Membranoproliferative glomerulonephritis

Membranoproliferative glomerulonephritis cuta ce ta koda wanda ya shafi kumburi da canje-canje ga ƙwayoyin koda. Yana iya haifar da gazawar koda.

Glomerulonephritis kumburi ne na glomeruli. Gwanin koda yana taimakawa wajen tace sharar ruwa da ruwa daga jini don samar da fitsari.

Membranoproliferative glomerulonephritis (MPGN) wani nau'i ne na glomerulonephritis wanda ya haifar da mummunan sakamako na rigakafi. Adana abubuwan rigakafin jikin mutum sun ginu a cikin wani bangare na kodan da ake kira membrane ginshiki mai danshi. Wannan membrane yana taimakawa wajen tace sharar da karin ruwa daga jini.

Lalacewa akan wannan membrane yana shafar kwayar koda don kirkirar fitsari kullum. Yana iya barin jini da furotin su zube cikin fitsarin. Idan isasshen furotin ya zube a cikin fitsarin, ruwa na iya fita daga jijiyoyin jini zuwa cikin kayan jikin mutum, wanda ke haifar da kumburi (edema). Hakanan abubuwan asirin nitrogen na iya zama a cikin jini (azotemia).

Siffofin 2 na wannan cutar sune MPGN I da MPGN II.

Yawancin mutanen da ke fama da cutar suna da nau'in I. MPGN II ba su da yawa. Hakanan yana saurin zama mafi muni fiye da MPGN I.

Dalilin MPGN na iya haɗawa da:

• Autoimmune cututtuka (tsarin lupus erythematosus, scleroderma, Sjögren ciwo, sarcoidosis)
• Ciwon daji (cutar sankarar bargo, lymphoma)
• Cututtuka (hepatitis B, hepatitis C, endocarditis, malaria)

Kwayar cutar na iya haɗawa da ɗayan masu zuwa:

• Jini a cikin fitsari
• Canje-canje a cikin halin tunani kamar rage faɗakarwa ko rage natsuwa
• Fitsari mai duhu
• Duhun fitsari (hayaki, cola, ko launin shayi)
• Rage yawan fitsarin
• Kumburin kowane bangare na jiki

Mai ba da sabis na kiwon lafiya zai bincika ku kuma ya yi tambaya game da alamunku. Mai ba da sabis ɗin na iya gano cewa kuna da alamun yawan ruwa a jiki, kamar:

• Kumburi, galibi a kafafu
• Sautunan da ba na al'ada ba lokacin sauraron zuciyar ku da huhunku tare da na'urar daukar hoto
• Kuna iya samun cutar hawan jini

Wadannan gwaje-gwajen suna taimakawa wajen tabbatar da cutar:

• BUN da gwajin jini na creatinine
• Matakan haɓaka jini
• Fitsari
• Fitsarin fitsari
• Koda biopsy (don tabbatar da membranoproliferative GN I ko II)

Jiyya ya dogara da alamun. Manufofin magani sune don rage bayyanar cututtuka, hana rikitarwa, da rage saurin ci gaban cutar.

Kuna iya buƙatar canjin abinci. Wannan na iya haɗawa da iyakance sodium, ruwaye, ko furotin don taimakawa sarrafa hawan jini, kumburi, da kuma tara abubuwan ɓarnatar a cikin jini.

Magunguna waɗanda za a iya tsara su sun haɗa da:

• Magungunan hawan jini
• Dipyridamole, tare da ko ba tare da asfirin ba
• Diuretics
• Magunguna don dakile tsarin garkuwar jiki, kamar cyclophosphamide
• Steroids

Jiyya ya fi tasiri ga yara fiye da na manya. Dialysis ko dashen koda na iya zama karshe a samu nasarar sarrafa gazawar koda.

Rashin lafiyar yakan zama da hankali sannu a hankali kuma a ƙarshe yana haifar da gazawar koda.

Rabin mutanen da ke da wannan yanayin suna haifar da gazawar koda na tsawon lokaci (cikin shekaru 10). Wannan ya fi dacewa ga waɗanda ke da matakan furotin da yawa a cikin fitsarinsu.

Matsalolin da zasu iya haifar da wannan cutar sun hada da:

• Ciwon nephritic ciwo
• M gazawar koda
• Ciwon koda na kullum

Kira don alƙawari tare da mai ba da sabis idan:

• Kuna da alamun wannan yanayin
• Alamun cutar ku na kara muni ko kuma basa tafiya
• Kuna inganta sababbin cututtuka, gami da rage fitowar fitsari

Yin rigakafin kamuwa da cututtuka irin su ciwon hanta ko sarrafa cututtuka kamar su lupus na iya taimakawa hana MPGN.

Membranoproliferative GN I; Membranoproliferative GN II; Mesangiocapillary glomerulonephritis; Membranoproliferative glomerulonephritis; GN mara amfani; Glomerulonephritis - membranoproliferative; Rubuta MPGN I; Nau'in MPGN

• Ciwon jikin koda

Roberts ISD. Cututtukan koda. A cikin: Cross SS, ed. Woodwararrun woodwararrun woodwararrun woodwararrun woodwararrun Underwararru. 7th ed. Philadelphia, PA: Elsevier; 2019: sura 21.

Saha MK, Pendergraft WF, Jennette JC, Falk RJ. Cutar farko ta glomerular. A cikin: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner da Rector na Koda. 11th ed. Philadelphia, PA: Elsevier; 2020: babi na 31.

Sethi S, De Vriese AS, Fervenza FC. Membranoproliferative glomerulonephritis da kuma cryoglobulinemic glomerulonephritis. A cikin: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. M Clinical Nephrology. Na 6 ed. Philadelphia, PA: Elsevier; 2019: sura 21.