Magunguna ga mutanen da ke fama da cutar Ulcerative Colitis

Wadatacce

• Amino-Sikeli (5-ASA)
• Mesalamine
• Sulfasalazine
• Olsalazine
• Balsalazide
• Corticosteroids
• Budesonide
• Prednisone da prednisolone
• Immunomodulators
• Tocacitinib
• Samun bayanai
• Azathioprine
• Kayan kwalliya
• Sakamakon sakamako na methotrexate, azathioprine, da mercaptopurine
• Ilimin halittu
• Guji NSAIDs
• Yi magana da likitanka

Gabatarwa

Ciwon gyambon ciki (ulcerative colitis) wani nau'in ciwo ne na hanji (IBD) wanda yafi shafar hanji (babban hanji). Zai iya faruwa ta hanyar martani mara kyau daga tsarin garkuwar jiki. Duk da yake babu sanannen magani na ulcerative colitis, ana iya amfani da nau'ikan magunguna da yawa don gudanar da alamun.

Kwayar cutar ulcerative colitis na iya hadawa da:

• ciwon ciki, rashin jin daɗi, ko kuma raɗaɗin ciki
• ciwan gudawa
• jini a cikin buta

Kwayar cututtukan na iya zama ta yau da kullun ko kuma zasu iya zama mafi muni yayin tashin hankali.

Za a iya amfani da magunguna daban-daban don rage kumburi (kumburi da haushi), rage yawan fitinar da kuke da ita, da kuma ba mahaifarku damar warkewa. Ana amfani da manyan nau'ikan magungunan guda hudu don kula da mutanen da ke fama da cutar ulcerative colitis.

Amino-Sikeli (5-ASA)

Ana amfani da aminosalicylates don rage bayyanar cututtuka na ulcerative colitis ta rage rage kumburi a cikin hanji. Ana amfani da waɗannan magungunan a cikin mutanen da ke fama da ciwon ulcerative ulitis. Suna iya taimakawa wajen hana fitina ko rage yawan fitinar da kake da ita.

Misalan waɗannan kwayoyi sun haɗa da:

Mesalamine

Mesalamine za a iya ɗauka da baki (da baki) azaman kwamfutar da aka jinkirta-fitarwa, ta ƙara kafunta, ko kuma ta jinkirta sakin ta. Hakanan ana samun Mesalamine azaman ƙoshin dubura ko ƙoshin dubura.

Mesalamine yana nan a matsayin magani na gama gari a wasu nau'ikan. Hakanan yana da nau'ikan suna-iri iri, kamar Delzicol, Apriso, Pentasa, Rowasa, sfRowasa, Canasa, Asacol HD, da Lialda.

Abubuwan illa mafi mahimmanci na mesalamine na iya haɗawa da:

• gudawa
• ciwon kai
• tashin zuciya
• ciwon ciki, ciwon ciki, da rashin jin daɗi
• ƙara yawan acidity na ciki ko reflux
• amai
• burping
• kurji

Ra'ayi mai sauƙi amma mai cutarwa na mesalamine na iya haɗawa da:

• ciwon kirji
• karancin numfashi
• bugun zuciya mara tsari

Misalan magungunan da mesalamine na iya hulɗa da su sun haɗa da:

• narayanan
• warfarin
• allurar rigakafin ƙwayar cuta

Sulfasalazine

Ana ɗaukar Sulfasalazine ta bakin azaman fitowar kai-tsaye ko jinkirin fitarwa. Sulfasalazine yana samuwa azaman magani na gama gari kuma azaman sanannen magani Azulfidine.

Abubuwan da suka fi dacewa na sulfasalazine na iya haɗawa da:

• rasa ci
• ciwon kai
• tashin zuciya
• amai
• ciki ciki
• matakan ruwan maniyyi a cikin maza

Sauran cututtukan cututtukan sulfasalazine masu wuya amma sun haɗa da:

• rikicewar jini kamar su anemia
• tsananin rashin lafiyan jiki irin su ciwon Stevens-Johnson
• gazawar hanta
• matsalolin koda

Sulfasalazine na iya yin ma'amala da wasu magunguna, kamar:

• digoxin
• folic acid

Olsalazine

Olsalazine yana zuwa kamar kwalliyar da kuke ɗauka da baki. Akwai shi azaman samfurin-sunan magani Dipentum. Ba a samo shi azaman magani na asali.

Abubuwan da suka fi dacewa na olsalazine na iya haɗawa da:

• gudawa ko tabon sako
• zafi a cikin ciki
• kurji ko itching

M sakamako mai illa na olsalazine na iya haɗawa da:

• rikicewar jini kamar su anemia
• gazawar hanta
• matsalolin zuciya irin su canzawar yanayin zuciya da kumburin zuciyar ka

Misalan magungunan da olsalazine na iya hulɗa da su sun haɗa da:

• heparin
• ƙananan heparins masu nauyin nauyi kamar enoxaparin ko dalteparin
• mercaptopurine
• narayanan
• allurar rigakafin ƙwayar cuta

Balsalazide

Ana ɗaukar Balsalazide ta baki azaman kamfani ko ƙaramin kwamfutar hannu. Capsule yana nan a matsayin magani na asali kuma a matsayin babban sanannen magani Colazal. Ana samun kwamfutar ne kawai a matsayin mai suna Giazo.

Abubuwan da suka fi dacewa na balsalazide na iya haɗawa da:

• ciwon kai
• ciwon ciki
• gudawa
• tashin zuciya
• amai
• numfashi kamuwa da cuta
• ciwon gwiwa

M sakamako mai illa na balsalazide na iya haɗawa da:

• rikicewar jini kamar su anemia
• gazawar hanta

Misalan magungunan da balsalazide na iya hulɗa da su sun haɗa da:

• narayanan
• warfarin
• allurar rigakafin ƙwayar cuta

Corticosteroids

Corticosteroids suna rage karfin garkuwar jikinka gaba daya don rage kumburi a jikinka. Ana amfani da ire-iren wadannan magungunan don magance mutane masu matsakaitan cutar ulcerative colitis. Corticosteroids sun hada da:

Budesonide

Hanyoyi biyu na budesonide da aka yarda da su don maganin cutar ulcerative su ne allunan da aka ba da su da kuma kara kumfa. Dukansu suna nan a matsayin samfurin-sunan magani Uceris. Ba a samo su azaman ƙwayoyi na gama gari.

Abubuwan da ke faruwa na yau da kullun na budesonide na iya haɗawa da:

• ciwon kai
• tashin zuciya
• rage matakan hormone cortisol
• ciwo a cikin ciki na sama
• gajiya
• kumburin ciki
• kuraje
• urinary fili kamuwa da cuta
• ciwon gwiwa
• maƙarƙashiya

M sakamako masu illa na budesonide na iya haɗawa da:

• matsalolin gani kamar su glaucoma, cataracts, da makanta
• hawan jini

Budesonide na iya hulɗa tare da wasu magunguna kamar:

• masu hana kariya ta protease kamar ritonavir, indinavir, da saquinavir, wadanda ake amfani dasu don magance cututtukan HIV
• magungunan antifungal kamar su itraconazole da ketoconazole
• erythromycin
• maganin hana daukar ciki na baki wanda ke dauke da ethinyl estradiol

Prednisone da prednisolone

Prednisone yana nan a cikin kwamfutar hannu, kwamfutar hannu da aka yi jinkirin fitarwa, da kuma nau'ikan hanyoyin magance ruwa Kuna ɗaukar ɗayan waɗannan ta bakinku. Prednisone yana nan a matsayin kwaya daya kuma a matsayin magunguna masu dauke da suna Deltasone, Prednisone Intensol, da Rayos.

Hanyoyin prednisolone wadanda aka yarda dasu don cutar ulcerative sune:

• allunan
• narkewa allunan
• ruwa bayani
• syrup

Kuna iya ɗaukar ɗayan waɗannan siffofin ta bakin. Prednisolone yana nan a matsayin magani na asali kuma a matsayin mai suna mai suna Millipred.

Abubuwan da suka fi dacewa na yau da kullun na prednisone da prednisolone na iya haɗawa da:

• ƙara yawan sukarin jini
• rashin natsuwa ko damuwa
• kara karfin jini
• kumburi saboda riƙewar ruwa a ƙafafunku ko idon sawunku
• ƙara yawan ci
• riba mai nauyi

M sakamako masu illa na prednisone da prednisolone na iya haɗawa da:

• osteoporosis da ƙara haɗarin karayar kashi
• matsalolin zuciya irin su ciwon zuciya, ciwon kirji, da sauyin yanayin zuciya
• kamuwa

Misalan magunguna waɗanda prednisone da prednisolone na iya hulɗa tare da sun hada da:

• antiseizure kwayoyi kamar phenobarbital da phenytoin
• masu rage jini kamar warfarin
• rifampin
• ketoconazole
• asfirin

Immunomodulators

Immunomodulators magunguna ne da ke rage amsawar jiki ga tsarin garkuwar kansa. Sakamakon yana rage kumburi a duk jikin mutum. Immunomodulators na iya rage yawan cututtukan cututtukan ulcerative colitis da kake da su kuma taimaka maka ka kasance ba da alama ba tsawon lokaci.

Immunomodulators ana amfani dasu gaba ɗaya a cikin mutanen da ba a sarrafa alamun su tare da aminosalicylates da corticosteroids. Koyaya, waɗannan kwayoyi na iya ɗaukar watanni da yawa don fara aiki.

Immunomodulators sun hada da:

Tocacitinib

Har zuwa kwanan nan, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da rigakafin cutar ba don kula da mutanen da ke fama da cutar ulcerative colitis. Duk da haka, wannan rukunin magungunan ya wani lokacin ana amfani da lakabin waje don kula da mutanen da ke fama da cutar ulcerative colitis.

Aya daga cikin irin wannan amfani da lakabin ya zama tarihi a cikin 2018 lokacin da FDA ta amince da amfani da immunomodulator ga mutanen da ke fama da cutar ulcerative colitis. Ana kiran wannan immunomodulator tofacitinib (Xeljanz). An riga an yarda da FDA don mutanen da ke fama da cututtukan cututtukan zuciya amma an yi amfani da lakabin waje don mutanen da ke fama da cututtukan ciki. Xeljanz shine magani na farko irinsa wanda ake bayarwa ta baki - maimakon allura - don jinyar dogon lokaci na mutanen da ke fama da cutar ulcerative colitis.

Ara koyo game da amfani da lakabin magani.

Samun bayanai

Methotrexate yana samuwa azaman kwamfutar hannu da kuka sha ta baki. Hakanan ana bayar dashi ta hanyar jigilar jijiyoyin jini (IV) kazalika da allurar subcutaneous da intramuscular. Ana samun kwamfutar a matsayin magani na asali kuma a matsayin mai suna mai suna Trexall. Maganin IV da allurar intramuscular suna samuwa ne kawai azaman ƙwayoyin cuta. Ana samun allurar ta karkashin jiki kawai azaman magungunan iri-iri Otrexup da Rasuvo.

Azathioprine

Don maganin ulcerative colitis, azathioprine yana zuwa azaman kwamfutar hannu da kuka sha da baki. Ana samunsa azaman magani na asali kuma kamar azaman magunguna masu suna Azasan da Imuran.

Kayan kwalliya

Mercaptopurine yana samuwa azaman kwamfutar hannu ko dakatar da ruwa, duka ana ɗauke da baki. Ana samun kwamfutar ne kawai a matsayin magani na gama gari, kuma dakatarwar kawai ana samunta ne azaman magani mai suna Purixan.

Sakamakon sakamako na methotrexate, azathioprine, da mercaptopurine

Abubuwan da suka fi dacewa na yau da kullun na waɗannan ƙwayoyin cuta na iya haɗawa da:

• ciwon kai
• tashin zuciya
• amai
• gudawa
• ciwon baki
• gajiya
• ƙananan matakan ƙwayoyin jini

Misalan magungunan da ƙwayoyin cuta na iya yin hulɗa da su sun haɗa da:

• allopurinol
• aminosalicylates kamar su sulfasalazine, mesalamine, da olsalazine
• angiotensin-converting enzyme (ACE) masu hanawa kamar lisinopril da enalapril
• warfarin
• ribavirin
• nonsteroidal anti-mai kumburi kwayoyi (NSAIDs) kamar naproxen da ibuprofen
• phenylbutazone
• phenytoin
• sulfonamides
• probenecid
• retinoids
• dannirin

Ilimin halittu

Ilimin halittar jiki an tsara shi ne da kwayar halittar gado wanda aka haɓaka a cikin dakin gwaje-gwaje daga kwayar halitta. Wadannan kwayoyi suna hana wasu sunadarai a jikinka haifar da kumburi. Ana amfani da magungunan ƙwayoyin cuta don mutanen da ke fama da cutar ulcerative ulitis. Ana amfani da su ma ga mutanen da ba a sarrafa alamunsu tare da jiyya kamar aminosalicylates, immunomodulators, ko corticosteroids.

Akwai kwayoyi guda biyar wadanda ake amfani dasu don maganin alamomin cutar ulcerative colitis. Waɗannan ana samun su ne kawai azaman ƙwayoyi masu suna, gami da:

• adalimumab (Humira), an bayar dashi ta hanyar allurar subcutaneous
• golimumab (Simponi), an ba shi ta hanyar allurar subcutaneous
• infliximab (Remicade), wanda aka bayar ta hanyar jiko na IV
• infliximab-dyyb (Inflectra), wanda aka bayar ta inginin IV
• vedolizumab (Entyvio), wanda aka bayar ta hanyar jiko na IV

Kila buƙatar ɗaukar adalimumab, golimumab, infliximab, ko infliximab-dyyb har zuwa makonni takwas kafin ka ga wani ci gaba. Vedolizumab yawanci yana farawa aiki cikin makonni shida.

Abubuwan da suka fi dacewa na magungunan ƙwayoyin cuta na iya haɗawa da:

• ciwon kai
• zazzaɓi
• jin sanyi
• amya ko kurji
• ƙara kamuwa da cuta

Magungunan ilimin halittu na iya yin hulɗa tare da sauran wakilan ilimin halittu. Misalan waɗannan sun haɗa da:

• natalizumab
• adalimumab
• golimumab
• infliximab
• anakinra
• abatacept
• tocilizumab
• warfarin
• cyclosporine
• dannirin
• rigakafin rayuwa irin su alurar rigakafin ƙwayar cuta

Guji NSAIDs

NSAIDs, kamar ibuprofen da naproxen, yawanci rage ƙonewa a cikin jiki. Idan kana da ciwon ulcerative colitis, kodayake, waɗannan kwayoyi na iya sa alamun ka su kara muni. Tabbatar da magana da likitanka kafin ɗaukar NSAID.

Yi magana da likitanka

Yawancin kwayoyi zasu iya taimakawa rage alamun cututtukan ku na ulcerative colitis. Idan kana da ciwon ulcerative colitis, sake nazarin wannan labarin tare da likitanka kuma kayi magana game da waɗanne magunguna na iya zama daidai a gare ka. Likitanku zai ba da shawarar magunguna dangane da dalilai kamar lafiyar ku gaba ɗaya da kuma yadda yanayin ku ya kasance mai tsanani.

Wataƙila kuna buƙatar gwada medicationsan magunguna kafin ku sami shirin maganin da zai amfane ku. Idan shan magani daya baya rage alamun ka sosai, likitanka na iya kara magani na biyu wanda zai sa na farko yayi tasiri. Yana iya ɗaukar ɗan lokaci, amma likitanka zai yi aiki tare da kai don nemo magungunan da suka dace don taimakawa alamomin cututtukan cututtukanku.