Stevia
Mawallafi:
Joan Hall
Ranar Halitta:
5 Fabrairu 2021
Sabuntawa:
23 Nuwamba 2024
Wadatacce
Stevia (Stevia rebaudiana) itaciya ce mai shuke shuke wacce ta fito daga arewa maso gabashin Paraguay, Brazil da Argentina. Yanzu ana shuka shi a wasu sassan duniya, gami da Kanada da wani yanki na Asiya da Turai. Tabbas tabbas anfi saninsa da tushen tushen kayan zaki na halitta.Wasu mutane suna ɗaukar stevia ta bakin don yanayi kamar hawan jini, ciwon sukari, ƙwannafi, da sauransu, amma babu kyakkyawar shaidar kimiyya don tallafawa waɗannan amfani.
Ana samo ruwa daga ganyen stevia azaman kayan zaki a ƙasashe da yawa. A Amurka, ba a yarda da ganyen stevia da ruwan 'ya'ya don amfani da shi a matsayin mai zaki ba, amma ana iya amfani da su azaman "karin abincin" ko kuma a kayayyakin kula da fata. A watan Disambar 2008, Hukumar Abinci da Magunguna ta Amurka (FDA) ta ba da cikakkiyar matsayin da aka Gane a matsayin Safe (GRAS) matsayin rebaudioside A, ɗayan sinadarai a cikin stevia, don amfani da shi azaman ɗanɗano mai daɗin abinci.
Magunguna na Compwararren Bayanan Bayanai ƙimar tasiri bisa ga shaidar kimiyya bisa ga mizani mai zuwa: Inganci, Mai yuwuwa Mai Yiwuwa, Yiwuwar Tasiri, Yiwuwar Mara Inganci, Mai yiwuwa Mara Inganci, Mara Inganci, da suarancin Shaida don Rate.
Effectivenessimar tasiri don STEVIA sune kamar haka:
Evidencearancin shaida don kimanta inganci don ...
- Ciwon suga. Wasu bincike na farko sun nuna cewa shan kwaya 1000 a kullun ganyen stevia na iya rage yawan sikarin cikin jini bayan cin wani adadi kaɗan na mutanen da ke da ciwon sukari na 2. Amma wasu bincike sun nuna cewa shan mg 250 na stevioside, wani sinadari da ake samu a cikin stevia, sau uku a kowace rana baya rage suga a cikin jini bayan wata uku na jinya.
- Hawan jini. Ba a san yadda stevia zai iya shafar hawan jini ba. Wasu bincike sun nuna cewa shan 750-1500 MG na stevioside, sinadarin sinadarai a cikin stevia, a kullum yana rage karfin hawan jini (lamba ta sama a cikin karatun hawan jini) da 10-14 mmHg da diastolic karfin jini (ƙananan lamba) da 6- 14 mmHg. Duk da haka, wasu bincike sun nuna cewa shan stevioside baya rage hawan jini.
- Matsalar zuciya.
- Bwannafi.
- Rage nauyi.
- Rike ruwa.
- Sauran yanayi.
Stevia tsire-tsire ne wanda ya ƙunshi kayan zaki na ƙasa waɗanda ake amfani da su a cikin abinci. Masu binciken sun kuma kimanta tasirin sunadarai a cikin stevia akan hawan jini da matakan suga. Koyaya, sakamakon bincike an gauraya.
Lokacin shan ta bakin: Stevia da sunadarai da ke cikin stevia, gami da stevioside da rebaudioside A, sune LAFIYA LAFIYA lokacin shan shi a baki a matsayin mai zaki a abinci. Rebaudioside A an san shi gabaɗaya matsayin amintacce (GRAS) a cikin Amurka don amfani azaman ɗan zaki don abinci. An yi amfani da Stevioside cikin aminci a cikin bincike na kusan har zuwa 1500 MG kowace rana don shekaru 2. Wasu mutanen da ke shan stevia ko stevioside na iya fuskantar kumburi ko tashin zuciya. Sauran mutane sun ba da rahoton jin jiri, raunin jijiyoyi, da kuma suma.
Wasu mutanen da ke shan stevia ko stevioside na iya fuskantar kumburi ko tashin zuciya. Sauran mutane sun ba da rahoton jin jiri, raunin jijiyoyi, da kuma suma.
Kariya & Gargaɗi na Musamman:
Ciki da shan nono: Babu isasshen bayani tabbatacce don sanin ko yana da lafiya a sha stevia lokacin da ake ciki ko ciyar da nono. Kasance a gefen aminci ka guji amfani.Allergy ga ragweed da alaƙa da shuke-shuke: Stevia yana cikin dangin Asteraceae / Compositae. Wannan dangin sun hada da ragweed, chrysanthemums, marigolds, daisies, da sauran tsire-tsire masu yawa. A ka'idar, mutanen da ke kula da ragweed da tsire-tsire masu alaƙa na iya zama masu damuwa da stevia.
Ciwon suga: Wasu bincike masu tasowa sun nuna cewa wasu sinadarai da ke cikin stevia na iya rage matakan sukarin jini kuma zai iya kawo cikas ga sarrafa suga. Koyaya, sauran bincike basu yarda ba. Idan kana da ciwon suga kuma ka sha stevia ko wani irin kayan zaki da ke ciki, ka kula da yadda jinin ka yake sosai sannan ka sanar da mai binciken lafiyar ka.
Pressureananan hawan jini: Akwai wasu shaidu, kodayake ba tabbatattu ba ne, cewa wasu sinadarai a cikin stevia na iya rage hawan jini. Akwai damuwa cewa waɗannan sunadarai na iya haifar da hawan jini ya ragu sosai a cikin mutanen da ke da ƙananan hawan jini. Samu shawarwarin maikatan lafiya kafin shan stevia ko kayan zaki da ke ciki, idan kana da karancin hawan jini.
- Matsakaici
- Yi hankali da wannan haɗin.
- Lithium
- Stevia na iya yin tasiri kamar kwayar ruwa ko "diuretic." Shan stevia na iya ragewa yadda jiki ke kawar da lithium. A ka'ida, wannan na iya kara yawan lithium din da ke cikin jiki kuma yana haifar da sakamako mai illa. Yi magana da mai baka sabis kafin amfani da wannan samfurin idan kana shan lithium. Yawan ku na lithium na iya buƙatar canzawa.
- Orananan
- Yi hankali da wannan haɗin.
- Magunguna don ciwon sukari (Magungunan cututtukan siga)
- Wasu bincike sun nuna cewa stevia na iya rage yawan suga a cikin mutane masu dauke da ciwon sukari na 2. A ka'idar, stevia na iya haifar da hulɗa tare da magungunan ciwon sikari wanda ke haifar da matakan sukarin jini da ƙasa sosai; duk da haka, ba duk bincike bane ya gano cewa stevia yana rage sukarin jini. Saboda haka, ba a bayyana ba idan wannan damar hulɗar ta kasance babban damuwa. Har sai an san da yawa, kula da sikarin jinin ku sosai idan kun sha stevia. Za a iya canza yawan adadin magungunan cutar sikari.
Wasu magunguna da ake amfani da su don ciwon sukari sun haɗa da glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (sauran) . - Magunguna don hawan jini (Magungunan antihypertensive)
- Wasu bincike sun nuna cewa stevia na iya rage hawan jini.A ka'ida, shan stevia tare da magungunan da ake amfani da su don rage hawan jini zai iya haifar da hawan jininka yayi kasa sosai. Duk da haka, wasu bincike sun nuna cewa stevia baya shafar jini. Sabili da haka, ba a san idan wannan damar hulɗar ta kasance babban damuwa ba.
Wasu magunguna don hawan jini sun haɗa da captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), da sauransu da yawa .
- Ganye da kari waɗanda zasu iya rage hawan jini
- Stevia na iya rage hawan jini. Amfani da shi tare da sauran ganyayyaki da kari waɗanda ke da wannan tasirin na iya ƙara haɗarin saukar da hawan jini sosai a cikin wasu mutane. Wasu daga cikin wadannan kayayyakin sun hada da andrographis, casein peptides, cat's claw, coenzyme Q-10, man kifi, L-arginine, lycium, stinging nettle, theanine, da sauransu.
- Ganye da kari waɗanda zasu iya rage sukarin jini
- Stevia na iya rage sukarin jini. Amfani da shi tare da sauran ganyayyaki da kari waɗanda ke da tasiri iri ɗaya na iya haifar da sukarin jini ya ragu sosai a cikin wasu mutane. Wasu daga cikin wadannan kayayyakin sun hada da alpha-lipoic acid, melon meya, chromium, ta shedan, fenugreek, tafarnuwa, guar gum, dokin kirjin iri, Panax ginseng, psyllium, Siberian ginseng, da sauransu.
- Babu sanannun hulɗa da abinci.
Azucacaa, Caa-He-É, Ca-A-Jhei, Ca-A-Yupi, Capim Doce, Chanvre d'Eau, Eira-Caa, Erva Doce, Estevia, Eupatorium rebaudianum, Green Stevia, Kaa Jhee, Mustelia eupatoria, Paraguayan Stevioside, Plante Sucrée, Reb A, Rebaudioside A, Rébaudioside A, Rebiana, Stévia, Stevia eupatoria, Stevia Plant, Stevia purpurea, Stevia rebaudiana, Stevioside, Sweet Herb na Paraguay, Sweet Herb, Leaf Sweet of Paraguay, Sweetleaf, Yerba Dulce.
Don ƙarin koyo game da yadda aka rubuta wannan labarin, da fatan za a duba Magunguna na Compwararren Bayanan Bayanai hanya.
- Stamataki NS, Scott C, Elliott R, McKie S, Bosscher D, McLaughlin JT. Amfani da Abincin Stevia kafin Abincin Rage Rage Cutar da Energyarfin Energyarfin makamashi ba tare da Shafar Glycemia ko Nuna Biiyayya ga Bayanai game da Abinci: -aramar Rarraba Doublearfin ido Biyu a cikin Manyan Lafiya. J Nutr. 2020; 150: 1126-1134. Duba m.
- Farhat G, Berset V, Moore L. Sakamakon Stevia Cire akan Amsar Glucose Postprandial, Satiety da Energy Intake: Gwajin roseta Uku. Kayan abinci. 2019; 11: 3036. Duba m.
- Ajami M, Seyfi M, Abdollah Pouri Hosseini F, et al. Hanyoyin stevia akan glycemic da lipid profile na nau'in 2 masu ciwon sukari: Gwajin gwajin da bazuwar. Avicenna J Daidaitawa. 2020; 10: 118-127. Duba m.
- Lemus-Mondaca R, Vega-Galvez A, Zura-Bravo L, Ah-Hen K. Stevia rebaudiana Bertoni, tushen asalin mai ɗanɗano mai ɗanɗano na yau da kullun: comprehensivearin nazari kan abubuwan da ke tattare da biochemical, sinadirai da yanayin aiki. Abincin Abinci. 2012; 132: 1121-1132.
- Taware, A. S., Mukadam, D. S., da Chavan, A. M. Ayyukan Antimicrobial na Extaramar Ruwa na Callus da Tungiyoyin ultungiyoyin Al'adu na Stevia Rebaudiana (Bertoni). Jaridar Nazarin Kimiyyar Kimiyya ta 2010; 6: 883-887.
- Yadav, A. Wani bita kan cigaban stevia [Stevia rebaudiana (Bertoni). Jaridar Kanada ta Kimiyyar Shuka 2011; 91: 1-27.
- Klongpanichpak, S., Temcharoen, P., Toskulkao, C., Apibal, S., da Glinsukon, T. Rashin mutagenicity na stevioside da steviol a Salmonella typhimurium TA 98 da TA 100. J Med Assoc Thai. 1997; 80 Gudanar da 1: S121-S128. Duba m.
- D'Agostino, M., De Simone, F., Pizza, C., da Aquino, R. [Sterols a Stevia rebaudiana Bertoni]. Boll.Soc Ital Itace Biol Sper. 12-30-1984; 60: 2237-2240. Duba m.
- Kinghorn, A. D., Soejarto, D. D., Nanayakkara, N. P., Compadre, C. M., Makapugay, H. C., Hovanec-Brown, J. M., Medon, P. J., da Kamath, S. K A tsarin aikin phytochemical don jin daɗin shigar kaurene glycosides a cikin jinsi Stevia. J Nat Prod. 1984; 47: 439-444. Duba m.
- Chaturvedula, V. S. da Prakash, I. Tsarin gine-ginen littafin diterpene glycosides daga Stevia rebaudiana. Carbohydr.Res 6-1-2011; 346: 1057-1060. Duba m.
- Chaturvedula, V. S., Rhea, J., Milanowski, D., Mocek, U., da Prakash, I. minor ƙananan ƙananan glycosides guda biyu daga ganyen Stevia rebaudiana. Nat Gudanar da 2011ungiyoyin 2011; 6: 175-178. Duba m.
- Li, J., Jiang, H., da Shi, R. Wani sabon acylated quercetin glycoside daga ganyen Stevia rebaudiana Bertoni. Tsarin Gudanar da Lafiya 2009; 23: 1378-1383. Duba m.
- Yang, P. S., Lee, J. J., Tsao, C. W., Wu, H. T., da Cheng, J. T. Tasirin motsa jiki na stevioside akan masu karɓar opioid na cikin dabbobi. Neurosci. Leet 4-17-2009; 454: 72-75. Duba m.
- Takasaki, M., Konoshima, T., Kozuka, M., Tokuda, H., Takayasu, J., Nishino, H., Miyakoshi, M., Mizutani, K., da Lee, K. H. Masu maganin rigakafin cutar kansa. Sashe na 8: Hanyoyin kariya daga stevioside da mahadi masu alaƙa. Bioorg.Med.Chem. 1-15-2009; 17: 600-605. Duba m.
- Yodyingyuad, V. da Bunyawong, S. Sakamakon stevioside akan girma da haifuwa. Hum.Rage. 1991; 6: 158-165. Duba m.
- Geuns, J. M., Buyse, J., Vankeirsbilck, A., da Temme, E. H. Metabolism na stevioside ta hanyar batutuwa masu lafiya. Exp Biol Med (Maywood.) 2007; 232: 164-173. Duba m.
- Boonkaewwan, C., Toskulkao, C., da Vongsakul, M. Ayyukan Anti-Inflammatory da Immunomodulatory na Stevioside da Metabolite Steviol akan Kwayoyin THP-1. J Agric. Abincin Chem 2-8-2006; 54: 785-789. Duba m.
- Chen, T. H., Chen, S. C., Chan, P., Chu, Y. L., Yang, H. Y., da Cheng, J. T. Mechanism na hypoglycemic sakamako na stevioside, glycoside na Stevia rebaudiana. Planta Med 2005; 71: 108-113. Duba m.
- Abudula, R., Jeppesen, P. B., Rolfsen, S. E., Xiao, J., da Hermansen, K. Rebaudioside Mai yuwuwa yana motsa kwayar insulin daga tsibirin berayen da aka ware: nazari kan yawan-, glucose-, da kuma dogaro da alli. Tsarin 2004; 53: 1378-1381. Duba m.
- Gardana, C., Simonetti, P., Canzi, E., Zanchi, R., da Pietta, P. Metabolism na stevioside da rebaudioside A daga Stevia rebaudiana abubuwan da aka samo daga microflora na mutum. J.Agric. Abincin Chem. 10-22-2003; 51: 6618-6622. Duba m.
- Jeppesen, PB, Gregersen, S., Rolfsen, SE, Jepsen, M., Colombo, M., Agger, A., Xiao, J., Kruhoffer, M., Orntoft, T., da Hermansen, K. Antihyperglycemic da rage tasirin hawan jini na stevioside a cikin beran Goto-Kakizaki mai ciwon sukari. Tsarin rayuwa 2003; 52: 372-378. Duba m.
- Koyama, E., Kitazawa, K., Ohori, Y., Izawa, O., Kakegawa, K., Fujino, A., da Ui, M. In vitro metabolism na glycosidic sweeteners, stevia cakuda da enzymatically gyara stevia a cikin microflora na hanji mutum. Abincin Abinci.Toxicol. 2003; 41: 359-374. Duba m.
- Yasukawa, K., Kitanaka, S., da Seo, S. Sakamakon hanawa na stevioside kan ci gaban tumo ta hanyar 12-O-tetradecanoylphorbol-13-acetate a cikin matakai biyu na cutar sankara a cikin fatar linzamin kwamfuta. Biol Pharm Bull. 2002; 25: 1488-1490. Duba m.
- Jeppesen, P. B., Gregersen, S., Alstrup, K. K., da Hermansen, K. Stevioside yana haifar da antihyperglycaemic, insulinotropic da glucagonostatic effects a cikin vivo: karatu a cikin berayen Goto-Kakizaki (GK). Maganin Phytomedicine 2002; 9: 9-14. Duba m.
- Lee, C. N., Wong, K. L., Liu, J. C., Chen, Y. J., Cheng, J. T., da Chan, P. Rashin tasirin maganin stevioside akan kwararar alli don samar da hauhawar jini. Planta Med 2001; 67: 796-799. Duba m.
- Aritajat, S., Kaweewat, K., Manosroi, J., da Manosroi, A. Babban gwajin kisa a cikin berayen da aka bi da su da wasu tsire-tsire. Tasashen Kudu maso gabashin Asiya J Trop. Kiwon Lafiyar Jama'a na 2000; 31 Gudanar da 1: 171-173. Duba m.
- Ferri LA, Alves-Do-Prado W, Yamada SS, et al. Bincike game da tasirin kwayar cutar cikin iska a cikin marasa lafiya da ke fama da hauhawar jini. Phytother Res 2006; 20: 732-6. Duba m.
- Barriocanal LA, Palacios M, Benitez G, et al. Rashin tasirin ilimin pharmacological na steviol glycosides da aka yi amfani dashi azaman zaki a cikin mutane. Nazarin jirgin sama na sake bayyanawa a wasu daidaitattun mutane da masu karfin zuciya kuma a cikin Nau'in 1 da Rubuta masu ciwon sukari na 2. Regul Toxicol Pharmacol 2008; 51: 37-41. Duba m.
- Boonkaewwan C, Ao M, Toskulkao C, Rao MC. Ayyuka na musamman na sirri da na sirri na stevioside da steviol a cikin ƙwayoyin hanji. J aikin abinci Chem 2008; 56: 3777-84. Duba m.
- Prakash I, Dubois GE, Clos JF, et al. Ci gaban rebiana, na halitta, wanda ba caloric mai zaki. Abincin Chem Toxicol 2008; 46 Gudanar da 7: S75-82. Duba m.
- Maki KC, Curry LL, Carakostas MC, et al. Hanyoyin hemodynamic na rebaudioside A cikin manya masu lafiya tare da hawan jini na yau da kullun. Abincin Chem Toxicol 2008; 46 Gudanar da 7: S40-6. Duba m.
- Brusick DJ. Bincike mai mahimmanci game da cututtukan kwayar halitta na steviol da steviol glycosides. Abincin Chem Toxicol 2008; 46 Gudanar da 7: S83-91. Duba m.
- CFSAN / Ofishin Kariyar Abincin Abinci. Harafin Amincewa da Hukumar: Sanarwa ta GRAS A'a. 000252. Gudanar da Abinci da Magunguna na Amurka, Disamba 17, 2008. Akwai a: http://www.cfsan.fda.gov/~rdb/opa-g252.html.
- CFSAN / Ofishin Kariyar Abincin Abinci. An Karɓi sanarwar GRAS a cikin 2008. GRN No. 252. U.S. Food and Drug Administration, Disamba 2008. Akwai a: http://www.cfsan.fda.gov/~rdb/opa-gn08.html.
- Lailerd N, Saengsirisuwan V, Sloniger JA, et al. Hanyoyin stevioside akan aikin jigilar glucose a cikin ƙwayar insulin mai larura da ƙwanƙwasa ƙwayar ƙwayar insulin. Tsarin 2004; 53: 101-7. Duba m.
- Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic sakamakon stevioside a cikin nau'in 2 masu ciwon sukari. Tsarin 2004; 53: 73-6. Duba m.
- Geuns JM. Stevioside. Magungunan 2003; 64: 913-21. Duba m.
- Chan P, Tomlinson B, Chen YJ, et al. Nazarin binciken wuri mai makafi biyu na tasiri da juriya na stevioside na baka a cikin hawan jini na mutum. Br J Clin Pharmacol 2000; 50: 215-20. Duba m.
- Hsieh MH, Chan P, Sue YM, et al. Inganci da jurewar maganin baka a cikin marasa lafiya tare da hauhawar hawan jini mai mahimmanci: shekaru biyu, bazuwar, nazarin-wuribo. Clin Ther 2003; 25: 2797-808. Duba m.
- FDA. Ofishin Kula da Ayyuka. Atomatik tsare na stevia ganye, tsantsa daga stevia ganye, da abinci dauke da stevia. http://www.fda.gov/ora/fiars/ora_import_ia4506.html (An shiga 21 Afrilu 2004).
- Morimoto T, Kotegawa T, Tsutsumi K, et al. Tasirin St. John's wort a kan magunguna na theophylline a cikin masu sa kai na lafiya. J Jarin Pharmacol 2004; 44: 95-101. Duba m.
- Wasuntarawat C, Temcharoen P, Toskulkao C, et al. Rashin ci gaban ci gaban steviol, mai narkewa daga stevioside, a cikin hamster. Magungunan Chem Toxicol 1998; 21: 207-22. Duba m.
- Toskulkao C, Sutheerawatananon M, Wanichanon C, et al. Hanyoyin stevioside da steviol akan shanyewar hanta cikin hanzari. J Nutr Sci Vitaminol (Tokyo) 1995; 41: 105-13. Duba m.
- Melis MS. Hanyoyin ci gaba na yau da kullun na Stevia rebaudiana akan haihuwa a cikin berayen. J Ethnopharmacol 1999; 67: 157-61. Duba m.
- Jeppesen PB, Gregersen S, Poulsen CR, Hermansen K. Stevioside suna aiki kai tsaye a kan ƙwayoyin beta na pancreatic don ɓoye insulin: ayyuka masu zaman kansu na aikin adenosine monophosphate na cyclic da adenosine triphosphate-mai saurin K + -karkon aiki. Tsarin 2000; 49: 208-14. Duba m.
- Melis MS, Sainati AR. Hanyoyin alli da verapamil akan aikin koda na berayen yayin magani tare da stevioside. J Ethnopharmacol 1991; 33: 257-622. Duba m.
- Hubler MO, Bracht A, Kelmer-Bracht AM. Tasirin stevioside akan matakan glycogen hanta a cikin berayen azumi. Res Commun Chem Pathol Pharmacol 1994; 84: 111-8. Duba m.
- Pezzuto JM, Compadre CM, Swanson SM, et al. Ana amfani da sinadarin motsa jiki wanda yake aiki, wanda shine aglycone na stevioside, mutagenic ne. Kamfanin Natl Acad Sci Amurka 1985; 82: 2478-82. Duba m.
- Matsui M, Matsui K, Kawasaki Y, et al. Bincike game da kwayar halittar stevioside da steviol ta amfani da shida in vitro kuma daya a cikin vivo mutagenicity assays. Mutagenesis 1996; 11: 573-9. Duba m.
- Melis MS. Tsarin mulki na yau da kullun na Stevia rebaudiana a cikin berayen: tasirin koda. J Ethnopharmacol 1995; 47: 129-34. Duba m.
- Melis MS. Extractarancin ɗanyen Stevia rebaudiana yana ƙaruwa da kwararar ƙwayar plasma na beraye na yau da kullun da hawan jini. Braz J Med Biol Res 1996; 29: 669-75. Duba m.
- Chan P, Xu DY, Liu JC, et al. Sakamakon stevioside akan hawan jini da plasma catecholamines a cikin berayen masu saurin hauhawar jini. Rayuwa Sci 1998; 63: 1679-84. Duba m.
- Curi R, Alvarez M, Bazotte RB, et al. Sakamakon Stevia rebaudiana akan haƙuri glukus a cikin mutane manya. Braz J Med Biol Sakamakon 1986; 19: 771-4. Duba m.
- Tomita T, Sato N, Arai T, et al. Ayyukan kwayar cuta na ruwan ɗumi mai ɗaci daga Stevia rebaudiana Bertoni zuwa enterohemorrhagic Escherichia coli O157: H7 da sauran ƙwayoyin cuta masu ɗauke da abinci. Microbiol Immunol 1997; 41: 1005-9. Duba m.