Tambayi Kwararren: Dr. Amesh Adalja kan Sabbin Hanyoyin Cutar Hepatitis C

Wadatacce

• Menene Hepatitis C, kuma yaya ya bambanta da sauran nau'ikan Ciwon hanta?
• Menene Matsayi na yau da kullun na Jiyya?
• Waɗanne Irin Sabbin Magunguna Suna Samun roundasa, kuma Yaya Ingancin Su Yake?
• Yaya waɗannan Sababbin Magunguna za su Kwatanta da Manyan Jiyya?
• Yaya Ya Kamata Marasa lafiya Su yanke Shawarwarin Jiyya?

Mun yi hira da Dokta Amesh Adalja, masanin cututtukan cututtuka tare da Cibiyar Kiwon Lafiya ta Jami'ar Pittsburgh, game da abubuwan da ya samu game da cutar hepatitis C (HCV). Kwararre a fagen, Dakta Adalja ya ba da cikakkun bayanai game da HCV, daidaitattun jiyya, da sabbin jinya masu kayatarwa waɗanda za su iya sauya wasan ga masu cutar hepatitis C ko'ina.

Menene Hepatitis C, kuma yaya ya bambanta da sauran nau'ikan Ciwon hanta?

Hepatitis C wani nau'in kwayar cutar hepatitis ce da ta banbanta da wasu nau'ikan kwayar cutar hepatitis ta yadda tana da halin yin tazara kuma tana iya haifar da cutar hanta, da ciwon hanta, da sauran rikice-rikicen tsarin. Yana tasiri kusan a cikin Amurka kuma shine babban abin da ke buƙatar buƙatar dashen hanta. Ana yada ta ta hanyar ɗaukar jini kamar ƙarin jini (kafin a nuna shi), yin amfani da magungunan ƙwayoyi da kuma da wuya ta hanyar yin jima'i. Cutar hepatitis A ba ta da wani tsayayyen tsari, ana iya yin rigakafin riga-kafi, ana yada ta ta hanyan baka, kuma baya haifar da cutar hanta da / ko cutar kansa. Hepatitis B, shima jini ne kuma yana haifar da cutar hanta da cutar kansa, rigakafin rigakafi ne kuma mafi sauƙin yaduwa ta hanyar saduwa da jima'i daga uwaye zuwa theira childrenansu yayin ciki da haihuwa. Hepatitis E yana kama da cutar hepatitis A amma, a wasu lokuta mawuyacin hali, na iya zama mai saurin faruwa, sannan kuma yana da yawan mace-macen mata masu ciki.

Menene Matsayi na yau da kullun na Jiyya?

Darussan maganin hepatitis C sun dogara ne kacokam kan wane nau'in ciwon hanta C wanda yake ɗauke da shi. Akwai nau'ikan halittar jini guda shida na hepatitis C wasu kuma sun fi sauran sauki. Gabaɗaya, maganin hepatitis C ya haɗa da haɗakar magunguna biyu zuwa uku, galibi ciki har da interferon, ana gudanar da su aƙalla makonni 12.

Waɗanne Irin Sabbin Magunguna Suna Samun roundasa, kuma Yaya Ingancin Su Yake?

Sabon magani mafi kayatarwa shine sofosbuvir na kwayar cutar ta kwayar cuta, wanda aka nuna bawai yana da tasiri sosai ba, amma kuma yana da ikon rage gajiyar karatun ta hanyar tsauraran matakai kafin gabatarwar.

Sofosbuvir yana aiki ta hanyar hana enzyme mai saurin yaduwar kwayar cutar RNA polymerase. Wannan ita ce hanyar da kwayar cutar ke iya yin kwafin kanta. A cikin gwaji na asibiti wannan magani, a hade, an nuna yana da matukar tasiri wajen kawar da kwayar cutar cikin sauri da ƙarfi, yana ba da gagarumar gajeriyar tsarin kulawa. Kodayake wasu kwayoyi sun yi niyya ga wannan enzyme, ƙirar wannan magani ya zama kamar yadda yake da sauri kuma ingantaccen ya canza shi zuwa yanayin aiki a cikin jiki, yana ba da izinin hana enzyme. Sofosbuvir ya kasance

Hakanan, a wasu lokuta, haɗuwa da ƙwayoyi waɗanda ke keɓance tsaka-tsakin tsaka-tsakin don tasirin tasirin tasirinsa mara kyau - ana iya aiki da su. [Kodayake yana da tasiri, interferon sananne ne ga haifar da damuwa da alamomin mura. Sofosbuvir shine magani na farko da FDA ta amince dashi don amfani ba tare da haɗin gwiwar interferon a wasu yanayi ba.]

Yaya waɗannan Sababbin Magunguna za su Kwatanta da Manyan Jiyya?

Fa'idodi, kamar yadda na ambata a sama, shi ne cewa sababbin ka'idoji sun fi guntu, sun fi juriya, kuma sun fi tasiri. Rashin fa'ida shine sabbin magunguna sun fi tsada. Koyaya, idan mutum ya kalli cikakkiyar mahallin, wanda ya haɗa da tsadar haɓaka magungunan ƙwayoyi, saboda ikon hana mafi munin-da tsada-rikitarwa na kamuwa da cutar hepatitis C, waɗannan sabbin magungunan suna da maraba da ƙari ga arsenal.

Yaya Ya Kamata Marasa lafiya Su yanke Shawarwarin Jiyya?

Ina bayar da shawarar cewa marassa lafiya su yanke shawarar magani tare da hadin gwiwar likitansu bayan tattaunawa kan halin da suke ciki a yanzu, halin hantarsu ta yanzu, da kuma karfinsu na bin magani.