Glucose-6-phosphate rashi dehydrogenase

Rashin gulukos-6-phosphate dehydrogenase (G6PD) rashi yanayi ne wanda jajayen kwayoyin jini ke karyewa yayin da jikin ya kamu da wasu magunguna ko damuwar kamuwa da cuta. Gadon gado ne, wanda ke nufin an wuce dashi cikin dangi.

Rashin G6PD yana faruwa ne lokacin da mutum ya ɓace ko ba shi da isasshen enzyme da ake kira glucose-6-phosphate dehydrogenase. Wannan enzyme yana taimakawa jan ƙwayoyin jini suyi aiki daidai.

Garancin G6PD yana haifar da lalata jajayen ƙwayoyin jini. Wannan tsari ana kiransa hemolysis. Lokacin da wannan aikin ke gudana, ana kiran sa abin da ke faruwa. Yawancin lokuta galibi gajeru ne. Wannan saboda jiki yana ci gaba da samar da sabbin jajayen ƙwayoyin jini, waɗanda suke da ayyukansu na yau da kullun.

Cututtuka na jan jini, wasu abinci (kamar su fava wake), da wasu magunguna, gami da:

• Magunguna masu maganin zazzaɓi kamar quinine
• Asfirin (babban allurai)
• Magungunan anti-inflammatory marasa ƙwayar cuta (NSAIDs)
• Quinidine
• Magungunan Sulfa
• Magungunan rigakafi irin su quinolones, nitrofurantoin
  

Sauran sunadarai, kamar waɗanda suke a cikin kwaroron roba, suma na iya haifar da wani abu.

A Amurka, rashi G6PD ya fi zama ruwan dare tsakanin baƙar fata fiye da fararen fata. Maza sun fi mata samun wannan matsalar.

Zai yuwu ku kamu da wannan yanayin idan kun:

• Shin Ba'amurke ne Ba'amurke
• 'Yan asalin Gabas ta Tsakiya ne masu mutunci, musamman Kurdawa ko Bayahude Sephardic
• Shin maza ne
• Yi tarihin iyali na rashi

Wani nau'i na wannan rikice-rikice sananne ne ga fararen fata na Bahar Rum. Wannan nau'in yana hade da aukuwa mai saurin hemolysis. Abubuwan da suka faru sun fi tsayi kuma sun fi tsanani fiye da sauran nau'ikan cutar.

Mutanen da ke da wannan matsalar ba sa nuna alamun cutar har sai jininsu na jini ya bayyana ga wasu sinadarai a cikin abinci ko magani.

Kwayar cututtukan sun fi yawa ga maza kuma suna iya haɗawa da:

• Fitsarin duhu
• Zazzaɓi
• Jin zafi a ciki
• Sara girman ciki da hanta
• Gajiya
• Maɗaukaki
• Saurin bugun zuciya
• Rashin numfashi
• Launin fata mai launin rawaya (jaundice)

Za'a iya yin gwajin jini don bincika matakin G6PD.

Sauran gwaje-gwajen da za'a iya yi sun haɗa da:

• Bilirubin matakin
• Kammala lissafin jini
• Hemoglobin - fitsari
• Matakan Haptoglobin
• LDH gwaji
• Gwajin rage Methemoglobin
• Icididdigar Reticulocyte

Jiyya na iya ƙunsar:

• Magunguna don magance cuta, idan sun kasance
• Dakatar da duk wani magani da ke haifar da lalata jinin jini
• Karin jini, a wasu lokuta

A mafi yawan lokuta, al'amuran hemolytic suna tafiya da kansu.

A cikin wani yanayi mai wuya, gazawar koda ko mutuwa na iya faruwa bayan mummunan hawan jini.

Kira mai ba da sabis na kiwon lafiya idan kuna da alamun wannan yanayin.

Kira mai ba ku sabis idan an gano ku tare da rashi G6PD kuma alamomi ba sa ɓace bayan jiyya.

Mutanen da ke da rashi G6PD dole ne su guji abubuwan da ka iya haifar da wani abu. Yi magana da mai baka game da magungunan ka.

Bayar da shawara kan kwayar halitta ko gwaji na iya samuwa ga waɗanda ke da tarihin iyali na yanayin.

Rashin G6PD; Hemolytic anemia saboda ƙarancin G6PD; Anemia - hemolytic saboda rashi G6PD

• Kwayoyin jini

Gregg XT, Prchal JT. Kwayar cutar jini ta enzymopathies. A cikin: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Ka'idoji da Aiki. 7th ed. Philadelphia, PA: Elsevier; 2018: babi na 44.

Lissauer T, Carroll W. Rashin lafiyar Haematological. A cikin: Lissauer T, Carroll W, eds. Littafin rubutu na likitan yara. 5th ed. Philadelphia, PA: Elsevier; 2018: babi na 23.

Michel M. Autoimmune da cutar hemolytic anemias. A cikin: Goldman L, Schafer AI, eds. Magungunan Goldman-Cecil. 26th ed. Philadelphia, PA: Elsevier; 2020: babi na 151.