Ketamine zai iya Taimakawa Maganin Bacin rai?

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Rashin damuwa ya fi kowa fiye da yadda kuke tunani. Yana shafar fiye da Amurkawa miliyan 15, kuma Hukumar Lafiya ta Duniya ta kiyasta cewa adadin ya karu zuwa miliyan 300 idan aka fadada duniya. Akwai kashe nau'ikan zaɓuɓɓukan magani daban-daban waɗanda ke samuwa don taimakawa wajen rage alamunta-tunanin damuwa, rashin bacci, gajiya, da asarar ci a tsakanin wasu-tare da mafi yawan jiyya shine masu hana masu satar maganin serotonin (ko SSRIs). Amma tun game da 2000, likitoci da masu bincike suna yin gwaji tare da ketamine-ainihin magungunan maganin ciwo mai zafi, yanzu ana amfani da su azaman maganin titi saboda tasirin hallucinogenic-a matsayin wata hanya mai mahimmanci don magance yanayin, a cewar Ruben Abagyan, Ph.D. , farfesa a fannin harhada magunguna a Jami'ar California San Diego (UCSD).

Wataƙila kuna tunani, "Dakata! Menene?" Idan kun ji ketamine, wanda kuma aka sani da Special K, kun san ba abin wasa ba ne ko magungunan OTC na yau da kullun. A zahiri, an san shi azaman dissociative disestative (ma'anar magani wanda ke gurbata hangen nesa da sauti, yayin da yake haifar da ji na zahiri daga kai da muhalli). Likitocin dabbobi ne ke amfani da shi da farko don magance ciwo a cikin dabbobi, amma kuma ana iya ba shi izini ga mutane don gudanar da ciwo mai tsanani, musamman waɗanda ke da lamuran neuropathic, wani nau'in ciwon jijiya mai ɗorewa, a cewar wani binciken da aka buga a cikin 2014. Jaridar British Journal of Pharmacology.

"An san cewa ciwo da damuwa suna da alaƙa," in ji Isaac Cohen, wani ɗalibin ilimin harhada magunguna wanda ya yi aiki a kan binciken. "Mutanen da ke cikin mawuyacin hali za su iya rayuwa kan jin zafi kuma mutanen da ke fama da matsanancin ciwo na iya zama masu baƙin ciki saboda raguwar motsi, ƙarancin motsa jiki, da sauran dalilai, in ji shi." Ketamine na musamman ne saboda yana iya magance duka ciwo da bacin rai a lokaci guda, yana haifar da ingantacciyar sakamako ga yanayin duka biyun." Kuma yanzu masana kimiyya suna jayayya cewa ba kawai shaidar zurfafa ba, har ma da bayanan ƙididdiga waɗanda ke nuna ketamine na iya taimakawa rage alamun damuwa.

A cikin bincike mai girma na farko na irinsa, wanda aka buga a Yanayi, masu bincike sun gano cewa marasa lafiya da suka karɓi ketamine sun ba da rahoton raguwar yanayin baƙin ciki sosai. Wannan binciken, wanda Makarantar Pharmacy da Kimiyyar Magunguna a UCSD suka gudanar, yana ƙarfafa bayanan anecdotal da ƙananan nazarin yawan jama'a waɗanda kuma suka ba da shawarar tasirin ketamine na antidepressive.

Abin da ke ketamine baya ga sauran jiyya, musamman, shine yadda sauri yake ɗaukar sakamako. Abaygan ya ce "Magungunan da FDA ta amince da su a halin yanzu sun gaza ga miliyoyin saboda ba sa aiki da sauri." Ketamine yana aiki a cikin sa'o'i kadan. Wannan ya yi ƙasa da SSRIs, alal misali, wanda zai iya ɗaukar makonni shida zuwa goma don isa ga cikakken ƙarfin su. Kuma wannan bambance-bambancen lokaci na iya kasancewa a zahiri lamari ne na rayuwa ko mutuwa, musamman tare da waɗanda ke fuskantar tunanin kashe kansu.

Don binciken su, Abaygan da tawagarsa sun yi bitar bayanai daga Tsarin Rahoton Rahoton Mutuwar FDA, hukumar da ke tattara bayanai game da illolin da ba su dace ba (ko ba da sani ba na kowane iri) na duk wani magani da aka amince da shi wanda likitoci da likitoci suka ruwaito. Musamman, sun sami marasa lafiya 40,000 waɗanda aka ba da magani don jin zafi kuma sun raba su zuwa ƙungiyoyi biyu-waɗanda suka ɗauki ketamine da waɗanda aka bi da su tare da wasu magunguna masu zafi (ban da NSAIDs).

Sakamakon ya nuna wani mahimmiyar “bonus,” duk da cewa ba a yi niyya ba, sakamako. Rabin mutanen da suka yi maganin ciwon su tare da ketamine sun ba da rahoton cewa ba su da ƙanƙantar da kai fiye da waɗanda suka ɗauki wasu magunguna na rage radadin ciwo. Kodayake ba mu sani ba ko wani daga cikin waɗannan marasa lafiya, musamman waɗanda ke ketamine, suna fuskantar alamun bacin rai kafin ɗaukar kowane meds, sakamako mai kyau akan yanayi, haɗe da haɗin haɗin gwiwa tsakanin zafi da ɓacin rai, na iya ba da ƙarin ƙarin tattaunawa kan amfani da ketamine. bi da bakin ciki kai tsaye.

A cewar masu binciken, ketamine ba shi da tsada sosai kuma idan a baya kun gwada aƙalla wasu magungunan rage damuwa guda uku ba tare da nasara ba, yawancin tsare-tsaren inshora na kiwon lafiya suna rufe shi. Nuna kasancewar? Kada ku yi gaggawar rubuta ketamine kamar hallucinogen. Yana iya zama na musamman bayan duk. (Kuma idan babu wani abu, mutane, duba waɗannan hanyoyin don sarrafa damuwa ko damuwa a kowane lokaci.)

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