Mawallafi: Randy Alexander
Ranar Halitta: 28 Afrilu 2021
Sabuntawa: 22 Yuni 2024
Anonim
Further Prescribing Considerations for Glecaprevir/Pibrentasvir (Mavyret (G/P))
Video: Further Prescribing Considerations for Glecaprevir/Pibrentasvir (Mavyret (G/P))

Wadatacce

Menene Mavyret?

Mavyret magani ne mai suna wanda ake amfani dashi don magance cutar hepatitis C virus (HCV). Wannan kwayar cutar tana cutar hanta kuma tana haifar da kumburi.

Mavyret na iya amfani da mutane tare da kowane nau'ikan nau'ikan HCV guda shida waɗanda ko dai ba su da ƙwayoyin cuta na hanta (ƙwanƙwasa hanta) ko kuma waɗanda suka ba da diyyar (m) cirrhosis. Hakanan za'a iya amfani da Mavyret don magance nau'ikan HCV na 1 a cikin mutanen da aka yiwa magani a baya (amma ba a warke ba) tare da nau'in magani daban.

An yarda da Mavyret don amfani dashi a cikin manya. An kuma yarda da amfani da shi a cikin yara masu shekaru 12 zuwa sama, ko waɗanda nauyinsu yakai aƙalla kilogram 45 (kimanin fam 99).

Mavyret ta zo ne a matsayin ƙaramar kwamfutar hannu guda wacce ta ƙunshi magungunan rigakafi guda biyu: glecaprevir (100 mg) da pibrentasvir (40 mg). Ana ɗaukar ta baki sau ɗaya kowace rana.

Inganci

A cikin gwaji na asibiti, an ba manya da ke da cutar ta HCV (nau'ikan 1, 2, 3, 4, 5, da 6) waɗanda ba a taɓa ba su magani ba game da kwayar cutar an ba su Mavyret. Daga cikin wadannan mutane, kashi 98% zuwa 100% sun warke bayan sati 8 zuwa 12 na jinya. A cikin waɗannan karatun, samun warkarwa yana nufin cewa gwajin jinin mutane, wanda aka yi watanni uku bayan jiyya, ba a nuna alamun kamuwa da cutar ta HCV a jikinsu ba.


Don ƙarin bayani game da tasiri, duba sashin "Inganci" a ƙarƙashin "Mavyret for hepatitis C" a ƙasa.

FDA amincewa

Mavyret ta sami amincewar Hukumar Abinci da Magunguna (FDA) a cikin Afrilu 2017 don magance cutar hepatitis C mai saurin (nau'in 1, 2, 3, 4, 5, da 6) a cikin manya.

A watan Afrilu 2019, FDA ta faɗaɗa yardar magani don haɗawa da amfani da ita a cikin yara. An yarda don amfani a cikin yara masu shekaru 12 zuwa sama, ko waɗanda nauyinsu yakai aƙalla kilogram 45 (kimanin kilogram 99).

Mavyret na asali

Ana samun Mavyret ne kawai azaman magani mai suna. Babu shi a halin yanzu a cikin sifa iri.

Mavyret ta ƙunshi abubuwa biyu masu ƙwayoyi masu aiki: glecaprevir da pibrentasvir.

Mavyret kudin

Kamar yadda yake tare da duk magunguna, farashin Mavyret na iya bambanta. Don neman farashi na yanzu don Mavyret a yankinku, bincika GoodRx.com.

Kudin da kuka samo akan GoodRx.com shine abin da zaku iya biya ba tare da inshora ba. Ainihin farashin da za ku biya ya dogara da tsarin inshorar ku, wurin ku, da kuma kantin da kuke amfani da shi.


Taimakon kuɗi da inshora

Idan kuna buƙatar tallafi na kuɗi don biyan Mavyret, ko kuma idan kuna buƙatar taimako game da ɗaukar inshorar ku, akwai taimako.

Abbvie, wanda ya kera Mavyret, yana bayar da wani shiri mai suna Mavyret Patient Support, wanda zai iya ba da taimako don rage farashin maganin. Don ƙarin bayani kuma don gano idan kun cancanci tallafi, kira 877-628-9738 ko ziyarci gidan yanar gizon shirin.

Mavyret sakamako masu illa

Mavyret na iya haifar da lahani ko mummunan sakamako. Jerin masu zuwa suna dauke da wasu daga cikin mahimman tasirin da zasu iya faruwa yayin shan Mavyret. Waɗannan jerin ba su haɗa da duk tasirin illa.

Don ƙarin bayani game da yuwuwar illa na Mavyret, yi magana da likitanka ko likitan magunguna. Za su iya ba ku shawarwari kan yadda za ku magance duk wata illa da ke iya zama damuwa.

Commonarin sakamako masu illa na kowa

Abubuwan da suka fi dacewa na Mavyret na iya haɗawa da:

  • ciwon kai
  • jin kasala
  • tashin zuciya
  • gudawa
  • daukaka bilirubin (gwajin gwajin da ke duba aikin hanta)

Yawancin waɗannan tasirin na iya wucewa cikin withinan kwanaki kaɗan ko makonni kaɗan. Idan sun fi tsanani ko basu tafi ba, yi magana da likitanka ko likitan magunguna.


M sakamako mai tsanani

M sakamako mai tsanani daga Mavyret ba abu bane na yau da kullun, amma suna iya faruwa. Kira likitanku nan da nan idan kuna da mummunar illa. Kira 911 idan alamunku suna jin barazanar rai ko kuma idan kuna tunanin kuna samun gaggawa na likita.

M sakamako masu illa, waɗanda aka tattauna a ƙasa a cikin "effectarin bayanan sakamako," sun haɗa da masu zuwa:

  • sake kunnawa cutar hepatitis B (wata kwayar cutar, idan ta riga ta cikin jikin ku) *
  • mai tsanani rashin lafiyan dauki

Bayanin sakamako na gefe

Kuna iya mamakin yadda sau da yawa wasu cututtukan illa ke faruwa tare da wannan magani, ko kuma wasu illoli sun shafi hakan. Anan ga wasu dalla-dalla akan wasu illolin da wannan maganin na iya haifar ko ba zai iya haifarwa ba.

Maganin rashin lafiyan

Kamar yadda yake da yawancin kwayoyi, wasu mutane na iya yin rashin lafiyan bayan shan Mavyret. Ba a san tabbatacce yadda sau da yawa mutane ke shan wannan magani ke da tasirin rashin lafiyan ba. Kwayar cututtukan rashin lafiyan rashin lafiya na iya haɗawa da:

  • kumburin fata
  • ƙaiƙayi
  • flushing (dumi da kuma ja a fatar ka)

Reactionwayar rashin lafiyan da ta fi tsanani ba safai ba amma zai yiwu. Kwayar cututtukan rashin lafiya mai haɗari na iya haɗawa da:

  • kumburi a ƙarƙashin fatar ku, galibi a cikin ƙasan idanunku, leɓunanku, hannuwanku, ko ƙafafunku
  • kumburin harshenka, bakinka, ko maqogwaronka
  • matsalar numfashi ko magana

Kira likitanku nan da nan idan kuna da mummunan rashin lafiyar Mavyret. Kira 911 idan alamunku suna jin barazanar rai ko kuma idan kuna tunanin kuna samun gaggawa na likita.

Itching

Kuna iya fuskantar ƙaiƙayi yayin amfani da Mavyret.A cikin gwaji na asibiti, wasu mutane suna da damuwa yayin shan wannan magani. Itanƙara yawanci yakan faru ne kawai a cikin mutanen da ke shan magani wanda ke da cutar koda da cutar ta kwayar cutar hepatitis C (HCV). A cikin wannan rukunin, kusan 17% na mutane sun ba da rahoton ƙaiƙayin a matsayin sakamako na illa.

Hakanan ƙaiƙayi wani lokaci alama ce da HCV ke haifarwa. Yin ciwo yana faruwa kusan 20% na mutanen da ke fama da cutar ta HCV. Wannan alama wataƙila saboda tarin sinadarin da ake kira bilirubin a cikin jikin ku. Aiƙai da cutar ta HCV ta haifar yana iya kasancewa a cikin yanki ɗaya ko kuma yana iya zama a jikin ku duka.

Idan kana da damuwa game da samun fata mai kaushi yayin shan Mavyret, yi magana da likitanka. Zasu iya ba da shawarar hanyoyi don taimakawa rage wannan tasirin yayin da kake amfani da magani.

Cutar hepatitis B

Kuna iya samun haɗarin sake kunnawa na kwayar cutar hepatitis B (HBV) yayin da kuke shan Mavyret.

Maganin Mavyret yana ƙara haɗarin sake kunnawa HBV a cikin mutane tare da duka HBV da HCV. A cikin yanayi mai tsanani, sake kunnawa na HBV na iya haifar da gazawar hanta ko ma mutuwa.

Kwayar cututtuka na sake kunnawa HBV na iya haɗawa da:

  • zafi a gefen dama na ciki
  • kujeru mai haske
  • jin kasala
  • raunin fata ko fararen idanun ki

Kafin fara Mavyret, likitanku zai gwada ku don cutar HBV. Idan kuna da HBV, kuna iya buƙatar a kula da shi kafin fara shan Mavyret. Ko kuma likitanka na iya ba da shawarar gwaji yayin kulawar Mavyret don saka idanu kan sake kunna HBV da magance yanayin idan an buƙata.

Canjin nauyi (ba sakamako ba)

Ba a bayar da rahoton asarar nauyi da ƙimar nauyi kamar tasirin Mavyret ba yayin gwajin asibiti. Koyaya, Mavyret na iya haifar da tashin zuciya, wanda zai haifar da asarar nauyi ga wasu mutane. Idan kun ji damuwa yayin shan wannan magani, kuna iya cin abinci kaɗan, wanda na iya haifar da asarar nauyi.

Idan kuna da damuwa game da karuwar nauyi ko asarar nauyi yayin ɗaukar Mavyret, yi magana da likitanku. Zasu iya taimaka maka shirya lafiyayyen abinci yayin maganin ka.

Rushewar fata (ba sakamako ba)

Ba a bayar da rahoton saurin fatar jiki a matsayin tasirin Mavyret ba yayin gwajin asibiti. Koyaya, HCV kanta na iya haifar da fatar wani lokacin. Wannan na iya kuskure don tasirin maganin. Rashin kuzarin da HCV ya haifar na iya zama ko'ina a jikinku, haɗe da fuskarku, kirjinku, ko hannayenku. Hakanan yana iya sa ka ji ƙaiƙayi.

Idan kana da fatar jiki yayin amfani da Mavyret, yi magana da likitanka. Zasu iya ba da shawarar hanyoyi don rage alamun ku kuma bayar da shawarar magani idan an buƙata.

Hanyoyi masu illa a cikin yara

Yayin karatun asibiti, illolin da aka gani a yara (shekaru 12 zuwa 17) shan Mavyret sun yi kama da illolin da ake gani a cikin manya da ke shan ƙwayoyi. A cikin waɗannan karatun, babu yara da suka daina magani saboda illolin da ke tattare da su.

Sakamakon illa na yau da kullun da aka gani a cikin yara sun haɗa da:

  • jin kasala
  • tashin zuciya
  • ciwon kai
  • daukaka bilirubin (gwajin gwajin da ke duba aikin hanta)

Idan kun damu game da illolin da ke faruwa a cikin yaro ta amfani da Mavyret, yi magana da likitan ku. Suna iya bayar da shawarar hanyoyin rage waɗannan illolin yayin shan magani.

Mavyret sashi

Bayani mai zuwa yana bayanin abubuwan da ake amfani dasu ko aka ba da shawarar. Koyaya, tabbatar da shan maganin da likitanka yayi maka. Likitan ku zai ƙayyade mafi kyawun sashi don dacewa da bukatun ku.

Magungunan ƙwayoyi da ƙarfi

Mavyret ta zo ne azaman kwamfutar hannu wanda aka ɗauka ta baki. Kowace kwamfutar hannu ta ƙunshi 100 mg na glecaprevir da 40 mg na pibrentasvir.

Sashi don hepatitis C

Sashin Mavyret na cutar hepatitis C mai ɗorewa (HCV) shine allunan guda uku waɗanda ake sha da baki sau ɗaya kowace rana. Wannan magani ya kamata a sha tare da abinci. Hakanan ya kamata a sha a kusan lokaci guda kowace rana.

Likitanku zai ƙayyade tsawon lokacin da kuke buƙatar ɗauka Mavyret. Wannan shawarar ta dogara da duk wani magani na HCV da kuka taɓa amfani da shi.

Kowane tsawon jiyyar mutum na iya bambanta, amma yawancin mutane suna ɗaukar Mavyret ko'ina daga makonni 8 zuwa makonni 16. Matsakaicin tsinkayen maganin Mavyret kamar haka:

  • Idan ba a taɓa ba ka magani ba game da cutar ta HCV, kuma ba ka da cutar cirrhosis (ciwon hanta), da alama za a kula da kai har tsawon makonni 8.
  • Idan ba a taɓa ba ka magani ba game da cutar ta HCV, kuma ka biya diyya (mai saurin kamuwa da cutar cirrhosis), mai yiwuwa za a kula da kai har tsawon makonni 12.
  • Idan a baya an ba ku magani don cutar ta HCV, kuma maganinku bai yi tasiri ba (bai warkar da cutar ku ba), tsawon maganin ku tare da Mavyret na iya bambanta. Yana iya wucewa ko'ina daga makonni 8 har zuwa makonni 16. Matsakaicin tsinkayar maganinku zai dogara da irin maganin HCV ɗin da kuka yi amfani dashi a baya.

Idan kana da wasu tambayoyi game da tsawon lokacin da zaka buƙaci ɗauka Mavyret, yi magana da likitanka. Suna iya bayar da shawarar mafi kyawun shirin kulawa a gare ku.

Sashin yara

Sashin likitan yara na Mavyret daidai yake da na manya: Allunan guda uku ana ɗauka ta baki (tare da abinci) sau ɗaya a rana. Yin maganin yara ya shafi yara:

  • shekara 12 zuwa 17, ko
  • wadanda nauyinsu yakai akalla kilogiram 45 (kimanin fam 99)

Ba a yarda da Mavyret a halin yanzu don amfani da shi a cikin yara ƙanana da shekara 12 ba ko kuma waɗanda ke da nauyin ƙasa da kilogiram 45.

Menene idan na rasa kashi?

Idan ka rasa kashi na Mavyret, ga abin da ya kamata kayi:

  • Idan kasa da awanni 18 daga lokacin da yakamata ka dauki Mavyret, ci gaba da shan kashin ka da zaran ka tuna. Bayan haka, ɗauki kashi na gaba a lokacin da aka saba.
  • Idan ya fi awa 18 daga lokacin da ya kamata ku sha Mavyret, kawai tsallake wannan maganin. Kuna iya ɗaukar nauyin ku na gaba a lokacin da kuka saba.

Don taimakawa tabbatar cewa baka rasa kashi ba, gwada saita tunatarwa akan wayarka. Lokaci na magani na iya zama da amfani, suma.

Shin zan buƙaci amfani da wannan magani na dogon lokaci?

Tsawon lokacin da zaku buƙaci ɗaukar Mavyret ya dogara da abubuwa biyu. Waɗannan sun haɗa da ko an taɓa ba ka magani ta HCV a da, kuma idan kana da tabon hanta (cirrhosis).

Yawanci, jiyya tare da Mavyret yana ɗaukar ko'ina daga makonni 8 zuwa 16. Yawanci baya wuce sati 16.

Mavyret da barasa

Mavyret ba ta da wata sananniyar hulɗa da barasa. Koyaya, bai kamata ku sha barasa ba idan kuna da cutar hepatitis C virus (HCV). Barasa yana sa HCV ya zama mafi muni, wanda zai haifar da mummunan rauni (cirrhosis) a cikin hanta.

Idan kun sha barasa, kuma kuna damuwa game da yadda za ku daina shan giya, kuyi magana da likitanku.

Madadin Mavyret

Wasu kwayoyi suna nan wadanda zasu iya magance cutar hepatitis C virus (HCV). Wasu na iya zama sun fi dacewa da kai fiye da wasu. Idan kana sha'awar neman madadin Mavyret, yi magana da likitanka. Zasu iya gaya muku game da wasu magunguna waɗanda zasu iya muku aiki da kyau.

Sauran magunguna, waɗanda suka ƙunshi haɗakar magungunan ƙwayoyin cuta don magance HCV, sun haɗa da masu zuwa:

  • ledipasvir da sofosbuvir (Harvoni)
  • sofosbuvir da kuma velpatasvir (Epclusa)
  • velpatasvir, sofosbuvir, da kuma voxilaprevir (Vosevi)
  • elbasvir da grazoprevir (Zepatier)
  • simeprevir (Olysio) da sofosbuvir (Sovaldi)

Kodayake ba su zo a matsayin haɗin magunguna ba, ana iya haɗa Simeprevir (Olysio) da sofosbuvir (Sovaldi) tare don kula da HCV.

Mavyret da Harvoni

Kuna iya mamakin yadda Mavyret ya kwatanta da sauran magunguna waɗanda aka tsara don amfani iri ɗaya. Anan zamu kalli yadda Mavyret da Harvoni suke da kamanceceniya da juna.

Game da

Mavyret ya ƙunshi magungunan glecaprevir da pibrentasvir. Harvoni ya ƙunshi magungunan ledipasvir da sofosbuvir. Dukansu Mavyret da Harvoni suna ɗauke da haɗin ƙwayoyin cuta, kuma suna cikin ajin magunguna iri ɗaya.

Yana amfani da

Mavyret an yarda da ita don magance cutar hepatitis C mai saurin cutar (HCV) a cikin manya. An kuma yarda da amfani da shi a cikin yara masu shekaru 12 ko sama da haka, ko waɗanda suka aƙalla aƙalla kilogram 45, wanda ya kai kimanin lbs 99.

Ana amfani da Mavyret don magance kowane nau'in (1, 2, 3, 4, 5, da 6) na HCV a cikin mutane:

  • ba tare da tabon hanta ba (cirrhosis), ko kuma a cikin waɗanda suke da cutar cirrhosis ba tare da alamun alamun yanayin ba
  • wadanda suka sami dashen hanta ko koda
  • waɗanda ke da cutar HIV

Hakanan za'a iya amfani da Mavyret don magance nau'ikan HCV na 1 a cikin mutanen da aka yiwa magani a baya (amma ba a warke ba) tare da nau'in magani daban.

Harvoni an yarda dashi don magance HCV a cikin manya. Ana iya amfani dashi don magance waɗannan nau'ikan HCV:

  • nau'ikan 1, 2, 5, ko 6 a cikin mutanen da ba su da cutar hanta (cirrhosis), ko kuma waɗanda ke da cutar cirrhosis ba tare da alamun alamun yanayin ba.
  • rubuta 1 a cikin mutanen da ke fama da cututtukan cirrhosis tare da alamun yanayin (a cikin waɗannan mutane, Harvoni ya kamata a haɗe shi da ribavirin)
  • rubuta nau'in 1 ko 4 a cikin mutanen da suka karɓi dashen hanta, kuma ko dai basu da tabon hanta, ko kuma suna da ciwon hanta ba tare da alamomi ba (a cikin waɗannan mutane, Harvoni kuma ya kamata a haɗa shi da ribavirin)

Har ila yau an yarda da Harvoni don amfani a cikin yara masu shekaru 12 zuwa sama, ko waɗanda suka aƙalla aƙalla kilo 35, wanda yake kusan 77 lbs. Ana iya amfani dashi a cikin yara masu zuwa:

  • waɗanda ke da nau'ikan HCV iri 1, 4, 5, ko 6
  • yara ba tare da tabon hanta ba (cirrhosis), ko waɗanda ke da cutar cirrhosis amma waɗanda ba su da alamun yanayin

Magungunan ƙwayoyi da gudanarwa

Mavyret na zuwa kamar allunan, waɗanda ake sha da baki (tare da abinci) sau ɗaya a rana. Yawanci ana bayarwa na tsawon sati 8, 12, ko 16 dangane da tarihin jiyya da kuma yadda cutar hanta ta kasance.

Harvoni kuma yana zuwa kamar allunan, waɗanda ake sha da baki (tare ko ba abinci) sau ɗaya kowace rana. Yawanci ana bayar dashi tsawon sati 8, 12, ko 24 dangane da tarihin jiyya da yanayin hanta.

Sakamakon sakamako da kasada

Mavyret da Harvoni ba su da magunguna iri ɗaya, amma suna cikin rukunin magunguna iri ɗaya. Wadannan magunguna na iya haifar da wasu illoli iri daban-daban da kuma wasu illa daban-daban. Da ke ƙasa akwai misalai na waɗannan tasirin.

Commonarin sakamako masu illa na kowa

Wadannan jerin suna dauke da misalai na cututtukan da suka fi dacewa wadanda zasu iya faruwa tare da Mavyret, tare da Harvoni, ko kuma tare da magungunan biyu (lokacin da aka ɗauke su ɗayansu).

  • Zai iya faruwa tare da Mavyret:
    • gudawa
    • daukaka bilirubin (gwajin gwajin da ke duba aikin hanta)
  • Zai iya faruwa tare da Harvoni:
    • jin rauni
    • rashin bacci (matsalar bacci)
    • tari
    • jin haushi
  • Zai iya faruwa tare da Mavyret da Harvoni:
    • ciwon kai
    • jin kasala
    • tashin zuciya

M sakamako mai tsanani

M sakamako masu illa waɗanda zasu iya faruwa tare da Mavyret da Harvoni (idan aka ɗauki ɗayansu) sun haɗa da masu zuwa:

  • sake kunnawa cutar hepatitis B (wata kwayar cutar, idan ta riga ta cikin jikin ku) *
  • mai tsanani rashin lafiyan dauki

Inganci

Dukansu Mavyret da Harvoni an yarda dasu don magance cutar hepatitis C virus (HCV). Koyaya, magani daya na iya zama mai tasiri a gare ku fiye da ɗayan, ya danganta da nau'in HCV ɗin da kuke dashi kuma ko kuna da tabon hanta (cirrhosis).

Wadannan kwayoyi ba a kwatanta su kai tsaye a cikin nazarin asibiti ba. Amma binciken daban ya gano cewa duka Mavyret da Harvoni suna da tasiri wajen magance HCV.

Kudin

Mavyret da Harvoni duka magunguna ne masu suna. A halin yanzu babu nau'ikan nau'ikan nau'ikan magunguna. Magungunan sunaye suna yawanci suna da tsada fiye da na zamani.

Dangane da ƙididdiga akan GoodRx.com, Mavyret da Harvoni yawanci suna biyan kuɗi ɗaya. Ainihin farashin da zaku biya ko dai magani ya dogara da tsarin inshorar ku, wurin ku, da kuma kantin da kuka yi amfani da shi.

Mavyret vs. Epclusa

Kuna iya mamakin yadda Mavyret ya kwatanta da sauran magunguna waɗanda aka tsara don amfani iri ɗaya. Anan zamu kalli yadda Mavyret da Epclusa suke da kamanceceniya da juna.

Game da

Mavyret ya ƙunshi magungunan glecaprevir da pibrentasvir. Epclusa yana dauke da magungunan velpatasvir da sofosbuvir. Dukansu Mavyret da Epclusa suna ɗauke da haɗin magungunan ƙwayoyin cuta, kuma suna cikin rukunin magunguna iri ɗaya.

Yana amfani da

Mavyret an yarda da ita don magance cutar hepatitis C mai saurin cutar (HCV) a cikin manya. An kuma yarda da amfani da shi a cikin yara masu shekaru 12 ko sama da haka, ko waɗanda suka aƙalla aƙalla kilogram 45, wanda ya kai kimanin lbs 99.

Ana amfani da Mavyret don magance kowane nau'in (1, 2, 3, 4, 5, da 6) na HCV a cikin mutane:

  • ba tare da tabon hanta ba (cirrhosis), ko kuma a cikin waɗanda suke da cutar cirrhosis ba tare da alamun alamun yanayin ba
  • wadanda suka sami dashen hanta ko koda
  • waɗanda ke da cutar HIV

Hakanan za'a iya amfani da Mavyret don magance nau'ikan HCV na 1 a cikin mutanen da aka yiwa magani a baya (amma ba a warke ba) tare da nau'in magani daban.

Yawanci kamar Mavyret, Epclusa shima an yarda dashi don magance cutar ta HCV mai saurin lalacewa ta kowane nau'in ƙwayar cuta (iri 1, 2, 3, 4, 5, da 6). Ana amfani da shi a cikin manya waɗanda ba su da ciwon hanta (cirrhosis), ko kuma waɗanda ke da ciwon hanta waɗanda ba su da wata alama ta yanayin.

Hakanan za'a iya amfani da Epclusa a cikin manya da ke fama da cutar cirrhosis waɗanda ke da alamun cutar.

Epclusa ba a yarda da amfani da shi a cikin yara ba.

Magungunan ƙwayoyi da gudanarwa

Mavyret na zuwa kamar allunan, waɗanda ake sha da baki (tare da abinci) sau ɗaya a rana. Yawanci ana bayarwa na tsawon makonni 8, 12, ko 16 dangane da tarihin jiyya da kuma yadda cutar hanta ta kasance.

Epclusa shima yana zuwa kamar allunan, ana shan shi sau ɗaya a rana. Ana iya ɗaukar Epclusa tare da ko ba tare da abinci ba. Yawanci ana bayarwa na tsawon makonni 12.

Sakamakon sakamako da kasada

Mavyret da Epclusa ba su da magunguna iri ɗaya a cikinsu. Koyaya, suna cikin ajin magunguna iri ɗaya. Sabili da haka, duka magunguna na iya haifar da irin wannan tasirin. Da ke ƙasa akwai misalai na waɗannan tasirin.

Commonarin sakamako masu illa na kowa

Waɗannan jerin suna ƙunshe da misalai na cututtukan cututtukan yau da kullun waɗanda zasu iya faruwa tare da Mavyret, tare da Epclusa, ko tare da magungunan duka biyu (lokacin ɗauka daban-daban).

  • Zai iya faruwa tare da Mavyret:
    • gudawa
    • daukaka bilirubin (gwajin gwajin da ke duba aikin hanta)
  • Zai iya faruwa tare da Epclusa:
    • jin rauni
    • rashin bacci (matsalar bacci)
  • Zai iya faruwa tare da Mavyret da Epclusa:
    • ciwon kai
    • jin kasala
    • tashin zuciya

M sakamako mai tsanani

M sakamako masu illa waɗanda zasu iya faruwa tare da Mavyret da Epclusa (lokacin ɗauka daban-daban) sun haɗa da masu zuwa:

  • sake kunnawa cutar hepatitis B (wata kwayar cutar, idan ta riga ta cikin jikin ku) *
  • mai tsanani rashin lafiyan dauki

Inganci

Mavyret da Epclusa duka ana amfani dasu don kula da nau'ikan nau'ikan HCV guda shida. Likitanku na iya ba da shawarar cewa ku ɗauki Epclusa ko Mavyret gwargwadon nau'in HCV da kuke da shi da yanayin hanta.

Wadannan kwayoyi ba a kwatanta su kai tsaye a cikin nazarin asibiti ba. Amma binciken daban ya gano cewa duka Mavyret da Epclusa suna da tasiri wajen magance HCV.

Kudin

Mavyret da Epclusa duka magunguna ne masu suna. A halin yanzu babu nau'ikan nau'ikan nau'ikan magunguna. Magungunan sunaye suna yawanci suna da tsada fiye da na zamani.

Dangane da ƙididdiga akan GoodRx.com, Mavyret da Epclusa gaba ɗaya farashinsu ɗaya ne. Ainihin farashin da zaku biya ko dai magani ya dogara da tsarin inshorar ku, wurin ku, da kuma kantin da kuka yi amfani da shi.

Mavyret don cutar hepatitis C

Hukumar Abinci da Magunguna (FDA) ta amince da magungunan ƙwayoyi kamar Mavyret don magance wasu sharuɗɗa.

Mavyret an yarda da FDA ne don magance cututtukan da ke saurin kamuwa da cutar hepatitis C virus (HCV). Wannan kwayar cutar tana cutar hanta kuma tana haifar da kumburi, wanda wani lokaci yakan haifar da tabon hanta (wanda ake kira cirrhosis). HCV na iya haifar da bayyanar cututtuka kamar:

  • raunin fata da fararen idanun ki
  • tarin ruwa a cikin cikinka
  • zazzaɓi
  • matsaloli na dogon lokaci, kamar su hanta

HCV yana yaduwa ta cikin jini wanda ya kamu da kwayar. Rarrabawa (yadawa) galibi yana faruwa ta hanyar mutane da ke amfani da allurar rigakafin juna. A cewar Cibiyoyin Kula da Rigakafin Cututtuka (CDC), a cikin 2016 game da mutane miliyan 2.4 a Amurka suna da cutar hepatitis C.

An yarda Mavyret ta kula da cutar ta HCV a cikin manya. An kuma yarda da amfani da shi a cikin yara masu shekaru 12 ko sama da haka, ko waɗanda suka aƙalla aƙalla kilogram 45, wanda ya kai kimanin lbs 99. Ana amfani da shi don magance dukkan nau'ikan HCV (1, 2, 3, 4, 5, da 6) a cikin mutane:

  • ba tare da tabon hanta ba (cirrhosis), ko kuma a cikin waɗanda ke da cutar cirrhosis ba tare da alamun alamun yanayin ba (wanda ake kira cirrhosis da ake biya)
  • wadanda suka sami dashen hanta ko koda
  • waɗanda ke da cutar HIV

Hakanan za'a iya amfani da Mavyret don magance nau'ikan HCV na 1 a cikin mutanen da aka yiwa magani a baya (amma ba a warke ba) tare da nau'in magani daban.

Inganci

A cikin gwaji na asibiti, an ba manya da ke da cutar ta HCV (nau'ikan 1, 2, 3, 4, 5, da 6) waɗanda ba a taɓa ba su magani ba game da kwayar cutar an ba su Mavyret. Daga cikin waɗannan mutanen, kashi 98% zuwa 100% sun warke cikin makonni 8 zuwa 12 na jiyya. A cikin waɗannan karatun, samun warkarwa yana nufin cewa gwajin jinin mutane, wanda aka yi watanni uku bayan jiyya, ba a nuna alamun kamuwa da cutar ta HCV a jikinsu ba.

Daga dukkan mutanen da ke cikin karatun (duka waɗanda aka yiwa magani a baya da waɗanda ba su yi ba), tsakanin 92% da 100% sun warke daga HCV. Sakamakon ya banbanta dangane da ko an yiwa mutanen da a baya kuma akan nau'in HCV da suke da shi.

Gwaje-gwajen asibiti kuma sun kwatanta Mavyret da haɗuwa da wasu magungunan ƙwayoyin cuta guda biyu da ake kira sofosbuvir (Sovaldi) da daclatasvir (Daklinza). Studyaya daga cikin binciken ya kalli mutanen da ke da nau'ikan HCV na 3, waɗanda ba a taɓa bi da su ba. Wadannan mutane ba su da wata damuwa ta hanta (cirrhosis).

Bayan makonni 12, kashi 95.3% na mutanen da ke shan Mavyret an ɗauka cewa sun warke (ba su da cutar HCV a gwajin jininsu). Daga waɗanda ke shan sofosbuvir da daclatasvir, kashi 96.5 cikin ɗari suna da sakamako iri ɗaya.

Mavyret ga yara

An yarda da Mavyret don kula da HCV a cikin yara masu shekaru 12 zuwa sama, ko kuma waɗanda ke aƙalla nauyin kilogiram 45, wanda yake kusan lbs 99.

Mavyret hulɗa

Mavyret na iya hulɗa tare da wasu magunguna da yawa. Hakanan yana iya ma'amala tare da wasu ƙarin abubuwa.

Hanyoyi daban-daban na iya haifar da sakamako daban-daban. Misali, wasu ma'amala na iya tsoma baki game da yadda kwayoyi ke aiki sosai. Sauran hulɗar na iya ƙara tasirin illa ko sanya su mafi tsanani.

Mavyret da sauran magunguna

Da ke ƙasa akwai jerin magunguna waɗanda zasu iya hulɗa tare da Mavyret. Waɗannan jerin ba su ƙunshi duk magungunan da za su iya hulɗa da Mavyret.

Kafin shan Mavyret, yi magana da likitanka da likitan magunguna. Faɗa musu game da duk takardar sayen magani, da kan-kan-kanta, da sauran magungunan da kuke sha. Har ila yau, gaya musu game da kowane bitamin, ganye, da abubuwan da kuke amfani da su. Raba wannan bayanin na iya taimaka maka ka guji yiwuwar mu'amala.

Idan kuna da tambayoyi game da ma'amalar miyagun ƙwayoyi waɗanda zasu iya shafar ku, tambayi likitan ku ko likitan magunguna.

Mavyret da carbamazepine (Tegretol)

Shan carbamazepine tare da Mavyret na iya rage adadin Mavyret a jikinka. Wannan na iya haifar da maganin baya aiki da kyau, wanda zai iya haifar da cutar hepatitis C virus (HCV) ba cikakkiyar kulawa. Yana da mahimmanci a guji shan carbamazepine da Mavyret tare.

Mavyret da warfarin (Coumadin)

Shan warfarin tare da Mavyret na iya canza matakin warfarin a jikinku. Wannan na iya haifar da canje-canje a kaurin jininka, ya sa ya zama ya zama sirara ko kauri sosai. Idan wannan ya faru, kuna iya kasancewa cikin haɗarin wasu rikice-rikice, kamar zub da jini ko kumburin jini.

Idan kana shan Mavyret da warfarin, yana da mahimmanci a yi wasu gwaje-gwajen jini akai-akai don bincika kaurin jininka. Idan kuna buƙatar shan waɗannan magunguna tare, likitanku zai ba da shawarar hanyoyin da za su taimaka don tabbatar da amincinku yayin jiyya.

Mavyret da digoxin (Lanoxin)

Shan Mavyret tare da digoxin na iya kara matakan digoxin a jikinka. Wannan na iya haifar da bayyanar cututtuka kamar:

  • tashin zuciya
  • amai
  • gudawa
  • bugun zuciya mara tsari

Idan kana shan digoxin yayin da kake amfani da Mavyret, likitanka na iya buƙatar rage yawan digoxin naka. Wannan zai taimaka hana matakan digoxin ku daga yin yawa da haifar da sakamako masu illa. Likitanku na iya bincika matakan digoxin ku akan gwajin jini sau da yawa fiye da yadda kuka saba yayin shan Mavyret.

Mavyret da dabigatran (Pradaxa)

Shan Mavyret tare da dabigatran yana kara matakan dabigatran a jikinku. Idan wannan matakin ya yi yawa, za ku sami haɗarin zubar jini ko rauni. Hakanan zaka iya jin rauni. Wadannan bayyanar cututtuka na iya zama wani lokaci mai tsanani.

Idan kana shan dabigatran yayin da kake amfani da Mavyret, likitanka na iya buƙatar rage sashinka na dabigatran. Wannan zai taimaka don hana waɗannan alamun bayyanar daga faruwa.

Mavyret da rifampin (Rifadin)

Shan Mavyret tare da rifampin yana rage matakan Mavyret a jikinka. Idan matakin Mavyret a jikinka ya sauka, maganin bazai yi aiki sosai ba don magance HCV. Ya kamata ku guji shan Mavyret da Rifampin a lokaci guda.

Mavyret da wasu magungunan hana haihuwa

Wasu magungunan hana haihuwa suna dauke da wani magani da ake kira ethinyl estradiol. Shan wannan magani a hade tare da Mavyret na iya kara matakan jikinka na wani enzyme na hanta da ake kira alanine aminotransferase (ALT). Levelsara matakan ALT na iya sa alamun cututtukan hanta su ta'azzara.

An ba da shawarar cewa kada ku yi amfani da maganin hana haihuwa wanda ya ƙunshi ethinyl estradiol yayin shan Mavyret.

Misalan kwayoyin hana daukar ciki wadanda suka hada da ethinyl estradiol sun hada da:

  • levonorgestrel da ethinyl estradiol (Lessina, Levora, Lokacin)
  • lalacewa da kuma ethinyl estradiol (Apri, Kariva)
  • norethindrone da ethinyl estradiol (Balziva, Junel, Loestrin / Loestrin Fe, Microgestin / Microgestin Fe)
  • norgestrel da kuma ethinyl estradiol (Cryselle, Lo / Ovral)
  • drospirenone da kuma ethinyl estradiol (Loryna, Yaz)
  • norgestimate da ethinyl estradiol (Ortho Tri-Cyclen / Ortho Tri-Cyclen Lo, Sprintec, Tri-Sprintec, TriNessa)

Wannan ba cikakken jerin kwayoyin hana haihuwa bane wadanda suke dauke da ethinyl estradiol. Idan baku da tabbas idan nakuda na haihuwa yana da ethinyl estradiol a ciki, tabbas ku tambayi likitanku ko likitan magunguna.

Wasu sauran hanyoyin sarrafa haihuwa banda kwayoyi suma suna dauke da ethinyl estradiol. Wadannan hanyoyin sun hada da facin hana haihuwa (Ortho Evra) da zoben farji (NuvaRing).

Idan kana amfani da maganin haihuwa wanda ya ƙunshi ethinyl estradiol, yi magana da likitanka game da wasu zaɓuɓɓuka don hana ɗaukar ciki yayin ɗaukar Mavyret.

Mavyret da wasu magungunan cutar kanjamau

Wasu magungunan HIV (da ake kira antivirals) na iya shafar adadin Mavyret a jikinka. Misalan magungunan ƙwayoyin cuta waɗanda zasu iya canza yawan Mavyret a jikin ku sun haɗa da:

  • Atazanavir (Reyataz)
  • darunavir (Prezista)
  • lopinavir da ritonavir (Kaletra)
  • ritonavir (Norvir)
  • efavirenz (Sustiva)

Kada a ɗauki Atazanavir tare da Mavyret. Yin waɗannan magungunan tare yana ƙara matakin jikinku na wani enzyme na hanta da ake kira alanine aminotransferase (ALT). Levelsara matakan ALT na iya sa alamun cututtukan hanta su ta'azzara.

Shan Mavyret tare da darunavir, lopinavir, ko ritonavir shima ba a ba da shawarar ba. Wannan saboda wadannan kwayoyi masu kare ƙwayar cuta na iya kara matakan Mavyret a jikin ku. Wannan na iya haifar da ƙarin illa daga Mavyret.

Shan Mavyret tare da efavirenz yana rage matakan Mavyret a jikinka. Wannan na iya haifar da Mavyret baya aiki sosai. Ya kamata ku guji amfani da efavirenz yayin shan Mavyret.

Mavyret da wasu magungunan cholesterol

Shan Mavyret tare da wasu magungunan cholesterol da ake kira statins na iya kara matakin sittin a jikinka. Samun ƙarin matakan statins yana ƙara haɗarin tasirinku (kamar ciwo na tsoka) daga statin.

Misalan statins sun hada da:

  • atorvastatin (Lipitor)
  • Lovastatin (Mevacor)
  • simvastatin (Zocor)
  • farashi (Pravachol)
  • rosuvastatin (Crestor)
  • fluvastatin (Lescol)
  • pitavastatin (Livalo)

An ba da shawarar cewa kar ku ɗauki Mavyret a haɗe tare da atorvastatin, lovastatin, ko simvastatin. Waɗannan ƙwayoyin suna da haɗarin haɗarin haɗarin haɗari yayin da aka dauke su da Mavyret.

Ana iya ɗaukar Pravastatin tare da Mavyret idan likitanku ya ba da shawarar cewa kuna buƙatar maganin cholesterol. Dole ne a sauko da adadin ku na pravastatin kafin fara shan Mavyret. Wannan zai taimaka wajen rage haɗarin tasirinku daga yanayin.

Idan ana shan fluvastatin da pitavastatin tare da Mavyret, ya kamata a basu a mafi ƙarancin magani. Wannan yana taimakawa rage haɗarin samun ƙarin lahani daga yanayin.

Mavyret da cyclosporine (Sandimmune)

Ba a ba da shawarar Mavyret don amfani a cikin mutanen da ke ɗaukar fiye da 100 MG kowace rana na cyclosporine. Wannan magani yana ƙaruwa matakan Mavyret a jikinku, wanda zai iya haɓaka haɗarin tasirinku daga Mavyret.

Idan kana shan cyclosporine, yi magana da likitanka game da wane sashi na cyclosporine mafi aminci a gare ka.

Mavyret da omeprazole (ba ma'amala bane)

Babu sanannun hulɗa tsakanin omeprazole da Mavyret. Ana ba Omeprazole wani lokacin ga mutanen da ke shan Mavyret idan suna jin jiri a lokacin magani. Wani lokaci, tashin zuciya yana haifar da haɓakar acid a cikin ciki. Shan omeprazole zai taimaka wajen rage adadin acid a cikin cikin ka, wanda zai iya taimakawa rage wannan tasirin.

Mavyret da ibuprofen (ba ma'amala bane)

Babu sanannun hulɗa tsakanin ibuprofen da Mavyret. Ana iya amfani da Ibuprofen don magance ciwon kai a cikin mutanen da ke shan Mavyret. Ciwon kai shine sakamako na gama gari wanda zai iya faruwa yayin shan Mavyret. Ibuprofen na iya taimakawa rage zafi da rashin jin daɗin ciwon kai.

Mavyret da ganye da kari

Mavyret na iya yin hulɗa tare da wasu ganyayyaki da kari, gami da St. John's wort (wanda ke da cikakken bayani a ƙasa). Wadannan hulɗar na iya shafar yadda Mavyret ke aiki a jikinku.

Ya kamata ku sake nazarin duk magungunan da kuka sha (gami da kowane ganye da kari) tare da likitanku ko likitan magunguna kafin fara shan Mavyret.

Mavyret da St. John's wort

Shan wort na St. John tare da Mavyret na iya rage matakan Mavyret a jikin ku sosai. Wannan na iya haifar da Mavyret baya aiki sosai wajen magance cutar hepatitis C ɗinku. An ba da shawarar cewa kar ku ɗauki warin St. John yayin da kuke amfani da Mavyret.

Mavyret da ciki

Babu wani karatu a cikin mutane da ke kallon ko Mavyret tana da lafiya a ɗauka yayin ciki.

A cikin karatun dabbobi, ba a ga wata cuta ba a cikin tayi waɗanda aka ba iyayensu Mavyret yayin da suke da ciki. Koyaya, sakamakon karatun dabbobi ba koyaushe yake hango abin da zai faru a cikin mutane ba.

Idan kana da ciki ko kuma zaka iya yin ciki yayin amfani da Mavyret, yi magana da likitanka. Zasu iya tattauna muku haɗari da fa'idodi na amfani da wannan magani a lokacin daukar ciki.

Mavyret da nono

Babu wani karatu a cikin mutane don sanin ko Mavyret ya shiga cikin nono, ko kuma idan yana da wani tasiri a kan yaron da ke shayarwa.

A cikin karatun dabbobi, Mavyret ya shiga cikin madarar berayen da ke shayarwa. Koyaya, wannan madarar ba ta cutar da dabbobin da suka cinye ta ba. Ka tuna cewa waɗannan sakamakon na iya bambanta da mutane.

Idan kuna shayarwa, ko shirin shayarwa yayin shan Mavyret, yi magana da likitanka game da ko wannan zaɓi ne mai aminci. Suna iya ba da shawarar wasu hanyoyin masu lafiya don ciyar da yaro.

Yadda ake shan Mavyret

Ya kamata ku ɗauki Mavyret bisa ga umarnin likitanku ko umarnin mai ba da lafiya.

Yaushe za'a dauka

Ba damuwa komai lokacin da kuka zaɓi ɗaukar Mavyret, amma yakamata ku ɗauke shi kusan lokaci ɗaya kowace rana. Wannan yana taimakawa magani yayi aiki yadda yakamata a cikin jikinku.

Don taimakawa tabbatar cewa baka rasa kashi ba, gwada saita tunatarwa akan wayarka. Lokaci na magani na iya zama da amfani, suma.

Shan Mavyret tare da abinci

Ya kamata a dauki Mavyret da abinci. Wannan yana taimakawa jikinka don karɓar maganin.

Shin za a iya murƙushe Mavyret, a raba shi, ko a tauna?

A'a, Mavyret bai kamata a raba shi, a murƙushe shi ba, ko kuma a tauna shi. Ana nufin allunan da za a haɗiye su duka. Rabawa, murkushe su, ko tauna su na iya rage adadin maganin da ke shiga jikin ku. Wannan na iya haifar da Mavyret baya aiki sosai wajen magance cutar hepatitis C ɗinku.

Ta yaya Mavyret ke aiki

An amince da Mavyret don magance cutar hepatitis C mai saurin cutar (HCV). Wannan kwayar cutar tana haifar da cuta a jikinka wanda ke shafar hanta. HCV na iya haifar da mummunan lahani na hanta idan ba a bi da shi daidai ba.

Mavyret ta ƙunshi kwayoyi biyu: glecaprevir da pibrentasvir. Yana aiki ta hanyar dakatar da kwayar hepatitis C daga ninkawa (yin ƙarin ƙwayoyin cuta) a cikin jikinku. Saboda kwayar cutar ba ta iya ninkawa, daga karshe za ta mutu.

Da zarar duk kwayar cutar ta mutu, kuma ba ta cikin jikinka, hanta zai iya fara warkewa. Mavyret tana aiki don magance dukkan nau'ikan guda shida (1, 2, 3, 4, 5, da 6) na HCV.

Yaya tsawon lokacin aiki?

Yayin karatun asibiti, 92% zuwa 100% mutanen da ke tare da HCV sun warke bayan shan Mavyret na tsawan lokacin da suka tsara. Wannan tsawon lokacin ya fara ne daga makonni 8 zuwa 16.

A cikin waɗannan karatun, samun warkarwa yana nufin cewa gwajin jinin mutane, wanda aka yi watanni uku bayan jiyya, ba a nuna alamun kamuwa da cutar ta HCV a jikinsu ba.

Tambayoyi gama gari game da Mavyret

Anan akwai amsoshi ga wasu tambayoyin da akai akai game da Mavyret.

Shin zan iya shan Mavyret idan ina da HIV da hepatitis C?

Ee, zaku iya shan Mavyret idan kuna da kwayar HIV da hepatitis C virus (HCV). Samun HIV ba zai canza yadda Mavyret ke aiki a jikinka don magance HCV ba.

Yaya nasarar Mavyret ta magance hepatitis C?

An nuna Mavyret tana da matukar tasiri wajen warkar da cututtukan hepatitis C (HCV). A cikin gwaji na asibiti, tsakanin 98% da 100% na mutanen da ke shan Mavyret sun warke daga HCV.

A cikin waɗannan karatun, samun warkarwa yana nufin cewa gwajin jinin mutane, wanda aka yi watanni uku bayan jiyya, bai nuna alamun kamuwa da cutar ta HCV ba. Yawan mutanen da aka warkar sun dogara da nau'in HCV da suke da shi, da kuma irin maganin da za su yi amfani da shi a baya.

Idan na sha wasu maganin hepatitis C, zan iya amfani da Mavyret?

Idan kun gwada wasu magunguna don cutar hepatitis C ɗin ku wanda bai yi aiki ba (ya warkar da cutar ku), mai yiwuwa har yanzu kuna iya amfani da Mavyret. Dogaro da waɗanne ƙwayoyi da kuka yi amfani da su a baya, tsayin maganinku tare da Mavyret zai iya zama ko'ina daga makonni 8 zuwa 16.

Idan kuna da tambayoyi game da ko zaku iya amfani da Mavyret, kuyi magana da likitanku.

Shin zan bukaci kowane gwaji kafin ko yayin jinyar Mavyret?

Kafin ka fara jiyya da Mavyret, likitanka zai gwada jininka game da cutar hepatitis B (HBV). Idan kana da HBV, zai iya sake kunnawa (yayi sama sama) yayin maganin Mavyret. Sake kunnawa na HBV na iya haifar da matsalolin hanta mai tsanani, gami da gazawar hanta da mutuwa.

Idan kuna da HBV, likitanku zai ba da shawarar gwajin jini yayin aikinku na Mavyret don bincika sake kunnawa HBV. Kuna iya buƙatar a yi muku maganin HBV kafin fara shan Mavyret.

Shin zan iya amfani da Mavyret idan ina da cutar cirrhosis?

Kuna iya iya, amma ya danganta da irin tsananin cutar kumburin hanji (hanjin hanta).

Ana iya amfani da Mavyret idan ka biya diyyar cutar sankarau. Tare da wannan yanayin, hantar ka na da tabo, amma ba ka da wata alama ta yanayin kuma hanta ta na aiki har yanzu.

Ba a riga an amince da Mavyret don amfani a cikin mutanen da ke fama da cututtukan cirrhosis ba. Da wannan yanayin, hantar ka tana da tabo kuma kana da alamun cutar. Kwayar cutar na iya haɗawa da:

  • raunin fata ko fararen idanun ki
  • karin ruwa a cikin ciki
  • faɗaɗa jijiyoyin jini a cikin maƙogwaronka, wanda na iya haifar da zub da jini

Idan kana da cutar cirrhosis amma ba ka tabbatar da wane iri ba, yi magana da likitanka.

Mavyret kiyayewa

Wannan magani ya zo tare da kariya da yawa.

Gargadin FDA: sake farfado da kwayar hepatitis B

Wannan magani yana da gargaɗin dambe. Wannan shine gargadi mafi tsanani daga Hukumar Abinci da Magunguna (FDA). Gargaɗin gargaɗi na faɗakarwa ga likitoci da marasa lafiya game da tasirin kwayoyi waɗanda na iya zama haɗari.

Maganin Mavyret yana kara haɗarin sake kamuwa da cutar hepatitis B (HBV) a cikin mutanen da ke da HBV da hepatitis C virus (HCV). A cikin yanayi mai tsanani, sake kunnawa na HBV na iya haifar da gazawar hanta ko ma mutuwa.

Kafin fara Mavyret, likitanku zai gwada ku don cutar HBV. Idan kuna da HBV, kuna iya buƙatar a kula da shi kafin fara shan Mavyret. Ko kuma likitanka na iya ba da shawarar gwaji yayin jinyar Mavyret don bincika sake kunnawa HBV.

Sauran gargadi

Kafin shan Mavyret, yi magana da likitanka game da tarihin lafiyar ku. Mavyret bazai dace da ku ba idan kuna da wasu sharuɗɗan likita. Wadannan sun hada da:

  • Rashin hanta. Idan kuna da gazawar hanta, shan Mavyret na iya tsananta yanayinku. Yi magana da likitanka idan kuna da tarihin cutar hanta ko gazawar hanta kafin fara magani tare da Mavyret.
  • Amfani atazanavir ko rifampin a yanzu. Kada a taɓa amfani da Mavyret a cikin mutanen da ke shan ko dai atazanavir ko rifampin. Maaukar Mavyret da rifampin tare na iya rage matakan Mavyret a jikin ku. Wannan na iya sa Mavyret ba ta da tasiri a gare ku. Shan atazanavir tare da Mavyret na iya kara yawan Mavyret a jikinka. Wannan na iya kara matakan enzyme na hanta (wanda ake kira alanine aminotransferase), wanda zai iya zama mai hatsari. Duba sashen "Mavyret interactions" don ƙarin bayani. Koyaushe yi magana da likitanka game da kowane magani da kake sha kafin ka fara Mavyret.
  • Ciki. Ba a san ko Mavyret na iya shafar ci gaban ciki. A cikin nazarin dabba, Mavyret bai haifar da lahani ba yayin amfani da shi yayin ɗaukar ciki. Koyaya wannan sakamakon na iya zama daban a cikin mutane. Don ƙarin bayani, da fatan za a duba sashin “Mavyret da ciki” da ke sama.
  • Shan nono. Ba a san ko Mavyret ta shiga cikin nono na ɗan adam ba, ko kuma idan ta cutar da yaro mai shayarwa. A cikin karatun dabbobi, Mavyret ta shiga cikin nono, amma hakan bai haifar da illa ga dabbobin da suka sha nonon ba. Koyaya, wannan sakamakon na iya zama daban a cikin mutane. Don ƙarin bayani, da fatan za a duba sashin “Mavyret da shayarwa” da ke sama.

Lura: Don ƙarin bayani game da tasirin mummunan tasirin Mavyret, duba sashin “Mavyret side effects” a sama.

Mavyret yawan abin da ya kamata

Yin amfani da fiye da shawarar Mavyret na iya haifar da mummunar illa. Kada ka taɓa ɗaukar fiye da abin da likitanka ya tsara maka.

Abin da za a yi idan ya wuce gona da iri

Idan ka yi tunanin kun sha da yawa daga wannan magani, kira likitan ku. Hakanan zaka iya kiran Associationungiyar ofungiyar Kula da Guba ta Amurka a 800-222-1222 ko amfani da kayan aikinsu na kan layi. Amma idan alamun ka masu tsanani ne, kira 911 ko ka je dakin gaggawa mafi kusa kai tsaye.

Vyarewar Mavyret, ajiya, da zubar dashi

Lokacin da ka samo Mavyret daga kantin magani, malamin likitancin zai ƙara kwanan wata da ƙarewa zuwa lakabin kan kwalban. Wannan kwanan wata galibi shekara ɗaya ce daga ranar da suka ba da magani.

Ranar karewa yana taimakawa tabbatar da ingancin magani a wannan lokacin. Matsayi na Hukumar Abinci da Magunguna ta yanzu (FDA) shine gujewa amfani da magungunan da suka ƙare. Idan kana da maganin da ba a amfani da shi wanda ya wuce ranar karewa, yi magana da likitan ka game da ko har yanzu zaka iya amfani da shi.

Ma'aji

Yaya tsawon magani ya kasance mai kyau na iya dogara da dalilai da yawa, gami da yadda da kuma inda kuka adana maganin.

Ya kamata a adana Allunan na Mavyret a zazzabin ɗaki (ƙasa da 86 ° F / 30 ° C) a cikin akwati da aka kulle sosai, nesa da haske. Guji adana wannan magani a wuraren da zai iya yin danshi ko rigar, kamar a cikin ɗakunan wanka.

Zubar da hankali

Idan baku da bukatar shan Mavyret kuma kuna da ragowar shan magani, yana da mahimmanci a zubar da shi lafiya. Wannan yana taimakawa hana wasu, gami da yara da dabbobin gida, daga shan ƙwaya kwatsam. Hakanan yana taimakawa kiyaye miyagun ƙwayoyi daga cutar da muhalli.

Yanar gizo na FDA yana ba da shawarwari masu amfani da yawa game da zubar da magani. Hakanan zaka iya tambayar likitan ka bayani game da yadda zaka zubar da maganin ka.

Bayani na ƙwararru don Mavyret

Ana ba da bayanin nan na gaba don likitoci da sauran ƙwararrun likitocin kiwon lafiya.

Manuniya

An nuna Mavyret don maganin cutar hepatitis C mai cutar (HCV) na jinsi na 1, 2, 3, 4, 5, da 6. Mavyret an yarda da amfani da ita a cikin manya da yara masu shekaru 12 zuwa sama, ko waɗanda suka aƙalla aƙalla 45 kg

Ya kamata a yi amfani dashi kawai ga marasa lafiya ba tare da cirrhosis ba, ko kuma a cikin waɗanda ke da cututtukan cirrhosis.

An kuma nuna Mavyret don magance kwayar cutar hepatitis C ta genotype 1 a cikin mutanen da magungunan da suka gabata ba su yi nasara ba. Wadannan jiyya na farko ya kamata su haɗa da mai hana HCV NS5A ko mai hana NS3 / 4A.

Ba a nuna Mavyret don amfani a marasa lafiya ba wanda magani na farko ya kasa amfani da mai hana HCV NS5A da mai hana NS3 / 4A.

Hanyar aiwatarwa

Mavyret ya ƙunshi glecaprevir da pibrentasvir. Wadannan kwayoyi sune magungunan rigakafin cutar kai tsaye wadanda ke yakar HCV.

Glecaprevir shine mai hana NS3 / 4A protease. Yana aiki ne ta hanyar niyya NS3 / 4A protease, wanda ya zama dole don ci gaban kwayar cutar hepatitis C.

Pibrentasvir shine mai hana NS5A. Ta hanyar toshe NS5A, pibrentasvir yana dakatar da kwayar cutar hepatitis C.

Mavyret yana da tasiri game da cututtukan hepatitis C kwayar cutar 1, 2, 3, 4, 5, da 6.

Pharmacokinetics da metabolism

A cikin wani binciken da ya shafi mutanen da ba su da cutar ta HCV waɗanda aka ɗauka suna da ƙoshin lafiya, kasancewar kasancewar abinci ya shafi tasirin Mavyret sosai. Lokacin da aka ɗauka tare da abinci, shan glecaprevir ya ƙaru da 83% zuwa 163%. An ƙara shan pibrentasvir da kashi 40% zuwa 53%. Saboda haka, ana ba da shawarar a dauki Mavyret tare da abinci don haɓaka haɓakar sa.

Matsakaicin ƙwayar plasma na Mavyret na faruwa kusan kimanin awanni 5 bayan an gama musu magani. Rabin rayuwar glecaprevir shine awanni 6, yayin da rabin rayuwar pibrentasvir shine awanni 13.

Mavyret galibi ana fitar dashi ta hanyar hanyar biliary-fecal. Mafi yawan glecaprevir da pibrentasvir sune daure protein mai jini.

Contraindications

Mavyret an hana shi cikin marasa lafiya da ke fama da cutar hanta mai haɗari, wanda aka bayyana a matsayin ƙimar yaro-Pugh C.

Har ila yau, Mavyret an hana shi ga marasa lafiya waɗanda ke shan ko dai atazanavir ko rifampin. Hankalin Mavyret ya ragu ƙwarai da rifampin, wanda na iya rage ko hana tasirin maganin Mavyret. Kada a ɗauki Mavyret tare da atazanavir saboda haɗuwa da ƙwayoyi na iya ƙara matakan alanine aminotransferase (ALT), wanda ke haifar da haɗarin gazawar hanta.

Ma'aji

Ya kamata a adana Mavyret a ko a ƙasa da 86 ° F (30 ° C) a cikin marufi, busassun akwati.

Bayanin sanarwa: Labaran Likita a Yau sun yi iya kokarinsu don tabbatar da cewa dukkan bayanan gaskiya ne, cikakke, kuma na zamani. Koyaya, wannan labarin bai kamata ayi amfani dashi azaman madadin ilimi da ƙwarewar ƙwararren likita mai lasisi ba. Ya kamata koyaushe ku tuntuɓi likitanku ko wasu masu sana'a na kiwon lafiya kafin shan kowane magani. Bayanin magani da ke cikin wannan batun na iya canzawa kuma ba ana nufin ya rufe duk amfanin da zai yiwu ba, kwatance, kiyayewa, gargaɗi, hulɗar miyagun ƙwayoyi, halayen rashin lafiyan, ko cutarwa. Rashin gargadin ko wasu bayanai don maganin da aka bayar baya nuna cewa magani ko haɗin magungunan yana da aminci, tasiri, ko dacewa ga duk marasa lafiya ko duk takamaiman amfani.

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