HER2 (Ciwon Nono) Gwaji

Wadatacce

• Menene HER2 gwajin ciwon nono?
• Me ake amfani da shi?
• Me yasa nake bukatar gwajin HER2 na kansar nono?
• Menene ya faru yayin gwajin HER2 na ciwon nono?
• Shin zan bukaci yin komai don shirya wa gwajin?
• Shin akwai haɗari ga gwajin?
• Menene sakamakon yake nufi?
• Shin akwai wani abin da ya kamata in sani game da gwajin cutar kansa na HER2?
• Bayani

Menene HER2 gwajin ciwon nono?

HER2 yana nufin mai karɓar haɓakar haɓakar ɗan adam epidermal factor 2. Jinsi ne wanda yake sanya furotin da ake samu a saman dukkan ƙwayoyin nono. Yana da hannu cikin ci gaban kwayar halitta ta al'ada.

Kwayoyin halitta sune asalin asalin gado, wanda aka samo daga mahaifinka da mahaifinka. A wasu cututtukan daji, musamman cutar sankarar mama, kwayar HER2 tana canzawa (canje-canje) kuma yana yin ƙarin kwafin halittar. Lokacin da wannan ya faru, kwayar HER2 tana haifar da furotin HER2 da yawa, yana haifar da ƙwayoyin halitta su rarraba da girma cikin sauri.

Cancers tare da matakan furotin HER2 an san su da HER2-tabbatacce. Cancers tare da ƙananan matakan furotin an san su da HER2-korau. Kimanin kashi 20 cikin 100 na cutar sankarar mama HER2-tabbatacce ne.

Gwajin HER2 ya kalli samfurin ƙwayar ƙwayar cuta. Hanyoyin da aka fi dacewa don gwada ƙwayoyin tumo sune:

• Gwajin Immunohistochemistry (IHC) yana auna furotin na HER2 akan saman ƙwayoyin
• Haskewa a cikin yanayin haɗuwa (FISH) yana neman ƙarin kofe na kwayar HER2

Dukkanin nau'ikan gwaje-gwajen na iya bayyana ko kuna da cutar HER2-tabbatacce. Magungunan da suka shafi cutar kansa ta HER2-tabbatacce na iya zama da tasiri sosai.

Sauran sunaye: haɓakar haɓakar ɗan adam epidermal factor 2 receptor, ERBB2 karawa, HER2 nunawa, HER2 / neu gwaje-gwaje

Me ake amfani da shi?

Ana amfani da gwajin HER2 mafi yawa don gano ko ciwon daji na HER2-tabbatacce ne. Hakanan wasu lokuta ana amfani dashi don ganin idan ciwon daji yana amsawa ga magani ko kuma idan kansar ta dawo bayan magani.

Me yasa nake bukatar gwajin HER2 na kansar nono?

Idan an gano ku da ciwon nono, kuna iya buƙatar wannan gwajin don gano ko kansar ku ta HER2-tabbatacce ce ko HER2-mara kyau. Idan an riga an ba ku magani don cutar HER2-tabbataccen ciwon nono, kuna iya buƙatar wannan gwajin zuwa:

• Gano idan maganinku yana aiki. Matakan al'ada na HER2 na iya nufin kuna amsawa ga magani. Babban matakan na iya nufin maganin ba ya aiki.
• Gano idan cutar daji ta dawo bayan jiyya.

Menene ya faru yayin gwajin HER2 na ciwon nono?

Yawancin gwajin HER2 sun haɗa da ɗaukar samfurin ƙwayar ƙwayar cuta a cikin hanyar da ake kira biopsy. Akwai manyan hanyoyi guda uku na hanyoyin binciken biopsy:

• Lafiya mai kyau allurar fata biopsy, wanda ke amfani da allura mai matukar siriri don cire samfurin ƙwayoyin mama ko ruwa
• Babban allurar biopsy, wanda ke amfani da babban allura don cire samfurin
• M biopsy, wanda ke cire samfuri a cikin ƙaramin, hanyar fita asibiti

Kyakkyawan burin allura da kuma ainihin allurar biopsies yawanci hada da matakai masu zuwa:

• Za ku kwanta a gefenku ko ku zauna a teburin gwaji.
• Mai ba da sabis na kiwon lafiya zai tsabtace shafin biopsy kuma ya yi masa allurar rigakafi don ba za ku ji zafi ba yayin aikin.
• Da zarar yankin ya dushe, mai ba da sabis zai saka ko dai allurar fata mai kyau ko allura mai mahimmanci a cikin shafin biopsy ɗin kuma cire samfurin nama ko ruwa.
• Kuna iya jin ɗan matsi lokacin da aka janye samfurin.
• Za a yi amfani da matsin lamba a wurin nazarin halittar har sai jinin ya tsaya.
• Mai ba da sabis ɗinku zai yi amfani da bandeji mara ɗari a shafin biopsy.

A cikin biopsy na tiyata, likita mai fiɗa zai yi ɗan yanka a cikin fata don cire duka ko ɓangaren curin nono. Ana yin aikin tiyata a wasu lokuta idan ba za a iya kaiwa dunƙulen tare da allurar ƙira ba. Yin aikin tiyata yana haɗa da matakai masu zuwa.

• Za ku kwanta akan teburin aiki. Ana iya sanya IV (layin jini) a hannu ko a hannu.
• Za a iya ba ku magani, wanda ake kira mai kwantar da hankali, don taimaka muku shakatawa.
• Za a ba ku maganin rigakafi na gida ko na asibiti don haka ba za ku ji zafi ba yayin aikin.
  • Don maganin rigakafi na cikin gida, mai ba da sabis na kiwon lafiya zai yi amfani da maganin ƙwaƙwalwar ajiyar biopsy tare da magani don rage yankin.
  • Don maganin saurara na gaba ɗaya, ƙwararren masani da ake kira anesthesiologist zai ba ku magani don haka za ku kasance cikin sume yayin aikin.
• Da zarar yankin biopsy ya dushe ko kuma ba ku da hankali, likitan zai yi ɗan yanka a cikin nono ya cire wani ɓangare ko duka dunƙulen. Hakanan za'a iya cire wasu kayan dake kusa da dunbun.
• Za a rufe abin da aka yanke a cikin fatarku tare da dinkakku ko madafan zaren.

Nau'in biopsy da kake dashi zai dogara da dalilai daban-daban, gami da girma da kuma wurin da cutar take. Hakanan ana iya auna HER2 a gwajin jini, amma gwajin jini don HER2 ba a tabbatar da zama mai amfani ga mafi yawan marasa lafiya ba. Don haka yawanci ba a ba da shawarar.

Bayan an ɗauke samfurin abinku, za'a gwada shi ta ɗayan hanyoyi biyu:

• Za a auna matakan furotin na HER2.
• Za a duba samfurin don ƙarin kofe na kwayar HER2.

Shin zan bukaci yin komai don shirya wa gwajin?

Ba za ku buƙaci kowane shiri na musamman ba idan kuna samun maganin ƙwayar cutar cikin gida (numbing of the biopsy site). Idan kana fama da cutar rigakafin cutar gabaɗaya, wataƙila za ka buƙaci yin azumi (ba ci ko sha ba) na wasu awowi kafin aikin tiyata. Kwararren likitan ku zai ba ku ƙarin takamaiman umarnin. Hakanan, idan kuna samun magani mai sa kuzari ko maganin sa barci gabadaya, tabbatar kun shirya wani ya kawo ku gida. Kuna iya zama mai rikitarwa da rikicewa bayan kun farka daga aikin.

Shin akwai haɗari ga gwajin?

Wataƙila kuna da ɗan rauni ko zubar jini a wurin biopsy. Wani lokaci shafin yakan kamu. Idan hakan ta faru, za'a baka maganin rigakafi. A biopsy na tiyata na iya haifar da ƙarin ƙarin ciwo da damuwa. Mai ba ku kiwon lafiya na iya bayar da shawarar ko rubuta magani don taimaka muku ku ji daɗi.

Akwai haɗari kaɗan don yin gwajin jini. Kuna iya samun ɗan ciwo ko rauni a wurin da aka sanya allurar, amma yawancin alamun suna tafi da sauri.

Menene sakamakon yake nufi?

Idan matakan furotin na HER2 sun fi yadda aka saba ko aka samo ƙarin kwafin halittar HER2, tabbas yana nufin kuna da cutar HER2-tabbatacce. Idan sakamakonku ya nuna yawan furotin na HER2 na al'ada ko adadin al'ada HER2, tabbas kuna da cutar HER2-korau.

Idan sakamakonku bai kasance tabbatacce mai kyau ko mara kyau ba, tabbas za a sake gwada ku, ko dai ta amfani da samfurin ƙari daban ko yin amfani da hanyar gwaji daban. Mafi yawanci, ana yin IHC (gwaji don sunadarin HER2) da farko, sai kuma FISH (gwaji don ƙarin kwafin kwayar halitta). Gwajin IHC bashi da tsada kuma yana bada sakamako mai sauri fiye da FISH. Amma yawancin kwararru kan nono suna ganin gwajin KIFI yafi dacewa.

Magunguna don HER2-tabbataccen ciwon nono na iya rage yawan ciwace-ciwacen daji, tare da 'yan illa kaɗan. Wadannan maganin ba su da tasiri a cikin cututtukan HER2.

Idan ana kula da ku don cutar HER2-tabbatacce, sakamako na yau da kullun na iya nufin kuna amsawa ga magani. Sakamako wanda ya nuna sama da adadin al'ada na iya nufin maganinku baya aiki, ko kuma cutar kansa ta dawo bayan magani.

Learnara koyo game da gwaje-gwajen gwaje-gwaje, jeri na tunani, da fahimtar sakamako.

Shin akwai wani abin da ya kamata in sani game da gwajin cutar kansa na HER2?

Duk da yake yafi yawa ga mata, cutar sankarar mama, gami da HER2-tabbatacciyar sankarar mama, na iya shafar maza. Idan mutum ya kamu da cutar sankarar mama, za'a iya bada shawarar gwajin HER2.

Bugu da kari, maza da mata na iya bukatar gwajin HER2 idan an gano su da wasu cututtukan ciki da na ciki. Wadannan cututtukan daji a wasu lokuta suna da matakan furotin na HER2 kuma suna iya amsawa da kyau ga maganin HER2-tabbatacce na ciwon daji.

Bayani

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Ba za a yi amfani da bayanan da ke wannan rukunin yanar gizon a madadin madadin ƙwararrun likitocin ko shawara ba. Tuntuɓi mai ba da kiwon lafiya idan kuna da tambayoyi game da lafiyarku.