BCR ABL Gwajin Halitta

Wadatacce

• Menene gwajin kwayoyin BCR-ABL?
• Me ake amfani da shi?
• Me yasa nake buƙatar gwajin kwayar BCR-ABL?
• Menene ya faru yayin gwajin ƙirar BCR-ABL?
• Shin zan bukaci yin komai don shirya wa gwajin?
• Shin akwai haɗari ga gwajin?
• Menene sakamakon yake nufi?
• Shin akwai wani abin da nake buƙatar sani game da gwajin ƙirar BCR-ABL?
• Bayani

Menene gwajin kwayoyin BCR-ABL?

Wani gwajin kwayar halittar BCR-ABL yana neman canjin kwayar halitta (canji) akan takamaiman chromosome.

Chromosomes sune sassan ƙwayoyinku waɗanda suka ƙunshi ƙwayoyinku. Kwayar halitta sassan DNA ne da aka ratsa daga uwa da uba. Suna ɗauke da bayanan da ke tantance halaye na musamman, kamar su tsayi da launin ido.

Kullum mutane suna da chromosomes 46, sun kasu kashi 23, a kowace kwaya. Ofaya daga cikin kowane chromosomes sun fito ne daga mahaifinka, ɗayan kuma daga mahaifinka ne.

BCR-ABL maye gurbi ne wanda ke samuwa ta hadewar wasu kwayoyin halitta guda biyu, wadanda ake kira BCR da ABL. Wani lokaci ana kiransa kwayar halitta.

• Kwayar ta BCR galibi akan lambar chromosome ce ta 22.
• Kwayar ABL galibi akan lambar chromosome ce 9.
• Canjin BCR-ABL na faruwa ne lokacin da wasu nau'ikan kwayoyin halittar BCR da ABL suka karye kuma suka sauya wurare.
• Maye gurbi ya bayyana akan chromosome 22, inda yanki na chromosome 9 ya haɗe kansa.
• Kwayar chromosome mai canzawa 22 ana kiranta chromosome ta Philadelphia saboda wannan shine garin da masu bincike suka fara gano shi.
• Kwayar halittar BCR-ABL ba nau'in maye gurbi bane wanda aka gada daga iyayenku. Nau'i ne na maye gurbi, wanda ke nufin ba a haife ku da shi ba. Kuna samun shi daga baya a rayuwa.

Kwayar BCR-ABL tana nunawa ga marasa lafiya da wasu nau'ikan cutar sankarar bargo, ciwon daji na ɓargo da ƙananan ƙwayoyin jini. Ana samun BCR-ABL a kusan duk marasa lafiya da ke da cutar sankarar bargo da ake kira myeloid leukemia na kullum (CML). Wani suna na CML na yau da kullun ne myelogenous cutar sankarar bargo. Dukansu sunaye suna nufin cuta iri ɗaya.

Hakanan ana samun kwayar ta BCR-ABL a cikin wasu marasa lafiya tare da wani nau'i na cutar sankarar bargo ta lymphoblastic (ALL) kuma da wuya a cikin marasa lafiya masu fama da cutar sankarar myelogenous (AML).

Wasu magunguna na kansar suna da tasiri musamman wajen kula da masu cutar sankarar bargo tare da maye gurbi na BCR-ABL. Wadannan magunguna ma suna da raunin sakamako fiye da sauran maganin cutar kansa. Magungunan guda ɗaya ba su da tasiri wajen magance nau'ikan cutar sankarar jini ko wasu cututtukan kansa.

Sauran sunaye: BCR-ABL1, BCR-ABL1 haɗuwa, Philadelphia chromosome

Me ake amfani da shi?

Ana amfani da gwajin BCR-ABL mafi yawancin lokuta don tantancewa ko kawar da cutar sankarar myeloid na yau da kullun (CML) ko takamaiman takamaiman nau'in cutar sankarar bargo ta lymphoblastic (ALL) da ake kira Ph-tabbatacce ALL. Ph-tabbatacce yana nufin an samo chromosome na Philadelphia. Ba a amfani da gwajin don gano wasu nau'ikan cutar sankarar bargo.

Hakanan za'a iya amfani da gwajin don:

• Duba idan maganin kansar yayi tasiri.
• Duba idan mai haƙuri ya ci gaba da juriya ga wasu magani. Wannan yana nufin maganin da ya kasance mai tasiri baya aiki.

Me yasa nake buƙatar gwajin kwayar BCR-ABL?

Kuna iya buƙatar gwajin BCR-ABL idan kuna da alamun cutar sankarar myeloid na yau da kullum (CML) ko Ph-tabbataccen m lymphoblastic leukemia (ALL). Wadannan sun hada da:

• Gajiya
• Zazzaɓi
• Rage nauyi
• Gumi na dare (yawan zufa yayin barci)
• Hadin gwiwa ko ciwon kashi

Wasu mutane masu cutar CML ko Ph-tabbatacce DUK ba su da wata alama, ko alamomi masu sauƙi, musamman ma a farkon matakan cutar. Don haka mai ba da lafiyarku na iya yin odar wannan gwajin idan cikakken jini ko wani gwajin jini ya nuna sakamakon da ba na al'ada ba. Hakanan ya kamata ku sanar da mai ba ku idan kuna da wasu alamun alamun da suka shafe ku. CML da Ph-tabbatacce DUK suna da sauƙin magancewa idan aka same su da wuri.

Hakanan kuna iya buƙatar wannan gwajin idan kuna halin yanzu don CML ko Ph-tabbatacce ALL. Jarabawar na iya taimaka wa mai ba ka damar ganin idan maganin ka na aiki.

Menene ya faru yayin gwajin ƙirar BCR-ABL?

Gwajin BCR-ABL yawanci gwajin jini ne ko kuma hanyar da ake kira fata ƙashi na kasusuwa da biopsy.

Idan kuna yin gwajin jini, wani kwararren mai kula da lafiya zai dauki samfurin jini daga jijiyar hannunka, ta amfani da karamin allura. Bayan an saka allurar, za a tara karamin jini a cikin bututun gwaji ko kwalba. Kuna iya jin ɗan kaɗan lokacin da allurar ta shiga ko fita. Wannan yawanci yakan dauki kasa da minti biyar.

Idan kuna samun fata na kasusuwa da biopsy, tsarinku na iya haɗawa da matakai masu zuwa:

• Za ku kwanta a gefenku ko cikinku, ya danganta da wane ƙashi za a yi amfani da shi don gwaji. Yawancin gwaje-gwajen kasusuwa ana ɗauke su daga ƙashin ƙugu.
• Za a rufe jikinka da zane, don haka yankin da ke wurin gwajin kawai yake nunawa.
• Za a tsabtace shafin tare da maganin kashe kwayoyin cuta.
• Za a yi muku allurar maganin narkar da numba. Yana iya jin zafi
• Da zarar yankin ya dushe, mai ba da kiwon lafiya zai ɗauki samfurin. Kuna buƙatar yin kwance sosai yayin gwaje-gwajen.
  • Don fatawar kashin kashi, wanda yawanci ake fara aiwatarwa, mai ba da kiwon lafiya zai saka allura ta cikin ƙashi kuma ya fitar da ruwa da ƙwayoyin halitta. Kuna iya jin zafi mai kaifi amma a taƙaice lokacin da aka saka allurar.
  • Don binciken kwayar halitta, kashin lafiya, mai ba da kiwon lafiya zai yi amfani da wani kayan aiki na musamman wanda zai murda cikin kashin don fitar da samfurin kashin kashin. Kuna iya jin danniya akan shafin yayin ɗaukar samfurin.
• Yana ɗaukar minti 10 don yin gwaje-gwajen biyu.
• Bayan gwajin, mai ba da lafiyar zai rufe shafin da bandeji.
• Yi shirin sanya wani ya kore ka gida, tun da ana iya ba ka maganin ƙyama kafin gwaji, wanda zai iya sa ka yin bacci.

Shin zan bukaci yin komai don shirya wa gwajin?

Yawanci baku buƙatar kowane shiri na musamman don gwajin jini ko ƙashi.

Shin akwai haɗari ga gwajin?

Akwai haɗari kaɗan don yin gwajin jini. Kuna iya samun ɗan ciwo ko rauni a wurin da aka sanya allurar, amma yawancin alamun suna tafi da sauri.

Bayan gwajin ɓarna, za ka iya jin tauri ko ciwo a wurin allurar. Wannan yawanci yakan shuɗe cikin daysan kwanaki. Mai ba da sabis na kiwon lafiya na iya bayar da shawarar ko kuma ba da umarnin rage zafi don taimakawa.

Menene sakamakon yake nufi?

Idan sakamakonku ya nuna kuna da kwayar BCR-ABL, da kuma yawan ƙwayoyin jinin jini, da alama za a bincikar ku tare da cutar sankarar myeloid na yau da kullun (CML) ko Ph-tabbatacce, mai saurin cutar sankarar bargo (ALL).

Idan a halin yanzu ana kula da ku don CML ko Ph-tabbatacce ALL, sakamakonku na iya nuna:

• Adadin BCR-ABL a cikin jinin ku ko kashin ƙashi yana ƙaruwa. Wannan na iya nufin maganin ku baya aiki kuma / ko kun zama mai tsayayya da wani magani.
• Adadin BCR-ABL a cikin jininku ko kashin ƙashi yana raguwa. Wannan na iya nufin maganinku yana aiki.
• Adadin BCR-ABL a cikin jininka ko kashin kashinka bai karu ko raguwa ba. Wannan na iya nufin cutar ku ta yi karko.

Idan kuna da tambayoyi game da sakamakonku, yi magana da mai ba ku kiwon lafiya.

Learnara koyo game da gwaje-gwajen gwaje-gwaje, jeri na tunani, da fahimtar sakamako.

Shin akwai wani abin da nake buƙatar sani game da gwajin ƙirar BCR-ABL?

Jiyya don cutar sankarar myeloid na yau da kullun (CML) da Ph-tabbatacce, cutar sankarar bargo (ALL) ta sami nasara ga marasa lafiya tare da waɗannan nau'ikan cutar sankarar bargo. Yana da mahimmanci a ga mai ba da sabis na kiwon lafiya a kai a kai don tabbatar da jiyya na ci gaba da aiki. Idan kun kasance juriya ga magani, mai ba ku sabis na iya bayar da shawarar wasu nau'ikan maganin cutar kansa.

Bayani

1. Canungiyar Ciwon Cancer ta Amurka [Intanet]. Atlanta: Cibiyar Cancer ta Amurka Inc ;; c2018. Abin da ke haifar da Ciwon Cutar sankarar Myeloid na kullum [sabunta 2018 Jun 19; wanda aka ambata 2018 Aug 1]; [game da fuska 4]. Akwai daga: https://www.cancer.org/cancer/chronic-myeloid-leukemia/causes-risks-prevention/what-causes.html
2. Cancer.net [Intanet]. Alexandria (VA): Societyungiyar (asar Amirka ta Clinical Oncology; c2005–2018. Ciwon sankarar jini: Myeloid na kullum: CML: Gabatarwa; 2018 Mar [wanda aka ambata 2018 Aug 1]; [game da fuska 3]. Akwai daga: https://www.cancer.net/cancer-types/leukemia-chronic-myeloid-cml/introduction
3. Cancer.net [Intanet]. Alexandria (VA): Societyungiyar (asar Amirka ta Clinical Oncology; c2005–2018. Cutar sankarar jini: Myeloid na kullum: CML: Zaɓuɓɓukan Jiyya; 2018 Mar [wanda aka ambata 2018 Aug 1]; [game da fuska 4]. Akwai daga: https://www.cancer.net/cancer-types/leukemia-chronic-myeloid-cml/treatment-options
4. Gwaje-gwajen Lab a kan layi [Intanet]. Washington DC: Associationungiyar (asar Amirka don Magungunan Kiwon Lafiya; c2001–2018. BCR-ABL1 [an sabunta 2017 Dec 4; wanda aka ambata 2018 Aug 1]; [game da allo 2]. Akwai daga: https://labtestsonline.org/tests/bcr-abl1
5. Gwaje-gwajen Lab a kan layi [Intanet]. Washington DC: Associationungiyar (asar Amirka don Magungunan Kiwon Lafiya; c2001–2018. Ciwon sankarar jini [updated 2018 Jan 18; wanda aka ambata 2018 Aug 1]; [game da allo 2]. Akwai daga: https://labtestsonline.org/conditions/leukemia
6. Cutar sankarar bargo da Lymphoma Society [Intanet]. Rye Brook (NY): Cutar sankarar bargo da Lymphoma Society; c2015. Chronic Myeloid Cutar sankarar bargo [wanda aka ambata 2018 Aug 1]; [game da fuska 3]. Akwai daga: http://www.lls.org/leukemia/chronic-myeloid-leukemia
7. Mayo Clinic [Intanet]. Gidauniyar Mayo don Ilimin Likita da Bincike; c1998–2018. Gwajin kasusuwa da fata: Siffar bayani; 2018 Jan 12 [wanda aka ambata 2018 Aug 1]; [game da fuska 4]. Akwai daga: https://www.mayoclinic.org/tests-procedures/bone-marrow-biopsy/about/pac-20393117
8. Mayo Clinic [Intanet]. Gidauniyar Mayo don Ilimin Likita da Bincike; c1998–2018. Tsarin cutar sankarar bargo na yau da kullun: Bayani; 2016 Mayu 26 [wanda aka ambata 2018 Aug 1]; [game da fuska 4]. Akwai daga: https://www.mayoclinic.org/diseases-condition/chronic-myelogenous-leukemia/symptoms-causes/syc-20352417
9. Mayo Clinic: Mayo Laboratories Medical [Internet]. Gidauniyar Mayo don Ilimin Likita da Bincike; c1995–2018. ID na Gwaji: BADX: BCR / ABL1, Qualitative, Diagnostic Assay: Clinical and Interpretive [wanda aka ambata 2018 Aug 1]; [game da fuska 4]. Akwai daga: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/89006
10. Shafin Kasuwancin Merck Manual [Internet]. Kenilworth (NJ): Kamfanin Merck & Co., Inc.; c2018. Jarrabawar Kashin Kashi [wanda aka ambata 2018 Aug 1]; [game da allo 2]. Akwai daga: http://www.merckmanuals.com/home/blood-disorders/symptoms-and-diagnosis-of-blood-disorders/bone-marrow-examination
11. Shafin Kasuwancin Merck Manual [Internet]. Kenilworth (NJ): Kamfanin Merck & Co., Inc.; c2018. Kullum Myelogenous Cutar sankarar jini [wanda aka ambata 2018 Aug 1]; [game da allo 2]. Akwai daga: https://www.merckmanuals.com/home/blood-disorders/leukemias/chronic-myelogenous-leukemia
12. Cibiyar Cancer ta Kasa [Intanet]. Bethesda (MD): Ma'aikatar Kiwon Lafiya ta Amurka da Ayyukan Dan Adam; Magungunan cutar sankarar bargo na Myelogenous (PDQ®) -Patient Version [wanda aka ambata 2018 Aug 1]; [game da fuska 4]. Akwai daga: https://www.cancer.gov/types/leukemia/patient/cml-treatment-pdq
13. Cibiyar Cancer ta Kasa [Intanet]. Bethesda (MD): Ma'aikatar Kiwon Lafiya ta Amurka da Ayyukan Dan Adam; Maganin Ciwon Cutar Cancer [wanda aka ambata 2018 Aug 1]; [game da fuska 4]. Akwai daga: https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet
14. Cibiyar Cancer ta Kasa [Intanet]. Bethesda (MD): Ma'aikatar Kiwon Lafiya ta Amurka da Ayyukan Dan Adam; NCI Dictionary of Cancer Terms: BCR-ABL fusion gene [wanda aka ambata 2018 Aug 1]; [game da fuska 3]. Akwai daga: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bcr-abl-fusion-gene
15. Cibiyar Cancer ta Kasa [Intanet]. Bethesda (MD): Ma'aikatar Kiwon Lafiya ta Amurka da Ayyukan Dan Adam; NCI Dictionary of Terms of Cancer Terms: BCR-ABL protein fusion [wanda aka ambata 2018 Aug 1]; [game da fuska 3]. Akwai daga: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bcr-abl-fusion-protein
16. Cibiyar Cancer ta Kasa [Intanet]. Bethesda (MD): U.S.Ma'aikatar Lafiya da Ayyukan Dan Adam; NCI Dictionary of Cancer Terms: gene [wanda aka ambata 2018 Aug 1]; [game da fuska 3]. Akwai daga: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=gene
17. Zuciyar Kasa, Huhu, da Cibiyar Jini [Intanet]. Bethesda (MD): Ma'aikatar Kiwon Lafiya ta Amurka da Ayyukan Dan Adam; Gwajin jini [wanda aka ambata 2018 Aug 1]; [game da fuska 3]. Akwai daga: https://www.nhlbi.nih.gov/health-topics/blood-tests
18. NIH Cibiyar Nazarin Halittar Mutum ta Duniya [Intanet]. Bethesda (MD): Ma'aikatar Kiwon Lafiya ta Amurka da Ayyukan Dan Adam; Matsalolin Chromosome; 2016 Jan 6 [wanda aka ambata 2018 Aug 1]; [game da fuska 3]. Akwai daga: https://www.genome.gov/11508982
19. NIH US National Library of Medicine: Nasihu na Gidajen Gida [Intanet]. Bethesda (MD): Ma'aikatar Kiwon Lafiya ta Amurka da Ayyukan Dan Adam; Abil1 ABL1; 2018 Jul 31 [wanda aka ambata 2018 Aug 1]; [game da allo 2]. Akwai daga: https://ghr.nlm.nih.gov/gene/ABL1#condition
20. Oncolink [Intanet]. Philadelphia: Amintattun na Jami'ar Pennsylvania; c2018. Duk Game da Babban Ciwon Cutar Sanyin Ido na Manya (ALL) [updated 2018 Jan 22; wanda aka ambata 2018 Aug 1]; [game da fuska 3]. Akwai daga: https://www.oncolink.org/cancers/leukemia/leukemia-acute-lymphocytic-leukemia-all/all-about-adult-acute-lymphocytic-leukemia-all
21. Oncolink [Intanet]. Philadelphia: Amintattun na Jami'ar Pennsylvania; c2018. Duk Game da Myeloid Leukemia na kullum (CML) [sabunta 2017 Oct 11; wanda aka ambata 2018 Aug 1]; [game da fuska 3]. Akwai daga: https://www.oncolink.org/cancers/leukemia/chronic-myelogenous-leukemia-cml/all-about-chronic-myeloid-leukemia-cml

Ba za a yi amfani da bayanan da ke wannan rukunin yanar gizon a madadin madadin ƙwararrun likitocin ko shawara ba. Tuntuɓi mai ba da kiwon lafiya idan kuna da tambayoyi game da lafiyarku.