Hormone far don ciwon daji na prostate

Maganin Hormone don cutar sankarar mafitsara yana amfani da tiyata ko magunguna don rage matakan homonin jima'i na namiji a jikin mutum. Wannan yana taimakawa rage saurin ciwan kansar.

Androgens sune halayen jima'i na maza. Testosterone shine babban nau'in androgen. Yawancin testosterone ana yin su ne ta hanyar kwayaye. Hakanan adrenal gland shima yana samar da karamin adadin.

Androgens na haifar da kwayar cutar kansar mafitsara don girma. Maganin Hormone don cutar sankarar mafitsara yana rage tasirin tasirin androgens a cikin jiki. Zai iya yin haka ta:

• Dakatar da kwayoyin halittar daga yin androgens ta amfani da tiyata ko magunguna
• Tarewa aikin androgens a cikin jiki
• Tsayawa jiki daga yin androgens

Ba a taɓa amfani da maganin Hormone ga mutanen da ke da Stage I ko Stage II na ciwon sankarar prostate ba.

Ana amfani dashi galibi don:

• Ciwon daji mai saurin gaske wanda ya bazu bayan glandon prostate
• Ciwon daji wanda ya kasa amsa tiyata ko kuma radiation
• Ciwon daji wanda ya sake dawowa

Hakanan za'a iya amfani dashi:

• Kafin radiation ko tiyata don taimakawa rage ƙumburai
• Tare da maganin fuka don cutar kansa wanda wataƙila zai sake faruwa

Magunguna mafi mahimmanci shine shan ƙwayoyi waɗanda ke rage adadin androgens waɗanda ƙwararru suka yi. Ana kiran su analogs na kwayar halitta mai sakin layi (LH-RH) analogs (injections) da anti-androgens (allunan baka). Wadannan kwayoyi ƙananan matakan inrogene kamar yadda tiyata keyi. Wannan nau'in magani wani lokaci ana kiransa "castration na sinadarai."

Maza maza da ke karɓar maganin hana ɓarkewar asrogen ya kamata su yi gwaji na gaba tare da likitan da ke ba da magungunan:

• A tsakanin watanni 3 zuwa 6 bayan fara magani
• Akalla sau daya a shekara, don lura da hawan jini da yin suga (glucose) da gwajin cholesterol
• Don samun gwajin jini na PSA don saka idanu kan yadda maganin ke aiki

Ana ba da analogs na LH-RH azaman harbi ko a matsayin ƙaramin abin dasawa da aka sanya ƙarƙashin fata. Ana ba su ko'ina daga sau ɗaya a wata zuwa sau ɗaya a shekara. Wadannan kwayoyi sun hada da:

• Leuprolide (Lupron, Eligard)
• Goserelin (Zoladex)
• Sawawan (Trelstar)
• Tarihin (Vantas)

Wani magani, degarelix (Firmagon), shine mai adawa da LH-RH. Yana rage matakan inrogene da sauri kuma yana da karancin illa. Ana amfani dashi ga maza masu fama da cutar kansa.

Wasu likitocin suna ba da shawarar dakatarwa da sake farawa magani (tsaka-tsakin magani). Wannan tsarin ya bayyana don taimakawa rage tasirin tasirin maganin hormone. Koyaya, ba a bayyana ba idan tsaka-tsakin aiki yana aiki tare da ci gaba da ci gaba. Wasu nazarin suna nuna cewa ci gaba da ci gaba ya fi tasiri ko kuma cewa yakamata a yi amfani da shi kawai don zaɓar nau'ikan cututtukan prostate.

Yin aikin tiyata don cire ƙwayoyin cuta (castration) yana dakatar da samar da mafi yawan androgens a cikin jiki. Wannan kuma yana raguwa ko dakatar da cutar sankarar mafitsara daga girma. Yayinda yake da tasiri, yawancin maza basu zaɓi wannan zaɓin ba.

Wasu kwayoyi waɗanda ke aiki ta hanyar toshe tasirin cutar asrogen akan ƙwayoyin cutar kanjamau. An kira su anti-androgens. Ana shan waɗannan magungunan azaman ƙwayoyi. Ana amfani dasu sau da yawa lokacin da magunguna don ƙananan matakan androgen basa aiki sosai.

Anti-androgens sun hada da:

• Flutamide (Eulexin)
• Enzalutamide (Xtandi)
• Abiraterone (Zytiga)
• Bicalutamide (Casodex)
• Nilutamide (Nilandron)

Ana iya samar da Androgens a wasu yankuna na jiki, kamar su adrenal gland. Wasu kwayoyin cutar kansar ta prostate suma zasu iya yin androgens. Magunguna uku suna taimakawa dakatar da jiki daga yin androgens daga kayan wanin ƙwayoyin cuta.

Magunguna biyu, ketoconazole (Nizoral) da aminoglutethimide (Cytradren), suna magance wasu cututtukan amma wasu lokuta ana amfani dasu don magance cutar ta prostate. Na uku, abiraterone (Zytiga) yana magance ci gaban cutar sankara wanda ya bazu zuwa wasu wurare a jiki.

Bayan lokaci, cutar sankarar prostate ta zama mai jure wa maganin hormone. Wannan yana nufin cewa ciwon daji kawai yana buƙatar ƙananan matakan androgen don yayi girma. Lokacin da wannan ya faru, ana iya ƙara ƙarin magunguna ko wasu jiyya.

Androgens suna da tasiri a ko'ina cikin jiki. Don haka, jiyya da ke saukar da waɗannan homon ɗin na iya haifar da illa daban-daban. Duk tsawon lokacin da ka sha wadannan magunguna, to da alama za ka iya samun illa.

Sun hada da:

• Matsalar samun tsayuwa da rashin sha'awar jima'i
• Rinarƙwarar ƙwarjiyoyin azzakari da azzakari
• Hasken walƙiya
• Raunana ko karayar ƙasusuwa
• Musclesarami, raunin tsokoki
• Canje-canje a cikin kitse na jini, kamar su cholesterol
• Canje-canje a cikin sukarin jini
• Karuwar nauyi
• Yanayin motsi
• Gajiya
• Girman nonuwan mama, taushin nono

Maganin hana cututtukan androgen na iya ƙara haɗarin kamuwa da ciwon sukari da cututtukan zuciya.

Yanke shawara game da maganin cututtukan ƙwayar cuta don cutar kanjamau na iya zama mai rikitarwa har ma da wahala. Nau'in magani na iya dogara da:

• Rashin haɗarin ku don dawo da kansa
• Yaya ci gaban ciwon kansa yake
• Ko wasu magungunan sun daina aiki
• Ko cutar daji ta bazu

Tattaunawa tare da mai ba ku sabis game da zaɓuɓɓukanku da fa'idodi da haɗarin kowane magani na iya taimaka muku yanke shawara mafi kyau a gare ku.

Maganin hana cututtukan inrogen; ADT; Androgen danniya far; Hada haɗin inrogen; Orchiectomy - ciwon daji na prostate; Castration - cutar sankarar mafitsara

• Jikin haihuwa na namiji

Tashar yanar gizon Cibiyar Cancer ta Amurka. Hormone far don ciwon daji na prostate. www.cancer.org/cancer/prostate-cancer/treating/hormone-therapy.html. An sabunta Disamba 18, 2019. An shiga Maris 24, 2020.

Yanar gizo Cibiyar Cancer ta Kasa. Hormone far don ciwon daji na prostate. www.cancer.gov/types/prostate/prostate-hormone-therapy-fact-sheet. An sabunta Fabrairu 28, 2019. An shiga 17 ga Disamba, 2019.

Yanar gizo Cibiyar Cancer ta Kasa. Maganin ciwon daji na ƙwayar cuta (PDQ) - fasalin ƙwararrun masu kiwon lafiya. www.cancer.gov/types/prostate/hp/prostate-treatment-pdq. An sabunta Janairu 29, 2020. An shiga Maris 24, 2020.

Yanar gizo Yanar Gizon Cutar Kanjamau ta Kasa. NCCN jagororin aikin likita a cikin ilimin ilimin halittar jiki (jagororin NCCN): cutar sankarar prostate. Sigar 1.2020. www.nccn.org/professionals/physician_gls/pdf/prostate.pdf. An sabunta Maris 16, 2020. An shiga Maris 24, 2020.

Eggener S. Hormonal far don ciwon daji na prostate. A cikin: Partin AW, Dmochowski RR, Kavoussi LR, Peters CA, eds. Campbell-Walsh Urology. 12th ed. Philadelphia, PA: Elsevier; 2021: babi na 161.

• Prostate Cancer