawai a cikin jiki. Saboda wannan, Aimovig na iya haifar da ƙaramar ma'amala da ƙwayoyi da kuma illa masu illa. Wannan na iya sanya shi kyakkyawan zaɓi na jiyya ga mutanen da ba za su iya shan wasu magunguna ba saboda illoli ko mu'amala da su.

Aimovig na iya kasancewa kyakkyawan zaɓi na jiyya ga mutanen da ba su sami wani magani ba wanda zai iya rage kwanakin ƙaurarsu da isa.

Yaya tsawon lokacin aiki?

Bayan kun fara shan Aimovig, zai ɗauki weeksan makonni don ganin ci gaban ciwon kai na ƙaura. Aimovig na iya ɗaukar cikakken sakamako bayan watanni da yawa.

Yawancin mutane da suka ɗauki Aimovig yayin gwajin asibiti suna da ƙananan kwanakin ƙaura a cikin wata ɗaya da fara maganin. Hakanan mutane basu da daysan kwanaki kaɗan na ƙaura bayan ci gaba da jiyya tsawon watanni da yawa.

Aimovig da ciki

Babu cikakken karatun da aka yi don sanin idan Aimovig yana da lafiya ya ɗauka yayin ɗaukar ciki. Nazarin dabba bai nuna wata haɗari ga mai ciki ba lokacin da aka ba Aimovig ga mace mai ciki. Koyaya, karatun dabbobi ba koyaushe yake hango ko kwayoyi zasu kasance cikin aminci cikin mutane ba.

Idan kana da ciki ko tunanin yin ciki, yi magana da likitanka don ganin idan Aimovig ya dace da kai. Wataƙila kuna buƙatar jira har sai kun daina yin ciki don amfani da Aimovig.

Aimovig da nono

Ba a san ko Aimovig ya shiga cikin nono ba. Sabili da haka, ba a bayyana ba idan Aimovig yana da lafiya don amfani yayin shayarwa.

Idan kuna la'akari da magani tare da Aimovig yayin da kuke shayar da yaro, yi magana da likitanka game da fa'idodi da haɗarinsa. Kuna iya dakatar da shayarwa idan kun fara shan Aimovig.

Tambayoyi gama gari game da Aimovig

Anan akwai amsoshi ga wasu tambayoyin da akai akai game da Aimovig.

Shin dakatar da Aimovig yana haifar da janyewa?

Babu rahoto game da tasirin janyewa bayan dakatar da Aimovig. Koyaya, Aimovig bai daɗe da amincewa da FDA ba, a cikin 2018. Adadin mutanen da suka yi amfani da kuma dakatar da maganin Aimovig har yanzu iyakance ne.

Shin Aimovig ilimin halittu ne?

Ee. Aimovig wani maganin rigakafi ne na monoclonal, wanda shine nau'in ilimin halittu. Ilimin halitta shine magani wanda aka haɓaka daga kayan ƙirar halitta, maimakon sinadarai.

Saboda suna hulɗa tare da takamaiman takamaiman ƙwayoyin garkuwar jiki da sunadarai, nazarin halittu kamar su Aimovig ana tsammanin suna da raunin sakamako kaɗan idan aka kwatanta da magungunan da ke shafar tsarin jiki da yawa, kamar yadda sauran magungunan ƙaura ke yi.

Shin zaku iya amfani da Aimovig don magance ƙaura?

A'a. Aimovig ana amfani dashi ne kawai don hana ciwon kai na ƙaura kafin ya fara. Ba zai yi aiki don magance ƙaura da tuni ta fara ba.

Shin Aimovig yana maganin ƙaura?

A'a, Aimovig ba zai warkar da ƙaura ba. Babu magunguna a halin yanzu don warkar da ƙaura.

Ta yaya Aimovig ya bambanta da sauran magungunan ƙaura?

Aimovig ya bambanta da yawancin sauran magungunan ƙaura saboda shine magani na farko da aka amince da shi na FDA musamman don hana ciwon kai na ƙaura. Aimovig wani ɓangare ne na sabon rukunin ƙwayoyi da ake kira antagonists masu alaƙa da peptide (CGRP).

Yawancin sauran magungunan da aka yi amfani da su don hana ciwon kai na ƙaura an halicce su ne da gaske saboda wasu dalilai, kamar su magance kamawa, hawan jini, ko baƙin ciki. Yawancin waɗannan kwayoyi ana amfani dasu a lakabin don hana ciwon kai na ƙaura.

Kasancewa allurar kowane wata ya sa Aimovig ya bambanta da yawancin sauran magungunan rigakafin ƙaura. Mafi yawan wadannan kwayoyi suna zuwa ne kamar alluna ko kwayoyi. Botox wani magani ne wanda yake zuwa kamar allura. Koyaya, dole ne a bashi a cikin ofishin likita sau ɗaya a kowane watanni uku. Kuna iya yiwa kanku allurar Aimovig a gida.

Kuma ba kamar sauran sauran magungunan rigakafin ƙaura ba, Aimovig babban antibody ne. Wannan wani nau'in magani ne wanda aka haɓaka a cikin lab. An yi shi ne daga ƙwayoyin garkuwar jiki.

Magungunan Monoclonal sun lalace cikin ƙwayoyin jiki daban-daban a jiki. Sauran ƙwayoyin rigakafin ƙaura sun lalata ta hanta. Saboda wannan banbancin, kwayar cutar ta monoclonal kamar su Aimovig tana da karancin mu'amala da kwayoyi fiye da sauran magungunan da ake amfani dasu don hana ciwon kai na migraine.

Idan na sha Aimovig, zan iya daina shan wasu magunguna na na rigakafin?

Yiwuwa. Jikin kowane mutum zai amsa wa Aimovig daban. Idan Aimovig ya rage yawan ciwon kai na ƙaura da kuke da shi, kuna iya dakatar da shan wasu magungunan rigakafin. Amma lokacin da kuka fara fara jiyya, likitanku zai iya ba da shawarar cewa ku fara shan Aimovig tare da sauran magungunan rigakafi.

Bayan ka ɗauki Aimovig na tsawon watanni biyu zuwa uku, likitanka zai yi magana da kai game da yadda magungunan ke aiki a gare ka. Ku da likitanku zaku iya tattauna dakatar da sauran magungunan rigakafin da kuke sha ko rage sashin ku na waɗannan magungunan.

Aimovig yawan abin sama

Yin allurar allurai da yawa na Aimovig na iya ƙara haɗarin halayen gidan yanar gizon allura. Idan kun kasance masu rashin lafiyan jiki ko nuna rashin kuzari ga Aimovig ko zuwa latex (wani sashi ne a cikin marufin Aimovig), kuna iya zama cikin haɗari don wani mummunan aiki.

Symptomsara yawan ƙwayoyi

Kwayar cututtukan ƙwayar ƙwayar cuta na iya haɗawa da:

• ciwo mai tsanani, ƙaiƙayi, ko ja a yankin kusa da allura
• wankewa
• amya
• angioedema (kumburi ƙarƙashin fata)
• kumburin harshe, maƙogwaro, ko bakin
• matsalar numfashi

Abin da za a yi idan ya wuce gona da iri

Idan kuna tsammanin kun sha da yawa daga wannan magani, kira likitanku ko ku nemi jagora daga Americanungiyar ofungiyar Kula da Guba ta Amurka a 800-222-1222 ko ta hanyar kayan aikin su na kan layi. Amma idan alamun ka masu tsanani ne, kira 911 ko ka je dakin gaggawa mafi kusa kai tsaye.

Gargadin Aimovig

Kafin ɗaukar Aimovig, yi magana da likitanka game da tarihin lafiyar ku. Aimovig bazai dace da kai ba idan kana da wasu halaye na likita. Wadannan sun hada da:

• Latex rashin lafiyan. Aimovig autoinjector ya ƙunshi wani nau'i na roba wanda yake kama da latex. Wannan na iya haifar da rashin lafiyan a cikin mutanen da ke rashin lafiyan latex. Idan kuna da tarihin halayen mai tsanani ga samfuran da ke ƙunshe da kututture, Aimovig bazai iya zama madaidaicin magani a gare ku ba.

Imoarewar Aimovig da adana shi

Lokacin da aka fitar da Aimovig daga kantin magani, likitan magunguna zai ƙara kwanan wata mai karewa ga lakabin akan kwalban. Wannan kwanan wata galibi shekara ɗaya ce daga ranar da aka ba da magani.

Dalilin waɗannan kwanakin karewar shine don tabbatar da ingancin magani a wannan lokacin. Matsayi na Hukumar Abinci da Magunguna ta yanzu (FDA) shine gujewa amfani da magungunan da suka ƙare.

Yaya tsawon magani ya kasance mai kyau na iya dogara da dalilai da yawa, gami da yadda da kuma inda ake adana maganin.

Yakamata a adana kayan aikin Aimovig a cikin firiji. Ana iya ajiye shi a waje na firiji har tsawon kwanaki bakwai. Kada a ajiye a cikin firiji da zarar ya kai zafin dakin.

Kar a girgiza ko daskare Aimovig autoinjector. Kuma adana autoinjector a cikin asalin kayan don kare shi daga haske.

Idan kana da maganin da ba a amfani da shi wanda ya wuce ranar karewa, yi magana da likitan ka game da ko har yanzu zaka iya amfani da shi.

Bayanan sana'a don Aimovig

Ana ba da bayanin nan na gaba don likitoci da sauran ƙwararrun likitocin kiwon lafiya.

Hanyar aiwatarwa

Aimovig (erenumab) wani dan adam ne wanda yake hade da mai karba na peptide (CGRP) mai karba kuma yana hana layin CGRP daga kunna mai karba.

Pharmacokinetics da metabolism

Ana gudanar da Aimovig kowane wata kuma ya kai matakin jihar-kwari bayan allurai uku. An kai matuka mafi girma cikin kwana shida. Metabolism baya faruwa ta hanyoyin cytochrome P450.

Indullawa ga CGRP yana da ma'ana kuma yana kawar da kawar da ƙananan ƙananan abubuwa. A mafi girman hankali, ana kawar da Aimovig ta hanyar hanyoyin proteolytic marasa mahimmanci. Ba a tsammanin lahani ko ƙarancin hanta don shafar kaddarorin magunguna.

Contraindications

Babu takaddama ga amfanin Aimovig.

Ma'aji

Aimovig preinilled autoinjector ya kamata a adana shi a cikin firiji a zazzabi tsakanin 36⁰F da 46⁰F (2⁰C da 8⁰C). Ana iya cire shi daga firiji kuma a adana shi a zafin ɗakin (har zuwa 77⁰F, ko 25⁰C) na tsawon kwanaki 7.

Sanya Aimovig a cikin asalin marufi don kare shi daga haske. Kar a mayar da shi cikin firiji da zarar ya zo zafin jiki na daki. Kada a daskare ko girgiza Aimovig autoinjector.

Bayanin sanarwa: Labaran Likita a Yau sun yi iya kokarinsu don tabbatar da cewa dukkan bayanan gaskiya ne, cikakke, kuma na zamani. Koyaya, wannan labarin bai kamata ayi amfani dashi azaman madadin ilimi da ƙwarewar ƙwararren likita mai lasisi ba. Ya kamata koyaushe ku tuntuɓi likitanku ko wasu masu sana'a na kiwon lafiya kafin shan kowane magani. Bayanin magani da ke cikin wannan batun na iya canzawa kuma ba ana nufin ya rufe duk amfanin da zai yiwu ba, kwatance, kiyayewa, gargaɗi, hulɗar miyagun ƙwayoyi, halayen rashin lafiyan, ko cutarwa. Rashin gargadin ko wasu bayanai don maganin da aka bayar baya nuna cewa magani ko haɗin magungunan yana da aminci, tasiri, ko dacewa ga duk marasa lafiya ko duk takamaiman amfani.