Mawallafi: John Stephens
Ranar Halitta: 2 Janairu 2021
Sabuntawa: 14 Nuwamba 2024
Anonim
GLEEVEC (IMATINIB) MOA
Video: GLEEVEC (IMATINIB) MOA

Wadatacce

Menene Gleevec?

Gleevec magani ne na takaddun magani. Ana amfani dashi don magance wasu nau'ikan cutar kansa a cikin manya da yara. Hakanan ana amfani da Gleevec don magance wani nau'in kansar fata da wani nau'in ciwon kansa na hanji.

Gleevec ya ƙunshi maganin imatinib mesylate, wanda ke cikin rukunin magungunan da ake kira masu hana maganin tyrosine kinase.

Gleevec ya zo ne azaman kwamfutar hannu wanda kuka sha da baki. Kuna shan miyagun ƙwayoyi ko sau ɗaya ko sau biyu a rana, gwargwadon yawan likitanku.

Abin da yake yi

Hukumar Abinci da Magunguna (FDA) ta amince da Gleevec don kula da wasu nau'ikan cutar kansa, da suka haɗa da:

  • Philadelphia chromosome-tabbatacce (Ph +) cutar sankara myeloid na kullum (CML) a cikin manya da yara
  • Ph + mai saurin cutar sankarar bargo (DUK) wannan ya sake komawa * ko ƙin yarda *
  • sabon bincikar Ph + DUK a cikin yara
  • cututtukan myelodysplastic / myeloproliferative (cututtukan kasusuwa na kasusuwa) a cikin manya tare da haɓakar haɓakar haɓakar haɓakar jini (PDGFR)
  • cututtukan hypereosinophilic ko cutar sankara ta eosinophilic a cikin manya
  • m mastocytosis na tsari a cikin manya ba tare da maye gurbin D816v c-Kit ba

* Ciwon da ya komo ya dawo bayan gafara, wanda shine raguwar alamomin cutar kansa. Ciwon kansa ba ya ba da amsa ga magungunan ciwon daji na baya.


Gleevec kuma an yarda dashi don magance:

  • wani nau'in kansar fata da ake kira dermatofibrosarcoma protuberans (DFSP) a cikin manya
  • wani nau'in cututtukan ciki da ake kira Kit-tabbatacce gastrointestinal stromal marurai (GIST) a cikin manya

Don cikakkun bayanai, duba sassan don "Gleevec for CML" da "Sauran amfani don Gleevec."

Tasirin Gleevec

Gleevec an sami inganci wajen magance nau'ikan cututtukan cututtukan jini da yawa.

A cikin binciken asibiti guda daya, manya tare da sabon CML da aka gano a cikin tsawan lokaci sun ɗauki Gleevec na shekaru bakwai. A cikin wannan rukuni, 96.6% na mutane suna da cikakken amsa ga magani. Wannan yana nufin cewa ba a sami ƙwayoyin cutar kansa a cikin jininsu ba, kuma ba su da alamun cutar kansa.

Cikakkiyar amsa ita ce hanya ɗaya don bayyana ƙimar nasarar. A cikin ƙungiyar mutanen da suka karɓi daidaitaccen ilimin sankarar magani, 56.6% sun sami cikakken amsa.

Hakanan an gano Gleevec mai tasiri wajen magance ciwan ciwan ciki na ciki (GIST) a karatun asibiti. Adadin rayuwar gabaɗaya ya kai kimanin shekaru huɗu. Wannan yana nufin rabin mutanen da ke cikin binciken sun rayu kimanin shekaru huɗu bayan sun fara shan Gleevec. Mutanen da suka ɗauki Gleevec bayan tiyata sun rayu kimanin shekaru biyar bayan fara maganin.


Don koyon yadda Gleevec ke da tasiri wajen magance wasu nau'ikan cututtukan kansa, duba sashin "Sauran amfani na Gleevec".

Gleevec na gama gari

Gleevec yana nan a matsayin magani mai suna kuma a matsayin nau'ikan sifa.

Gleevec yana dauke da sinadarin magani imatinib mesylate.

Sakamakon sakamako na Gleevec

Gleevec na iya haifar da lahani ko mummunan sakamako. Jerin masu zuwa suna dauke da wasu daga cikin mahimman tasirin da zasu iya faruwa yayin shan Gleevec. Waɗannan jerin ba su haɗa da duk illa mai yuwuwa ba.

Don ƙarin bayani game da yuwuwar illa na Gleevec, yi magana da likitanka ko likitan magunguna. Za su iya ba ku shawarwari kan yadda za ku magance duk wata illa da ke iya zama damuwa.

Commonarin sakamako masu illa na kowa

Abubuwan da suka fi dacewa na Gleevec na iya haɗawa da:

  • gudawa
  • ciwon ciki
  • gajiya (rashin ƙarfi)
  • edema (kumburi, yawanci a ƙafafunku, idon kafa, ko ƙafa da kewaye idanunku)
  • ciwon tsoka ko ciwo
  • tashin zuciya
  • amai
  • kurji

Yawancin waɗannan tasirin na iya wucewa cikin fewan kwanaki kaɗan ko makonni kaɗan. Idan sun fi tsanani ko basu tafi ba, yi magana da likitanka ko likitan magunguna.


M sakamako mai tsanani

Mahimman sakamako masu illa daga Gleevec ba su da yawa, amma suna iya faruwa. Kira likitanku nan da nan idan kuna da mummunar illa. Kira 911 idan alamunku suna jin barazanar rai ko kuma idan kuna tunanin kuna samun gaggawa na likita.

M sakamako masu illa da alamomin su na iya haɗawa da masu zuwa:

  • Fluidaukewar ruwa mai yawa (ruwa mai yawa ko ruwa) a ciki da kewayen zuciyarka, huhu (ƙone ciki), da ciki (ascites). Kwayar cutar na iya haɗawa da:
    • ba tsammani, saurin riba
    • ciwon kirji
    • karancin numfashi
    • matsala shan iska mai zurfi
    • matsalar numfashi lokacin da kake kwance
    • tari bushewa
    • kumbura ciki
  • Rikicin jini, gami da ƙarancin jini (ƙananan ƙwayoyin jinin jini), neutropenia (ƙananan ƙwayoyin jinin jini), da thrombocytopenia (ƙananan matakan platelets). Kwayar cutar na iya haɗawa da:
    • gajiya (rashin ƙarfi)
    • saurin bugun zuciya
    • karancin numfashi
    • m cututtuka
    • zazzabi
    • bruising sauƙi
    • zubar da gumis
    • jini a cikin fitsari ko bayan gida
  • Ciwon zuciya mai narkewa da sauran matsalolin zuciya, kamar rashin zuciya ta gefen hagu. Kwayar cutar na iya haɗawa da:
    • samun nauyi mara nauyi
    • edema (kumburin ƙafafunku, idon kafa, da ƙafafu)
    • bugun zuciya mara kyau ko kari (bugun zuciya da ke da sauri, da sauri, ko mara kyau)
    • ciwon kirji
    • karancin numfashi
  • Lalacewar hanta ko gazawar hanta. Kwayar cutar na iya haɗawa da:
    • tashin zuciya
    • gudawa
    • rasa ci
    • fata mai ƙaiƙayi
    • jaundice (launin fata mai launin rawaya da fararen idanun ku)
    • edema (kumburin ƙafafunku, ƙafafunku, da ƙafafunku)
    • ascites (haɓakar ruwa a cikin cikin ku)
    • yawan yin rauni
    • yawan zubar jini
  • Zubar jini mai tsanani (zubar jini wanda baya tsayawa), galibi a cikin hanjin ka. Kwayar cutar na iya haɗawa da:
    • jini a cikin buta
    • baƙi ko tartsatsin tarry
    • gajiya (rashin ƙarfi)
    • tari na jini
    • tari har bakin sluded
    • tashin zuciya
    • ciwon ciki
  • Matsalolin ciki, ciki har da raɗaɗi (hawaye) a cikin ciki ko hanji. Kwayar cutar na iya haɗawa da:
    • tashin zuciya
    • amai
    • ciwo mai tsanani a cikin ciki
    • zazzaɓi
    • karancin numfashi
    • bugun zuciya mai sauri
  • Matsalolin fata masu tsanani. Kwayar cutar na iya haɗawa da:
    • erythema multiforme (jan faci ko kumfa, galibi akan tafin ƙafarku ko tafin hannayenku)
    • Ciwon Stevens-Johnson (zazzabi; ciwo mai zafi a bakinka, maƙogwaronka, idanunka, al'aurarka, ko duk jikinka)
    • zazzaɓi
    • ciwon jiki
  • Hypothyroidism (ƙananan matakan thyroid) a cikin mutanen da aka cire maganin ka kuma suna shan maganin maye gurbin ka. Kwayar cutar na iya haɗawa da:
    • gajiya (rashin ƙarfi)
    • maƙarƙashiya
    • damuwa
    • jin sanyi
    • bushe fata
    • riba mai nauyi
    • matsalolin ƙwaƙwalwa
  • Rage girma a cikin yara. Kwayar cutar na iya haɗawa da:
    • ba girma a cikin al'ada
    • karami fiye da sauran yaran shekarunsu
  • Ciwon lumɓus na Tumor (lokacin da ƙwayoyin daji ke sakin ƙwayoyin cuta masu cutarwa a cikin jininka). Kwayar cutar na iya haɗawa da:
    • gajiya (rashin ƙarfi)
    • tashin zuciya
    • amai
    • gudawa
    • Ciwon tsoka
    • bugun zuciya mara kyau (bugun zuciya da ke da sauri, da sauri, ko mara kyau)
    • kamuwa
  • Lalacewar koda. Kwayar cutar na iya haɗawa da:
    • yin fitsari kasa da yadda aka saba
    • edema (kumburin ƙafafunku, ƙafafunku, da ƙafafunku)
    • gajiya (rashin ƙarfi)
    • tashin zuciya
    • rikicewa
    • hawan jini
  • Illolin da zasu haifar da hatsarin motar. Kwayar cutar na iya haɗawa da:
    • jiri
    • bacci
    • hangen nesa

Bayanin sakamako na gefe

Kuna iya mamakin yadda sau da yawa wasu cututtukan illa ke faruwa tare da wannan magani, ko kuma wasu abubuwan illa suna da nasaba da ita.Anan ga wasu bayanai dalla-dalla kan da yawa daga cikin illolin da wannan kwayar cutar ke haifarwa ko kuma ba zata iya haifarwa ba.

Maganin rashin lafiyan

Kamar yadda yake da yawancin kwayoyi, wasu mutane na iya samun rashin lafiyan bayan shan Gleevec. Kwayar cututtukan rashin lafiyan rashin lafiya na iya haɗawa da:

  • kumburin fata
  • ƙaiƙayi
  • flushing (dumi da kuma ja a fatar ka)

Reactionwayar rashin lafiyan da ta fi tsanani ba safai ba amma zai yiwu. Kwayar cututtukan rashin lafiya mai haɗari na iya haɗawa da:

  • angioedema (kumburi a ƙarƙashin fatarka, galibi a cikin gashin ido, lebe, hannu, ko ƙafa)
  • kumburin harshenka, bakinka, ko maqogwaronka
  • matsalar numfashi

Kira likitanku nan da nan idan kuna da mummunan rashin lafiyar Gleevec. Kira 911 idan alamunku suna jin barazanar rai ko kuma idan kuna tunanin kuna samun gaggawa na likita.

Illolin aiki na dogon lokaci

Wasu daga cikin illolin da ake gani a cikin karatun asibiti na iya faruwa tare da amfani da Gleevec na dogon lokaci. Wadannan sun hada da matsalolin zuciya, irin su ciwon zuciya da kuma gazawar zuciya ta bangaren hagu.

A cikin binciken asibiti, mutane sama da 500 da suka ɗauki Gleevec don cutar sankarar myeloid na yau da kullun (CML) an bi su har zuwa shekaru 11. Mutanen da ke cikin wannan nazarin na dogon lokaci suna da yawancin illolin da ke tattare da su guda ɗaya waɗanda aka ruwaito a cikin gajeren karatu. Koyaya, waɗannan tasirin sun yi kama da inganta lokaci.

M sakamako masu illa da aka gani tare da amfani na dogon lokaci sun haɗa da:

  • mummunan cuta (ƙananan matakan jajayen jini, farin jini, ko platelets) a cikin mutane shida
  • matsalolin zuciya, gami da ciwon zuciya, a cikin mutane bakwai
  • lokuta shida na sabon cutar kansa, gami da myeloma da yawa a cikin mutum ɗaya da kuma cutar kansar cikin wani mutum

Sakamakon illa ya zama sananne a cikin shekarar farko ta jiyya tare da Gleevec. Amma tsawon lokacin da mutane suka ɗauki Gleevec, ƙarancin sau da yawa suna da yawancin waɗannan tasirin. Misali, a shekarar farko ta binciken, mutane uku sun kamu da cuta mai tsanani, amma bayan shekara ta biyar, mutum daya ne kawai ya kamu.

A cikin binciken shekaru biyar na mutanen da ke fama da ciwan ciki na ciki (GIST), kashi 16% na mutane sun daina shan Gleevec saboda sakamakon illa. Abubuwan sakamako masu illa sun yi kama da waɗanda aka bayyana a cikin binciken CML da ke sama. Kashi arba'in na mutanen da ke cikin binciken an ba su ƙananan ƙwayoyi na miyagun ƙwayoyi don sauƙaƙe tasirin su.

Idan kun damu game da yuwuwar tasirin Gleevec na dogon lokaci, yi magana da likitanku. Zasu iya ba da shawarar hanyoyi don rage haɗarinku ga wasu lahani.

Illolin da suka shafi ido

A cikin karatun asibiti na Gleevec, wasu mutane suna da lahani masu nasaba da ido kamar kumburi da hangen nesa.

Kumburin ido da kumburi a kusa da idanuwa wasu illoli ne da aka fi amfani dasu. Har zuwa 74.2% na mutanen da suka ɗauki Gleevec suna da cutar ɓarna (kumburin yankin ido).

Idan kuna da wannan tasirin, likitanku na iya ba da umarnin yin maganin diuretic (wanda ake kira kwayar ruwa). Diuretics suna taimakawa jikinka wajen kawar da karin ruwa da gishiri idan kayi fitsari. Wannan yana saukaka haɓakar ruwa. Hakanan likitan ku na iya rage adadin Gleevec ɗin ku, idan an buƙata.

Bugu da ƙari, nazarin asibiti ya ba da rahoton cewa har zuwa 11.1% na mutanen da suka ɗauki Gleevec suna da hangen nesa. Idan kana da hangen nesa, kar ka tuƙa ko amfani da injina masu nauyi. Kuma ka tabbata ka gaya wa likitanka cewa ba za ka iya gani a sarari ba.

Sauran cututtukan da ba su da alaƙa da ido sosai sun haɗa da:

  • ido bushe
  • idanu masu ruwa
  • fushin ido
  • conjunctivitis (wanda ake kira ruwan hoda)
  • karyewar jijiyoyin jini a ido
  • kumburin ido (wani layin nama a bayan idonka)

Idan kana shan Gleevec kuma kana da duk wata illa da ta shafi ido, yi magana da likitanka. Zasu iya ba da shawarar hanyoyin da za su sauƙaƙa alamun ku.

Rashin gashi

Rashin gashi (alopecia) sakamako ne mai yuwuwa na shan Gleevec.

Studyaya daga cikin binciken an gwada yadda Gleevec ke aiki a cikin mutane tare da Philadelphia chromosome-tabbatacce (Ph +) cutar sankarar myeloid na kullum (CML). Kashi bakwai cikin ɗari na waɗannan mutanen suna da zubewar gashi bayan sun sha maganin.

A wani binciken, mutane sun dauki Gleevec don magance cututtukan ciki na ciki (GIST). Tsakanin 11.9% da 14.8% na waɗannan mutanen suna da asarar gashi. Ana ganin wannan tasirin sau da yawa a cikin mutanen da suka ɗauki ƙwayoyin Gleevec.

Rashin gashi saboda maganin cutar kansa yawanci na ɗan lokaci ne. Idan kun damu game da wannan tasirin, kuyi magana da likitanku. Zasu iya ba da shawarar nasihu don taimaka muku rage zubewar gashi yayin jiyya.

Rash da sauran illolin fata

Gleevec na iya haifar da lahani da mawuyacin illa ga fata.

Commonarin halayen fata na kowa

Rashes da sauran maganganun fatar jiki suna da mahimmanci a cikin mutanen da suke ɗaukar Gleevec.

A cikin karatun asibiti, mutane sun ɗauki Gleevec don magance Ph + na kullum myeloid leukemia (CML). Har zuwa 40.1% na waɗannan mutane suna da rashes ko wasu halayen fata bayan shan magani.

A wasu nazarin na asibiti, mutane sun ɗauki Gleevec don ciwan ciwan ciki na ciki (GIST). Bayan shan magani, har zuwa 49.8% na waɗannan mutane suna da rashes ko wasu halayen fata. Wadannan sun hada da:

  • peeling na fata
  • bushe fata
  • canza launin fata (launin shuɗi ga fata)
  • cututtukan cututtukan gashi (jaka a ƙarƙashin fatarka waɗanda ke riƙe tushen gashinku)
  • erythema (jan fata)
  • purpura (launuka masu launin shuɗi akan fata)

Wadannan cututtukan sun fi yawa ga mutanen da suka ɗauki ƙwayoyin Gleevec.

Idan kun damu game da rashes ko wasu mawuyacin tasirin fata saboda Gleevec, yi magana da likitan ku. Zasu iya ba da shawarar hanyoyi don taimakawa sauƙaƙe alamunku.

M halayen halayen

A cikin karatun asibiti, munanan halayen fata basu da yawa a cikin mutanen da suka ɗauki Gleevec. Har zuwa 1% na mutanen da suka sha wannan magani suna da mummunan tasirin fata. Misalan cututtukan fata masu alaƙa da ƙwayoyi sun haɗa da:

  • Ciwon Stevens-Johnson (zazzabi; ciwo mai zafi a bakinka, maƙogwaronka, idanunka, al'aurarka, ko duk jikinka)
  • exfoliative dermatitis (peeling fata a kan manyan sassan jikin ku)
  • vesicular rash (ƙananan blisters da rash)

Rashes da kumfa na iya zama mai zafi sosai. Kuma idan ba a magance su ba, za su iya kama ƙwayoyin cuta kuma su haifar da mummunan cututtuka. Don haka idan kuna shan Gleevec kuma kuna da kurji ko kumfa tare da zazzaɓi ko ba ku da lafiya, gaya wa likitanku nan da nan. Har ila yau ambaci duk wani halayen fata da kuke da shi.

Illolin da suka shafi tuki

A cikin karatun asibiti, wasu mutanen da suka ɗauki Gleevec suna da lahanin da zai iya shafar ikon tuki. Wadannan sun hada da:

  • dizziness: har zuwa 19.4% na mutane
  • hangen nesa: har zuwa 11.1% na mutane
  • gajiya: a cikin 74,9% na mutane

Wadannan illolin na iya shafar ikonka na tuki ko amfani da injina masu nauyi. Akwai rahotanni game da haɗarin mota na mutanen da suka ɗauki Gleevec. Don haka ya kamata kayi amfani da taka tsantsan yayin tuki ko amfani da kayan aiki yayin ɗaukar Gleevec.

Sannu ahankali warkar da rauni (ba sakamako ba)

Ba a ba da rahoton raunin rauni a hankali a cikin karatun asibiti na Gleevec.

Wasu nau'ikan maganin cutar kansa, kamar su radiation da chemotherapy, na iya raunana garkuwar jikinka. Wannan na iya sanya rauni ya warke a hankali.

Idan kun damu game da jinkirin warkar da rauni, tambayi likitan ku ko kuna da haɗari mafi girma ga wannan matsalar dangane da yanayin lafiyar ku.

Ciwon hanta (bazai zama tasiri ba)

Ba a bayar da rahoton ciwon daji na hanta ba a matsayin sakamako mai illa a cikin karatun asibiti na Gleevec. Koyaya, lalacewar hanta ya faru a duka gajere da kuma dogon lokacin amfani da Gleevec. Wasu lamura na cutar hanta sun haifar da gazawar hanta da dasa hanta.

Lalacewar hanta galibi ana samunsa yayin da likitoci ke lura da enzymes (sunadarai na musamman) waɗanda aka yi a cikin hanta. Matakan enzyme waɗanda suke sama da al'ada na iya zama alamar lalacewar hanta.

Wasu alamun bayyanar cututtukan hanta sun hada da:

  • tashin zuciya
  • gudawa
  • rasa ci
  • fata mai ƙaiƙayi
  • jaundice (launin kalar rawaya na fata da fararen idanu)
  • edema (kumburin ƙafafunku, ƙafafunku, da ƙafafunku)
  • ascites (haɓakar ruwa a cikin cikin ku)
  • yawan yin rauni
  • yawan zubar jini

A lokacin karatun asibiti, har zuwa 5% na mutanen da ke fama da cutar sankarar bargo (CML) na yau da kullun suna da matakan haɓakar enzyme mai haɗari yayin maganin Gleevec. Har zuwa 6.8% na mutanen da ke fama da ciwan ciki na ciki (GIST) suna da matakan haɓakar hanta mai haɗari yayin jiyya. Kuma har zuwa kashi 0.1% na mutanen da suka ɗauki Gleevec suna da ciwon hanta.

Yayinda kuke ɗaukar Gleevec, likitanku zai lura da yadda hanta ke aiki. Idan kana da alamun cutar hanta yayin shan Gleevec, likitanka na iya rage adadin ka. Wannan na iya hana lalacewa wanda zai iya haifar da gazawar hanta.

Hanyoyi masu illa a cikin yara

Yara a cikin karatun asibiti waɗanda suka ɗauki Gleevec suna da tasirin illa waɗanda suke kamanceceniya da na manya. Amma masu bincike sun sami waɗannan keɓaɓɓun:

  • yara ƙanana da ke da tsoka ko ƙashin kashi fiye da na manya
  • edema (kumburin ƙafafu, idon kafa, ƙafa, da yanki a kusa da idanu) ba a ba da rahoton a cikin yara ba

Mafi yawan cututtukan da aka ruwaito game da yara sune tashin zuciya da amai. Abubuwan illa masu haɗari na yau da kullun sune ƙananan ƙwayoyin farin jini da platelets.

Idan ɗanka yana da waɗannan larurorin, yi magana da likitan ɗanka game da hanyoyin da za ka kula da su.

Gleevec don CML

Hukumar Abinci da Magunguna (FDA) ta amince da Gleevec ga wasu mutane tare da Philadelphia chromosome-tabbatacce (Ph +) cutar sankarar myeloid na kullum (CML). Kwayar chromosome ta Philadelphia lamba 22 ce mai chromosome. Mutanen da ke da Ph + CML suna da takamaiman canji a cikin DNA ɗinsu wanda ke haifar da farin ƙwayoyin jini da yawa su samar.

CML ya kasu kashi uku:

  • Tsarin lokaci. Wannan shine farkon matakin CML. Yawancin mutane suna bincikar su tare da CML yayin lokacin da suke ci gaba. Kwayar cutar galibi ba ta da sauƙi, idan akwai su kwata-kwata.
  • Hanzari mai sauri. A wannan zangon na biyu, adadin kwayoyin cutar kansa a cikin jininka yana ƙaruwa. Kuna iya samun ƙarin alamun bayyanar, kamar zazzaɓi da rage nauyi.
  • Bakin rikicin lokaci. A wannan mafi girman yanayin, kwayoyin cutar kansa a cikin jininka sun bazu zuwa sauran gabobi da kyallen takarda. Alamunka na iya zama mafi tsanani.

An yarda da Gleevec don kula da sabon binciken Ph + CML a cikin mawuyacin lokaci a cikin mutane na kowane zamani.

Hakanan an yarda da shi don magance Ph + CML a cikin yanayin rikice-rikice na yau da kullun, hanzari, ko fashewa don mutanen da suka sami nasarar rashin nasara ta hanyar maganin interferon-alpha. Interferon-alpha magani ne wanda aka yi amfani dashi sau da yawa a baya don magance CML. An maye gurbinsa da ƙwayoyi irin su Gleevec waɗanda aka nuna sun fi tasiri.

Inganci

A cikin binciken asibiti na shekaru bakwai, yawan rayuwar wadanda suka dauki Gleevec don sabon binciken Ph + CML shine 86.4%. Wannan yana nufin cewa kashi 86.4% na manya sun rayu tsawon shekaru bakwai bayan sun fara shan Gleevec. An kwatanta wannan da kashi 83.3% na mutanen da suka ɗauki magungunan ƙwayoyi na yau da kullun.

A cikin binciken asibiti, mutanen da a baya suka gwada interferon-alpha na CML sun ɗauki Gleevec. Wasu daga cikin waɗannan mutanen suna da cikakken amsa game da maganin Gleevec. Wannan yana nufin cewa ba a sami ƙwayoyin cutar kansa a cikin jininsu ba, kuma ba su da alamun cutar kansa. Ga yadda mutane da yawa tare da CML suka sami cikakken amsa don shan Gleevec:

  • 95% na mutane a cikin lokaci mai tsawo
  • 38% na mutane a cikin saurin lokaci
  • 7% na mutanen da ke cikin rikicin rikicin

Binciken na asibiti ya hada da yara tare da Ph + CML a cikin tsawan lokaci. A cikin ƙungiyar da suka ɗauki Gleevec, kashi 78% na yara suna da cikakken amsa ga maganin.

Sauran amfani don Gleevec

Baya ga cutar sankarar myeloid na yau da kullun (duba sama), Hukumar Abinci da Magunguna (FDA) ta amince da Gleevec don magance wasu yanayi da yawa.

Gleevec don cutar sankaran jini na lymphocytic (ALL)

Gleevec an yarda da FDA don bi da:

  • Philadelphia chromosome-tabbatacce (Ph +) cutar sankarar bargo ta lymphocytic (ALL) wanda ya sake komawa * ko rashin ƙarfi * a cikin manya
  • sabon bincikar Ph + DUK a cikin yara lokacin amfani da chemotherapy

* Ciwon da ya komo ya dawo bayan gafara, wanda shine raguwar alamomin cutar kansa. Ciwon kansa ba ya ba da amsa ga magungunan ciwon daji na baya.

A cikin binciken asibiti, kashi 19% na manya tare da koma baya ko ƙin yarda DUK waɗanda suka ɗauki Gleevec sun sami cikakkiyar amsa a cikin jinin su zuwa magani. Wannan yana nufin cewa basu da alamun cutar kansa.

Har ila yau, nazarin asibiti ya kalli yara tare da DUK waɗanda suka ɗauki Gleevec kuma suka sami ilimin kimiya. Ga kashi 70% na yaran, cutar sankararsu ba ta yi tsanani ba tsawon shekaru huɗu.

Gleevec don wasu nau'ikan cutar kansa

Gleevec an yarda da FDA don magance wasu nau'ikan cututtukan jini, gami da:

  • Cututtukan Myelodysplastic / myeloproliferative (cututtukan kasusuwa na kasusuwa) a cikin manya tare da haɓakar haɓakar haɓakar haɓakar jini (PDGFR). A cikin karamin binciken asibiti, kashi 45% na mutanen da aka yiwa jiyya tare da Gleevec sun sami cikakken amsa a cikin jinin su zuwa magani. Wannan yana nufin cewa ba a sami ƙwayoyin cutar kansa a cikin jininsu ba, kuma ba su da alamun cutar kansa.
  • Ciwon Hypereosinophilic da / ko cutar sankarar bargo a cikin manya, gami da mutanen da ke da FIP1L1-PDGFRα fusion kinase. A cikin karamin binciken asibiti, 100% na mutanen da ke dauke da kwayar cutar ta PDGFR wadanda suka dauki Gleevec suna da cikakkiyar amsa a cikin jinin su zuwa magani. Tsakanin 21% da 58% na mutane ba tare da maye gurbin kwayar halitta ba ko kuma tare da matsayin maye gurbi wanda ba a san shi ba wanda ya ɗauki Gleevec ya sami cikakkiyar amsa a cikin jinin su.
  • Tsarin mastocytosis mai tsauri a cikin manya ba tare da maye gurbin D816v c-Kit ba. A cikin ƙaramin binciken asibiti, 100% na mutanen da ke tare da maye gurbin FIP1L1-PDGFRα fusion kinase waɗanda aka kula da su tare da Gleevec suna da cikakkiyar amsa ga magani.

Gleevec don ciwon daji na fata

Gleevec an yarda da FDA ne don magance dermatofibrosarcoma protuberans, wani nau'in nau'in cutar kansa na fata, a cikin manya. An yarda da shi ga mutanen da cutar kansa:

  • ba za a iya aiki da shi ba
  • ya dawo bayan jiyya
  • metastatic ne (ya yadu zuwa wasu sassan jiki)

Numberananan mutane an kula da su tare da Gleevec don wannan yanayin a cikin karatun asibiti. Daga cikin mutanen da suka ɗauki Gleevec, 39% sun sami cikakken amsa game da magani. Wannan yana nufin cewa biopsy na fata (cirewa da gwada ƙaramin samfurin fata) bai nuna alamun cutar kansa ba.

Gleevec don ciwon daji na ciki

Gleevec an yarda da FDA don magance ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta (GIST) a cikin manya waɗanda ba za a iya aiki da su ba ko kuma suna da ƙwayar cuta (sun yada zuwa wasu sassan jiki). An kuma yarda da Gleevec don kula da GIST a cikin manya waɗanda suka yi tiyata don cire ƙari. Wannan nau'i na magani (adjuvant treatment) ana amfani dashi don hana kansar dawowa bayan tiyata.

A cikin karatun asibiti, mutanen da ke tare da GIST waɗanda ba za a iya cirewa ta hanyar tiyata ba sun ɗauki 400 ko 800 na Gleevec. Sun rayu kimanin shekaru hudu.

Sauran mutanen da ke tare da GIST sun yi tiyata. Tsakanin kwanaki 14 zuwa 70 bayan haka, sun fara shan Gleevec a cikin binciken. Suna da kusan kasada 60% na haɗarin mutuwa ko ciwon kansa ya dawo cikin tsawon watanni 12. An kwatanta wannan da mutanen da suka ɗauki placebo (magani ba tare da magani mai aiki ba).

Alamar kashewa don Gleevec

Baya ga amfani da aka lissafa a sama, ana iya amfani da Gleevec a kashe-lakabin sauran amfani. Amfani da lakabin lakabi shine lokacin da aka ba da magani wanda aka yarda dashi don amfani ɗaya don wani daban wanda ba a yarda dashi ba.

Ana iya amfani da Gleevec a kashe-lakabin sauran cututtuka, gami da:

  • cututtukan prostate, a cewar wani binciken na 2015
  • melanoma, bisa ga jagororin kula da Cibiyar Nazarin Cutar Cancer ta Kasa
  • rubuta ciwon sukari na 1, bisa ga gwajin asibiti na 2018

Koyaya, babu bincike da yawa akan yadda Gleevec ke aiki a cikin mutane tare da waɗannan sharuɗɗan. Ana buƙatar ƙarin karatu don sanin ko Gleevec yana taimaka wajan magance kowane yanayi.

Gleevec don yara

Gleevec an yarda da FDA a matsayin magani ga yara tare da halaye masu zuwa:

  • sabon binciken da aka gano a Philadelphia-tabbatacce (Ph +) cutar sankarar bargo na yau da kullum (CML) a cikin tsawan lokaci (ɓangaren farko na cutar)
  • sabon binciken da aka gano Ph + mai saurin cutar sankarar bargo (ALL) lokacin amfani dashi tare da chemotherapy

An yarda da Gleevec don amfani dashi a cikin yara na kowane zamani. Koyaya, ba a taɓa yin karatu kan yadda aminci ko tasiri Gleevec ke cikin yara ƙanana da shekara 1 da haihuwa ba.

Kudin Gleevec

Kamar yadda yake tare da duk magunguna, farashin Gleevec na iya bambanta.

Ainihin farashin da za ku biya ya dogara da inshorarku na inshora da kantin magani da kuke amfani da shi.

Taimakon kuɗi da inshora

Idan kuna buƙatar tallafi na kuɗi don biyan Gleevec, ko kuma idan kuna buƙatar taimako game da ɗaukar inshorar ku, akwai taimako.

Novartis Pharmaceutical Corporation, mai kera Gleevec, yana ba da wani shiri mai suna Novartis Oncology Universal Co-pay Program. Don ƙarin bayani kuma don gano idan kun cancanci tallafi, kira 877-577-7756 ko ziyarci gidan yanar gizon shirin.

Gleevec sashi

Mitar Gleevec da likitanku ya rubuta zai dogara ne da dalilai da yawa. Wadannan sun hada da:

  • nau'in da tsananin yanayin da kake amfani da Gleevec don magancewa
  • shekaru
  • nauyi (ga yara)
  • kasancewar maye gurbi
  • wasu yanayin kiwon lafiyar da zaka iya samu
  • wasu magunguna da zaku iya sha
  • sakamako masu illa da za ku iya samu

Adadin da za ku karɓa ya dogara da cutar kansa. Don wasu cututtukan daji, likitanka na iya fara maka a kan ƙananan sashi. Sannan za su daidaita shi a kan lokaci don isa sashin da ya dace da kai.

Bayani mai zuwa yana bayanin abubuwan da ake amfani dasu ko aka ba da shawarar. Koyaya, tabbatar da shan maganin da likitanka yayi maka. Likitan ku zai ƙayyade mafi kyawun sashi don dacewa da bukatun ku.

Magungunan ƙwayoyi da ƙarfi

Gleevec ya zo a matsayin kwamfutar hannu wanda kuka sha ta bakinku (kuka haɗiye shi). Akwai shi a cikin kwayoyi 100-mg da allunan 400-mg.

Kwayoyin 100-mg da 400-mg sun zo cikin kwalabe. Hakanan allunan na 400-mg sunada yawa a cikin fakiti wadanda suke da wahala yara su bude.

Gleevec sashi

Wadannan allurai sune abubuwan farawa na farawa na kowane yanayi:

  • tsofaffi tare da Philadelphia-tabbatacce (Ph +) cutar sankarar bargo na yau da kullum (CML) a cikin lokaci mai tsawo (ɓangaren farko na cutar): 400 mg / rana
  • manya tare da Ph + CML a cikin saurin rikice-rikice ko rikice-rikice (fasali na biyu da na uku na cutar): 600 mg / rana
  • manya tare da Ph + mai saurin cutar sankarar bargo (ALL): 600 mg / rana
  • manya tare da myelodysplastic / myeloproliferative cuta: 400 mg / rana
  • manya tare da m mastocytosis na tsari: 100 mg ko 400 mg / rana
  • manya da cututtukan cututtukan hypereosinophilic da / ko cutar sankarar bargo ta eosinophilic: 100 mg / rana ko 400 mg / rana
  • manya da cututtukan fata na dermatofibrosarcoma: 800 mg / rana
  • manya da cututtukan ciki na ciki (GIST): 400 mg / rana

Likitan ku na iya rubuta muku wani maganin daban. Za su kafa shi a kan yadda jikinka ya amsa da maganin, yadda tsananin tasirinka yake, da sauran abubuwan. Idan kuna da tambayoyi game da madaidaicin maganin Gleevec a gare ku, kuyi magana da likitan ku.

Sashin yara

Abubuwan da aka yi wa yara sune masu zuwa:

  • yara tare da Ph + CML a cikin lokaci mai tsawo (ɓangaren farko na cutar): 340 mg / m2 / rana
  • yara tare da Ph + ALL: 340 mg / m2 / rana don ɗauka tare da chemotherapy

Likitan ɗanka zai ɗora abin a kan tsayin ɗanka da nauyinsa. (Don haka 340 mg / m2 na nufin 340 MG a kowace murabba'in mita na yanayin fuskar jiki.) Misali, idan ɗanka ya kai ƙafa 4 tsayi kuma yana da nauyin lbs 49., Yanayin jikinsu ya kai kimanin 0.87 m2. Don haka sashi don Ph + CML zai zama 300 MG.

Menene idan na rasa kashi?

Idan ka rasa kashi na Gleevec, ɗauki guda da zaran ka tuna. Idan kusan lokaci ne don maganin ku na gaba, jira kuma ku ɗauki kashi na gaba kamar yadda aka tsara. Kar ka ɗauki allurai biyu don cika adadin da aka rasa. Wannan na iya haɓaka haɗarinku don mummunar illa.

Shin zan buƙaci amfani da wannan magani na dogon lokaci?

Ana nufin amfani da Gleevec azaman magani na dogon lokaci. Idan kai da likitanka sun ƙayyade cewa Gleevec yana da aminci da tasiri a gare ku, ƙila za ku ɗauke shi na dogon lokaci.

Madadin Gleevec

Akwai wasu kwayoyi waɗanda zasu iya magance yanayin ku. Wasu na iya zama sun fi dacewa da kai fiye da wasu. Idan kuna sha'awar neman madadin zuwa Gleevec, yi magana da likitan ku don ƙarin koyo game da wasu magunguna waɗanda zasu iya muku aiki da kyau.

Lura: Wasu magungunan da aka lissafa a nan ana amfani dasu don lakabin waɗannan takamaiman yanayin.

Sauran don CML

Misalan wasu kwayoyi waɗanda za'a iya amfani dasu don magance Philadelphia-tabbatacce (Ph +) cutar sankarar myeloid na kullum (CML) sune:

  • dasatinib (Sprycel)
  • nilotinib (Tasigna)
  • bosutinib (Bosulif)
  • ponatinib (Iclusig)
  • omacetaxine (Synribo)
  • daunorubicin (Cerubidine)
  • cytarabine
  • interferon-alpha (Intron A)

Madadin GIST

Misalan wasu kwayoyi waɗanda za'a iya amfani dasu don magance cututtukan ciki na ciki (GIST) sune:

  • sunitinib (Sutent)
  • regorafenib (Stivarga)
  • sorafenib (Nexavar)
  • nilotinib (Tasigna)
  • dasatinib (Sprycel)
  • pazopanib (Votrient)

Sauran hanyoyin don sauran yanayin Gleevec na iya magance su suma suna nan. Yi magana da likitanka game da waɗanne magunguna za a iya amfani dasu don yanayinku.

Gleevec vs. Tasigna

Kuna iya mamakin yadda Gleevec yake kwatanta da sauran magunguna waɗanda aka tsara don amfani iri ɗaya. Anan zamu kalli yadda Gleevec da Tasigna suke da kuma banbanci.

Yana amfani da

Hukumar Abinci da Magunguna (FDA) ta amince da Gleevec da Tasigna don magance wasu nau'ikan cutar kansa.

Dukkanin kwayoyi guda biyu an yarda da FDA don kula da sabon cutar Philadelphia-tabbatacce (Ph +) cutar sankarar myeloid na yau da kullun (CML) a cikin mawuyacin lokaci a cikin manya da yara.

Myeloid leukemia na kullum (CML) ya kasu kashi uku:

  • Tsarin lokaci. Wannan shine farkon matakin CML. Yawancin mutane suna bincikar su tare da CML yayin lokacin da suke ci gaba. Kwayar cutar galibi ba ta da sauƙi, idan akwai su kwata-kwata.
  • Hanzari mai sauri. A wannan zangon na biyu, adadin kwayoyin cutar kansa a cikin jininka yana ƙaruwa. Kuna iya samun ƙarin alamun bayyanar, kamar zazzaɓi da rage nauyi.
  • Bakin rikicin lokaci. A wannan mafi girman yanayin, kwayoyin cutar kansa a cikin jininka sun bazu zuwa sauran gabobi da kyallen takarda. Alamunka na iya zama mafi tsanani.

An yarda da Gleevec don kula da Philadelphia-tabbatacce (Ph +) CML a cikin manya waɗanda ke cikin mawuyacin hali, hanzari, ko fashewar rikici idan maganin interferon-alpha bai yi aiki ba.

Interferon-alpha magani ne wanda aka saba amfani dashi don magance CML a baya. Magunguna ne da mutum yayi wanda yake aiki kamar wasu sunadarai masu garkuwar jiki kuma yana hana ci gaban ƙwayoyin kansa.

Tasigna an yarda da shi don magance Ph + CML a cikin tsauraran matakai ko haɓaka cikin manya idan sauran jiyya basu yi aiki ba, gami da magani tare da Gleevec. Ba a yarda da Tasigna ba don lokacin rikicin fashewar abubuwa.

An kuma yarda da Tasigna don kula da Ph + CML a cikin yara masu shekara 1 zuwa sama idan sauran jiyya ba su yi aiki ba. An yarda da Gleevec don kula da sabon binciken Ph + CML a cikin yara.

Hakanan an yarda da Gleevec don magance wasu nau'ikan cutar kansa. Duba sashin “Sauran amfani don Gleevec” don ƙarin koyo.

Magungunan ƙwayoyi da gudanarwa

Gleevec ya ƙunshi maganin imatinib. Tasigna ya ƙunshi maganin nilotinib.

Gleevec ya zo a matsayin kwamfutar hannu. Tasigna ya zo a matsayin kwantena Ana amfani da magungunan biyu ta bakinsu.

Ana ɗaukar Gleevec sau ɗaya ko sau biyu a rana, ya dogara da yawan ku. Ana daukar Tasigna sau biyu a rana.

Gleevec yazo kamar 100-mg da 400-mg mg. Tasigna yazo kamar 50-mg, 150-mg, da 200-mg capsules.

Sakamakon sakamako da kasada

Gleevec da Tasigna suna dauke da irin wannan kwayoyi. Sabili da haka, duka magunguna na iya haifar da sakamako mai kama da juna. Da ke ƙasa akwai misalai na waɗannan tasirin.

Commonarin sakamako masu illa na kowa

Waɗannan jerin suna ƙunshe da misalai na cututtukan cututtukan da suka fi dacewa waɗanda zasu iya faruwa tare da Gleevec, tare da Tasigna, ko kuma tare da magungunan duka biyu (lokacin ɗauka daban-daban).

  • Zai iya faruwa tare da Gleevec:
    • edema (kumburin ƙafafunku, idon sawu, da ƙafa, da kuma idanun ku)
    • Ciwon tsoka
    • ciwon tsoka
    • ciwon kashi
    • ciwon ciki
  • Zai iya faruwa tare da Tasigna:
    • ciwon kai
    • fata mai ƙaiƙayi
    • tari
    • maƙarƙashiya
    • ciwon gwiwa
    • nasopharyngitis (ciwon sanyi na yau da kullun)
    • zazzaɓi
    • zufa na dare
  • Zai iya faruwa tare da Gleevec da Tasigna:
    • tashin zuciya
    • amai
    • gudawa
    • kurji
    • gajiya (rashin ƙarfi)

M sakamako mai tsanani

Waɗannan jerin suna ƙunshe da misalai na larura masu haɗari waɗanda zasu iya faruwa tare da Gleevec, tare da Tasigna, ko tare da magungunan duka biyu (lokacin ɗauka daban-daban).

  • Zai iya faruwa tare da Gleevec:
    • rikicewar zuciya ko matsalolin zuciya irin su ciwon zuciya na hagu
    • cututtukan ciki (ramuka a cikin ciki ko hanji)
    • mummunan halayen mutum, gami da ciwon Stevens-Johnson (zazzabi; ciwo mai zafi a bakinka, maƙogwaronka, idanunka, al'aurarka, ko duk jikinka)
    • lalacewar koda
    • hypothyroidism (ƙananan matakan thyroid) a cikin mutanen da aka cire maganin ka
  • Zai iya faruwa tare da Tasigna:
    • dogon lokacin QT (aikin lantarki mara kyau a zuciyar ka), wanda ba safai bane amma zai iya haifar da mutuwar kwatsam
    • toshe magudanar jini a cikin zuciya
    • pancreatitis
    • rashin daidaiton lantarki (manya ko ƙananan matakan wasu ma'adanai)
  • Zai iya faruwa tare da Gleevec da Tasigna:
    • rikicewar jini, gami da ƙarancin jini (ƙananan ƙwayoyin jinin jini), neutropenia (ƙananan ƙwayoyin farin jini), da thrombocytopenia (ƙananan matakan platelets)
    • hanta lalacewa
    • Ciwon ƙwayar ƙwayar ƙwayar cuta (ƙwayoyin kansar suna sakin sunadarai masu cutarwa a cikin jininka)
    • zubar jini (zubar jini wanda ba ya tsayawa)
    • riƙe ruwa mai tsanani (ruwa mai yawa ko ruwa)
    • ragu girma a cikin yara

Inganci

Gleevec da Tasigna suna da banbancin amfani da FDA. Amma dukansu suna bi da Ph + CML a cikin tsauraran matakai da haɓaka idan wasu wasu maganin basuyi aiki ba. CML yana da matakai uku: na yau da kullun (lokaci na 1), haɓaka (lokaci na 2), da rikicin hargitsi (lokaci na 3).

Amfani da Gleevec da Tasigna wajen magance sabon kamuwa da cutar Ph + CML a cikin manya an kwatanta su kai tsaye a cikin binciken asibiti. Masu binciken sun kwatanta mutanen da suka sha ko dai MG 400 na Gleevec sau ɗaya a rana ko 300 mg na Tasigna sau biyu a rana.

Bayan watanni 12 na jiyya, 65% na mutanen da suka ɗauki Gleevec ba su da ƙwayoyin Ph + a cikin kashin jikinsu (inda ƙwayoyin CML masu ciwon daji ke girma). Na mutanen da suka ɗauki Tasigna, 80% ba su da ƙwayoyin Ph + a cikin kashin jikinsu.

Bayan shekara biyar na jinya, kashi 60% na mutanen da suka ɗauki Gleevec sun rage ƙwayoyin halittar kansa da yawa a cikin jininsu. An kwatanta wannan da kashi 77% na mutanen da suka ɗauki Tasigna.

Hakanan bayan shekaru biyar na jinya, 91.7% na mutanen da suka ɗauki Gleevec suna da rai. Wannan idan aka kwatanta da 93.7% na mutanen da suka ɗauki Tasigna.

Sakamakon wannan binciken ya ba da shawarar cewa Tasigna na iya zama mafi tasiri fiye da Gleevec wajen kula da sabon likitan da aka gano Ph + CML a cikin tsawan lokaci.

Kudin

Gleevec da Tasigna duka magunguna ne masu suna. Tasigna bashi da sifa iri iri, amma Gleevec tana da nau'in tsari wanda ake kira imatinib. Magungunan sunaye suna yawanci suna da tsada fiye da na zamani.

Dangane da ƙididdiga akan GoodRx.com, sunan mai suna Gleevec na iya cin kuɗi ƙasa da Tasigna. Siffar ta Gleevec (imatinib) ita ma ba ta wuce Tasigna ba. Ainihin farashin da zaku biya ko dai magani ya dogara da yawan ku, shirin inshora, wurin ku, da kuma kantin da kuka yi amfani da shi.

Gleevec vs. Sprycel

Kuna iya mamakin yadda Gleevec ya kwatanta da sauran magunguna waɗanda aka tsara don amfani iri ɗaya. Anan zamu kalli yadda Gleevec da Sprycel suka yi kama da daban.

Yana amfani da

Hukumar Abinci da Magunguna (FDA) ta amince da Gleevec da Sprycel don kula da wasu nau'ikan cutar kansa.

Dukkanin kwayoyi guda biyu duk sun yarda da FDA don magance sabon cutar ta Philadelphia-tabbatacce (Ph +) cutar sankarar myeloid na yau da kullun (CML) a cikin mawuyacin lokaci a cikin manya da yara.

CML ya kasu kashi uku:

  • Tsarin lokaci. Wannan shine farkon matakin CML. Yawancin mutane suna bincikar su tare da CML yayin lokacin da suke ci gaba. Kwayar cutar galibi ba ta da sauƙi, idan akwai su kwata-kwata.
  • Hanzari mai sauri. A wannan zangon na biyu, adadin kwayoyin cutar kansa a cikin jininka yana ƙaruwa. Kuna iya samun ƙarin alamun bayyanar, kamar zazzaɓi da rage nauyi.
  • Bakin rikicin lokaci. A wannan mafi girman yanayin, kwayoyin cutar kansa a cikin jininka sun bazu zuwa sauran gabobi da kyallen takarda. Alamunka na iya zama mafi tsanani.

Gleevec da Sprycel ana amfani dasu don magance Ph + CML a cikin manya a cikin tsawan lokaci.

Hakanan ana amfani da Gleevec don magance Ph + CML a cikin manya a cikin mawuyacin hali, hanzari, ko fashewar rikice-rikice idan maganin interferon-alpha baiyi aiki ba. Interferon-alpha magani ne wanda aka saba amfani dashi don magance CML a baya. Magunguna ne da mutum yayi wanda yake aiki kamar wasu sunadarai masu garkuwar jiki kuma yana hana ci gaban ƙwayoyin kansa.

Ana amfani da Sprycel don magance Ph + CML a cikin manya a cikin tsauraran matakai, haɓakawa, ko fashewar rikici idan Gleevec bai yi aiki ba.

Dukansu Gleevec da Sprycel an yarda su kula da Ph + CML a cikin tsawan lokaci na yara. An yarda su duka biyun don magance cutar sankarar bargo (ALL) a cikin yara tare da chemotherapy.

Hakanan an yarda da Gleevec don magance wasu nau'ikan cutar kansa. Duba sashin “Sauran amfani don Gleevec” don ƙarin koyo.

Magungunan ƙwayoyi da gudanarwa

Gleevec ya ƙunshi maganin imatinib. Sprycel ya ƙunshi maganin dasatinib.

Gleevec da Sprycel duk sun zo ne azaman Allunan da kuke ɗauka da baki (kuna haɗiye su).

Gleevec Allunan sunada ƙarfi biyu: 100 MG da 400 MG. Ana shan sau ɗaya ko sau biyu a rana, gwargwadon yawan ku.

Sprycel Allunan sunzo cikin masu zuwa masu zuwa: 20 mg, 50 mg, 70 mg, 80 mg, 100 mg, and 140 mg. Ana ɗaukar Sprycel sau ɗaya a rana.

Sakamakon sakamako da kasada

Gleevec da Sprycel sun yi kama da juna amma suna dauke da kwayoyi daban-daban. Sabili da haka, duka magunguna na iya haifar da sakamako mai kama da juna. Da ke ƙasa akwai misalai na waɗannan tasirin.

Commonarin sakamako masu illa na kowa

Waɗannan jerin suna ƙunshe da misalai na abubuwan illa na yau da kullun waɗanda zasu iya faruwa tare da Gleevec, tare da Sprycel, ko tare da magungunan duka biyu (lokacin ɗauka daban-daban).

  • Zai iya faruwa tare da Gleevec:
    • amai
    • Ciwon tsoka
    • ciwon ciki
    • edema-yanki edema (kumburi a kusa da idanu)
  • Zai iya faruwa tare da Sprycel:
    • matsalar numfashi
    • ciwon kai
    • zub da jini
    • ya raunana garkuwar jiki (jikinka ba zai iya yaƙar cututtuka ba)
  • Zai iya faruwa tare da Gleevec da Sprycel:
    • edema (kumburin ƙafafunku, ƙafafunku, da ƙafafunku)
    • tashin zuciya
    • ciwon tsoka
    • ciwon kashi
    • gudawa
    • kurji
    • gajiya (rashin ƙarfi)

M sakamako mai tsanani

Waɗannan jerin suna ƙunshe da misalai na larura masu haɗari waɗanda zasu iya faruwa tare da Gleevec, tare da Sprycel, ko tare da magungunan biyu (lokacin da aka ɗauka ɗayansu).

  • Zai iya faruwa tare da Gleevec:
    • matsalolin zuciya, kamar wadatar zuci
    • hanta lalacewa
    • cututtukan ciki (ramuka a cikin ciki ko hanji)
    • lalacewar koda
    • hypothyroidism (ƙananan matakan thyroid) a cikin mutanen da aka cire maganin ka
  • Zai iya faruwa tare da Sprycel:
    • jijiyar jini na jijiya (hawan jini a magudanar jini a cikin huhu)
    • dogon lokacin QT (wani nau'in aikin lantarki ne mara kyau a zuciyar ka)
    • ciwon zuciya na zuciya (rashin isashshen oxygen zuwa tsokoki na zuciya)
  • Zai iya faruwa tare da Gleevec da Sprycel:
    • tsananin riƙe ruwa (ruwa da yawa ko ruwa) a kewayen huhunka, zuciya, da ciki
    • mummunan cuta (ƙananan matakan jajayen jini, platelets, ko farin ƙwayoyin jini)
    • zubar jini mai tsanani (zubar jini wanda baya tsayawa)
    • mummunan halayen mutum, gami da ciwon Stevens-Johnson (zazzabi; ciwo mai zafi a bakinka, maƙogwaronka, idanunka, al'aurarka, ko duk jikinka)
    • Ciwon ƙwayar ƙwayar ƙwayar cuta (ƙwayoyin kansar suna sakin sunadarai masu cutarwa a cikin jininka)
    • bugun zuciya mara kyau ko kari (bugun zuciya da ke da sauri, da sauri, ko mara kyau)
    • ci gaban yara

Inganci

Gleevec da Sprycel suna da banbancin amfani da FDA. Amma dukansu suna bi da sabon binciken da aka gano Ph + CML a cikin lokaci mai tsauri (farkon matakin CML) a cikin manya da yara. Gleevec da Sprycel suma suna kula da Ph + DUK a cikin yara yayin amfani dasu tare da chemotherapy.

Bugu da ƙari, duka Gleevec da Sprycel suna kula da Ph + CML a cikin ci gaba da ɓarna a cikin manya, ko Ph + ALL, idan sauran magunguna ba su yi aiki a kansu ba.

Amfani da Gleevec da Sprycel wajen magance sabon kamuwa da cutar Ph + CML a cikin manya an kwatanta su kai tsaye a cikin binciken asibiti. Masu binciken sun kwatanta mutanen da suka sha ko dai 400 mg na Gleevec a rana ko 100 mg na Sprycel a rana.

A tsakanin watanni 12, kashi 66.2% na mutanen da suka ɗauki Gleevec ba su da ƙwayoyin Ph + a cikin kashin jikinsu (inda ƙwayoyin CML masu ciwon daji ke ɓullowa). A cikin rukunin da ya ɗauki Sprycel, kashi 76.8% na mutanen ba su da ƙwayoyin Ph + a cikin ɓacin kashinsu.

Bayan shekaru biyar na jinya, kimanin mutane 89.6% na mutanen da suka ɗauki Gleevec suna da rai. Wannan idan aka kwatanta da kimanin 90.9% na mutanen da suka ɗauki Sprycel.

Sakamakon wannan binciken ya ba da shawarar cewa Sprycel na iya zama da ɗan tasiri fiye da Gleevec wajen kula da sabon likitan da aka gano Ph + CML a cikin tsawan lokaci.

Kudin

Gleevec da Sprycel duka magunguna ne masu suna. Sprycel bashi da nau'in tsari, amma Gleevec tana da nau'in tsari wanda ake kira imatinib. Magungunan sunaye suna yawanci suna da tsada fiye da na zamani.

Dangane da ƙididdiga akan GoodRx.com, sunan mai suna Gleevec na iya cin kuɗi ƙasa da Sprycel. Hakanan nau'in Gleevec (imatinib) na iya cin kuɗi ƙasa da Sprycel. Ainihin farashin da zaku biya na kowane magani ya dogara da yawan ku, shirin inshorar ku, wurin ku, da kuma kantin da kuke amfani da shi.

Gleevec da barasa

Ba a san ko Gleevec da barasa suna hulɗa da juna ba.

Koyaya, hanta yana narkewa (ya karye) duka Gleevec da barasa. Don haka yawan shan giya yayin shan Gleevec na iya hana hanta daga farfashe maganin. Wannan na iya ɗaga matakan Gleevec a cikin jikin ku kuma ƙara haɗarin ku ga mummunar illa, gami da lalata hanta.

Dukansu Gleevec da barasa na iya haifar da illa kamar:

  • tashin zuciya
  • gudawa
  • ciwon kai
  • gajiya (rashin ƙarfi)

Shan barasa a lokacin maganin Gleevec na iya ƙara haɗarin samun waɗannan cututtukan.

Idan kun sha barasa, yi magana da likitanku game da menene amintacce a gare ku yayin maganin Gleevec.

Hulɗar Gleevec

Gleevec na iya hulɗa tare da wasu magunguna da yawa. Hakanan yana iya ma'amala tare da wasu abubuwan haɓaka da wasu abinci.

Hanyoyi daban-daban na iya haifar da sakamako daban-daban. Misali, wasu na iya tsoma baki game da yadda kwayoyi ke aiki da kyau, yayin da wasu na iya haifar da ƙarin illa.

Gleevec da sauran magunguna

Da ke ƙasa akwai jerin magungunan da za su iya hulɗa tare da Gleevec. Wannan jeren ba ya ƙunsar duk magungunan da zasu iya hulɗa da Gleevec.

Kafin shan Gleevec, yi magana da likitanka da likitan magunguna. Faɗa musu game da duk takardar sayen magani, da kan-kan-kanta, da sauran magungunan da kuke sha. Har ila yau, gaya musu game da kowane bitamin, ganye, da abubuwan da kuke amfani da su. Raba wannan bayanin na iya taimaka maka ka guji yiwuwar mu'amala.

Idan kuna da tambayoyi game da ma'amalar miyagun ƙwayoyi waɗanda zasu iya shafar ku, tambayi likitan ku ko likitan magunguna.

Gleevec da Tylenol

Shan Gleevec tare da Tylenol (acetaminophen) na iya kara yawan haɗarinku ga mummunar illa, kamar lalata hanta.

Enzymes (sunadarai na musamman) a cikin hanta sun farfasa duka Gleevec da Tylenol. Tare, magungunan biyu zasu iya mamaye enzymes da lalata ƙwayoyin hanta.

Tambayi likitanku ko lafiya ba ku da ku ɗauki Tylenol yayin jinyar Gleevec.

Gleevec da wasu magungunan kwace

Shan Gleevec tare da wasu magungunan kwacewa na iya rage matakan Gleevec a jikin ku. Wannan na iya sa Gleevec ya zama mai ƙarancin tasiri (aiki ƙasa da kyau).

Misalan magungunan ƙwace waɗanda zasu iya rage matakan Gleevec sun haɗa da:

  • phenytoin (Dilantin, Phenytek)
  • carbamazepine (Carbatrol, Tegretol)
  • hanadarin

Idan kana shan Gleevec da wasu magunguna masu kamuwa da cuta, likitanka na iya rubuta maka wani magani na daban ko kuma daidaita Gleevec.

Gleevec da wasu maganin rigakafi

Shan Gleevec tare da wasu magungunan rigakafi (magungunan da ke magance cututtukan ƙwayoyin cuta) na iya ƙara matakan Gleevec a cikin jikinku. Magungunan rigakafi suna hana Gleevec karyewar cikin jikinka. Wannan yana ƙara haɗarinku don mummunar illa.

Misali na maganin rigakafi wanda zai iya ƙara matakan Gleevec shine clarithromycin (Biaxin XL).

Idan kuna shan Gleevec kuma kuna buƙatar maganin rigakafi, likitanku na iya sa ido akan abubuwan da ke faruwa. Hakanan suna iya rage muku maganin Gleevec na ɗan lokaci.

Gleevec da wasu kayan maganin cuta

Shan Gleevec tare da wasu magungunan kariya (magungunan da ke magance cututtukan fungal) na iya hana raunin Gleevec a cikin jikin ku. Wannan na iya ɗaga matakan Gleevec a cikin jininka kuma ya ƙara haɗarin ku ga mummunar illa.

Misalan antifungals da zasu iya ƙara matakan Gleevec sune:

  • itraconazole (Onmel, Sporanox, Tolsura)
  • ketoconazole (Extina, Ketozole, Xolegel)
  • voriconazole (Vfend)

Idan kuna shan Gleevec kuma kuna buƙatar maganin antifungal, likitanku zai kula da ku don sakamako masu illa. Hakanan suna iya rage muku maganin Gleevec na ɗan lokaci.

Gleevec da opioids

Shan Gleevec tare da wasu magungunan ciwo na iya kara matakan jin zafi a jikinka. Wannan na iya sa ku iya samun illa mai tsanani kamar su laulayi (jin bacci da ƙarancin faɗakarwa) da baƙin ciki na numfashi (jinkirin numfashi).

Misalan magunguna masu zafi na opioid waɗanda zasu iya haɓaka matakan Gleevec sun haɗa da:

  • oxycodone (Oxycontin, Roxicodone, Xtampza ER)
  • tramadol (ConZip, Ultram)
  • methadone (Dolophine, Methadose)

Yi magana da likitanka game da ko yana da lafiya don shan maganin ciwo yayin maganin Gleevec. Suna iya ba da shawarar wasu hanyoyi don sauƙaƙa wahalar ku.

Gleevec da wasu magungunan HIV

Shan Gleevec tare da wasu magungunan HIV na iya kara yawan haɗarinku ga mummunar illa. Wasu magungunan HIV na iya hana Gleevec lalacewa, wanda ke haifar da matakan Gleevec mafi girma a jikin ku.

Misalan magungunan HIV waɗanda zasu iya haɓaka matakan Gleevec sun haɗa da:

  • Atazanavir (Reyataz)
  • Nevirapine (Viramune)
  • Saquinavir (Invirase)

Wani maganin HIV, efavirenz (Sustiva), na iya rage matakan Gleevec a jikin ku. Wannan na iya sa Gleevec ya zama ba shi da tasiri.

Magungunan HIV da yawa suna zuwa kamar allunan haɗuwa, wanda ke nufin sun haɗa da ƙwayoyi fiye da ɗaya. Don haka ka tabbata kayi magana da likitanka game da duk magungunan cutar kanjamau da kake sha.

Idan kuna buƙatar shan Gleevec tare da wasu magungunan HIV, likitanku na iya canza muku maganin Gleevec.

Gleevec da wasu magungunan hawan jini

Shan Gleevec tare da wasu magungunan hawan jini na iya kara ko rage matakan ko dai magani a jikin ku. Wannan na iya baka damar samun illa ko rage yadda magunguna suke aiki.

Misalin wadannan magungunan sun hada da verapamil (Calan, Tarka).

Idan kuna buƙatar ɗaukar Gleevec tare da ɗayan waɗannan magungunan, likitanku zai kula da ku sosai don abubuwan illa. Hakanan zasu iya daidaita jigilar ko dai magani ko bayar da shawarar wani magani daban.

Gleevec da warfarin

Shan Gleevec tare da warfarin (Coumadin, Jantoven) na iya kara yawan zubar jini. Gleevec yana hana warfarin lalacewa a jikinku. Wannan yana ƙaruwa matakan warfarin kuma yana iya haifar da zub da jini mai wuyar sarrafawa.

Idan kuna buƙatar maganin ƙwayar cuta (mai ƙwanƙwasa jini) yayin shan Gleevec, likitanku zai iya ba da umarnin wani magani banda warfarin.

Gleevec da St. John's wort

Shan Gleevec tare da St. John's wort na iya rage matakan Gleevec a jikinka. Wannan na iya sa Gleevec ya zama ba shi da tasiri (ba aiki sosai ba).

Tambayi likitanku ko St. John's wort yana da lafiya a gare ku ku ɗauka yayin maganin Gleevec. Suna iya ba da shawarar madadin zuwa St. John's Wort ko ƙara yawan ku Gleevec.

Gleevec da inabi

Cin 'ya'yan inabi ko shan ruwan' ya'yan itace a lokacin aikin Gleevec na iya kara kasadar ku don mummunar illa. Auren peapean itacen inabi yana ɗauke da sinadarai da ke hana Gleevec lalacewa a jikinku. Wannan yana haifar da ƙaruwar matakan Gleevec, wanda zai haifar da sakamako mai tsanani.

Tabbatar kauce wa cin ɗan itacen inabi da shan ruwan anab a lokacin jinyar Gleevec.

Yadda ake ɗaukar Gleevec

Tabbatar ɗaukar Gleevec bisa ga likitanku ko umarnin mai ba da lafiya.

Yaushe za'a dauka

Don allurar Gleevec na 600 MG ko ƙasa da haka, ya kamata a sha maganin sau ɗaya a rana. Kuna iya ɗauka a kowane lokaci.

Idan likitanku ya ba da shawarar 800 MG na Gleevec a rana, za ku sha shi a cikin allurai biyu: 400 MG da safe da 400 MG da yamma.

Kwararka zai ba ka umarni kan lokacin da ya kamata ka sha kashi.

Shan Gleevec tare da abinci

Gauki Gleevec tare da abinci da babban gilashin ruwa. Wannan na iya taimakawa wajen hana ciwon ciki.

Shin ana iya niƙe Gleevec, raba, ko tauna?

Bai kamata ka murkushe, raba, ko tauna allunan Gleevec ba. Tabletsuƙe kuma raba allunan na iya zama cutarwa ga kowane fata ko wasu sassan jikin da ya sadu da su.

Idan kuna da matsala haɗiye allunan Gleevec, sanya kwamfutar a cikin babban gilashin ruwa ko ruwan apple. Sanya ruwan da cokali don taimakawa kwamfutar ta narke. Sannan sha hadin hadin kai tsaye.

Yadda Gleevec ke aiki

Gleevec ya ƙunshi maganin imatinib, wanda ke cikin rukunin magungunan da ake kira masu hana ƙwayoyin cuta na tyrosine kinase (TKIs). Magunguna a cikin ajin likitancin TKI sune hanyoyin kwantar da hankali. Suna shafar takamaiman sunadarai a cikin kwayoyin cutar kansa.

An yarda da Gleevec don magance yanayi daban-daban. Anan zamu bincika yadda Gleevec ke aiki don magance biyu daga cikinsu.

Na Ph + CML

A cikin Philadelphia-tabbatacce (Ph +) cutar sankarar myeloid na yau da kullun (CML), ƙwayoyin da ke ƙirƙirar farin ƙwayoyin jini suna da kuskure a tsarin halittar su. Wannan kuskuren kwayar halitta ana samunta ne akan layin DNA wanda ake kira chromosome na Philadelphia.

Kwayar chromosome ta Philadelphia tana dauke da kwayar halittar da ba ta dace ba (BCR-ABL1) wanda ke sa fararen jini da yawa su samu. Wadannan fararen kwayoyin jinin basa girma kuma suna mutuwa kamar yadda yakamata. Farin jinin jini mara girma wanda ake kira "blasts" ya tara wasu nau'ikan ƙwayoyin jinin da jininku yake buƙata suyi aiki daidai.

Gleevec yana aiki ta haɗuwa da furotin, wanda ake kira tyrosine kinase, a cikin ƙwayoyin da BCR-ABL1 yayi. Lokacin da Gleevec ya ɗaura ga wannan furotin, maganin zai hana tantanin halitta aika sakonni waɗanda ke faɗin tantanin ya girma. Ba tare da waɗannan alamun girma ba, ƙwayoyin jini masu cutar kansa suna mutuwa. Wannan yana taimakawa dawo da adadin ƙwayoyin fashewar zuwa lambar lafiya.

Don GIST

Gleevec shima yana taimakawa wajen magance ciwan ciwan ciki na ciki (GIST). A cikin ƙwayoyin tumo na GIST da yawa, akwai adadin wasu sunadarai masu yawa, waɗanda ake kira Kit da haɓakar haɓakar platelet (PDGF), fiye da na ƙwayoyin al'ada. Wadannan sunadarai suna taimakawa kwayoyin cutar kansa girma da rarrabuwa.

Kamfanin Gleevec yana niyya ga waɗannan sunadaran kuma yana hana su aiki. Wannan yana jinkirta haɓakar kansa. Hakanan yana haifar da kwayoyin cutar kansa su mutu.

Yaya tsawon lokacin aiki?

Ya dogara. Lokaci lokacin da Gleevec zai fara aiki ya bambanta ga kowane mutum.

Nazarin asibiti ya kalli mutanen da ke tare da CML waɗanda suka ɗauki Gleevec. A cikin wata guda, an rage adadin ƙwayoyin cutar kansa a cikin jini a cikin rabin mutanen da ke cikin rikicin rikici (matakin ci gaba na CML). A cikin karatun mutane tare da GIST waɗanda suka ɗauki Gleevec, ciwace-ciwacen sun daina girma ko raguwa cikin watanni uku.

Kullum likitanku zai kula da jininka koyaushe don ganin idan Gleevec yana muku aiki.

Gleevec da ciki

Ya kamata ku guji Gleevec idan kuna da ciki. Akwai rahotanni game da ɓarna da lahani ga ɗan tayi a cikin matan da suka ɗauki Gleevec yayin da suke da juna biyu. Kuma a cikin karatun dabbobi, mata masu ciki waɗanda aka baiwa Gleevec suna da haɗarin haɗarin haihuwa.

Idan kun kasance masu ciki, likitanku na iya ba ku shawara ku jira har sai kun haihu don fara shan Gleevec. Ko za su bayar da shawarar wani magani na daban.

Idan kuna shan Gleevec, yana da mahimmanci a yi amfani da maganin hana haihuwa yadda ya kamata don kar ku yi ciki. Bayan ka sha kashi na karshe na Gleevec, ci gaba da amfani da maganin haihuwa na tsawon kwanaki 14.

Gleevec da nono

Nazarin ya nuna cewa Gleevec ya shiga cikin nono na mama. Wannan na iya haifar da mummunar illa ga jaririn da ke shayarwa.

Idan kuna shayarwa kuma kuna la'akari da shan Gleevec, likitanku na iya ba ku shawara ku daina shayarwa lokacin da kuka fara jiyya.

Bayan ka sha kashi na karshe na Gleevec, jira a kalla wata daya kafin ka fara shayarwa.

Gleevec ya wuce gona da iri

Shan Gleevec da yawa na iya ƙara haɗarin ku don mummunar illa.

Symptomsara yawan ƙwayoyi

Kwayar cututtukan ƙwayar ƙwayar cuta na iya haɗawa da:

  • tashin zuciya
  • amai
  • gudawa
  • ciwon ciki
  • mummunan rash
  • jijiyoyin jijiyoyi (twitches)
  • ciwon kai
  • rashin ci
  • rauni na tsoka
  • gajiya (rashin ƙarfi)
  • kumburi
  • rikicewar jini, kamar ƙananan matakan platelets, jan jini, ko fararen ƙwayoyin jini
  • zazzaɓi

Abin da za a yi idan ya wuce gona da iri

Idan ka yi tunanin kun sha da yawa daga wannan magani, kira likitan ku. Hakanan zaka iya kiran Associationungiyar ofungiyar Kula da Guba ta Amurka a 800-222-1222 ko amfani da kayan aikinsu na kan layi. Amma idan alamun ka masu tsanani ne, kira 911 ko ka je dakin gaggawa mafi kusa kai tsaye.

Tambayoyi gama gari game da Gleevec

Anan akwai amsoshi ga wasu tambayoyin da akai akai game da Gleevec.

Shin Gleevec wani nau'i ne na ilimin kimiya?

Gleevec ba fasaha ba ce ta hanyar maganin ƙwaƙwalwa. Gleevec magani ne mai mahimmanci wanda ke shafar takamaiman ƙwayoyin cuta a cikin ƙwayoyin kansa.

Ta hanyar keɓance takamaiman ƙwayoyin cuta, hanyoyin kwantar da hankali kamar Gleevec suna taimaka rage jinkirin girma da yaduwar ƙwayoyin kansa. Kullum likitanku zai tsara muku maganin cutar da kuka yi niyya dangane da irin cutar kansar da kuke da ita.

Magungunan Chemotherapy sun bambanta da hanyoyin kwantar da hankali. Magungunan maganin ƙwaƙwalwa suna aiki a kan dukkan ƙwayoyin jiki waɗanda ke girma cikin sauri, ba ƙwayoyin kansa kawai ba. Magungunan Chemotherapy yawanci suna kashe ƙwayoyin da ke girma kuma suna shafar ƙwayoyin jiki a jiki fiye da maganin da ake niyya.

Shin nau'ikan nau'ikan Gleevec yana da tasiri kamar magungunan ƙwayoyi?

Hukumar Abinci da Magunguna (FDA) tana buƙatar masu yin magungunan ƙwayoyi don tabbatar da cewa samfurin su yana da:

  • irin kayan aikin da ake amfani dasu kamar sunan magani
  • wannan ƙarfi da sifa iri ɗaya kamar magani mai suna
  • wannan hanyar gudanarwar (yadda kuke shan magani)

Hakanan ana buƙatar magungunan ƙwayoyi suyi aiki iri ɗaya kuma daidai da samfurin suna.

A cewar FDA, nau'ikan nau'ikan Gleevec ya cika waɗannan buƙatun. Wannan yana nufin cewa FDA ta tabbatar da cewa nau'in tsari yana da tasiri kamar magungunan ƙwayoyi.

Shin zan iya inganta juriya zuwa jiyya tare da Gleevec?

Ee. Yana yiwuwa a gare ku ku ci gaba da juriya ga Gleevec. Juriya yana nufin cewa miyagun ƙwayoyi ya daina aiki a kan lokaci. Ana tunanin cewa wannan yana haifar da canji a cikin ƙwayoyin ƙwayoyin cuta.

Idan kun haɓaka juriya ga Gleevec, likitanku na iya ba da izini mafi girma. Za su gani idan kwayoyin cutar kansa sun sake amsawa ga maganin. Hakanan likitan ku na iya ba da magani na daban wanda ba ku da juriya.

Shin akwai iyakance abincin da zan bi yayin shan Gleevec?

Babu wasu takunkumi na abinci na yau da kullun waɗanda yakamata ku bi yayin ɗaukar Gleevec. Koyaya, yakamata ku guji cin inabi da shan ruwan anab. An itacen inabi ya ƙunshi wani sinadari da zai iya hana jikinka yin kumburi (farfashewa) Gleevec. Wannan na iya haifar da matakan magani mafi girma a cikin jininka. Matakan Gleevec waɗanda suke sama da al'ada suna ƙara haɗarinku don mummunar illa.

Bugu da ƙari, likitanku na iya ba ku shawara ta musamman game da abincinku don taimakawa sauƙaƙa wasu sakamako masu illa. Misali, Gleevec yana haifar da jiri da amai ga mutane da yawa. Don taimakawa hana wannan, likitanku na iya ba da shawarar cewa ku guji abincin da zai iya sa tashin zuciya ya yi muni. Waɗannan sun haɗa da abinci mai nauyi, mai ƙanshi, ko mai mai, da abinci mai yaji ko mai guba. Misalai sune mafi yawan jan biredi, soyayyen abinci, da kayan abinci da sauri.

A ƙarshe, idan kuna shan Gleevec don ciwon daji na ciki, kamar ƙwayoyin cuta na ciki (GIST), likitanku na iya bayar da shawarar takamaiman ƙayyadadden abincin. Makasudin shine don hana matsaloli a cikin ciki ko hanji. Yi magana da likitanka game da waɗanne irin abinci ne mafi kyawu a gare ku.

Shin zan sami bayyanar cututtuka idan na daina amfani da Gleevec?

Kuna iya. Wasu mutane sun sami bayyanar cututtuka bayan sun ƙare maganin Gleevec. A cikin ƙaramin binciken asibiti, 30% na mutane suna da tsoka ko ƙashin kashi bayan sun daina Gleevec. Ciwon ya kasance galibi a kafaɗunsu, kwatangwalo, ƙafafu, da hannayensu. Wannan alamar cirewar ta faru ne tsakanin makonni ɗaya zuwa shida na dakatar da magani.

Kimanin rabin mutanen sun bi da zafin su tare da masu rage radadin ciwo. Sauran rabin suna bukatar maganin sayan magani. A mafi yawan mutanen da suke da waɗannan alamun bayyanar, ciwon tsoka da ƙashi sun tafi cikin watanni uku zuwa shekara ko mafi tsayi.

Shin zan buƙaci amfani da wasu kwayoyi tare da Gleevec don magani?

Ya dogara da yadda ciwan kansa yake. Don matakan ci gaba na ciwon daji ko cututtukan daji waɗanda suka bazu zuwa cikin kwakwalwa ko kashin baya, likitanku na iya ƙara ƙwayar cuta don maganin Gleevec ɗinku. Kari akan haka, yara masu dauke da cutar sankarar bargo (ALL) na iya karɓar Gleevec tare da maganin cutar sankara ta jiki (Ph +) mai saurin gaske (Ph +).

Ga wasu nau'ikan cututtukan daji, likitan ku na iya tsara steroid. Kuma zaka iya buƙatar amfani da magunguna don gudanar da lahani, kamar masu ba da ciwo don ciwon tsoka.

Garewar Gleevec, ajiya, da zubar dashi

Lokacin da kuka samo Gleevec daga kantin magani, mai harhaɗa magunguna zai ƙara ranar karewa zuwa lakabin akan kwalban. Wannan kwanan wata galibi shekara ɗaya ce daga ranar da suka ba da magani.

Ranar karewa yana taimakawa tabbatar da ingancin magani a wannan lokacin. Matsayi na Hukumar Abinci da Magunguna ta yanzu (FDA) shine gujewa amfani da magungunan da suka ƙare. Idan kana da magungunan da ba a amfani da su wanda ya wuce ranar karewa, yi magana da likitan ka. Suna iya gaya maka ko har yanzu kuna iya amfani da shi.

Ma'aji

Yaya tsawon magani ya kasance mai kyau na iya dogara da dalilai da yawa, gami da yadda da kuma inda kuka adana maganin.

Adana ƙwayoyin Gleevec ɗinka a zazzabin ɗaki a cikin akwati da aka toshe da ƙarfi. Tabbatar kare su daga danshi.

Zubar da hankali

Idan baku da bukatar shan Gleevec kuma ku sami ragowar magunguna, yana da mahimmanci a zubar da shi lafiya.

Wannan yana taimakawa hana wasu, gami da yara da dabbobin gida, daga shan ƙwaya kwatsam. Hakanan yana taimakawa kiyaye miyagun ƙwayoyi daga cutar da muhalli.

Yanar gizo na FDA yana ba da shawarwari masu amfani da yawa game da zubar da magani. Hakanan zaka iya tambayar likitan ka bayani game da yadda zaka zubar da maganin ka.

Bayani na ƙwararru don Gleevec

Ana ba da bayanin nan na gaba don likitoci da sauran ƙwararrun likitocin kiwon lafiya.

Manuniya

Gleevec (imatinib) an yarda da FDA don bi da waɗannan masu zuwa:

  • manya da yara tare da sabon cutar da aka gano ta Philadelphia-tabbatacce (Ph +) cutar sankarar bargo mai ƙarfi (CML) a cikin tsawan lokaci
  • manya tare da Ph + CML a kowane yanayi, biyo bayan gazawar maganin interferon-alpha
  • manya tare da sake kamuwa da cutar Phukewar cutar sankarar bargo (ALL)
  • yara tare da sabon binciken Ph + ALL a hade tare da chemotherapy
  • manya tare da cututtukan myelodysplastic / myeloproliferative wanda ke haɗuwa da haɓakar haɓakar ƙarfe mai haifar da tasirin mai karɓar kwayar halitta
  • manya tare da tsananin mastocytosis ba tare da maye gurbin D816V c-Kit ba ko kuma ba a san matsayin c-Kit ba
  • manya da cututtukan cututtukan hypereosinophilic da / ko cutar sankara ta eosinophilic tare da FIP1L1-PDGFRα fusion kinase, mummunan ga FIP1L1-PDGFRα fusion kinase, ko matsayin da ba a sani ba
  • manya tare da marasa ƙarfi, maimaitawa, ko metastatic dermatofibrosarcoma protuberans (DFSP)
  • manya tare da ƙananan ƙwayoyin cuta na kit + ƙananan ciwan ciki (GIST)
  • adjuvant far ga manya tare da Kit + GIST bayan cikakken dawo da babban aiki

Hanyar aiwatarwa

Gleevec ya hana BCR-ABL tyrosine kinase, wanda shine mummunan tyrosine kinase da aka samu a cikin Ph + CML. Rashin hana BCR-ABL tyrosine kinase yana hana yaduwar salula kuma yana haifar da apoptosis a cikin layin sel na BCR-ABL kuma a cikin layin cell na cutar sankarar bargo. Gleevec kuma yana hana haɓakar tyrosine don haɓakar haɓakar platelet (PDGF) da sel sel (SCF) da c-Kit, wanda ke hana haɓaka da haifar da apoptosis a cikin ƙwayoyin GIST.

Pharmacokinetics da metabolism

Ma'anar cikakkiyar kwayar halittar samuwa shine 98% bayan bin baka. Kimanin kashi 95% na kashi yana ɗaure ne da sunadaran plasma (galibi albumin da α1-acid glycoprotein).

Metabolism yana faruwa da farko ta hanyar CYP3A4 zuwa aiki mai narkewa, tare da ƙaramar metabolism da ke faruwa ta hanyar CYP1A2, CYP2D6, CYP2C9, da CYP2C19. CYP3A4 ne ya kirkira babban aikin motsa jiki mai gudana. An kashe kusan 68% a cikin najasa, tare da 13% a cikin fitsari. Kashe rabin rai na magungunan da ba a canza ba shine awanni 18 kuma kawar da rabin rayuwar babban mai aiki mai narkewa shine awanni 40.

Contraindications

Babu cikakkun takaddama ga amfani da Gleevec.

Adanawa da sarrafawa

Ya kamata a adana Allunan Gleevec a zazzabin ɗaki (77 ° F / 25 ° C) a cikin akwati da aka toshe da ƙarfi. Kare allunan daga danshi.

Ana ɗaukar allunan Gleevec a matsayin mai haɗari, bisa ga ƙa'idodin Tsaron Aiki da Gudanar da Lafiya (OSHA). Bai kamata a farfasa allunan ba. Guji taɓa tabon allunan. Idan membobi na fata ko na gamsai sun haɗu da rubutattun allunan, wanke yankin da abin ya shafa bisa ga jagorancin OSHA.

Bayanin sanarwa: Labaran Likita a Yau sun yi iya kokarinsu don tabbatar da cewa dukkan bayanan gaskiya ne, cikakke, kuma na zamani. Koyaya, wannan labarin bai kamata ayi amfani dashi azaman madadin ilimi da ƙwarewar ƙwararren likita mai lasisi ba. Ya kamata koyaushe ku tuntuɓi likitanku ko wasu masu sana'a na kiwon lafiya kafin shan kowane magani. Bayanin magani da ke cikin wannan batun na iya canzawa kuma ba ana nufin ya rufe duk amfanin da zai yiwu ba, kwatance, kiyayewa, gargaɗi, hulɗar miyagun ƙwayoyi, halayen rashin lafiyan, ko cutarwa. Rashin gargadin ko wasu bayanai don maganin da aka bayar baya nuna cewa magani ko haɗin magungunan yana da aminci, tasiri, ko dacewa ga duk marasa lafiya ko duk takamaiman amfani.

Mai Ban Sha’Awa A Shafin

Poller Allergies
Kiwon Lafiya

Poller Allergies

Menene cutar ra hin lafiyar pollen?Pollen hine ɗayan ananniyar anadin ra hin lafiyar a Amurka.Pollen kyakkyawan foda ne mai kyau wanda bi hiyoyi, furanni, ciyawa, da ciyawa ke amarwa don takin wa u t...
Duk Game da Haihuwa
Kiwon Lafiya

Duk Game da Haihuwa

BayaniCiki hine lokacin da maniyyi yayi tafiya ta cikin farji, zuwa cikin mahaifa, kuma ya hadu da kwan da aka amu a bututun mahaifa.T inkaye - kuma a ƙar he, ciki - na iya ƙun ar jerin matakai ma u ...