Nexium vs. Prilosec: Jiyya biyu na GERD

Wadatacce

• Me yasa PPI suke aiki
• Me yasa aka tsara su
• Bambanci
• Inganci
• Farashin taimako
• Sakamakon sakamako
• Gargadi da mu'amala
• Hanyoyin haɗari
• Hadin magunguna
• Takeaway

Mun haɗa da kayayyakin da muke tsammanin suna da amfani ga masu karatu. Idan ka siya ta hanyoyin yanar gizo a wannan shafin, zamu iya samun ƙaramin kwamiti. Ga tsarinmu.

Fahimtar hanyoyin ku

Bwannafi yana da wahala isa. Yin hankali game da zaɓin maganinku don cututtukan reflux na gastroesophageal (GERD) na iya sa ya zama mafi ƙalubale.

Biyu daga cikin kwayoyi masu hana ruwa gudu (PPIs) sune omeprazole (Prilosec) da esomeprazole (Nexium). Dukansu yanzu ana samunsu azaman magungunan kan-kan-kan (OTC).

Dubi duka biyun don ganin fa'idar da magani guda ɗaya zai iya bayarwa akan ɗayan.

Me yasa PPI suke aiki

Furododin Proton sune enzymes da ake samu a cikin kwayoyin halittar ciki. Suna yin hydrochloric acid, babban sinadarin acid ciki.

Jikinka yana buƙatar ruwan ciki don narkewa. Koyaya, lokacin da tsokar da ke tsakanin ciki da esophagus ba ta rufe yadda ya kamata, wannan acid ɗin zai iya ƙarewa a cikin hancinku. Wannan yana haifar da jin ƙonewa a kirjinka da maƙogwaronka mai alaƙa da GERD.

Hakanan yana iya haifar da:

• asma
• tari
• namoniya

PPIs na rage adadin acid din da proton pumps keyi. Suna aiki mafi kyau lokacin da ka ɗauki su awa ɗaya zuwa minti 30 kafin cin abinci. Kuna buƙatar ɗaukar su na tsawon kwanaki kafin suyi tasiri sosai.

An yi amfani da PPIs tun 1981. Ana ɗaukar su magani mafi inganci don rage ruwan ciki.

Me yasa aka tsara su

Ana amfani da PPI kamar Nexium da Prilosec don magance yanayin alaƙa da ciki, gami da:

• GERD
• ƙwannafi
• esophagitis, wanda shine kumburi ko yashwa cikin esophagus
• ciki da duodenal ulcers, waɗanda suke haifar da Helicobacter pylori (H. pylori) kamuwa da cuta ko cututtukan cututtukan ƙwayoyin cuta (NSAIDs)
• Ciwon Zollinger-Ellison, wanda shine cuta wanda ciwace-ciwace ke haifar da samar da ruwan ciki mai yawa

Bambanci

Omeprazole (Prilosec) da esomeprazole (Nexium) suna kama da kwayoyi. Koyaya, akwai ƙananan bambance-bambance a cikin kayan aikin sunadarai.

Prilosec ya ƙunshi isomers biyu na maganin omeprazole, yayin da Nexium ya ƙunshi isomer ɗaya kawai.

Isomer kalma ce ta kwayar halitta wacce ta hada da irin wannan sanadarai, amma an tsara ta ta wata hanya daban.Don haka, kuna iya cewa omeprazole da esomeprazole an yi su ne da tubali iri ɗaya, amma an haɗa su daban.

Duk da yake bambance-bambance a cikin isomers na iya zama kamar ƙarami, suna iya haifar da bambance-bambance game da yadda kwayoyi ke aiki.

Misali, isomer din da ke Nexium ana sarrafa shi a hankali fiye da Prilosec a jikinka. Wannan yana nufin cewa matakan maganin sun fi girma a cikin jini, kuma cewa esomeprazole na iya rage yawan samarwar acid na wani lokaci mai tsayi.

Hakanan yana iya aiki da sauri sauri don magance alamunku idan aka kwatanta da omeprazole. Hakanan Esomeprazole ya rabu daban ta hanta, don haka yana iya haifar da ƙara hulɗar magunguna fiye da omeprazole.

Inganci

Wasu nazarin suna nuna cewa bambance-bambance tsakanin omeprazole da esomeprazole na iya bayar da wasu fa'idodi ga mutanen da ke da wasu yanayi.

Wani binciken da ya gabata daga 2002 ya gano cewa esomeprazole ya samar da ingantaccen iko akan GERD fiye da omeprazole a wannan allurai.

Dangane da bincike na gaba a cikin 2009, esomeprazole ya ba da taimako mai sauri fiye da omeprazole a makon farko na amfani. Bayan mako guda, taimakon bayyanar cututtuka yayi kama.

Koyaya, a cikin labarin 2007 a cikin Likitan Iyali na Amurka, likitoci sunyi tambayoyi game da waɗannan da sauran nazarin akan PPIs. Sun ambaci damuwa kamar:

• bambance-bambance a cikin adadin abubuwan haɗin da aka bayar a cikin karatun
• girman karatun
• hanyoyin asibiti da ake amfani dasu don auna tasiri

Marubutan sun binciki nazarin 41 kan tasirin PPIs. Sun kammala cewa akwai ɗan bambanci kaɗan a cikin tasirin PPIs.

Don haka, yayin da akwai wasu bayanai da ke nuna cewa esomeprazole ya fi tasiri a sauƙaƙe alamun, yawancin masana sun yarda cewa PPIs suna da irin wannan tasirin gaba ɗaya.

Kwalejin Nazarin Gastroenterology ta Amurka ta bayyana cewa babu manyan bambance-bambance game da yadda PPI daban-daban suke aiki don magance GERD.

Farashin taimako

Babban bambanci tsakanin Prilosec da Nexium shine farashi idan aka duba.

Har zuwa Maris 2014, Nexium yana samuwa ne kawai ta hanyar takardar sayan magani kuma a ƙimar mafi girma. Nexium yanzu yana bayar da samfurin kan-kan-kan-kan (OTC) wanda ke tsada tare da Prilosec OTC. Koyaya, omeprazole na yau da kullun na iya zama ƙasa da Prilosec OTC.

A al'ada, kamfanonin inshora ba su rufe kayayyakin OTC. Koyaya, kasuwar PPI ta jagoranci mutane da yawa don sake duba labaran su na Prilosec OTC da Nexium OTC. Idan inshorar ku har yanzu ba ta rufe OTC PPIs ba, takardar sayan magani don kwayar omeprazole ko esomeprazole na iya zama mafi kyawun zaɓi.

Nexium wani lokaci ana kiransa "ni ma" magani saboda yana kama da Prilosec, magani mai kasancewa. Wasu mutane suna tunanin cewa "ni ma" magungunan wata hanya ce kawai da kamfanonin magani ke samun kuɗi ta hanyar kwafin magungunan da tuni akwai su. Amma wasu sun yi jayayya cewa "ni ma" magunguna na iya zahiri rage farashin magunguna, saboda suna ƙarfafa gasa tsakanin kamfanonin magunguna.

Yi aiki tare da likitanka ko likitan magunguna don yanke shawarar wane PPI ya fi dacewa a gare ku. Baya ga farashi, la'akari da abubuwa kamar:

• sakamako masu illa
• sauran yanayin kiwon lafiya
• sauran magunguna da kuke sha

Sakamakon sakamako

Yawancin mutane ba su da illa daga abubuwan PPIs. Ba safai ba, mutane na iya fuskantar:

• gudawa
• tashin zuciya
• amai
• ciwon kai

Wadannan cututtukan na iya zama wata ila tare da esomeprazole fiye da omeprazole.

Haka kuma an yi imanin cewa duka waɗannan abubuwan na iya ƙara haɗarin:

• kashin baya da wuyan wuyan hannu a cikin matan da suka gama haihuwa, musamman idan an sha magungunan na tsawon shekara guda ko sama da haka ko kuma a manyan allurai
• kumburin ƙwayoyin cuta na hanji, musamman bayan kwanciya asibiti
• namoniya
• rashin abinci mai gina jiki, gami da bitamin B-12 da karancin magnesium

An bayar da rahoton hanyar haɗi zuwa yiwuwar cutar hauka a cikin 2016, amma babban binciken tabbatarwa a cikin 2017 ya ƙaddara cewa babu wata haɗarin cutar rashin hankali daga amfani da PPIs.

Mutane da yawa suna fuskantar haɓakar haɓakar acid lokacin da suka daina amfani da PPIs. Koyaya, dalilin da ya sa wannan ya faru ba a fahimta gaba ɗaya.

Don yawancin al'amuran acid na ciki, ana ba da shawarar cewa ka ɗauki PPIs ba fiye da makonni huɗu zuwa takwas ba sai dai idan likitanka ya ƙayyade tsawon lokacin maganin da ake buƙata.

A ƙarshen lokacin shawarar da aka ba da shawarar, ya kamata ku sha kan shan magani a hankali. Yi aiki tare da likitanka don yin haka.

Gargadi da mu'amala

Kafin shan kowane magani, yi magana da likitanka don koyo game da abubuwan haɗari da ma'amala da ƙwayoyi masu alaƙa da su.

Hanyoyin haɗari

• 'yan asalin Asiya ne, saboda jikinku na iya ɗaukar tsawon lokaci don aiwatar da PPI kuma kuna iya buƙatar sashi daban
• da ciwon hanta
• sun sami ƙananan matakan magnesium
• suna da ciki ko shirin yin ciki
• suna nono

Hadin magunguna

Koyaushe gaya wa likitanka game da duk ƙwayoyi, ganye, da bitamin da kuke sha. Prilosec da Nexium na iya hulɗa tare da wasu magunguna da zaku iya sha.

Hukumar Abinci da Magunguna ta Amurka (FDA) ta ba da gargaɗi cewa magani a cikin Prilosec yana rage tasirin kwayar cutar clopidogrel (Plavix).

Kada ku ɗauki magungunan biyu tare. Sauran PPIs ba a haɗa su cikin gargaɗin ba saboda ba a gwada su don wannan aikin ba.

Bai kamata a sha waɗannan kwayoyi tare da Nexium ko Prilosec ba:

• clopidogrel
• delavirdine
• nelfinavir
• rifampin
• rilpivirine
• sarkakum
• St John's wort

Sauran kwayoyi na iya ma'amala da Nexium ko Prilosec, amma har yanzu ana iya sha tare da kowane magani. Faɗa wa likitanka idan ka ɗauki ɗayan waɗannan magungunan don su iya tantance haɗarinka:

• amphetamine
• aripiprazole
• atazanavir
• bisphosphonates
• bosentan
• carvedilol
• cilostazol
• citalopram
• clozapine
• cyclosporine
• dextroamfetamine
• escitalopram
• antifungal magunguna
• fosphenytoin
• baƙin ƙarfe
• hydrocodone
• mesalamini
• methotrexate
• methylphenidate
• phenytoin
• karafarini
• saquinavir
• tacrolimus
• warfarin ko wasu masu adawa da bitamin K
• voriconazole

Takeaway

Gabaɗaya, zaku iya zaɓar PPI wanda ake samun sa da ƙima. Amma ka tuna cewa PPIs suna magance alamun GERD da sauran rikice-rikice ne kawai. Ba su magance dalilin kuma ana nuna su ne kawai don amfani da gajeren lokaci sai dai idan likitanku ya ƙayyade in ba haka ba.

Canje-canjen salon zama sune matakanku na farko wajen sarrafa GERD da ƙwannafi. Kuna so ku gwada:

• kula da nauyi
• guje wa cin abinci tun kafin bacci
• daina ko barin shan taba, idan kuna amfani dashi

Bayan lokaci, GERD na dogon lokaci na iya haifar da cutar kansa. Kodayake mutane kalilan da ke da cutar GERD suna kamuwa da cutar kansa, amma yana da muhimmanci a san haɗarin.

PPIs suna tasiri a hankali, don haka ƙila ba su da amsar ciwon zuciya lokaci-lokaci ko narkewa.

Sauran za su iya ba da taimako don amfani lokaci-lokaci, kamar:

• chewable alli carbonate Allunan
• ruwa kamar aluminum hydroxide da magnesium hydroxide (Maalox) ko aluminium / magnesium / simethicone (Mylanta)
• magunguna masu rage acid kamar famotidine (Pepcid) ko cimetidine (Tagamet)

Duk waɗannan ana samun su azaman magungunan OTC.