Anti-glomerular ginshiki membrane cuta

Cututtukan membrane na ƙasa na anti-glomerular (cututtukan GBM) cuta ce mai saurin gaske wanda zai iya ƙunsar saurin lalacewar koda da cutar huhu.

Wasu nau'ikan cutar sun hada da huhu ko koda kawai. Anti-GBM cuta da aka sani da suna Goodpasture syndrome.

Anti-GBM cuta cuta ce ta autoimmune. Yana faruwa ne lokacin da tsarin garkuwar jiki yayi kuskuren kai hari tare da lalata ƙoshin lafiyar jiki. Mutanen da ke fama da wannan ciwo suna haɓaka abubuwa waɗanda ke kai hari ga furotin da ake kira collagen a cikin ƙananan jakar iska a cikin huhu da kuma abubuwan da ake tacewa (glomeruli) na kodan.

Wadannan abubuwa ana kiransu antiglomerular ginshikin membrane membrane. Brawayar ginshiƙin ƙasa mai ɗaukaka wani ɓangare ne na kodan da ke taimakawa wajen tace sharar gida da ƙarin ruwa daga jini. Antiglomerular ginshiki membrane antibodies sunadarai akan wannan matattarar. Suna iya lalata membrane ginshiki, wanda zai haifar da lahani na koda.

Wani lokaci, wannan rikicewar yana haifar da kamuwa da ƙwayoyin cuta na ƙwayoyin cuta ko numfashi a cikin ƙwayoyin hydrocarbon. A irin waɗannan halaye, tsarin garkuwar jiki na iya kai hari ga gabobi ko kyallen takarda saboda yana kuskuren su game da waɗannan ƙwayoyin cuta ko magungunan ƙetare.

Rashin amsar tsarin garkuwar jiki yana haifar da zub da jini a cikin jakar iska na huhu da kumburi a cikin sassan tacewar koda.

Kwayar cututtukan na iya faruwa a hankali a hankali tsawon watanni ko ma shekaru, amma galibi suna haɓaka cikin sauri cikin kwanaki zuwa makonni.

Rashin ci, gajiya, da rauni sune alamomin farkon cutar.

Alamun huhu na iya haɗawa da:

• Tari da jini
• Dry tari
• Rashin numfashi

Koda da sauran alamun cutar sun haɗa da:

• Fitsarin jini
• Jin zafi yayin fitsari
• Tashin zuciya da amai
• Fata mai haske
• Kumbura (edema) a kowane yanki na jiki, musamman a kafafu

Gwajin jiki na iya bayyana alamun cutar hawan jini da yawan ruwa. Mai ba da sabis na kiwon lafiya na iya jin motsin zuciya da huhu mara kyau yayin sauraron kirji tare da stethoscope.

Sakamakon fitsari yawanci ba matsala, kuma yana nuna jini da furotin a cikin fitsari. Ba za a iya ganin jan jini ba.

Hakanan za'a iya yin gwaje-gwaje masu zuwa:

• Antiglomerular ginshikin membrane membrane
• Gas na jini na jini
• BUN
• Kirjin x-ray
• Creatinine (magani)
• Binciken huhu
• Koda biopsy

Babban hadafin shine cire kayan kariya daga jini. Jiyya na iya haɗawa da:

• Plasmapheresis, wanda ke cire kwayoyi masu cutarwa don taimakawa rage kumburi a cikin koda da huhu.
• Magungunan Corticosteroid (kamar su prednisone) da wasu kwayoyi, waɗanda ke dankwafe ko sanyaya garkuwar jiki.
• Magunguna kamar masu hana angiotensin-converting enzyme (ACE) masu hanawa da kuma toshe masu karɓar mai karɓar angiotensin (ARBs), waɗanda ke taimakawa wajen sarrafa hawan jini.
• Dialysis, wanda za a iya yi idan ba za a iya magance ciwon koda ba.
• Dashen koda, wanda za'a iya yi yayin da kodanku suka daina aiki.

Za'a iya gaya maka ka rage cin gishirin da ruwa don sarrafa kumburi. A wasu lokuta, ana iya bada shawarar rage cin abinci mai gina jiki mai ƙarancin matsakaici.

Waɗannan albarkatun na iya samar da ƙarin bayani game da cutar ta GBM:

• Cibiyar Nazarin Ciwon Suga ta Duniya da Cututtukan narkewar abinci da Koda - www.niddk.nih.gov/health-information/kidney-disease/glomerular-diseases/anti-gbm-goodpastures-disease
• Gidauniyar Koda ta Kasa - www.kidney.org/atoz/content/goodpasture
• Nationalungiyar forasa don Rare Rashin Lafiya - rarediseases.org/rare-diseases/goodpasture-syndrome

Gano asali da wuri yana da mahimmanci.Hangen nesa ya fi muni idan kodan sun riga sun lalace sosai lokacin fara jiyya. Lalacewar huhu zai iya zama daga m zuwa mai tsanani.

Mutane da yawa zasu buƙaci dialysis ko dashen koda.

Ba a magance shi ba, wannan yanayin na iya haifar da ɗayan masu zuwa:

• Ciwon koda na kullum
• Kidneyarshen-koda cuta
• Rashin huhu
• Ci gaban glomerulonephritis cikin sauri
• Ciwon jini mai tsananin huhu (huhun jini)

Kira ga alƙawari tare da mai bayarwa idan kuna samar da ƙananan fitsari, ko kuma kuna da wasu alamun alamun cutar ta GBM.

Kada ka taba shan manne ko siphon fetur tare da bakinka, wanda ke fitar da huhu ga sinadarin hydrocarbon kuma zai iya haifar da cutar.

Ciwon Goodpasture; Ci gaba da saurin ciwan glomerulonephritis tare da zubar jini na huhu; Ciwon koda na huhu; Glomerulonephritis - zubar jini na huhu

• Gudanar da jinin koda
• Glomerulus da nephron

Collard HR, King TE, Schwarz MI. Zubar da jini na Alveolar da cututtukan infiltrative. A cikin: Broaddus VC, Mason RJ, Ernst JD, et al, eds. Littafin rubutu na Murray da Nadel na Magungunan numfashi. Na 6 ed. Philadelphia, PA: Elsevier Saunders; 2016: babi na 67.

Phelps RG, Turner AN. Anti-glomerular ginshiki na membrane cuta da Goodpasture cuta. A cikin: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. M Clinical Nephrology. Na 6 ed. Philadelphia, PA: Elsevier; 2019: sura 24.

Radhakrishnan J, Appel GB, D'Agati VD. Secondary glomerular cuta. A cikin: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner da Rector na Koda. 11th ed. Philadelphia, PA: Elsevier; 2020: babi na 32.