Mawallafi: William Ramirez
Ranar Halitta: 16 Satumba 2021
Sabuntawa: 13 Nuwamba 2024
Anonim
Cannabidiol (CBD) and Health | Pharmacology
Video: Cannabidiol (CBD) and Health | Pharmacology

Wadatacce

Cannabidiol sinadarai ne a cikin tsiron wiwi na wiwi, wanda aka fi sani da marijuana ko hemp. Fiye da sunadarai 80, da aka sani da suna cannabinoids, an gano su a cikin tsiren Cannabis sativa. Yayinda delta-9-tetrahydrocannabinol (THC) shine babban sinadarin aiki a cikin marijuana, ana samun cannabidiol daga hemp, wanda ya ƙunshi ƙananan ƙananan THC kawai.

Wucewar Dokar Gona ta 2018 ta halatta a sayar da kayan kwalliya da kayan kwalliya a cikin Amurka Amma wannan ba yana nufin cewa duk samfuran cannabidiol da aka samo daga hemp halal ne ba. Tun lokacin da aka yi nazarin cannabidiol a matsayin sabon magani, ba za a iya haɗa shi da doka ba cikin abinci ko abincin abincin. Hakanan, cannabidiol ba za a iya haɗa shi cikin kayayyakin da aka tallata tare da iƙirarin warkewa ba. Cannabidiol za a iya haɗa shi cikin kayayyakin "kwaskwarima" kuma kawai idan ya ƙunshi ƙasa da 0.3% THC. Amma har yanzu akwai samfuran da aka lakafta su azaman kayan abincin abincin akan kasuwa waɗanda ke ɗauke da cannabidiol. Adadin cannabidiol da ke cikin waɗannan samfuran ba koyaushe ana ba da rahoton daidai a kan samfurin samfurin ba.

Cannabidiol an fi amfani dashi don rikicewar cuta (epilepsy). Hakanan ana amfani dashi don damuwa, zafi, cututtukan tsoka da ake kira dystonia, cututtukan Parkinson, cutar Crohn, da sauran yanayi, amma babu kyakkyawar shaidar kimiyya don tallafawa waɗannan amfani.

Magunguna na Compwararren Bayanan Bayanai ƙimar tasiri bisa ga shaidar kimiyya bisa ga mizani mai zuwa: Inganci, Mai yuwuwa Mai Yiwuwa, Yiwuwar Tasiri, Yiwuwar Mara Inganci, Mai yiwuwa Mara Inganci, Mara Inganci, da suarancin Shaida don Rate.

Effectivenessimar tasiri don CANNABIDIOL (CBD) sune kamar haka:


Da alama tasiri ga ...

  • Ciwon cuta (farfadiya). Wani takamaiman samfurin cannabidiol (Epidiolex, GW Pharmaceuticals) an nuna don rage kamuwa da cuta a cikin manya da yara tare da yanayi daban-daban waɗanda ke da alaƙa da haɗuwa. Wannan samfurin magani ne na likitanci don magance cututtukan da cutar ta Dravet, Lennox-Gastaut ta ciwo, ko ƙwayar cuta ta ƙwayar cuta. Hakanan an nuna shi don rage kamuwa da cuta a cikin mutanen da ke fama da cutar Sturge-Weber, cututtukan cututtukan zazzaɓi da ke da alaƙa da cututtukan zazzaɓi (FIRES), da takamaiman cututtukan kwayar halitta waɗanda ke haifar da cututtukan kwakwalwa. Amma ba a yarda da shi ba don magance waɗannan nau'ikan nau'ikan kamawa. Ana ɗaukar wannan samfurin a haɗe tare da magungunan rigakafi na yau da kullun. Wasu samfuran cannabidiol da aka yi a cikin dakin gwaje-gwaje kuma ana nazarin su don farfadiya. Amma bincike yana iyakance, kuma babu ɗayan waɗannan samfuran da aka yarda da su azaman magunguna.

Evidencearancin shaida don kimanta inganci don ...

  • Wani nau'in cututtukan hanji mai kumburi (cutar Crohn). Binciken farko ya nuna cewa shan cannabidiol baya rage ayyukan cuta ga manya da cutar Crohn.
  • Ciwon suga. Bincike na farko ya nuna cewa shan cannabidiol ba ya inganta manya masu kula da glucose na jini tare da ciwon sukari na 2.
  • Rikicin motsi wanda aka alama da nakasar tsoka mara izini (dystonia). Babu tabbas idan cannabidiol yana da amfani ga dystonia.
  • Yanayin gado wanda aka yiwa alama ta nakasasun karatu (mai saurin lalacewa- X ciwo). Binciken farko ya nuna cewa yin amfani da gel na cannabidiol na iya rage damuwa da haɓaka halayyar yara da ke fama da cutar ta X.
  • Halin da dasawa ke afkawa cikin jiki (cututtukan-da-mai-karbar bakunci ko GVHD). Cututtukan da suke dauke da daskararren cuta shine rikitarwa wanda zai iya faruwa bayan dashen daskarewa da jijiya. Binciken farko ya gano cewa shan cannabidiol a kowace rana yana farawa kwanaki 7 kafin daskarewar kashi da ci gaba na tsawon kwanaki 30 bayan dasawar na iya tsawaita lokacin da mutum zai dauka don bunkasa GVHD.
  • Cutar ƙwaƙwalwar da aka gada wacce ke shafar motsi, motsin rai, da tunani (cutar Huntington). Binciken farko ya nuna cewa shan cannabidiol kowace rana baya inganta alamun cutar Huntington.
  • Mahara sclerosis (MS). Binciken farko ya nuna cewa yin amfani da maganin cannabidiol a ƙarƙashin harshe na iya inganta ciwo da ƙuntata tsoka a cikin mutane tare da MS.
  • Saukewa daga heroin, morphine, da sauran magungunan opioid. Binciken farko ya nuna cewa shan cannabidiol na tsawon kwanaki 3 na iya rage sha’awa da damuwa a cikin mutanen da ke fama da rikicewar amfani da tabar heroin.
  • Cutar Parkinson. Bincike na farko ya nuna cewa cannabidiol na iya rage damuwa da alamun cututtukan kwakwalwa a cikin mutanen da ke da cutar Parkinson.
  • Schizophrenia. Binciken farko ya nuna cewa shan cannabidiol yana inganta alamomin da jin daɗin mutanen da ke fama da cutar rashin lafiya.
  • Barin shan taba. Binciken farko ya nuna cewa shaƙar cannabidiol tare da inhaler na mako ɗaya na iya rage adadin sigarin da masu shan sigari ke sha.
  • Nau'in damuwa da ke nuna tsoro a cikin wasu ko duk saitunan zamantakewar (rikicewar tashin hankali). Binciken farko ya nuna cewa cannabidiol na iya haɓaka damuwa ga mutanen da ke da wannan cuta. Amma ba a bayyane yake ba idan yana taimakawa rage tashin hankali yayin magana a gaban jama'a.
  • Wani rukuni na yanayi mai raɗaɗi wanda ya shafi haɗin muƙamuƙin da tsoka (rikice-rikicen lokaci ko TMD). Binciken farko ya nuna cewa shafa mai mai dauke da cannabidiol ga fata na iya rage zafi ga mutanen da ke tare da TMD.
  • Lalacewar jijiyoyi a hannaye da kafafu (neuropathy na gefe).
  • Cutar rashin lafiya.
  • Rashin bacci.
  • Sauran yanayi.
Ana buƙatar ƙarin shaida don kimanta tasirin cannabidiol don waɗannan amfani.

Cannabidiol yana da tasiri akan kwakwalwa. Ainihin dalilin wadannan tasirin bai bayyana ba. Koyaya, cannabidiol kamar yana hana rugujewar wani sunadarai a cikin kwakwalwa wanda ke shafar ciwo, yanayi, da aikin tunani. Tsayar da lalacewar wannan sinadarin da haɓaka matakansa a cikin jini kamar yana rage alamun bayyanar cututtuka da ke haɗuwa da yanayi kamar schizophrenia. Hakanan Cannabidiol na iya toshe wasu daga tasirin tasirin psychota-9-tetrahydrocannabinol (THC). Hakanan, cannabidiol kamar yana rage zafi da damuwa.

Lokacin shan ta bakin: Cannabidiol shine MALAM LAFIYA lokacin da aka ɗauke ta baki ko aka fesa ta ƙarƙashin harshen yadda ya dace. Cannabidiol a cikin allurai har zuwa 300 MG kowace rana ana ɗauke da baki lafiya har zuwa watanni 6. An ɗauki mafi yawan allurai na 1200-1500 MG kowace rana ta bakin lafiya har zuwa makonni 4. Kayan magani na cannabidiol (Epidiolex) an yarda da shi don ɗaukar baki a cikin allurai har zuwa 25 mg / kg kowace rana. Cannabidiol sprays da ake amfani da su a ƙarƙashin harshe an yi amfani dasu a cikin allurai na 2.5 MG har zuwa makonni 2.

Wasu sakamako masu illa na cannabidiol sun hada da bushewar baki, ƙarancin jini, ƙoshin haske, da bacci. Hakanan an bayar da rahoton alamun cutar hanta ga wasu marasa lafiya, amma wannan ba shi da yawa.

Lokacin amfani da fata: Babu isasshen ingantaccen bayani don sanin ko cannabidiol yana da lafiya ko kuma menene tasirin illa na iya zama.

Kariya & Gargaɗi na Musamman:

Ciki da shan nono: Cannabidiol shine YIWU KA KIYAYE don amfani idan kun kasance masu ciki ko ciyar da nono. Za a iya gurɓata kayayyakin Cannabidiol tare da wasu sinadaran da za su iya zama lahani ga ɗan tayi ko jariri. Kasance a gefen aminci ka guji amfani.

Yara: Kayan maganin maganin cannabidiol (Epidiolex) shine MALAM LAFIYA lokacin shan ta baki cikin allurai har zuwa 25 mg / kg kowace rana. An yarda da wannan samfurin don amfani da wasu yara 1an shekara 1 zuwa sama.

Ciwon Hanta: Mutanen da ke da cutar hanta na iya buƙatar yin amfani da ƙananan maganin cannabidiol idan aka kwatanta da marasa lafiya.

Cutar Parkinson: Wasu bincike na farko sun nuna cewa shan allurai masu yawa na cannabidiol na iya haifar da motsin jiki da rawar jiki cikin wasu mutane da ke fama da cutar Parkinson.

Matsakaici
Yi hankali da wannan haɗin.
Brivaracetam (Briviact)
Jikin Brivaracetam ya canza kuma ya karye shi. Cannabidiol na iya rage yadda sauri jiki ke rushe brivaracetam.Wannan na iya kara matakan brivaracetam a jiki.
Carbamazepine (Tegretol)
Jikin Carbamazepine ya canza kuma ya karye shi. Cannabidiol na iya rage yadda sauri jiki ke farfasa carbamazepine. Wannan na iya kara yawan sinadarin carbamazepine a cikin jiki da kuma kara tasirinsa.
Clobazam (Onfi)
Clobazam ya canza kuma hanta ta karye shi. Cannabidiol na iya rage yadda hanta ke saurin karye clobazam. Wannan na iya haɓaka sakamako da illa na clobazam.
Eslicarbazepine (Aptiom)
Jikin Eslicarbazepine ya canza kuma ya karye ta jiki. Cannabidiol na iya rage yadda sauri jiki ke rushe eslicarbazepine. Wannan na iya kara matakan eslicarbazepine a cikin jiki da karamin adadi.
Everolimus (Zostress)
Everolimus ya canza kuma jiki ya karye shi. Cannabidiol na iya rage yadda sauri jiki ke rushe everolimus. Wannan na iya kara yawan matakan everolimus a jiki.
Lithium
Shan mafi yawan allurai na cannabidiol na iya ƙara matakan lithium. Wannan na iya kara haɗarin guba na lithium.
Magunguna sun canza ta hanta (Cytochrome P450 1A1 (CYP1A1) substrates)
Wasu magunguna ana canza su ta hanta. Cannabidiol na iya rage yadda hanta ke saurin wargaza wasu magunguna. A ka'idar, amfani da cannabidiol tare da wasu magunguna waɗanda hanta ke lalata na iya ƙara tasiri da tasirin wasu magunguna. Kafin amfani da cannabidiol, yi magana da mai ba ka kiwon lafiya idan ka sha magunguna wadanda hanta ke canza su.

Wasu magunguna da hanta ta canza sun hada da chlorzoxazone (Lorzone) da theophylline (Theo-Dur, wasu).
Magunguna da hanta suka canza (Cytochrome P450 1A2 (CYP1A2) substrates)
Wasu magunguna ana canza su ta hanta. Cannabidiol na iya rage yadda hanta ke saurin wargaza wasu magunguna. A ka'idar, amfani da cannabidiol tare da wasu magunguna waɗanda hanta ke lalata na iya haɓaka sakamako da illa na wasu magunguna. Kafin amfani da cannabidiol, yi magana da mai ba ka kiwon lafiya idan ka sha magunguna wadanda hanta ke canza su.

Wasu magunguna da hanta ta canza sun hada da amitriptyline (Elavil), haloperidol (Haldol), ondansetron (Zofran), propranolol (Inderal), theophylline (Theo-Dur, wasu), verapamil (Calan, Isoptin, wasu), da sauransu.
Magunguna sun canza ta hanta (Cytochrome P450 1B1 (CYP1B1) substrates)
Wasu magunguna ana canza su ta hanta. Cannabidiol na iya rage yadda hanta ke saurin wargaza wasu magunguna. A ka'idar, amfani da cannabidiol tare da wasu magunguna waɗanda hanta ke lalata na iya ƙara tasiri da tasirin wasu magunguna. Kafin amfani da cannabidiol, yi magana da mai ba ka kiwon lafiya idan ka sha magunguna wadanda hanta ke canza su.

Wasu magunguna da hanta ta canza sun hada da theophylline (Theo-Dur, wasu), omeprazole (Prilosec, Omesec), clozapine (Clozaril, FazaClo), progesterone (Prometrium, wasu), lansoprazole (Prevacid), flutamide (Eulexin), oxaliplatin (Eloxatin) ), erlotinib (Tarceva), da maganin kafeyin.
Magunguna sun canza ta hanta (Cytochrome P450 2A6 (CYP2A6) substrates)
Wasu magunguna ana canza su ta hanta. Cannabidiol na iya rage yadda hanta ke saurin wargaza wasu magunguna. A ka'idar, amfani da cannabidiol tare da wasu magunguna waɗanda hanta ke lalata na iya haɓaka sakamako da illa na wasu magunguna. Kafin amfani da cannabidiol, yi magana da mai ba ka kiwon lafiya idan ka sha magunguna wadanda hanta ke canza su.

Wasu magunguna da hanta ta canza sun hada da nicotine, chlormethiazole (Heminevrin), coumarin, methoxyflurane (Penthrox), halothane (Fluothane), valproic acid (Depacon), disulfiram (Antabuse), da sauransu.
Magunguna sun canza ta hanta (Cytochrome P450 2B6 (CYP2B6) substrates)
Wasu magunguna ana canza su ta hanta. Cannabidiol na iya rage yadda hanta ke saurin wargaza wasu magunguna. A ka'idar, amfani da cannabidiol tare da wasu magunguna waɗanda hanta ke lalata na iya ƙara tasiri da tasirin wasu magunguna. Kafin amfani da cannabidiol, yi magana da mai ba ka kiwon lafiya idan ka sha magunguna wadanda hanta ke canza su.

Wasu magunguna da hanta ta canza sun hada da ketamine (Ketalar), phenobarbital, orphenadrine (Norflex), secobarbital (Seconal), da dexamethasone (Decadron).
Magunguna da hanta suka canza (Cytochrome P450 2C19 (CYP2C19) substrates)
Wasu magunguna ana canza su ta hanta. Cannabidiol na iya rage yadda hanta ke saurin wargaza wasu magunguna. A ka'idar, amfani da cannabidiol tare da wasu magunguna waɗanda hanta ke lalata na iya ƙara tasiri da tasirin wasu magunguna. Kafin amfani da cannabidiol, yi magana da mai ba ka kiwon lafiya idan ka sha magunguna wadanda hanta ke canza su.

Wasu magunguna da hanta ta canza sun hada da proton pump inhibitors wadanda suka hada da omeprazole (Prilosec), lansoprazole (Prevacid), da pantoprazole (Protonix); diazepam (Valium); carisoprodol (Soma); nelfinavir (Viracept); da sauransu.
Magunguna sun canza ta hanta (Cytochrome P450 2C8 (CYP2C8) substrates)
Wasu magunguna ana canza su ta hanta. Cannabidiol na iya rage yadda hanta ke saurin wargaza wasu magunguna. A ka'idar, amfani da cannabidiol tare da wasu magunguna waɗanda hanta ke lalata na iya ƙara tasiri da tasirin wasu magunguna. Kafin amfani da cannabidiol, yi magana da mai ba ka kiwon lafiya idan ka sha magunguna wadanda hanta ke canza su.
Wasu magunguna da hanta ta canza sun hada da amiodarone (Cordarone), carbamazepine (Tegretol), chloroquine (Aralen), diclofenac (Voltaren), paclitaxel (Taxol), repaglinide (Prandin) da sauransu.
Magunguna sun canza ta hanta (Cytochrome P450 2C9 (CYP2C9) substrates)
Wasu magunguna ana canza su ta hanta. Cannabidiol na iya rage yadda hanta ke saurin wargaza wasu magunguna. A ka'idar, amfani da cannabidiol tare da wasu magunguna waɗanda hanta ke lalata na iya ƙara tasiri da tasirin wasu magunguna. Kafin amfani da cannabidiol, yi magana da mai ba ka kiwon lafiya idan ka sha magunguna wadanda hanta ke canza su.

Wasu magungunan da hanta ta canza sun hada da nonsteroidal anti-inflammatory anti-inflammatory drugs (NSAIDs) kamar diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), piroxicam (Feldene), da celecoxib (Celebrex); amitriptyline (Elavil); warfarin (Coumadin); glipizide (Glucotrol); losartan (Cozaar); da sauransu.
Magunguna sun canza ta hanta (Cytochrome P450 2D6 (CYP2D6) substrates)
Wasu magunguna ana canza su ta hanta. Cannabidiol na iya rage yadda hanta ke saurin wargaza wasu magunguna. A ka'idar, amfani da cannabidiol tare da wasu magunguna waɗanda hanta ke lalata na iya ƙara tasiri da tasirin wasu magunguna. Kafin amfani da cannabidiol, yi magana da mai ba ka kiwon lafiya idan ka sha magunguna wadanda hanta ke canza su.

Wasu magunguna da hanta ta canza sun hada da amitriptyline (Elavil), codeine, desipramine (Norpramin), flecainide (Tambocor), haloperidol (Haldol), imipramine (Tofranil), metoprolol (Lopressor, Toprol XL), ondansetron (Zofran), paroxetil ), risperidone (Risperdal), tramadol (Ultram), venlafaxine (Effexor), da sauransu.
Magunguna da hanta suka canza (Cytochrome P450 3A4 (CYP3A4) substrates)
Wasu magunguna ana canza su ta hanta. Cannabidiol na iya rage yadda hanta ke saurin wargaza wasu magunguna. A ka'idar, amfani da cannabidiol tare da wasu magunguna waɗanda hanta ke lalata na iya haɓaka sakamako da illa na wasu magunguna. Kafin amfani da cannabidiol, yi magana da mai ba ka kiwon lafiya idan ka sha magunguna wadanda hanta ke canza su.

Wasu magunguna da hanta ta canza sun hada da alprazolam (Xanax), amlodipine (Norvasc), clarithromycin (Biaxin), cyclosporine (Sandimmune), erythromycin, lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), trixof) (Halcion), verapamil (Calan, Isoptin) da sauransu da yawa.
Magunguna sun canza ta hanta (Cytochrome P450 3A5 (CYP3A5) substrates)
Wasu magunguna ana canza su ta hanta. Cannabidiol na iya rage yadda hanta ke saurin wargaza wasu magunguna. A ka'idar, amfani da cannabidiol tare da wasu magunguna waɗanda hanta ke lalata na iya haɓaka sakamako da illa na wasu magunguna. Kafin amfani da cannabidiol, yi magana da mai ba ka kiwon lafiya idan ka sha magunguna wadanda hanta ke canza su.

Wasu magunguna da hanta ta canza sun hada da testosterone, progesterone (Endometrin, Prometrium), nifedipine (Adalat CC, Procardia XL), cyclosporine (Sandimmune), da sauransu.
Magunguna sun canza ta hanta (Magungunan Glucuronidated)
Wasu magunguna ana canza su ta hanta. Cannabidiol na iya rage yadda hanta ke saurin wargaza wasu magunguna. Shan cannabidiol tare da wasu magunguna waɗanda hanta ke lalata na iya ƙara tasiri da tasirin tasirin waɗannan magunguna.
Wasu daga cikin wadannan magungunan da hanta ta canza sun hada da acetaminophen (Tylenol, wasu) da oxazepam (Serax), haloperidol (Haldol), lamotrigine (Lamictal), morphine (MS Contin, Roxanol), zidovudine (AZT, Retrovir), da sauransu.
Magunguna waɗanda ke rage raunin wasu magunguna ta hanta (Masu hanawa na Cytochrome P450 2C19 (CYP2C19))
Cannabidiol ya lalace ta hanta. Wasu magunguna na iya rage yadda hanta ke hanzarta saukar da cannabidiol. Shan cannabidiol tare da waɗannan magunguna na iya ƙara tasiri da illa masu illa na cannabidiol.
Wasu magunguna waɗanda zasu iya rage raunin cannabidiol a cikin hanta sun haɗa da cimetidine (Tagamet), fluvoxamine (Luvox), omeprazole (Prilosec); ticlopidine (Ticlid), topiramate (Topamax), da sauransu.
Magunguna waɗanda ke rage raunin wasu magunguna a cikin hanta (Masu hanawa na Cytochrome P450 3A4 (CYP3A4))
Cannabidiol ya lalace ta hanta. Wasu magunguna na iya rage yadda hanta ke hanzarta saukar da cannabidiol. Shan cannabidiol tare da waɗannan magunguna na iya ƙara tasiri da illa masu illa na cannabidiol.
Wasu magunguna da zasu iya rage yadda hanta ke saurin lalacewa cannabidiol sun hada da amiodarone (Cordarone), clarithromycin (Biaxin), diltiazem (Cardizem), erythromycin (E-mycin, Erythrocin), indinavir (Crixivan), ritonavir (Norvir), saquinavir (Fortovase , Invirase), da sauransu.
Magunguna waɗanda ke ƙara ragargaza wasu magunguna ta hanta (masu ba da magani na Cytochrome P450 3A4 (CYP3A4))
Cannabidiol ya lalace ta hanta. Wasu magunguna na iya ƙaruwa da sauri hanta ta lalace cannabidiol. Shan cannabidiol tare da waɗannan magunguna na iya rage tasirin cannabidiol.
Wasu daga cikin wadannan magunguna sun hada da carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), da sauransu.
Magunguna waɗanda ke ƙara ragargaza wasu magunguna ta hanta (masu shigar da cuta na Cytochrome P450 2C19 (CYP2C19))
Cannabidiol ya lalace ta hanta. Wasu magunguna na iya ƙaruwa da sauri hanta ta lalace cannabidiol. Shan cannabidiol tare da waɗannan magunguna na iya rage tasirin cannabidiol.
Wasu magunguna waɗanda zasu iya ƙara lalatawar cannabidiol a cikin hanta sun haɗa da carbamazepine (Tegretol), prednisone (Deltasone), da rifampin (Rifadin, Rimactane).
Methadone (Dolophine)
Hanta ne ya farfasa methadone Cannabidiol na iya rage yadda hanta ke saurin warke methadone. Shan cannabidiol tare da methadone na iya haɓaka sakamako da illa na methadone.
Rufinamide (Banzel)
Rufinamide ya canza kuma jiki ya karye shi. Cannabidiol na iya rage yadda sauri jiki ke rushe rufinamide. Wannan na iya ƙara matakan rufinamide a cikin jiki da ɗan kaɗan.
Magungunan kwantar da hankali (CNS depressants)
Cannabidiol na iya haifar da bacci da bacci. Ana kiran magungunan da ke haifar da bacci. Shan cannabidiol tare da magungunan kwantar da hankali na iya haifar da yawan bacci.

Wasu magungunan kwantar da hankali sun hada da benzodiazepines, pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), thiopental (Pentothal), fentanyl (Duragesic, Sublimaze), morphine, propofol (Diprivan), da sauransu.
Sirolimus (Rapamune)
Sirolimus ya canza kuma jiki ya karye shi. Cannabidiol na iya rage yadda sauri jiki ke rushe sirolimus. Wannan na iya kara yawan sirolimus a jiki.
Stiripentol (Diacomit)
Stiripentol ya canza kuma jiki ya karye shi. Cannabidiol na iya rage yadda sauri jiki ke rushe stiripentol. Wannan na iya kara matakan stiripentol a cikin jiki kuma ya kara illolinta.
Tacrolimus (Shirya)
Tacrolimus ya canza kuma jiki ya karye shi. Cannabidiol na iya rage yadda sauri jiki ke rushe tacrolimus. Wannan na iya kara matakan tacrolimus a jiki.
Topiramate foda (Tompamax)
Topiramate foda ya canza kuma ya rushe ta jiki. Cannabidiol na iya rage yadda sauri jiki ke rushe topiramate. Wannan na iya ƙara matakan Topiramate a cikin jiki da ɗan kaɗan.
Matsayi
Valproic acid na iya haifar da raunin hanta. Shan cannabidiol tare da valproic acid na iya kara damar cutar hanta. Cannabidiol da / ko valproic acid na iya buƙatar dakatarwa, ko kuma ana buƙatar rage adadin.
Warfarin
Cannabidiol na iya ƙara matakan warfarin, wanda zai iya ƙara haɗarin zub da jini. Cannabidiol da / ko warfarin na iya buƙatar dakatarwa, ko kuma ana buƙatar rage adadin.
Zonisamide
Zonisamide ya canza kuma jiki ya rushe shi. Cannabidiol na iya rage yadda sauri jiki ke rushe zonisamide. Wannan na iya kara yawan matakan zonisamide a jiki ta karamin adadin.
Ganye da kari tare da kayan haɓaka
Cannabidiol na iya haifar da bacci ko bacci. Amfani da shi tare da sauran ganyayyaki da kari waɗanda ke da tasiri iri ɗaya na iya haifar da yawan bacci. Wasu daga cikin wadannan ganyayyaki da kari sun hada da calamus, California poppy, catnip, hops, Jamaica dogwood, kava, L-tryptophan, melatonin, sage, SAMe, St. John’s wort, sassafras, skullcap, da sauransu.
Alkahol (Ethanol)
Shan cannabidiol tare da barasa yana kara adadin cannabidiol wanda jiki ke sha. Wannan na iya haɓaka sakamako da illa na cannabidiol.
Fats da abinci mai dauke da mai
Shan cannabidiol tare da abinci mai dauke da mai ko kuma a kalla yana dauke da wani kitse, yana kara adadin cannabidiol da jiki ke sha. Wannan na iya haɓaka sakamako da illa na cannabidiol.
Madara
Shan cannabidiol tare da madara yana kara adadin cannabidiol wanda jiki ke sha. Wannan na iya haɓaka sakamako da illa na cannabidiol.
An yi nazarin ƙwayoyi masu zuwa a cikin binciken kimiyya:

MAGABATA

DA BAKI:
  • Don farfadiya: An yi amfani da samfurin maganin cannabidiol (Epidiolex). Amfani da shawarar farawa don cutar Lennox-Gastaut da Ciwan Dravet shine 2.5 mg / kg sau biyu a rana (5 mg / kg / day). Bayan mako guda ana iya ƙara nauyin zuwa 5 mg / kg sau biyu a rana (10 mg / kg / day). Idan mutum bai amsa wannan maganin ba, matsakaicin shawarar shine 10 mg / kg sau biyu a rana (20 mg / kg / day). Abun da aka fara farawa don hadadden ƙwayar cuta na ƙwayar cuta shine 2.5 MG / kg sau biyu a rana (5 mg / kg / day). Ana iya haɓaka wannan a tsaka-tsakin mako idan ya cancanta, har zuwa kusan 12.5 mg / kg sau biyu a rana (25 mg / kg / day). Babu wata shaidar kimiyya mai ƙarfi da ta nuna cewa samfuran cannabidiol da ba a yin rajista ba suna da amfani ga farfadiya.
YARA

DA BAKI:
  • Don farfadiya: An yi amfani da samfurin maganin cannabidiol (Epidiolex). Amfani da shawarar farawa don cutar Lennox-Gastaut da Ciwan Dravet shine 2.5 mg / kg sau biyu a rana (5 mg / kg / day). Bayan mako guda ana iya ƙara nauyin zuwa 5 mg / kg sau biyu a rana (10 mg / kg / day). Idan mutum bai amsa wannan maganin ba, matsakaicin shawarar shine 10 mg / kg sau biyu a rana (20 mg / kg / day). Abubuwan da aka fara farawa don hadadden ƙwayar cuta na ƙwayar cuta shine 2.5 MG / kg sau biyu a rana (5 mg / kg / day). Ana iya haɓaka wannan a tsaka-tsakin mako idan ya cancanta, har zuwa kusan 12.5 mg / kg sau biyu a rana (25 mg / kg / day). Babu wata hujja mai ƙarfi ta kimiyya da ke nuna cewa samfuran cannabidiol ba sa rajista suna da amfani ga farfadiya.
2 - [(1R, 6R) -3-Methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl] -5-pentylbenzene-1,3-diol, CBD.

Don ƙarin koyo game da yadda aka rubuta wannan labarin, da fatan za a duba Magunguna na Compwararren Bayanan Bayanai hanya.


  1. Singh RK, Dillon B, Tatum DA, Van Poppel KC, Bonthius DJ. Magungunan ƙwayoyi-Magunguna tsakanin Cannabidiol da Lithium. Yaron Neurol Buɗe. 2020; 7: 2329048X20947896. Duba m.
  2. Izgelov D, Davidson E, Barasch D, Regev A, Domb AJ, Hoffman A. Binciken kantin magani na maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin. Eur J Pharm Biopharm. 2020; 154: 108-115. Duba m.
  3. Gurley BJ, Murphy TP, Gul W, Walker LA, ElSohly M. Abun ciki game da Da'awar Label a Cannabidiol (CBD) - Samun Samfuran da Aka Samu daga Kasuwancin Kasuwanci a Jihar Mississippi. J Abincin Abincin. 2020; 17: 599-607. Duba m.
  4. McGuire P, Robson P, Cubala WJ, et al. Cannabidiol (CBD) azaman Magungunan Magunguna a cikin Schizophrenia: Gwajin Tsarin Gudanar da Balaguro da yawa. Am J Zuciyar. 2018; 175: 225-231. Duba m.
  5. Cortopassi J. Warfarin gyaran fuska da ake buƙata bayan ƙaddamarwar cannabidiol da ƙaddamarwa. Am J Kiwon Lafiya Syst Pharm. 2020; 77: 1846-1851. Duba m.
  6. Bloomfield MAP, Green SF, Hindocha C, et al. Abubuwan da ke cikin cannabidiol mai haɗari a kan ƙwayar jini da alaƙar sa da ƙwaƙwalwa: Nazarin zane-zane mai laushi wanda ke nuna tasirin maganadisu. J Psychopharmacol. 2020; 34: 981-989. Duba m.
  7. Wang GS, Bourne DWA, Klawitter J, et al. Yin amfani da maganin Cannabidiol-mai wadataccen Cannabis a cikin Yaran da ke fama da farfadiya. Clin Pharmacokinet. 2020. Duba m.
  8. Taylor L, Crockett J, Tayo B, Checketts D, Sommerville K. Kashewar cannabidiol (CBD) ba zato ba tsammani: Gwajin gwaji. Farfadiya Behav. 2020; 104 (Pt A): 106938. Duba m.
  9. McNamara NA, Dang LT, Sturza J, et al. Thrombocytopenia a cikin marasa lafiya na yara akan biyun cannabidiol da valproic acid. Farfadiya. 2020. Duba m.
  10. Rianprakaisang T, Gerona R, Hendrickson RG. Kasuwancin cannabidiol na kasuwanci wanda aka gurɓata tare da roba cannabinoid AB-FUBINACA da aka ba wa mai haƙuri na yara. Clin Toxicol (Phila). 2020; 58: 215-216. Duba m.
  11. Morrison G, Crockett J, Blakey G, Sommerville K. A Phase 1, Buɗe-Label, Gwajin Magungunan Magunguna don Bincike Hanyoyin Haɗarin Magungunan Magunguna tsakanin Clobazam, Stiripentol, ko Valproate da Cannabidiol a cikin Lafiya. Clin Pharmacol Drug Dev. 2019; 8: 1009-1031. Duba m.
  12. Miller I, Scheffer IE, Gunning B, et al. Arfin searfafawa na Maganin Cannabidiol na Magani da Placebo a kan Conarfafa Searfafawa a cikin Ciwon Cutar Dravet: Gwajin Gwajin Rashin Lafiya. JAMA Neurol. 2020; 77: 613-621. Duba m.
  13. Lattanzi S, Trinka E, Striano P, et al. Cannabidiol inganci da halin clobazam: Bincike na yau da kullun da meta-bincike. Farfadiya. 2020; 61: 1090-1098. Duba m.
  14. Hobbs JM, Vazquez AR, Remijan ND, et al. Bincike na ilimin kantin magani da kuma yiwuwar saurin kumburi na shirye-shiryen maganin cannabidiol guda biyu a cikin manya masu lafiya. Phytother Res. 2020; 34: 1696-1703. Duba m.
  15. Ebrahimi-Fakhari D, Agricola KD, Tudor C, Krueger D, Franz DN. Cannabidiol yana Taraukaka Maƙasudin Maƙasudin Maɗaukaki na Matakan Masu hanawa na Rapamycin a cikin Marasa Lafiya tare da rousarfin ƙwayar Sclerosis na Tuberous Neurol na yara. 2020; 105: 59-61. Duba m.
  16. de Carvalho Reis R, Almeida KJ, da Silva Lopes L, de Melo Mendes CM, Bor-Seng-Shu E. Inganci da munanan abubuwan da suka faru na cannabidiol da maganin magani don maganin farfadiya mai jurewa: Nazarin tsari da meta-bincike. Farfadiya Behav. 2020; 102: 106635. Duba m.
  17. Darweesh RS, Khamis TN, El-Elimat T. Sakamakon cannabidiol akan kantin magani na carbamazepine a cikin berayen. Naunyn Schmiedebergs Arch Pharmacol. 2020. Duba m.
  18. Crockett J, Critchley D, Tayo B, Berwaerts J, Morrison G. Wani lokaci na 1, bazuwar, gwajin magani na tasirin tasirin abinci daban-daban, madara mai madara, da barasa akan tasirin cannabidiol da aminci a cikin batutuwa masu lafiya. Farfadiya. 2020; 61: 267-277. Duba m.
  19. Chesney E, Oliver D, Green A, et al. Hanyoyin illa na cannabidiol: nazari na yau da kullun da ƙididdigar gwaji na gwaji na asibiti. Neuropsychopharmacology. 2020. Duba m.
  20. Ben-Menachem E, Gunning B, Arenas Cabrera CM, et al. Wani gwaji na Zamani na Biyu don bincika Damar Yiwuwar Magungunan Magungunan Magungunan Magunguna tare da Stiripentol ko Valproate lokacin da aka Haɗa tare da Cannabidiol a cikin Marasa lafiya da Cutar. Magungunan CNS. 2020; 34: 661-672. Duba m.
  21. Bass J, Linz DR. Shari'ar Guba daga Cannabidiol Gummy Ingestion. Cureus. 2020; 12: e7688. Duba m.
  22. Hampson AJ, Grimaldi M, Axelrod J, Wink D. Cannabidiol da (-) Delta9-tetrahydrocannabinol sune antioxidants masu kare lafiyar jiki. Kamfanin Natl Acad Sci U S A. 1998; 95: 8268-73. Duba m.
  23. Hacke ACM, Lima D, de Costa F, et al. Binciken aikin antioxidant na [delta] -tetrahydrocannabinol da cannabidiol a cikin Cannabis sativa ruwan 'ya'ya. Mai nazari. 2019; 144: 4952-4961. Duba m.
  24. Madden K, Tanco K, Bruera E. Mahimmancin Haɗakar Magungunan Magunguna da Magunguna tsakanin Methadone da Cannabidiol. Ilimin likitan yara. 2020; e20193256. Duba m.
  25. Hazekamp A. Matsalar da mai na CBD. Mad Cannabis Cannabinoids. 2018 Jun; 1: 65-72.
  26. Xu DH, Cullen BD, Tang M, Fang Y. Tasirin Ingancin Cannabidiol na Topical a cikin Taimako na Taimako na patananan Neuropathy na Extananan remananan. Kimiyyar Kimiyyar kere kere ta Curr. 2019 Dec 1. Duba m.
  27. de Faria SM, de Morais Fabrício D, Tumas V, et al. Hanyoyin gaggawa na maganin cannabidiol akan damuwa da girgizar ƙasa ta hanyar gwajin Magana game da Jama'a da aka Kwafsa a cikin marasa lafiya da cutar ta Parkinson. J Psychopharmacol. 2020 Jan 7: 269881119895536. Duba m.
  28. Nitecka-Buchta A, Nowak-Wachol A, Wachol K, et al. Sakamakon Myorelaxant na Aikace-aikacen Transdermal Cannabidiol Aikace-aikacen a cikin Marasa lafiya tare da TMD: Randaddara, Gwajin Makafi Biyu. J Clin Likita. 2019 Nuwamba 6; 8. yawa: E1886. Duba m.
  29. Masataka N. Hanyoyin Rashin Lafiya na Maimaita Cannabidiol Jiyya a Matasa Tare da Rashin Tashin hankali na Jama'a. Gaba Psychol. 2019 Nuwamba 8; 10: 2466. Duba m.
  30. Appiah-Kusi E, Petros N, Wilson R, et al. Hanyoyin maganin cannabidiol na gajeren lokaci akan martani ga damuwar zamantakewar al'umma a cikin batutuwan da ke tattare da babban haɗarin haɓaka psychosis. Ilimin halin dan adam (Berl). 2020 Jan 8. Duba m.
  31. Hussain SA, Dlugos DJ, Cilio MR, Parikh N, Oh A, Sankar R. Magungunan maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin zafin jiki: Tsarin nazarin 2-mai yawa. Farfadiya Behav. 2020 Jan; 102: 106826. Duba m.
  32. Klotz KA, Grob D, Hirsch M, Metternich B, Schulze-Bonhage A, Jacobs J. Inganci da Haƙuri na Cannabidiol na Roba don Kula da Magungunan Magungunan Magunguna. Neurol na gaba. 2019 Dec 10; 10: 1313. Duba m.
  33. "GW Pharmaceuticals plc da kuma reshenta na Amurka Greenwich Biosciences, Inc. Sun Sanar da Cewa An Kashe Magani na EPIDIOLEX® (cannabidiol) Kuma Ba Ya Iya Zama Wani Abin Sarrafawa." GW Pharmaceuticals, 6 Afrilu 2020. http://ir.gwpharm.com/node/11356/pdf. Sanarwar sanarwa.
  34. Wiemer-Kruel A, Stiller B, Bast T. Cannabidiol yayi hulɗa mai mahimmanci tare da Everolimus-Rahoton mai haƙuri tare da kwayar cuta ta Tuberous Sclerosis. Neuropediatrics. 2019. Duba m.
  35. Sabunta masu Amfani na FDA: Abin da Ya Kamata Ku sani Game da Amfani da Cannabis, Ciki har da CBD, Lokacin da ke da ciki ko Shayarwa. U. Gudanar da Abinci da Magunguna (FDA). Oktoba 2019. Akwai a: https://www.fda.gov/consumers/consumer-updates/what-you-should-know-about-using-cannabis-including-cbd-when-pregnant-or-breastfeeding.
  36. Taylor L, Crockett J, Tayo B, Morrison G. A Phase 1, Buɗe-Label, Paraungiya mai daidaituwa, Gwajin Singleaya daga cikin Magungunan Pharmacokinetics da Tsaro na Cannabidiol (CBD) a cikin Batutuwa Masu Sauƙin Zuwa Cutar Hanta. J Clin Pharmacol. 2019; 59: 1110-1119. Duba m.
  37. Szaflarski JP, Hernando K, Bebin EM, et al. Matakan plasma mafi girma na Cannabidiol suna haɗuwa da mafi kyawun amsar kamawa bayan magani tare da maganin magunguna na cannabidiol. Farfadiya Behav. 2019; 95: 131-136. Duba m.
  38. Pretzsch CM, Voinescu B, Mendez MA, et al. Tasirin cannabidiol (CBD) akan aiki mai saurin-aiki da haɗin aiki a cikin kwakwalwar manya tare da ba tare da rikicewar ɓarna ba (ASD). J Psychopharmacol. 2019: 269881119858306. Duba m.
  39. Pretzsch CM, Freyberg J, Voinescu B, da al. Hanyoyin cannabidiol a kan motsawar kwakwalwa da tsarin hanawa; gwajin gwagwarmaya guda-wuri mai rikitarwa yayin yaduwar maganadisu a cikin manya tare da kuma ba tare da rikicewar yanayin autism ba. Neuropsychopharmacology. 2019; 44: 1398-1405. Duba m.
  40. Patrician A, Versic-Bratincevic M, Mijacika T, et al. Binciken Sabuwar Hanyar Isarwa don Maganin Cannabidiol na Lafiya a cikin Lafiyayyun Batutuwa: Nazarin Bazuwar ido, Makafi biyu, Nazarin Pharmacokinetics na Wuri. Adv Ther. 2019. Duba m.
  41. Martin RC, Gaston TE, Thompson M, et al. Yin aiki da hankali bayan amfani da cannabidiol na dogon lokaci a cikin manya tare da farfadiya mai juriya. Farfadiya Behav. 2019; 97: 105-110. Duba m.
  42. Leino AD, Emoto C, Fukuda T, Privitera M, Vinks AA, Alloway RR. Shaida game da cudanya tsakanin magungunan miyagun ƙwayoyi da magunguna tsakanin cannabidiol da tacrolimus. Am J dashi. 2019; 19: 2944-2948. Duba m.
  43. Laux LC, Bebin EM, Checketts D, et al. Tsaro na dogon lokaci da inganci na cannabidiol a cikin yara da manya tare da maganin cutar Lennox-Gastaut ko cututtukan Dravet: Fadada sakamakon shirin samun dama. Farfadiya Res. 2019; 154: 13-20. Duba m.
  44. Knaub K, Sartorius T, Dharsono T, Wacker R, Wilhelm M, Schön C. Tsarin Labaran Isar da Magunguna na Kai-tsaye (SEDDS) Dangane da Fasahar Kirkirar VESIsorb Inganta Ingantaccen Bakin Bayar da Cannabidiol a cikin Lafiya. Kwayoyin halitta 2019; 24. pii: E2967. Duba m.
  45. Klotz KA, Hirsch M, Heers M, Schulze-Bonhage A, Jacobs J. Hanyoyin cannabidiol akan matakan plasma brivaracetam. Farfadiya. 2019; 60: e74-e77. Duba m.
  46. Heussler H, Cohen J, Silove N, et al. Yanayin 1/2, ƙididdigar lakabi na aminci, haƙuri, da ingancin transdermal cannabidiol (ZYN002) don maganin cututtukan yara masu rauni na X. J Neurodev Rashin Lafiya. 2019; 11: 16. Duba m.
  47. Couch DG, Cook H, Ortori C, Barrett D, Lund JN, OSullivan SE. Palmitoylethanolamide da Cannabidiol na hana Kumburi-haifar da Hyperpermeability na Gan Adam a cikin Vitro da In Vivo-A Randomized, placebo-sarrafawa, Double-makafi sarrafa gwaji. Lamunƙarar Cikin Cikin Dis. 2019; 25: 1006-1018. Duba m.
  48. Birnbaum AK, Karanam A, Marino SE, et al. Tasirin abinci akan kantin magunguna na cannabidiol capsules na baka a cikin marasa lafiyar manya tare da raunin farfadiya. Farfadiya. 2019 Aug; 60: 1586-1592. Duba m.
  49. Arkell TR, Lintzeris N, Kevin RC, et al. Cannabidiol (CBD) abun ciki a cikin ƙwayar ƙwayar iska ba zai hana tetrahydrocannabinol (THC) rashin nakasa na tuki da cognition. Ilimin halin dan adam (Berl). 2019; 236: 2713-2724. Duba m.
  50. Anderson LL, Absalom NL, Abelev SV, et al. Canidion sarrafa cannabidiol da clobazam: Shaida ta farko game da hulɗar magunguna da haɓakawa ta hanyar magani. Farfadiya. 2019. Duba m.
  51. Bayanin samfurin don Marinol. AbbVie. Arewacin Chicago, IL 60064. Agusta 2017. Ana samunsa a: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/018651s029lbl.pdf.
  52. Epidiolex (cannabidiol) mai tsara bayanai. Greenwich Biosciences, Inc., Carlsbad, CA, 2019. Akwai a: https://www.epidiolex.com/sites/default/files/EPIDIOLEX_Full_Prescribing_Information.pdf (an isa ga 5/9/2019)
  53. Sanarwa daga Kwamishinan FDA Scot Gottlieb, MD, kan sanya hannu kan Dokar Inganta Aikin Noma da kuma tsarin hukumar na kayayyakin da ke dauke da sinadarin wiwi da na tabar wiwi. Gidan yanar gizon Gidan Abinci da Magunguna na Amurka. Akwai a: https://www.fda.gov/news-events/press-announcements/statement-fda-commissioner-scott-gottlieb-md-signing-agriculture-improvement-act-and-agencys. (An shiga Mayu 7, 2019).
  54. Dokar Inganta Aikin Noma, S. 10113, 115th Cong. ko S. 12619, 115th Cong. .
  55. Gudanar da Dokar hana Safarar Miyagun Kwayoyi, Ma'aikatar Shari'a. Jadawalin abubuwan da aka sarrafa: Sanya a cikin Jadawalin V na Wasu Magungunan Ingantaccen FDA da ke dauke da Cannabidiol; Canji mai dacewa da Bukatun Izini. Tsarin karshe. Fed Regist. 2018 Satumba 28; 83: 48950-3. Duba m.
  56. Schoedel KA, Szeto I, Setnik B, et al. Amfani da ƙimar cin zarafin cannabidiol (CBD) a cikin masu amfani da polydrug na nishaɗi: Bazuwar, makafi biyu, gwajin gwaji. Farfadiya Behav. 2018 Nuwamba; 88: 162-171. Doi: 10.1016 / j.yebeh.2018.07.027. Epub 2018 Oct 2. Duba m.
  57. Devinsky O, Verducci C, Thiele EA, et al. Amfani da buɗaɗɗen lakabi na CBD mai tsarkakakke (Epidiolex®) a cikin marasa lafiya tare da rashi ƙarancin CDKL5 da Aicardi, Dup15q, da Doose syndromes. Farfadiya Behav. 2018 Satumba; 86: 131-137. Epub 2018 Jul 11. Duba m.
  58. Szaflarski JP, Bebin EM, Cutter G, DeWolfe J, et al.Cannabidiol yana inganta mita da kuma tsananin kamuwa da cutar kuma yana rage abubuwa masu haɗari a cikin alamar buɗe-mai-ɗari akan binciken mai yiwuwa. Farfadiya Behav. 2018 Oktoba; 87: 131-136. Epub 2018 Aug 9. Duba m.
  59. Linares IM, Zuardi AW, Pereira LC, et al. Cannabidiol yana gabatar da madaidaiciyar ƙirar amsa-kashi a cikin gwajin magana ta jama'a. Braz J Zuciyar. 2019 Janairu-Feb; 41: 9-14. Epub 2018 Oct 11. Duba m.
  60. Poklis JL, Mulder HA, Aminci MR. Binciken da ba zato ba tsammani na cannabimimetic, 5F-ADB, da dextromethorphan a cikin kasuwancin cannabidiol e-ruwa. Binciken Sci Int. 2019 Janairu; 294: e25-e27. Epub 2018 Nov 1. Duba m.
  61. Hurd YL, Spriggs S, Alishayev J, et al. Cannabidiol don Rage Cutar da ke Cutar da Tashin hankali a cikin -wararrun Drugwararrun Withwararrun Mutane Tare da Rashin Lafiya ta Heroin: Gwajin Makafi Mai Rarraba Mai Sau Biyu. Am J Zuciyar. 2019: appiajp201918101191. Duba m.
  62. Thiele EA, Marsh ED, Faransanci JA, et al. Cannabidiol a cikin marasa lafiya tare da haɗuwa da ke haɗuwa da cutar Lennox-Gastaut (GWPCARE4): bazuwar, makafi biyu, gwajin gwajin wuribo na 3. Lancet. 2018 Mar 17; 391: 1085-1096. Duba m.
  63. Devinsky O, Patel AD, Giciye JH, et al. Hanyoyin Cannabidiol akan Rashin Kwacewa a cikin Cutar Lennox-Gastaut. N Engl J Med. 2018 Mayu 17; 378: 1888-1897. Duba m.
  64. Pavlovic R, Nenna G, Calvi L, da sauransu. Halayen Inganci na "Mai na Cannabidiol": Cannabinoids Abun ciki, Tsarin yatsa na Terpene da abilityarfafawar Oxidation na Shirye-shiryen Samfuran Kasuwancin Turai. Kwayoyin halitta 2018 Mayu 20; 23. pii: E1230. Duba m.
  65. Jannasch F, Kröger J, Schulze MB. Ka'idodin Abincin Abinci da Rubuta Ciwon sukari na 2: Binciken Nazarin Adabi da Meta-Analysis na Nazarin Nazari. J Nutr. 2017 Jun; 147: 1174-1182. Duba m.
  66. Naftali T, Mechulam R, Marii A, et al. Cannabananan cannabidiol yana da lafiya amma ba shi da tasiri a cikin maganin Cututtukan Crohn, gwajin gwajin bazuwar. Dig Dis Sci. 2017 Jun; 62: 1615-20. Duba m.
  67. Kaplan EH, Offermann EA, Sievers JW, Comi AM. Cannabidiol magani don kamuwa da cututtuka a cikin Sturge-Weber Syndrome. Neurol na yara. 2017 Jun; 71: 18-23.e2. Duba m.
  68. Yeshurun ​​M, Shpilberg O, Herscovici C, et al. Cannabidiol don rigakafin cututtukan ƙwayoyin cuta bayan an dasa kwayar halitta ta hematopoietic: sakamakon binciken lokaci na II. Biol Marrow Dasawa. 2015 Oktoba; 21: 1770-5. Duba m.
  69. Geffrey AL, Pollack SF, Bruno PL, Thiele EA. Cutar hulɗa da ƙwayoyi tsakanin clobazam da cannabidiol a cikin yara masu fama da farfadiya. Farfadiya. 2015 Agusta; 56: 1246-51. Duba m.
  70. Devinsky O, Marsh E, Friedman D, et la. Cannabidiol a cikin marasa lafiya tare da farfadiya mai juriya: gwajin buɗewa mai lakabi. Lancet Neurol. 2016 Mar; 15: 270-8. Duba m.
  71. 97021 Jadoon KA, Ratcliffe SH, Barrett DA, et al. Inganci da amincin cannabidiol da tetrahydrocannabivarin akan sifofin glycemic da lipid a cikin marasa lafiya da ke dauke da ciwon sukari na 2: bazuwar, makafi biyu, sarrafa wuribo, nazarin matukin jirgi kwatankwacinsu. Ciwon suga. 2016 Oktoba; 39: 1777-86. Duba m.
  72. Gofshteyn JS, Wilfong A, Devinsky O, et al. Cannabidiol a matsayin magani mai mahimmanci don cututtukan cututtukan cututtukan cututtukan ƙwayar cuta (FIRES) a cikin mawuyacin hali da na yau da kullun. J Yara Neurol. 2017 Janairu; 32: 35-40. Duba m.
  73. Hess EJ, Moody KA, Geffrey AL, et al. Cannabidiol a matsayin sabon magani don farfadiya mai jure wa ƙwayoyi a cikin ƙwayar ƙwayar ƙwayar cuta ta tuberous. Farfadiya. 2016 Oktoba; 57: 1617-24. Duba m.
  74. Gaston TE, Bebin EM, Cutter GR, Liu Y, Szaflarski JP; UAB CBD Shirin. Hanyoyin hulɗa tsakanin cannabidiol da magungunan antiepileptic da aka saba amfani dasu. Farfadiya. 2017 Satumba; 58: 1586-92. Duba m.
  75. Devinsky O, Cross JH, Laux L, et al. Gwajin cannabidiol don kamuwa da cututtukan ƙwayoyi a cikin cututtukan Dravet. N Engl J Med. 2017 Mayu 25; 376: 2011-2020. Duba m.
  76. Bonn-Miller MO, Loflin MJE, Thomas BF, Marcu JP, Hyke T, Vandrey R. Rubuta daidaito na ɗakunan cannabidiol da aka sayar akan layi. JAMA 2017 Nuwamba; 318: 1708-9. Duba m.
  77. Malfait AM, Gallily R, Sumariwalla PF, et al. Cannabisungiyar cannabidiol mai ba da halayyar kwakwalwa ba ta maganin cututtukan cututtukan zuciya ne a cikin cututtukan cututtukan ƙwayoyin cuta. Kamfanin Natl Acad Sci Amurka 2000; 97: 9561-6. Duba m.
  78. Formukong EA, Evans AT, Evans FJ. Analgesic da anti-inflammatory aiki na abubuwan da ke cikin Cannabis sativa L. Kumburi 1988; 12: 361-71. Duba m.
  79. Valvassori SS, Elias G, de Souza B, et al. Hanyoyin cannabidiol akan amphetamine wanda ya haifar da yanayin damuwa a cikin dabba na mania. J Psychopharmacol 2011; 25: 274-80. Duba m.
  80. Esposito G, Scuderi C, Savani C, et al. Cannabidiol a cikin vivo blunts beta-amyloid haifar da neuroinflammation ta hanyar hana IL-1beta da iNOS magana. Br J Pharmacol 2007; 151: 1272-9. Duba m.
  81. Esposito G, De Filippis D, Maiuri MC, et al. Cannabidiol yana hana haɓakar haɓakar nitric oxide synthase furotin da haɓakar nitric a cikin beta-amyloid ya haɓaka ƙwayoyin PC12 ta hanyar p38 MAP kinase da NF-kappaB hannu. Neurosci Lett 2006; 399 (1-2): 91-5. Duba m.
  82. Iuvone T, Esposito G, De Filippis D, et al. Cannabidiol: sabon magani ne mai ba da gudummawa don cututtukan neurodegenerative? CNS Neurosci Ther 2009; 15: 65-75. Duba m.
  83. Bisogno T, Di Marzo Y. Matsayin tsarin endocannabinoid a cikin cutar Alzheimer: gaskiya da zato. Curr Pharm Des 2008; 14: 2299-3305. Duba m.
  84. Zuardi AW. Cannabidiol: daga cannabinoid mai aiki zuwa magani tare da nau'ikan aiki. Rev Bras Psiquiatr 2008; 30: 271-80. Duba m.
  85. Izzo AA, Borelli F, Capasso R, et al. Rashin tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire-tsire. Yanayin Pharmacol Sci 2009; 30: 515-27. Duba m.
  86. Booz GW. Cannabidiol azaman ingantacciyar hanyar dabarun warkewa don rage tasirin kumburi akan damuwa mai kumburi. Free Radic Biol Med 2011; 51: 1054-61. Duba m.
  87. Pickens JT. Ayyukan kwantar da hankali na cannabis dangane da delta’-trans-tetrahydrocannabinol da abun ciki na cannabidiol. Br J Pharmacol 1981; 72: 649-56. Duba m.
  88. Monti JM. Hanyoyin cututtuka irin na cannabidiol a cikin bera. Psychopharmacology (Berl) 1977; 55: 263-5. Duba m.
  89. Karler R, Turkanis SA. Subacute cannabinoid jiyya: aiki mai rikitarwa da janyewar ficewa a cikin beraye. Br J Pharmacol 1980; 68: 479-84. Duba m.
  90. Karler R, Cely W, Turkanis SA. Ayyukan anticonvulsant na cannabidiol da cannabinol. Rayuwa Sci 1973; 13: 1527-31. Duba m.
  91. Consroe PF, Wokin AL. Haɗakar Anticonvulsant na cannabidiol da ethosuximide a cikin berayen. J Pharm Pharmacol 1977; 29: 500-1. Duba m.
  92. Consroe P, Wolkin A. Cannabidiol-antiepilpetic miyagun ƙwayoyi kwatancen da hulɗa a cikin gwajin haifar da kama a cikin berayen. J Pharmacol Exp Ther 1977; 201: 26-32. Duba m.
  93. Carlini EA, Leite JR, Tannhauser M, Berardi AC. Harafi: Cannabidiol da Cannabis sativa cire kare beraye da beraye daga jami'ai masu girgizawa. J Pharm Pharmacol 1973; 25: 664-5. Duba m.
  94. Cryan JF, Markou A, Lucki I. Tantance aikin kawar da damuwa a cikin jijiyoyi: abubuwan da suka faru kwanan nan da bukatun gaba. Yanayin Pharmacol Sci 2002; 23: 238-45. Duba m.
  95. El-Alfy AT, Ivey K, Robinson K, da al. Maganin antidepressant-kamar sakamako na delta9-tetrahydrocannabinol da sauran cannabinoids ware daga Cannabis sativa L. Pharmacol Biochem Behav 2010; 95: 434-42. Duba m.
  96. Resstel LB, Tavares RF, Lisboa SF, et al. 5-HT1A masu karɓa suna da hannu a cikin haɓakar haɓaka ta cannabidiol na halayyar mutum da martani na zuciya da jijiyoyin jiki don damuwa mai tsanani a cikin berayen. Br J Pharmacol 2009; 156: 181-8. Duba m.
  97. Granjeiro EM, Gomes FV, ​​Guimaraes FS, et al. Hanyoyin gudanarwar intracisternal na cannabidiol a kan jijiyoyin jijiyoyin jiki da halayyar halayya ga matsanancin ƙuntatawa. Pharmacol Biochem Behav 2011; 99: 743-8. Duba m.
  98. Murillo-Rodriguez E, Millan-Aldaco D, Palomero-Rivero M, et al. Cannabidiol, wani ɓangaren Cannabis sativa, yana daidaita bacci a cikin beraye. FEBS Labarin 2006; 580: 4337-45. Duba m.
  99. De Filippis D, Esposito G, Cirillo C, et al. Cannabidiol yana rage kumburin hanji ta hanyar sarrafa axis neuroimmune. Koma Daya 2011; 6: e28159. Duba m.
  100. Bhattacharyya S, Fusar-Poli P, Borgwardt S, et al. Delta9-tetrahydrocannabinol: canjin canjin yanayi da aiki na iska a cikin mutane: tushen jijiyoyi game da tasirin Cannabis sativa akan ilmantarwa da psychosis. Arch Gen Magunguna 2009; 66: 442-51. Duba m.
  101. Dalton WS, Martz R, Lemberger L, et al. Tasirin cannabidiol akan tasirin Delta-9-tetrahydrocannabinol. Clin Pharmacol Ther 1976; 19: 300-9. Duba m.
  102. Guimaraes VM, Zuardi AW, Del Bel EA, Guimaraes FS. Cannabidiol yana haɓaka Fos magana a cikin ƙananan ƙwayoyin cuta amma ba a cikin dorsal striatum ba. Rayuwa Sci 2004; 75: 633-8. Duba m.
  103. Moreira FA, Guimaraes FS. Cannabidiol yana hana haɓakar hyperlocomotion da ƙwayoyin psychomimetic ke haifarwa a cikin yara. Eur J Pharmacol 2005; 512 (2-3): 199-205. Duba m.
  104. Long LE, Chesworth R, Huang XF, et al. Misali na kwatankwacin Delta9-tetrahydrocannabinol mai ɗaci da ciwuka a cikin ƙananan yara C57BL / 6JArc. Int J Neuropsychopharmacol 2010; 13: 861-76. Duba m.
  105. Zuardi AW, Rodriguez JA, Cunha JM. Hanyoyin cannabidiol a cikin dabbobin dabarun tsinkayen aikin antipsychotic. Psychopharmacology (Berl) 1991; 104: 260-4. Duba m.
  106. Malone DT, Jongejan D, Taylor DA. Cannabidiol ya sauya raguwar hulɗar zamantakewar da aka samar ta hanyar ƙananan ƙwayoyin Delta-tetrahydrocannabinol a cikin berayen. Pharmacol Biochem Behav 2009; 93: 91-6. Duba m.
  107. Schubart CD, Sommer IE, Fusar-Poli P, et al. Cannabidiol a matsayin magani mai mahimmanci don psychosis. Eur Neuropsychopharmacol 2014; 24: 51-64. Duba m.
  108. Campos AC, Moreira FA, Gomes FV, ​​et al. Hanyoyi da yawa da ke tattare da tasirin maganin wariyar launin magani na cannabidiol a cikin rikicewar hauka. Philos Trans R Soc Lond B Biol Sci 2012; 367: 3364-78. Duba m.
  109. Fusar-Poli P, Allen P, Bhattacharyya S, et al. Canjin yanayin haɗi mai tasiri yayin aiki na motsa rai ta hanyar Delta 9-tetrahydrocannabinol da cannabidiol. Int J Neuropsychopharmacol 2010; 13: 421-32. Duba m.
  110. Casarotto PC, Gomes FV, ​​Resstel LB, Guimaraes FS. Cannabidiol sakamako mai hanawa akan halayyar marmara: sa hannun masu karɓar CB1. Behav Pharmacol 2010; 21: 353-8. Duba m.
  111. Uribe-Marino A, Francisco A, Castiblanco-Urbina MA, et al. Hanyoyin da ke haifar da rikice-rikice na cannabidiol akan dabi'un da ke haifar da tsoro wanda aka haifar da shi ta hanyar tsarin dabi'a na hare-haren firgita wanda ya danganci ganima da macijin daji Epicrates cenchria crassus confrontation paradigm. Neuropsychopharmacology 2012; 37: 412-21. Duba m.
  112. Campos AC, Guimaraes FS. Ofaddamar da masu karɓar 5HT1A suna ƙaddamar da tasirin tashin hankali na cannabidiol a cikin samfurin PTSD. Behav Pharmacol 2009; 20: S54.
  113. Resstel LB, Joca SR, Moreira FA, et al. Hanyoyin cannabidiol da diazepam akan halayen hali da na jijiyoyin zuciya wanda ya haifar da yanayin yanayin yanayin beraye. Behav Brain Res 2006; 172: 294-8. Duba m.
  114. Moreira FA, Aguiar DC, Guimaraes FS. Xarancin-kamar sakamako na cannabidiol a cikin bera Vogel rikici rikici. Prog Neuropsychopharmacol Biol Neman 2006; 30: 1466-71. Duba m.
  115. Onaivi ES, Green MR, Martin BR. Halin ilimin likitanci na cannabinoids a cikin haɓaka da maze. J Pharmacol Exp Ther 1990; 253: 1002-9. Duba m.
  116. Guimaraes FS, Chairetti TM, Graeff FG, Zuardi AW. Rashin tashin hankali na tasirin cannabidiol a cikin haɓaka da-maze. Psychopharmacology (Berl) 1990; 100: 558-9. Duba m.
  117. Magen I, Avraham Y, Ackerman Z, et al. Cannabidiol yana haɓaka ƙwarewa da raunin motsa jiki a cikin ƙananan yara tare da layin bile bututun ƙarfe. J Hepatol 2009; 51: 528-34. Duba m.
  118. Rajesh M, Mukhopadhyay P, Batkai S, et al. Cannabidiol yana haɓaka lalacewar zuciya, damuwa na oxyidative, fibrosis, da hanyoyin kumburi da ƙwayoyin cuta masu mutuwa a cikin cututtukan zuciya na ciwon sukari. J Am Coll Cardiol 2010; 56: 2115-25. Duba m.
  119. El-Remessy AB, Khalifa Y, Ola S, et al. Cannabidiol yana kare ƙananan ƙwayoyin ido ta hanyar adana aikin kwayar cutar cikin ciwon sukari. Mol Vis 2010; 16: 1487-95. Duba m.
  120. El-Remessy AB, Al-Shabrawey M, Khalifa Y, et al. Neuroprotective da jini-retinal shinge-adana tasirin cannabidiol a cikin ciwon sukari gwaji. Am J Pathol 2006; 168: 235-44. Duba m.
  121. Rajesh M, Mukhopadhyay P, Batkai S, et al. Cannabidiol yana haɓaka babban glucose-yana haifar da amsa mai kumburi na endothelial da rikicewar shinge. Am J Physiol Zuciya Circ Physiol 2007; 293: H610-H619. Duba m.
  122. Toth CC, Jedrzejewski NM, Ellis CL, Frey WH. Cannabinoid-matsakaiciyar yanayin yanayin ciwon neuropathic da tarin microglial a cikin samfurin nau'in murfin ciwon sukari na 1 mai ciwon sukari. Mol Pain. 2010; 6: 16. Duba m.
  123. Aviello G, Romano B, Borrelli F, et al. Hanyoyin da ke tattare da cututtukan cututtukan zuciya ba tare da psychotropic phytocannabinoid cannabidiol akan cutar kansa ba. J Mol Med (Berl) 2012; 90: 925-34. Duba m.
  124. Lee CY, Wey SP, Liao MH, et al. Nazarin kwatancen kan apoptosis na cannabidiol wanda ke haifar da murfin thymocytes da EL-4 thymoma cells. Int Immunopharmacol 2008; 8: 732-40. Duba m.
  125. Massi P, Valenti M, Vaccani A, et al. 5-Lipoxygenase da anandamide hydrolase (FAAH) suna yin sulhu akan ayyukan antitumor na cannabidiol, mai ba da psychoactive cannabinoid. J Neurochem 2008; 104: 1091-100. Duba m.
  126. Valenti M, Massi P, Bolognini D, et al. Cannabidiol, wani hadadden maganin Cannabinoid mara hauka yana hana hijirar kwayar halittar mutum da kuma mamayewa. 34th National Congress na Societyungiyar Italiyanci na Ilimin Magunguna 2009.
  127. Torres S, Lorente M, Rodriguez-Fornes F, et al. Haɗin haɗin kai tsaye na cannabinoids da temozolomide akan glioma. Ciwon Magunguna Ther 2011; 10: 90-103. Duba m.
  128. Yakubusson SO, Rongard E, Stridh M, et al. Sakamakon ƙwayoyin cuta na tamoxifen da cannabinoids akan C6 glioma cell viability. Biochem Pharmacol 2000; 60: 1807-13. Duba m.
  129. Shrivastava A, Kuzontkoski PM, Groopman JE, Prasad A. Cannabidiol yana haifar da mutuwar kwayar halitta a cikin ƙwayoyin kansar nono ta hanyar daidaita magana tsakanin apoptosis da autophagy. Ciwon Magunguna Ther 2011; 10: 1161-72. Duba m.
  130. McAllister SD, Murase R, Kirista RT, et al. Hanyoyi masu sasanta tasirin cannabidiol akan rage yaduwar kwayar sankarar mama, mamayewa, da kuma yaduwar cutar. Ciwon nono ya bi da 2011; 129: 37-47. Duba m.
  131. McAllister SD, Kirista RT, Horowitz MP, et al. Cannabidiol a matsayin mawallafin mai hana fassarar Id-1 a cikin kwayoyin cutar kansar mama. Ciwon Magunguna Ther 2007; 6: 2921-7. Duba m.
  132. Ligresti A, Moriello AS, Starowicz K, et al. Ayyukan antitumor na tsire-tsire cannabinoids tare da girmamawa akan tasirin cannabidiol akan ƙwayar nono ɗan adam. J Pharmacol Exp Ther 2006; 318: 1375-87. Duba m.
  133. Massi P, Solinas M, Cinquina V, Parolaro D. Cannabidiol a matsayin mai yiwuwar maganin cutar kansa. Br J Clin Pharmacol 2013; 75: 303-12. Duba m.
  134. Schubart CD, Sommer IE, van Gastel WA, et al. Cannabis tare da babban abun ciki na cannabidiol yana da alaƙa da ƙananan ƙwarewar hauka. Schizophr Res 2011; 130 (1-3): 216-21. Duba m.
  135. Englund A, Morrison PD, Nottage J, et al. Cannabidiol yana hana THC-wanda ke haifar da alamun rashin lafiya da nakasar ƙwaƙwalwar ajiya mai dogaro da hippocampal. J Jarin Jumma'a 2013; 27: 19-27. Duba m.
  136. Devinsky O, Cilio MR, Cross H, et al. Cannabidiol: ilimin kimiyyar magani da kuma tasirin maganin warkewa a cikin farfadiya da sauran cututtukan neuropsychiatric. Cutar 2014; 55: 791-802. Duba m.
  137. Serpell MG, Notcutt W, Collin C. Sativex amfani da dogon lokaci: gwajin buɗe lakabi a cikin marasa lafiya tare da spasticity saboda yawan sclerosis. J Neurol 2013; 260: 285-95. Duba m.
  138. Notcutt W, Langford R, Davies P, et al. Tsarin sarrafa wuribo, rukuni na layi daya, bazuwar nazarin batutuwa tare da alamomi na spasticity saboda yawan sclerosis waɗanda ke karɓar Sativex na dogon lokaci (nabiximols). Mawallafin Mult 2012; 18: 219-28. Duba m.
  139. Brady CM, DasGupta R, Dalton C, et al. Nazarin lakabin buɗaɗɗen ɗakunan abubuwan da aka samo asali na cannabis don dysfuntion mafitsara a cikin ci gaban ƙwayar cuta mai yawa. Mult Scler 2004; 10: 425-33. Duba m.
  140. Kavia RB, De Ridder D, Constantinescu CS, et al. Gwajin sarrafawa na bazata na Sativex don magance ƙarancin haɓaka a cikin ƙwayar cuta mai yawa. Mult Scler 2010; 16: 1349-59. Duba m.
  141. Wade DT, Makela PM, Gidan H, et al. Amfani na dogon lokaci na maganin cannabis a cikin spasticity da sauran alamun cututtuka a cikin cutar sclerosis da yawa. Mult Scler 2006; 12: 639-45. Duba m.
  142. Novotna A, Mares J, Ratcliffe S, et al. Wani bazuwar, makafi biyu, mai sarrafa wuribo, rukuni-rukuni, nazarin zane-zane na nabiximols * (Sativex), azaman ƙarin ƙari, a cikin batutuwan da ke da ƙyamar splastity da ke haifar da ƙwayar cuta mai yawa. Eur J Neurol 2011; 18: 1122-31. Duba m.
  143. Bayani. Gidan yanar gizon GW Pharmaceuticals. Akwai a: http://www.gwpharm.com/about-us-overview.aspx. An shiga: Mayu 31, 2015.
  144. Cannabidiol Yanzu Yana Nunawa Cikin Ciyarwar Abinci. Shafin Yanar Gizo na Magunguna. https://naturalmedicines.therapeuticresearch.com/news/news-items/2015/march/cannabidiol-now-showing-up-in-dietary-supplement.aspx. (An shiga Mayu 31, 2015).
  145. Zuardi AW, Cosme RA, Graeff FG, Guimaraes FS. Hanyoyin ipsapirone da cannabidiol akan damuwar gwajin ɗan adam. J Psychopharmacol 1993; 7 (1 Gudanarwa): 82-8. Duba m.
  146. Matsakaicin EG, Fentiman AF Jr, Foltz RL. Abubuwan da aka yi amfani da su na tsawon lokaci na delta9- da delta8-tetrahydrocannabinols da aka gano a matsayin masu haɗin mai ƙanshi mai ƙanshi. Res Commun Chem Pathol Pharmacol 1976; 14: 13-28. Duba m.
  147. Samara E, Bialer M, Mechoulam R. Pharmacokinetics na cannabidiol a cikin karnuka. Magungunan Magungunan Magunguna 1988; 16: 469-72. Duba m.
  148. Consroe P, Sandyk R, Snider SR. Bude lakabin kimantawa na cannabidiol a cikin rikicewar motsi na dystonic. Int J Neurosci 1986; 30: 277-82. Duba m.
  149. Crippa JA, Derenusson GN, Ferrari TB, et al. Tushen yanayin tasirin tasirin cannabidiol (CBD) a cikin rikicewar rikicewar zamantakewar jama'a: rahoto na farko. J Psychopharmacol 2011; 25: 121-30. Duba m.
  150. Bornheim LM, Everhart ET, Li J, Correia MA. Halin yanayin aikin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin jininka. Biochem Pharmacol 1993; 45: 1323-31. Duba m.
  151. Harvey DJ. Samun ciki, rarrabawa, da canjin halitta na cannabinoids. Marijuana da Magani. 1999; 91-103.
  152. Yamaori S, Ebisawa J, Okushima Y, et al. Inhibarfin hana haɓakar ɗan adam P450 3A isoforms ta hanyar cannabidiol: rawar ƙungiyoyin hydroxyl phenolic a cikin resorcinol moiety. Rayuwa Sci 2011; 88 (15-16): 730-6. Duba m.
  153. Yamaori S, Okamoto Y, Yamamoto I, Watanabe K. Cannabidiol, babban phytocannabinoid, a matsayin mai hanawa mara ƙarfi ga CYP2D6. Magungunan Magungunan Magunguna 2011; 39: 2049-56. Duba m.
  154. Yamaori S, Maeda C, Yamamoto I, Watanabe K. Bambancin hana mutum cytochrome P450 2A6 da 2B6 ta manyan phytocannabinoids. Ciwon Lafiya mai guba 2011; 29: 117-24.
  155. Yamaori S, Kushihara M, Yamamoto I, Watanabe K. Halin fasalin manyan phytocannabinoids, cannabidiol da cannabinol, a matsayin masu hana keɓaɓɓen zaɓi na ƙarancin CYP1 enzymes. Biochem Pharmacol 2010; 79: 1691-8. Duba m.
  156. Zuardi AW, Crippa JA, Hallak JE, et al. Cannabidiol don maganin psychosis a cikin cututtukan Parkinson. J Psychopharmacol 2009; 23: 979-83. Duba m.
  157. Morgan CJ, Das RK, Joye A, et al. Cannabidiol yana rage yawan shan sigari a cikin masu shan sigari: binciken farko. Rikicin Behav 2013; 38: 2433-6. Duba m.
  158. Pertwee RG. Bambancin CB1 da CB2 na ilimin kimiyyar magani na tsire-tsire guda uku cannabinoids: delta9-tetrahydrocannabinol, cannabidiol da delat9-tetrahydrocannabivarin. Br J Pharmacol 2008; 153: 199-215. Duba m.
  159. Leweke FM, Kranaster L, Pahlisch F, et al. Amfani da cannabidiol a cikin maganin schizophrenia - hanyar fassara. Schizophr Bull 2011; 37 (Gudanar da 1): 313.
  160. Leweke FM, Piomelli D, Pahlisch F, et al. Cannabidiol yana haɓaka siginar anandamide kuma yana sauƙaƙa alamun cututtukan ƙwaƙwalwa na schizophrenia. Transl Neman 2012; 2: e94. Duba m.
  161. Carroll CB, Bain PG, Hawaye L, et al. Cannabis don dyskinesia a cikin cututtukan Parkinson: nazarin bazuwar makafi biyu. Neurology 2004; 63: 1245-50. Duba m.
  162. Bergamaschi MM, Queiroz RH, Chagas MH, et al. Cannabidiol yana rage tashin hankali wanda aka haifar da shi ta hanyar magana a bainar jama'a a cikin marasa lafiya-marasa tsoron phobia. Neuropsychopharmacology 2011; 36: 1219-26. Duba m.
  163. Zuardi AW, Crippa JA, Hallak JE, et al. Cannabidiol, wani yanki na sativa na Cannabis, a matsayin magani na antipsychotic. Braz J Med Biol Res 2006; 39: 421-9. Duba m.
  164. Yadav V, Bever C Jr, Bowen J, et al. Takaitaccen bayanin shaidun shaida: gamsuwa da madadin magani a cikin cututtukan sclerosis da yawa: rahoto na karamin kwamiti na ci gaban jagora na Cibiyar Nazarin Lafiyar Jiki ta Amurka. Neurology. 2014; 82: 1083-92. Duba m.
  165. Trembly B, Sherman M. Bincike na asibiti mai sau biyu na cannabidiol a matsayin mai rikitarwa na biyu. Marijuana '90 Taron Duniya kan Cannabis da Cannabinoids 1990; 2: 5.
  166. Srivastava, M. D., Srivastava, B. I., da Brouhard, B. Delta9 tetrahydrocannabinol da cannabidiol sun canza samarwar cytokine ta jikin kwayoyin halitta. Immunopharmacology 1998; 40: 179-185. Duba m.
  167. Cunha, JM, Carlini, EA, Pereira, AE, Ramos, OL, Pimentel, C., Gagliardi, R., Sanvito, WL, Lander, N., da Mechoulam, R. Gwargwadon mulkin cannabidiol ga masu aikin sa kai masu lafiya da marasa lafiya . Pharmacology 1980; 21: 175-185. Duba m.
  168. Carlini EA, Cunha JM. Rashin hankali da cututtukan cututtuka na cannabidiol. J Clin Pharmacol 1981; 21 (8-9 Gudanarwa): 417S-27S. Duba m.
  169. Zuardi, A. W., Shirakawa, I., Finkelfarb, E., da Karniol, I. G. Ayyukan cannabidiol akan damuwa da sauran tasirin da delta 9-THC ya samar a cikin al'amuran yau da kullun. Psychopharmacology (Berl) 1982; 76: 245-250. Duba m.
  170. Ames, F. R. da Cridland, S. Anticonvulsant sakamako na cannabidiol. SAFr.Med.J. 1-4-1986; 69: 14. Duba m.
  171. Ohlsson, A., Lindgren, J. E., Andersson, S., Agurell, S., Gillespie, H., da Hollister, L. E. Kayan kwaya daya tak da ake kira cannabidiol da ke dauke da sinadarin deuterium a cikin mutum bayan shan sigari da kuma maganin cikin jini. Masana kimiyya. 1986; 13: 77-83. Duba m.
  172. Wade, D. T., Collin, C., Stott, C., da Duncombe, P. Meta-bincike game da inganci da amincin Sativex (nabiximols), a kan spasticity a cikin mutane da yawa sclerosis. Masana. 2010; 16: 707-714. Duba m.
  173. Collin, C., Ehler, E., Waberzinek, G., Alsindi, Z., Davies, P., Powell, K., Notcutt, W., O'Leary, C., Ratcliffe, S., Novakova, I ., Zapletalova, O., Pikova, J., da Ambler, Z. Makafi guda biyu, bazuwar, sarrafa wuribo, nazarin rukuni-rukuni na Sativex, a cikin batutuwa masu alamun bayyanar spasticity saboda cutar sclerosis da yawa. Neurol.Res. 2010; 32: 451-459. Duba m.
  174. Crippa, J. A., Zuardi, A. W., Martin-Santos, R., Bhattacharyya, S., Atakan, Z., McGuire, P., da Fusar-Poli, P. Cannabis da damuwa: nazari mai mahimmanci game da shaidar. Hum.Psychopharmacol. 2009; 24: 515-523. Duba m.
  175. Consroe, P., Laguna, J., Allender, J., Snider, S., Stern, L., Sandyk, R., Kennedy, K., da Schram, K. An sarrafa gwajin asibiti na cannabidiol a cikin cutar Huntington. Pharmacol Biochem. Ciwon. 1991; 40: 701-708. Duba m.
  176. Harvey, D. J., Samara, E., da Mechoulam, R. Kwatancen metabolism na cannabidiol a cikin kare, bera da mutum. Pharmacol Biochem. Ciwon. 1991; 40: 523-532. Duba m.
  177. Collin, C., Davies, P., Mutiboko, I. K., da Ratcliffe, S. Randomized gwajin sarrafawa na maganin tushen cannabis a cikin spasticity lalacewa da yawa sclerosis. Eur.J.Neurol. 2007; 14: 290-296. Duba m.
  178. Massi, P., Vaccani, A., Bianchessi, S., Costa, B., Macchi, P., da Parolaro, D. Cannabidiol da ba na psychoactive ba yana haifar da kunnawa da damuwa a cikin kwayoyin glioma na mutum. Cell Mol.Life Sci. 2006; 63: 2057-2066. Duba m.
  179. Weiss, L., Zeira, M., Reich, S., Har-Noy, M., Mechoulam, R., Slavin, S., da Gallily, R. Cannabidiol ya rage yawan ciwon sukari a cikin mice masu ciwon sukari marasa kiba Autoarfafa kai 2006; 39: 143-151. Duba m.
  180. Watzl, B., Scuderi, P., da Watson, R. R. Marijuana sunadaran sunadaran kwayar halittar dan adam na kwayar halitta ta hanyar interferon-gamma da danne interleukin-1 alpha a cikin vitro. Int J Immunopharmacol. 1991; 13: 1091-1097. Duba m.
  181. Consroe, P., Kennedy, K., da Schram, K. Assay na plasma cannabidiol ta hanyar maganin gas chromatography / ion trap mass spectroscopy bayan yawan kwayoyi da ake gudanarwa yau da kullum a cikin mutane. Pharmacol Biochem. Ciwon. 1991; 40: 517-522. Duba m.
  182. Barnes, M. P. Sativex: inganci na asibiti da haƙuri a cikin maganin alamun cututtukan cututtukan sclerosis da ciwon neuropathic da yawa. Gwani.Opin.Pacacacother. 2006; 7: 607-615. Duba m.
  183. Wade, D. T., Makela, P., Robson, P., House, H., da Bateman, C. Shin abubuwan da aka samo daga maganin cannabis suna da cikakke ko takamaiman tasiri kan alamun bayyanar cututtukan ƙwayoyin cuta da yawa? Makafi biyu, bazuwar, binciken sarrafa wuribo akan marasa lafiya 160. Masana. 2004; 10: 434-441. Duba m.
  184. Iuvone, T., Esposito, G., Esposito, R., Santamaria, R., Di Rosa, M., da Izzo, AA Neuroprotective sakamako na cannabidiol, wani ɓangaren da ba psychoactive daga Cannabis sativa, a kan beta-amyloid-jawo yawan guba a cikin ƙwayoyin PC12. J Neurochem. 2004; 89: 134-141. Duba m.
  185. Massi, P., Vaccani, A., Ceruti, S., Colombo, A., Abbracchio, M. P., da Parolaro, D. Antitumor sakamakon cannabidiol, cannabinoid mai ba da hankali ba, akan layin glioma na mutum. J Pharmacol ya ƙarfe. 2004; 308: 838-845. Duba m.
  186. Crippa, JA, Zuardi, AW, Garrido, GE, Wichert-Ana, L., Guarnieri, R., Ferrari, L., Azevedo-Marques, PM, Hallak, JE, McGuire, PK, da Filho, Busatto G. Tasirin na cannabidiol (CBD) a kan kwararar jini a yankin. Neuropsychopharmacology 2004; 29: 417-426. Duba m.
  187. Wade, D. T., Robson, P., House, H., Makela, P., da Aram, J. Nazarin binciken farko don tantance ko tsire-tsire masu tsire-tsire na tsire-tsire na iya inganta alamun cutar neurogenic. Clin. Farfadowa. 2003; 17: 21-29. Duba m.
  188. Covington TR, et al. Littafin Jagora na Magungunan Rubuce-rubuce 11th ed. Washington, DC: Pharmungiyar Magunguna ta Amurka, 1996.
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