Abin da Kowa da Cutar psoriasis ke Bukatar Sanin Game da Masu hana PDE4

Wadatacce

• Bayani
• Menene masu hana PDE4?
• Ta yaya suke aiki don cutar psoriasis?
• PDE4 maganin hanawa vs. sauran maganin psoriasis
• Abubuwan amfani
• Illoli da gargaɗi
• Takeaway

Bayani

Rubutun almara na yau da kullun shine yanayin rashin lafiyar jiki. Wato, garkuwar jiki ta kuskure kan jiki. Yana haifar da ja, facin faci don ci gaba akan fata. Waɗannan facin na iya jin wani lokacin ƙaiƙayi ko raɗaɗi.

Zaɓuɓɓukan magani suna nufin rage waɗannan alamun. Saboda kumburi yana tushen asalin cutar psoriasis, maƙasudin magunguna da yawa shine rage wannan amsa garkuwar jiki da ƙirƙirar daidaituwar al'ada.

Idan kana zaune tare da matsakaiciyar cutar mai tsanani psoriasis, mai hana PDE4 na iya zama kayan aiki mai mahimmanci wajen sarrafa alamun.

Koyaya, maganin ba na kowa bane. Ya kamata ku tattauna hanyoyin maganin ku tare da likitan ku.

Menene masu hana PDE4?

Masu hana PDE4 sabon magani ne. Suna aiki don kawar da tsarin rigakafi, wanda ya rage kumburi. Suna aiki a matakin salula don dakatar da samar da enzyme mai saurin aiki wanda ake kira PDE4.

Masu bincike sun san cewa phosphodiesterases (PDEs) suna lalata adenosine monophosphate (CAMP). CAMP suna ba da gudummawa sosai ga hanyoyin sigina tsakanin ƙwayoyin halitta.

Ta dakatar da PDE4s, ƙaruwa ta CAMP.

Dangane da binciken 2016, wannan ƙimar mafi girma na CAMP na iya samun sakamako mai saurin kumburi, musamman a cikin mutanen da ke fama da cutar psoriasis da atopic dermatitis.

Ta yaya suke aiki don cutar psoriasis?

Masu hana PDE4, kamar apremilast (Otezla), suna aiki a cikin jiki don hana kumburi.

A matsayin ma'auni na rigakafi, yana iya zama da amfani ga mutane masu cutar psoriasis don sarrafa kumburi. Rage kumburi na iya haifar da ɓarkewar cutar ya zama mai saurin yawa da rashin tsanani.

Hakanan yana iya tsayawa ko hana ci gaba da cutar don haifar da cututtukan zuciya na psoriatic (PsA).

Daga waɗanda ke zaune tare da kowane irin ƙwayar cuta, kusan kashi 30 cikin ɗari a ƙarshe suna haifar da PsA, wanda ke haifar da rauni mai haɗari da haɗari. PsA na iya rage darajar rayuwar ku.

PDE4 maganin hanawa vs. sauran maganin psoriasis

Apremilast, mai hana PDE4, ana ɗauke shi da baki. Hakanan yana aiki akan wata hanya mai mahimmanci ta hanyar katse martanin kumburi wanda ke ba da gudummawa ga alamun alamun psoriasis.

Magungunan ilimin halittar jiki kamar adalimumab (Humira), etanercept (Enbrel), da infliximab (Remicade) ana allura su cikin jiki.

Sauran maganin ilimin halittu masu allura sun hada da:

• Ustekinumab (Mai hana IL-12/23)
• secukinumab (mai hana IL-17A)
• ixekizumab (mai hana IL-17A)
• guselkumab (mai hana IL-23)
• risankizumab (mai hana IL-23)

Tofacitinib shine mai hana Janus kinase (JAK) wanda aka yarda dashi azaman maganin baka.

Abatacept shine mai hanawa mai kunnawa na T-cell wanda aka bashi azaman jigilar intravenous (IV) ko allura.

Abubuwan amfani

Ana ba da shawarar Apremilast ga mutanen da ke rayuwa tare da matsakaiciyar cuta mai tsanani psoriasis waɗanda su ma 'yan takara ne don tsarin jiyya ko maganin hoto.

A cikin, mafi yawan mutanen da ke shan apremilast sun sami kyakkyawan sakamako a kan duka Assimar Likita na Duniya (sPGA) da Yankin Psoriasis da Severity Index (PASI) idan aka kwatanta da waɗanda ke shan placebo.

Illoli da gargaɗi

Kodayake masu hana PDE4 suna nuna babban alƙawari, ba na kowa bane. Ba a gwada Apremilast a cikin mata masu ciki ko masu shayarwa ba. A halin yanzu, an yarda da shi ne kawai ga manya.

Har ila yau yana da mahimmanci a auna haɗarin haɗari da fa'idodin masu hana PDE4.

Apremilast ya zo tare da wasu sanannun haɗari.

Mutanen da ke shan apremilast na iya fuskantar halayen kamar:

• tashin zuciya
• gudawa
• kamuwa da cuta ta sama
• ciwon kai

Wasu mutane suma suna fuskantar babbar asara.

Hakanan Apremilast na iya haɓaka baƙin ciki da tunanin kashe kansa.

Ga mutanen da ke da tarihin ɓacin rai ko halayyar kashe kansu, ana ba da shawarar cewa su yi magana da likitansu don taimaka musu a hankali su auna fa'idodin maganin a kan haɗarin.

Idan kun sami sakamako masu illa, likitanku na iya ba da shawarar dakatar da shan magani.

Takeaway

Psoriasis yanayin ciwo ne na yau da kullun - amma ana iya sarrafawa. Matsayin da kumburi ke takawa shine mai da hankali ga jiyya da bincike.

Idan likitanku ya tabbatar da cewa alƙawarinku na psoriasis yana da sauƙi ko an sarrafa shi da kyau, za su iya ba da shawarar ƙwayoyin cututtukan cututtukan cututtukan ƙwayoyin cuta (NSAIDs) Hakanan suna iya ba da shawarar magungunan jiki.

Wataƙila za su iya gwada waɗannan shawarwarin duka biyu kafin yin la'akari da amfani da mai hana PDE4 ko wasu masu gyaran garkuwar jiki.

Masu bincike sun gano ƙarin abubuwa game da hanyoyin da ke haifar da kumburi. Wannan bayanin ya taimaka wajen samar da sabbin magunguna wadanda za su iya samar da sauki ga wadanda ke dauke da cutar ta psoriasis.

Masu hana PDE4 sune sabon ƙira, amma sun zo da haɗari. Ya kamata ku da likitanku suyi la'akari da waɗannan abubuwan a hankali kafin fara sabon nau'in magani.