Jagora Mai Sauƙi ga Tsarin Endocannabinoid

Wadatacce

• Ta yaya yake aiki?
• Endocannabinoids
• Endocannabinoid masu karɓa
• Enzymes
• Menene ayyukanta?
• Ta yaya THC ke hulɗa tare da ECS?
• Ta yaya CBD ke hulɗa tare da ECS?
• Me game rashi endocannabinoid?
• Layin kasa

Tsarin endocannabinoid (ECS) tsari ne mai rikitarwa na siginar sigina wanda aka gano a farkon shekarun 1990 ta masu bincike masu binciken THC, sanannen Cannabinoid. Cannabinoids sune mahaɗan da aka samo a cikin wiwi.

Masana har yanzu suna ƙoƙari su fahimci ECS sosai. Amma ya zuwa yanzu, mun san tana taka rawa wajen daidaita yawancin ayyuka da matakai, gami da:

• barci
• yanayi
• ci abinci
• ƙwaƙwalwar ajiya
• haifuwa da haihuwa

ECS ya wanzu kuma yana aiki a jikinku koda kuwa baku amfani da wiwi.

Karanta don ƙarin koyo game da ECS gami da yadda yake aiki da ma'amala da wiwi.

Ta yaya yake aiki?

ECS ya ƙunshi abubuwa uku masu mahimmanci: endocannabinoids, masu karɓa, da enzymes.

Endocannabinoids

Endocannabinoids, wanda ake kira endogenous cannabinoids, kwayoyin ne da jikinku yayi. Suna kama da cannabinoids, amma jikinku ne yake samar dasu.

Masana sun gano manyan abubuwa biyu endocannabinoids har yanzu:

• anandamide (AEA)
• 2-arachidonoylglyerol (2-AG)

Waɗannan suna taimakawa ci gaba da ayyukan cikin gida suna gudana lami lafiya. Jikin ku yana samar da su kamar yadda ake buƙata, yana sa ya zama da wuya a san irin matakan da ake bi na kowane.

Endocannabinoid masu karɓa

Ana samun waɗannan masu karɓa a jikin ku duka. Endocannabinoids sun ɗaure su don nuna alama cewa ECS yana buƙatar ɗaukar mataki.

Akwai manyan masu karɓa na endocannabinoid guda biyu:

• Masu karɓar CB1, waɗanda galibi aka samo su a cikin tsarin kulawa na tsakiya
• Masu karɓar CB2, waɗanda galibi ana samun su a cikin tsarin juyayinku na gefe, musamman ƙwayoyin cuta na rigakafi

Endocannabinoids na iya ɗaure ga kowane mai karɓa. Sakamakon da ya haifar ya dogara da inda mai karɓa yake da kuma abin da endocannabinoid yake ɗaure da shi.

Misali, endocannabinoids na iya yin niyya ga masu karɓar CB1 a cikin jijiyar jijiyoyi don taimakawa ciwo. Wasu na iya ɗaure ga mai karɓar CB2 a cikin ƙwayoyin jikinku don yin alama cewa jikinku yana fuskantar kumburi, alama ce ta gama gari ta rashin lafiyar autoimmune.

Enzymes

Enzymes suna da alhakin lalata endocannabinoids da zarar sun aiwatar da aikin su.

Akwai manyan enzymes guda biyu masu alhakin wannan:

• fatty acid amide hydrolase, wanda ke lalata AEA
• monoacylglycerol acid lipase, wanda yawanci yakan rushe 2-AG

Menene ayyukanta?

ECS yana da rikitarwa, kuma masana basu riga sun ƙayyade ainihin yadda yake aiki ba ko duk ayyukansa masu yuwuwa.

ya danganta ECS zuwa matakai masu zuwa:

• ci da narkewa
• metabolism
• ciwo na kullum
• kumburi da sauran martani na tsarin garkuwar jiki
• yanayi
• ilmantarwa da ƙwaƙwalwa
• sarrafawar mota
• barci
• aiki na zuciya da jijiyoyin jini
• samuwar tsoka
• gyaran kashi da girma
• hanta aiki
• aikin tsarin haihuwa
• damuwa
• aikin fata da jijiya

Waɗannan ayyukan duk suna ba da gudummawa ga homeostasis, wanda ke nufin zaman lafiyar yanayin cikin ku. Misali, idan karfi daga waje, kamar ciwo daga rauni ko zazzaɓi, ya zubar da homeostasis na jikinka, ECS ɗinka zai shiga don taimakawa jikinka komawa ga aikin da ya dace.

A yau, masana sunyi imanin cewa kiyaye homeostasis idan babban aikin ECS.

Ta yaya THC ke hulɗa tare da ECS?

Tetrahydrocannabinol (THC) shine ɗayan manyan cannabinoids da ake samu a cikin wiwi. Haɗin ne ya sa ka “ɗaukaka.”

Sau ɗaya a jikinka, THC yana hulɗa tare da ECS ɗinka ta hanyar ɗaure ga masu karɓa, kamar endocannabinoids. Yana da ƙarfi sashi saboda yana iya ɗaure ga masu karɓar CB1 da CB2.

Wannan yana ba shi damar samun tasiri mai yawa a jikinku da tunaninku, wasu sun fi wasu kyau. Misali, THC na iya taimakawa wajen rage ciwo da kuma motsa sha'awar ku. Amma kuma yana iya haifar da damuwa da damuwa a wasu yanayi.

Masana a halin yanzu suna bincika hanyoyin samar da roba THC cannabinoids wanda ke hulɗa tare da ECS ta hanyoyi masu fa'ida kawai.

Ta yaya CBD ke hulɗa tare da ECS?

Sauran manyan cannabinoid da aka samo a cikin wiwi shine cannabidiol (CBD). Ba kamar THC ba, CBD ba ya sanya ku "mai girma" kuma yawanci baya haifar da mummunan sakamako.

Masana ba su da cikakken tabbaci game da yadda CBD ke hulɗa da ECS. Amma sun san cewa ba ya ɗaure ga masu karɓar CB1 ko CB2 kamar yadda THC ke yi.

Madadin haka, da yawa suna gaskata cewa yana aiki ta hana hana endocannabinoids. Wannan yana basu damar samun karin tasiri a jikinka. Sauran sun gaskata cewa CBD yana ɗaure ga mai karɓa wanda ba a gano shi ba tukuna.

Yayinda ake bayani game da yadda yake aiki har yanzu ana tattaunawa, bincike ya nuna cewa CBD na iya taimakawa tare da ciwo, tashin zuciya, da sauran alamun cututtukan da ke tattare da yanayi da yawa.

Me game rashi endocannabinoid?

Wasu masana sunyi imani da ka'idar da aka sani da raunin endocannabinoid na asibiti (CECD). Wannan ka'idar tana nuna cewa ƙananan matakan endocannabinoid a cikin jikin ku ko lalacewar ECS na iya ba da gudummawa ga ci gaban wasu yanayi.

Yin bita sama da shekaru 10 na bincike akan lamarin ya nuna ka'idar zata iya bayyana dalilin da yasa wasu mutane ke samun ciwan kai, fibromyalgia, da ciwon mara na hanji.

Babu ɗayan waɗannan sharuɗɗan da ke da dalilin asali. Hakanan suna yawan juriya ga magani kuma wani lokacin suna faruwa tare da juna.

Idan CECD ba ta da kowane irin matsayi a cikin waɗannan yanayin, yin niyya ga ECS ko samar da endocannabinoid na iya zama mabuɗin ɓataccen magani, amma ana buƙatar ƙarin bincike.

Layin kasa

ECS tana taka muhimmiyar rawa wajen tabbatar da tsarin cikin ku ya daidaita. Amma har yanzu akwai da yawa da ba mu sani ba game da shi. Yayinda masana ke haɓaka kyakkyawar fahimta game da ECS, a ƙarshe zai iya riƙe mabuɗin don magance yanayi da yawa.