Nicotinamide Riboside: Fa'idodi, Tasirin Gyara da Amfani

Wadatacce

• Menene Nicotinamide Riboside?
• Abubuwan Fa'ida
• Sauƙaƙe An Sauya Cikin NAD +
• Kunna Enzymes Masu Iya Inganta Lafiya
• Zan Iya Taimakawa Kare ƙwayoyin inwalwa
• Mai Yiwuwar Hadarin Cutar Zuciya
• Sauran Fa'idodin Dama
• Hadarin da ke tattare da shi da kuma Illolin da ke faruwa
• Sashi da Shawarwarin
• Layin .asa

Kowace shekara, Amurkawa suna kashe biliyoyin daloli kan kayayyakin tsufa.

Yayinda yawancin kayan tsufa ke kokarin jujjuya alamun tsufa akan fatarka, nicotinamide riboside - wanda ake kira niagen - da nufin juya alamun tsufa daga cikin jikinka.

A cikin jikinku, nicotinamide riboside ya canza zuwa NAD +, kwayar taimakon da ke wanzu a cikin kowace kwayarku kuma tana tallafawa fannoni da yawa na tsufa mai lafiya.

Wannan labarin yana bayanin duk abin da kuke buƙatar sani game da nicotinamide riboside, gami da fa'idodi, sakamako masu illa da sashi.

Menene Nicotinamide Riboside?

Nicotinamide riboside, ko niagen, wani nau'i ne na bitamin B3, wanda ake kira niacin.

Kamar sauran nau'ikan bitamin B3, nicotinamide riboside yana jujjuyawar jikinku zuwa nicotinamide adenine dinucleotide (NAD +), coenzyme ko molin taimakon.

NAD + yana aiki da man fetur don yawancin hanyoyin nazarin halittu, kamar (,):

• Canza abinci zuwa makamashi
• Gyara DNA da ya lalace
• Tifarfafa ƙwayoyin tsarin tsaro
• Kafa agogon cikin jikinka ko kuma motsin circadian

Koyaya, adadin NAD + a cikin jikinku kwatankwacin tsufa ().

Beenananan matakan NAD + sun haɗu da damuwa na kiwon lafiya kamar tsufa da cututtuka na yau da kullun, irin su ciwon sukari, cututtukan zuciya, cutar Alzheimer da rashin gani ().

Abin sha'awa shine, binciken dabba ya gano cewa haɓaka matakan NAD + na iya taimakawa wajen kawar da alamun tsufa da rage haɗarin yawancin cututtuka na yau da kullun (,,).

Nicotinamide riboside kari - kamar niagen - sun zama sanannun mutane da sauri saboda suna nuna suna da tasiri musamman wajen haɓaka matakan NAD + ().

Hakanan ana samun Nicotinamide riboside a cikin adadin da aka gano a madarar shanu, yisti da giya ().

Nicotinamide riboside, ko niagen, wani nau'i ne na bitamin B3. An inganta shi azaman ƙarin haɓakar tsufa saboda yana haɓaka matakan jikinku na NAD +, wanda ke aiki azaman mai don yawancin mahimman hanyoyin nazarin halittu.

Abubuwan Fa'ida

Saboda yawancin bincike akan nicotinamide riboside da NAD + sun fito ne daga karatun dabba, ba za'a yanke hukunci mai ma'ana game da tasirin sa ga mutane ba.

Wancan ya ce, a nan akwai wasu fa'idodi masu fa'ida ga lafiyar nicotinamide riboside.

Sauƙaƙe An Sauya Cikin NAD +

NAD + shine coenzyme, ko kuma molecule mai taimakon, wanda ke shiga cikin halayen halayen rayuwa da yawa.

Duk da yake yana da mahimmanci ga lafiyar mafi kyau duka, bincike ya nuna cewa matakan NAD + na ci gaba da faɗuwa tare da shekaru. Levelsananan matakan NAD + suna da alaƙa da rashin tsufa da ƙananan cututtuka masu cutarwa (,).

Aya daga cikin hanyoyin haɓaka matakan NAD + shine cinye magabatan NAD + - tubalin ginin NAD + - kamar su nicotinamide riboside.

Karatun dabbobi ya nuna cewa nicotinamide riboside yana haɓaka matakan NAD + na jini har zuwa sau 2.7. Abin da ya fi haka, jikinka ya fi amfani da shi fiye da sauran magabatan NAD + ().

Kunna Enzymes Masu Iya Inganta Lafiya

Nicotinamide riboside yana taimakawa haɓaka matakan NAD + a jikinku.

A cikin martani, NAD + yana kunna wasu enzymes waɗanda zasu iya inganta tsufa mai kyau.

Groupungiya ɗaya ita ce sirtuins, waɗanda ke bayyana inganta rayuwa da lafiyar lafiyar dabbobi. Nazarin ya nuna cewa sirtuins na iya gyara DNA da aka lalata, haɓaka ƙarfin juriya, rage kumburi da bayar da wasu fa'idodi waɗanda ke inganta tsufa mai lafiya (,,).

Sirtuins suma suna da alhakin tsawon lokacin fa'idar taƙaitawar kalori ().

Wani rukuni kuma shine Poly (ADP-Ribose) polymerases (PARPs), wanda ke gyara DNA mai lalacewa. Karatun yana danganta aikin PARP mafi girma zuwa ƙananan lalacewar DNA da tsawon rayuwa (,).

Zan Iya Taimakawa Kare ƙwayoyin inwalwa

NAD + yana taka muhimmiyar rawa wajen taimakawa ƙwayoyin kwakwalwarka tsufa da kyau.

A cikin ƙwayoyin kwakwalwa, NAD + yana taimakawa sarrafa PGC-1-alpha, furotin wanda ya bayyana don taimakawa kare ƙwayoyin cuta daga stressarfin oxidative da nakasa aikin mitochondrial ().

Masu binciken sun yi imanin cewa damuwar rashin karfin jiki da nakasa aikin mitochondrial suna da nasaba da cututtukan kwakwalwa da suka shafi shekaru kamar cutar Alzheimer da cutar Parkinson (,,).

A cikin beraye tare da cutar Alzheimer, nicotinamide riboside ya haɓaka ƙwaƙwalwar NAD + matakan da samar da PGC-1-alpha har zuwa 70% da 50%, bi da bi. A ƙarshen binciken, ɓerayen sun yi rawar gani cikin ayyukan da suka shafi ƙwaƙwalwa ().

A cikin binciken-tube tube, nicotinamide riboside ya haɓaka matakan NAD + kuma ya inganta ingantaccen aiki na mitochondrial a cikin ƙwayoyin ƙwayoyin cuta da aka ɗauka daga mai cutar Parkinson ().

Koyaya, har yanzu ba a bayyana yadda taimako yake ba don haɓaka matakan NAD + a cikin mutanen da ke fama da larurar ƙwaƙwalwar ajiya. Ana buƙatar ƙarin nazarin ɗan adam.

Mai Yiwuwar Hadarin Cutar Zuciya

Tsufa babban haɗari ne ga cututtukan zuciya, wanda shine babban dalilin mutuwa a duniya ().

Zai iya haifar da jijiyoyin jini kamar aorta su zama su yi kauri, su kahu da rashin sassauci.

Irin waɗannan canje-canjen na iya ɗaga matakan hawan jini kuma ya sa zuciyarka ta yi aiki tuƙuru.

A cikin dabbobi, haɓaka NAD + ya taimaka juyawa canje-canje masu alaƙa da jijiyoyi ().

A cikin mutane, nicotinamide riboside ya ɗaga matakan NAD +, ya taimaka rage ƙarfi a cikin aorta kuma ya saukar da hawan jini a cikin manya mai haɗarin hawan jini (22).

Wannan ya ce, ana buƙatar ƙarin binciken ɗan adam.

Sauran Fa'idodin Dama

Bugu da kari, nicotinamide riboside na iya samar da wasu fa'idodi da yawa:

• Zai iya taimakawa asarar nauyi: Nicotinamide riboside ya taimaka saurin saurin ƙwayar beraye. Koyaya, ba a san ko zai sami tasiri iri ɗaya a cikin mutane ba kuma yaya ƙarfin wannan tasirin yake da gaske ().
• Zai iya rage haɗarin cutar kansa: Matakan NAD + masu girma suna taimakawa kariya daga lalacewar DNA da stressarfin oxidative, waɗanda ke da alaƙa da ci gaban ciwon daji (,).
• Zai iya taimakawa wajen magance matsalar jet: NAD + yana taimakawa wajen daidaita agogon cikin jikin ku, don haka shan niagen na iya taimakawa wajan magance lag lag ko wasu rikice-rikicen tashin hankali ta hanyar sake saita agogon cikin jikin ku ().
• Zai iya inganta tsufa mai kyau: Haɓaka matakan NAD + ya taimaka inganta haɓaka tsoka, ƙarfi da juriya a cikin tsofaffin yara (,).

Nicotinamide riboside yana haɓaka matakan NAD +, wanda ke da alaƙa da fa'idodin kiwon lafiya game da tsufa, lafiyar kwakwalwa, haɗarin cututtukan zuciya da ƙari.

Hadarin da ke tattare da shi da kuma Illolin da ke faruwa

Nicotinamide riboside na iya zama mai aminci tare da kaɗan - idan wani - sakamako masu illa.

A cikin karatun ɗan adam, shan 1,000-2,000 MG kowace rana ba shi da wata illa (,).

Koyaya, yawancin karatun ɗan adam gajere ne kuma suna da karancin mahalarta. Don cikakkiyar ma'anar amincin ta, ana buƙatar ƙarin nazarin ɗan adam mai ƙarfi.

Wasu mutane sun ba da rahoton sakamako mai laushi zuwa matsakaici, kamar tashin zuciya, gajiya, ciwon kai, gudawa, rashin jin daɗin ciki da rashin narkewar abinci ().

A cikin dabbobi, shan 300 MG da kilogiram na nauyin jiki (136 MG da laban) kowace rana don kwanaki 90 ba shi da wata illa mai cutarwa ().

Abin da ya fi haka, ba kamar abubuwan bitamin B3 (niacin) ba, nicotinamide riboside bai kamata ya haifar da fuskokin fuska ba ().

Nicotinamide riboside ya bayyana yana da aminci tare da effectsan sakamako masu illa. Koyaya, tasirinsa na dogon lokaci a cikin mutane har yanzu ba a san shi ba.

Sashi da Shawarwarin

Nicotinamide riboside yana samuwa a cikin kwamfutar hannu ko kuma kawunansu kuma ana kiran shi niagen.

Ana samun sa a zaɓi shagunan abinci-na abinci, a kan Amazon ko ta hanyar dillalai na kan layi.

Abubuwan Niagen yawanci suna dauke da sinadarin nicotinamide riboside kawai, amma wasu masana'antun sun hada shi da sauran sinadaran kamar Pterostilbene, wanda shine polyphenol - antioxidant wanda yake da kama da resveratrol ().

Yawancin samfuran niagen suna ba da shawarar shan 250-300 MG kowace rana, kwatankwacin 1-2 na capsules kowace rana dangane da alama.

Yawancin masana'antun niagen suna ba da shawarar shan 250-300 mg na nicotinamide riboside kowace rana.

Layin .asa

Nicotinamide riboside wani nau'i ne na bitamin B3 tare da fewan sakamako masu illa. Ana yawan sayar dashi azaman kayan tsufa.

Jikinku ya canza shi zuwa NAD +, wanda ke inganta dukkan ƙwayoyinku. Yayinda matakan NAD + suka faɗi ta ɗabi'a tare da tsufa, haɓaka matakan NAD + na iya sauya alamun da yawa na tsufa.

Koyaya, yawancin bincike akan nicotinamide riboside da NAD + yana cikin dabbobi. Ana buƙatar ƙarin karatun ɗan adam mai ƙwarewa sosai kafin a ba da shawarar a matsayin magani.