Hanyoyin Hormone da Magungunan da ba na Hormone ba don Ciwon Proan Ciwon Cutar Ciwon Mara

Wadatacce

• Magungunan hormone na ciwon daji na ci gaba
• Yaya aikin maganin hormone ke aiki?
• Magungunan hormone da aka amince da su
• Manufofin magani
• Yaya ake gudanar da jiyya?
• Wanene dan takara?
• Illolin gama gari
• Magungunan ba na hormone don ci gaba da ciwon sankara ba
• Magungunan da ba na hormone ba
• Manufofin magani
• Wanene dan takara?
• Yaya ake gudanar da jiyya?
• Illolin gama gari
• Layin kasa

Idan cutar sankarar prostate ta kai wani mataki na ci gaba kuma kwayoyin cutar kansa sun bazu zuwa wasu sassan jiki, magani yana da larura. Tsayawa a hankali ba shine zaɓi ba, idan hakan shine hanyar da aka sanar da likitanka.

Abin farin ciki, maza masu fama da ciwon sankarar hanji yanzu suna da wadatar zafin magani fiye da kowane lokaci. Waɗannan sun haɗa da hanyoyin kwantar da hanji da zaɓuɓɓukan maganin ba na hormone ba. Hakikanin maganin da zaku karɓa ya dogara da matakinku na cutar sankarar prostate da kowane irin yanayin da kuke ciki. Ka tuna cewa kwarewar maganin ka na iya zama daban da na wani.

Don yanke shawara kan magani, kuna buƙatar la'akari da maƙasudin mahimmancin maganin, illolin sa, da kuma ko kun kasance ɗan takarar kirki. Sanarwa game da samfuran da ke akwai na iya taimaka maka da likitanka yanke shawarar wane magani, ko haɗin jiyya, ya fi kyau a gare ku.

Magungunan hormone na ciwon daji na ci gaba

Maganin Hormone kuma ana kiranta azaman maganin ɓarkewar asrogen (ADT). An bayyana shi sau da yawa azaman babban mahimmanci don maganin ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta.

Yaya aikin maganin hormone ke aiki?

Magungunan hormone yana aiki ta rage matakan hormones (androgens) a cikin jiki. Androgens sun hada da testosterone da dihydrotestosterone (DHT). Wadannan sinadarai suna karfafa cutar kansar mafitsara ta ninka. Ba tare da androgens ba, ci gaban tumo ya yi jinkiri kuma kansa na iya ma shiga cikin gafara.

Magungunan hormone da aka amince da su

Akwai magunguna da yawa da aka yarda da su don cutar sankarar mahaifa. Wadannan sun hada da:

• GnRH agonists, kamar leuprolide (Eligard, Lupron) da goserelin (Zoladex). Wadannan suna aiki ne ta hanyar rage yawan kwayar halittar testosterone da kwayoyin halittar suka yi.
• Anti-androgens, kamar nilutamide (Nilandron) da enzalutamide (Xtandi). Waɗannan yawanci ana ƙara su ne ga masu ƙyamar GnRH don taimakawa hana testosterone daga haɗuwa zuwa ƙwayoyin tumo.
• Wani nau'in agnist na GnRH da ake kira degarelix (Firmagon), wanda ke toshe sakonni daga kwakwalwa zuwa gwajin saboda a daina samar da androgens.
• Yin aikin tiyata don cire ƙwayoyin cuta (orchiectomy). A zahiri, wannan zai dakatar da samar da homon namiji.
• Abiraterone (Zytiga), mai kishiyar LHRH wanda ke aiki ta hanyar toshe enzyme da ake kira CYP17 don dakatar da samar da androgens ta ƙwayoyin jiki.

Manufofin magani

Manufar maganin hormone shine gafartawa. Gafara yana nufin cewa dukkan alamu da alamomin cutar sankarar prostate suna tafiya. Mutanen da suka sami gafara ba "warkewa ba," amma suna iya yin shekaru da yawa ba tare da nuna alamun cutar kansa ba.

Hakanan za'a iya amfani da maganin Hormone don rage haɗarin sake dawowa bayan magani na farko a cikin maza waɗanda ke cikin haɗarin sake dawowa.

Yaya ake gudanar da jiyya?

GnRH agonists ana yin allura ko sanya su azaman ƙaramin abin talla a ƙarƙashin fata. Ana daukar anti-androgens a matsayin kwaya sau ɗaya a rana. An ba Degarelix a matsayin allura. Wani lokacin ana amfani da magani na chemotherapy da ake kira docetaxel (Taxotere) a haɗe tare da waɗannan hanyoyin maganin na hormone.

Ana shan Zytiga da baki sau daya a rana a hada shi da wani maganin da ake kira prednisone.

Za a iya yin aikin tiyata don cire ƙwayoyin cuta a matsayin hanyar fita daga asibitin. Ya kamata ku sami damar komawa gida hoursan awanni bayan an gama aikin gyaran ciki.

Wanene dan takara?

Yawancin maza da ke fama da ciwon sankarar hanji 'yan takara ne don maganin hormone. Yawanci ana la'akari da shi lokacin da cutar sankarar mafitsara ta bazu fiye da ta prostate, kuma tiyata don cire kumburin ba zai yiwu ba.

Kafin fara magani, kuna buƙatar yin gwajin aikin hanta tare da gwajin jini don tabbatar da cewa hanta zai iya lalata magunguna yadda ya kamata.

A halin yanzu, an yarda da enzalutamide (Xtandi) ne kawai don amfani ga maza masu fama da ciwon sankara wanda ya rigaya ya bazu zuwa wasu sassan jiki, kuma waɗanda ba sa ƙara jin magani ko magani don rage matakan testosterone.

A wasu lokuta, kwayoyin cutar kansar mafitsara na iya tsayayya da jijiyoyin jijiyoyin kuma su ninka koda ba kwayar halittar maza. Wannan ana kiransa mai juriya mai juriya (ko jure jurewa) cutar sankara. Maza da ke fama da cutar sankarar mahaifa ba 'yan takara ba ne don ci gaba da maganin hormone.

Illolin gama gari

Abubuwan da aka fi sani da cututtukan hormone sun haɗa da:

• walƙiya mai zafi
• thinning, karyewar kasusuwa (osteoporosis) saboda ƙananan matakan testosterone suna haifar da asarar alli
• riba mai nauyi
• asarar ƙwayar tsoka
• rashin karfin erectile
• asarar sha'awar jima'i

Magungunan ba na hormone don ci gaba da ciwon sankara ba

Idan maganin hormone ba ya aiki ko cutar kansa tana girma da sauri da sauri, ana iya ba da shawarar magani tare da wasu zaɓuɓɓukan da ba na hormone ba.

Magungunan da ba na hormone ba

Magungunan da ba na hormone ba don ci gaba da ciwon sankara ta prostate sun hada da:

• Chemotherapy, kamar docetaxel (Taxotere), cabazitaxel (Jevtana), da mitoxantrone (Novantrone). Wani lokaci ana ba Chemotherapy a hade tare da steroid wanda aka sani da prednisone.
• Radiation radiation, wanda ke amfani da katako mai ƙarfi mai ƙarfi ko ƙwayoyin rediyo don lalata ciwace-ciwacen daji. Radiation yawanci ana amfani dashi tare da chemotherapy.
• Immunotherapy, ciki har da sipuleucel-T (Provenge). Immunotherapy yana aiki ta amfani da tsarin garkuwar jiki don kashe ƙwayoyin kansa.
• Radium Ra 223 (Xofigo), wanda ke dauke da dan karamin iska kuma ana amfani da shi ne wajen lalata kwayoyin cutar kansar mafitsara wadanda suka bazu zuwa kashi.

Manufofin magani

Makasudin cutar sankara, radiation, da sauran magungunan da ba na hormone ba shine a rage saurin ciwan kansa da tsawaita rayuwar mutum. Chemotherapy da sauran abubuwan da ba na hormone ba mai yiwuwa ba za su iya warkar da cutar kansa ba, amma suna iya tsawanta rayuwar maza da ke fama da ciwon sankarar mahaifa.

Wanene dan takara?

Kuna iya zama ɗan takarar don maganin marasa hormone kamar su chemotherapy ko radiation idan:

• matakan PSA ɗinka suna tashi da sauri don maganin hormone don sarrafa shi
• cutar kansa tana yaduwa cikin sauri
• alamominka suna ta munana
• maganin hormone sun kasa aiki
• kansar ta bazu zuwa kashinku

Yaya ake gudanar da jiyya?

Chemotherapy yawanci ana bayar dashi a cikin hawan keke. Kowane zagaye yawanci yana ɗaukar fewan makonni. Kuna iya buƙatar zagaye na jiyya da yawa, amma yawanci akwai lokacin hutawa tsakanin. Idan wani nau'in ilimin kimiya ya daina aiki, likitanka na iya ba da shawarar wasu zaɓuɓɓuka na chemotherapy.

Sipuleucel-T (Provenge) ana bayar dashi azaman guda uku cikin jijiya, tare da kimanin makonni biyu tsakanin kowane jiko.

Radium Ra 223 shima ana bashi allura.

Illolin gama gari

Sakamakon illa na yau da kullun na chemotherapy sun haɗa da:

• asarar gashi
• tashin zuciya da amai
• gudawa
• gajiya
• rasa ci
• ƙananan ƙwayoyin jini (neutropenia) da haɗarin kamuwa da cuta
• canje-canje a ƙwaƙwalwar ajiya
• suma ko tsukewa a hannu da ƙafa
• sauki rauni
• ciwon baki

Magungunan radiation na iya rage yawan kwayar jinin ku kuma haifar da karancin jini. Ruwan jini yana haifar da gajiya, jiri, ciwon kai, da sauran alamu. Hakanan zafin fitila zai iya haifar da asarar maganin mafitsara (rashin nutsuwa) da kuma rashin karfin kafa.

Layin kasa

Magungunan kwantar da hanzari da tiyata yawanci ana ba da shawarar farko don magance ci gaba da ciwon sankara. Ana iya amfani dasu tare da chemotherapy. Amma bayan wani lokaci, yawancin cututtukan cututtukan prostate na iya zama tsayayya da maganin hormone. Zaɓuɓɓukan da ba na hormone ba sun zama mafi kyawun zaɓi ga maza masu fama da cututtukan cututtukan ƙwayar cuta wanda ba zai iya ba da amsa ga maganin hormone ko ƙarancin magani ba.

Ko da da magani ne, ba dukkan al'amuran da suka shafi ciwon sankarar prostate bane ake iya warkewa ba, amma jiyya na iya rage ci gaban kansa, rage alamun, da inganta rayuwa. Maza da yawa suna rayuwa tsawon shekaru tare da ci gaba da ciwon sankara.

Yin yanke shawara game da jiyya na iya zama mai rikitarwa da ƙalubale saboda akwai abubuwa da yawa da za a yi la’akari da su. Ka tuna cewa ba ka bukatar ka yanke shawara kai kaɗai. Tare da jagora daga likitan ilimin likitan ku da ƙungiyar kiwon lafiya, zaku iya yanke shawara game da mafi kyawun shirin kulawa a gare ku.